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Cyclodextrin-included florfenicol quick-release water-soluble powder preparation and preparation method thereof

A technology of water-soluble powder and florfenicol, which is applied in powder transportation, medical preparations of non-active ingredients, pharmaceutical formulas, etc., can solve the problems of affecting drug efficacy, single dosage form, and low technical content, so as to improve water solubility , good solubility and high bioavailability

Inactive Publication Date: 2011-08-24
GUANGDONG YANGBLE BIOPHARMLS
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  • Abstract
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Problems solved by technology

[0007] At present, veterinary preparations have the characteristics of single dosage form and low technical content
Oral administration of some insoluble drugs such as florfenicol, tilmicosin, tylosin, diclazuril, etc. can only be administered in mixed feeding, which will have a great impact on poultry and livestock when their appetite is lost. the efficacy of the drug

Method used

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  • Cyclodextrin-included florfenicol quick-release water-soluble powder preparation and preparation method thereof
  • Cyclodextrin-included florfenicol quick-release water-soluble powder preparation and preparation method thereof
  • Cyclodextrin-included florfenicol quick-release water-soluble powder preparation and preparation method thereof

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Embodiment Construction

[0026] The present invention will be further described below in conjunction with the drawings and embodiments.

[0027] Such as Figure 1 to Figure 3 As shown, an immediate-release water-soluble powder formulation of florfenicol containing cyclodextrin is characterized in that it is made by inclusion of florfenicol, cyclodextrin and water at a uniform speed. The fluorobenzene The mass percentages of Nicol, cyclodextrin and water are determined by orthogonal design and the final ratio is 17:50:140.

[0028] The cyclodextrin may be one of α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin, and β-cyclodextrin is selected in this embodiment.

[0029] A method for preparing the above-mentioned cyclodextrin-containing florfenicol immediate-release water-soluble powder formulation, such as Figure 4 As shown, including the following steps:

[0030] (1) Inclusion reaction: using the saturated aqueous solution method, put the prepared florfenicol, cyclodextrin and water into a stainless steel...

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Abstract

The invention relates to a cyclodextrin-included florfenicol quick-release water-soluble powder preparation and a preparation method thereof. The preparation is prepared by stirring florfenicol, cyclodextrin and water at a uniform speed and including by using an inclusion technology. The preparation can be directly dissolved in water to be taken by livestock, and has the characteristics of high medicine dissolution rate, high dissolubility, high bioavailability, good absorption and the like; and the medicine (florfenicol) is included in a carrier material, the bitterness of the florfenicol can be masked, and the intake or drinking of animals cannot be influenced by the bitterness of the medicine.

Description

Technical field [0001] The invention relates to the technical field of an animal-specific water-soluble florfenicol powder preparation, in particular to a florfenicol quick-release water-soluble powder preparation containing cyclodextrin and a preparation method thereof. Background technique [0002] Florfenicol (florfenicol. Fluormethanin): is a new broad-spectrum antibiotic for chemical synthesis of chloramphenicol in animals. It was developed by Schering-Plough in the United States in the late 1980s and was first listed in Japan in 1990, mainly used in aquaculture. The drug is favored by domestic and foreign veterinary circles due to its wide antibacterial spectrum, safety and efficiency, good absorption, wide distribution in the body and no potential aplastic anemia. [0003] At present, florfenicol has been registered and marketed in more than 20 countries in Asia, Europe and the Americas. It was approved for marketing in my country in 1999 and is mainly used for the preventi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/165A61K47/48A61P31/04A61K47/69
Inventor 杨少林
Owner GUANGDONG YANGBLE BIOPHARMLS
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