22 results about "Fluorobenzene" patented technology

This invention discloses a polysubstituted indole[1,2-a]quinoxaline compound, its preparation method, and its applications. The structural formula of the polysubstituted indole[1,2-a]quinoxaline compound of this invention is or , where R 1 Selected from -H or -F, R 2 The compounds are selected from phenyl, 4-methylphenyl, 4-methoxyphenyl, or 4-fluorophenyl. The polysubstituted indole[1,2-a]quinoxaline compounds of this invention have novel structures and significant antitumor activity, making them suitable for the synthesis of anticancer drugs. Furthermore, their preparation methods offer advantages such as readily available and inexpensive catalysts, broad substrate applicability, good functional group tolerance, simple operation, mild reaction conditions, and high step economy, making them suitable for large-scale industrial production and application.

This invention discloses a synthetic process for an empagliflozin intermediate, belonging to the technical field of pharmaceutical intermediate synthesis. The synthetic process is as follows: 2-chloro-5-bromobenzoic acid is first mixed with dichloromethane and N,N-dimethylformamide, and thionyl chloride is added dropwise to obtain a dichloromethane solution of acyl chloride. Then, it is reacted with fluorobenzene under anhydrous aluminum trichloride catalysis to obtain intermediate EGAB-3. Then, it is dehydrated by azeotropic reaction with potassium hydroxide aqueous solution in toluene, and then refluxed with 3-hydroxytetrahydrofuran under tetrabutylammonium bromide catalysis to obtain intermediate EGAB-7. Then, it is reacted with 1,1,3,3-tetramethyldisiloxane under anhydrous aluminum trichloride and nitrogen protection, dried, and tested to be qualified to obtain empagliflozin intermediate. This process achieves high purity, high yield, and low isomer impurities in the preparation of empagliflozin intermediate.

This invention relates to the field of alkali metal-chlorine secondary battery technology, and discloses an electrolyte additive, an electrolyte, and an alkali metal-chlorine secondary battery. The additive contains components A, B, and C in a mass ratio of 1:0.2-2.0:0.5-3.0; component A is selected from at least one of ethyl viologen dibromide, benzyl viologen diiodide, and 1,4-phenylenediamine hydroiodate; component B is selected from at least one of 3-(4-iodophenyl)-3-(trifluoromethyl)-3H-bisacrylidine, 1-bromo-2-fluorobenzene, and 4-(benzyloxy)-1-bromo-2-fluorobenzene; and component C is selected from at least one of 3-(trifluoromethyl)phenyltrimethylammonium bromide, (3-fluoro-4-iodophenyl)methylamine, and 3-iodobenzylamine. The electrolyte provided by this invention, when applied in an alkali metal-chlorine secondary battery system, exhibits high reversible capacity, cycle stability, and environmental adaptability.

The present application relates to the technical field of chemical synthesis, and particularly relates to a preparation method of 4,4'-difluorobenzophenone and a method for synthesizing polyether ether ketone by two steps of carbon tetrachloride. The preparation method of 4,4'-difluorobenzophenone comprises the following steps: under the condition that trifluoromethanesulfonic acid and N-methyl pyrrolidone exist, CCl4 and fluorobenzene are reacted, and the product is hydrolyzed to obtain 4,4'-difluorobenzophenone. The present application solves the problems of high cost, poor environmental protection and performance that cannot meet market requirements of PEEK by innovating raw material route, catalytic system and process parameters, realizes low-cost, green and high-performance synthesis of PEEK, the purity of the prepared DFBP monomer can reach >=99.99%, and the PEEK molecular weight distribution (PDI<=1.9) can be narrowed, and the method is suitable for industrialized production of PEEK materials used in high-end fields such as aerospace, medical devices and electronic and electrical appliances.

The application discloses a synthesis method of an atorvastatin intermediate. The method comprises the following steps: firstly, using a solidized Brønsted-Lewis acidic ionic liquid as a catalyst, catalyzing a Friedel-Crafts acylation reaction of alpha-chlorobenzene acyl chloride and fluorobenzene, then, under the action of alkali and microwave assistance, performing a condensation reaction of the product and isobutyryl acetanilide, and finally, obtaining the atorvastatin intermediate 2-[2-(4-fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide. The method uses the characteristics of a large specific surface area and rich active sites of graphite-like carbon nitride, simultaneously uses the graphite-like carbon nitride as an ionic liquid solid carrier and as a mother nucleus to participate in the preparation process of the ionic liquid, retains the catalytic activity of the ionic liquid, improves the reaction rate and selectivity through simple separation of the catalyst, and has the advantages of low cost, high yield, easy reaction conditions, and improved application prospect.

This application discloses trisubstituted quinazoline derivatives, their acid addition salts, pharmaceutical compositions thereof, and uses. Specifically, the trisubstituted quinazoline derivatives are (E)-4-(dimethylamino)-N-(4-((4-(4-fluoro-phenoxy)phenyl)amino)-7-ethoxyquinazoline-6-yl)but-2-enamides. This application also discloses (E)-4-(dimethylamino)-N-(4-((4-(4-fluoro-phenoxy)phenyl)amino)-7-ethoxyquinazoline-6-yl)but-2-enamide acid addition salts, their solvates or hydrates, or pharmaceutical compositions thereof. The substances disclosed in this application can be used for the prevention, inhibition, or treatment of cancer.

Methods for treating patients with moderate-to-severe asthma comprising administering a therapeutically effective amount of at least one compound chosen from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile (rilzabrutinib) and pharmaceutically acceptable salts thereof are disclosed.

This invention belongs to the field of organic synthesis, specifically relating to a method for preparing 2,6-dichlorofluorobenzene, comprising: phenol and a chlorination reagent. N Chlorosuccinimide undergoes a chlorination reaction in the presence of a Pd catalyst and 1,10-phenanthroline-5,6-dione to produce 2,6-dichlorophenol. 2,6-Dichlorophenol, fluorinating agent NFSI, photocatalyst 4-CzIPN, and an ionic liquid undergo a deoxyfluorination reaction under blue LED irradiation to produce 2,6-dichlorofluorobenzene. This invention offers high product yield and purity, mild reaction conditions, and avoids the use of hazardous raw materials, making it suitable for industrial production.

This invention relates to m-diamid compounds containing imidazo[1,2-a]pyridine groups, their preparation methods, and applications. The compounds use a m-diamid as the parent nucleus, with one end of the nucleus connected to a polyhalogenated benzene ring via an amide bond, and the other end connected to an imidazo[1,2-a]pyridine group via an amide bond. The imidazo[1,2-a]pyridine group is connected to the parent nucleus at its 2- or 7-position, and the imidazo[1,2-a]pyridine group has substituents such as halogen, hydroxyl, alkoxy, alkylthio, methyl, trifluoromethyl, cyano, trifluoromethyl sulfone, or trifluoromethyl sulfoxide. Hydrogen, methyl, ethyl, or cyclopropylmethyl groups can be introduced onto the amide nitrogen linked to the imidazo[1,2-a]pyridine group. This compound exhibits good control effects against insect pests and nematode diseases, demonstrating excellent activity at low doses. It overcomes the resistance problems of bromuconazole and its analogues, reduces pesticide application, and combines high efficiency, safety, and environmental friendliness.

A method for treating patients with moderate to severe asthma is disclosed, comprising administering a therapeutically effective amount of at least one compound selected from (R)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-carbonyl]-4-methyl-4-[4-(oxocyclobutane-3-yl)piperazin-1-yl]pent-2-enonitrile (rizabrutinib) and pharmaceutically acceptable salts thereof.

The invention relates to a lithium-ion electrochemical element comprising: a) a positive electrode comprising a lithium phosphate of at least one transition metal operating at a potential greater than or equal to 3.6 V vs. Li+ / Li; b) a negative electrode; c) an electrolyte comprising: - one or more solvents, one being methyl propionate, - one or more diluents selected from a fluorinated alkyl ether, fluorobenzene, 1,2-difluorobenzene and isomers thereof, 1,2,3-trifluorobenzene and isomers thereof, 1,2,3,4-tetrafluorobenzene and isomers thereof, pentafluorobenzene, hexafluorobenzene, 2-fluorotoluene and isomers thereof and a mixture thereof, the volume proportion of the one or more diluents representing from 50 to 80% of the total volume of the one or more solvents and the one or more diluents, - lithium bis(fluorosulfonyl)imide, - a negative-electrode passivation additive selected from ethylene monofluorocarbonate and / or vinylene carbonate.

This invention relates to the fields of organic chemistry and organic optoelectronic functional materials, specifically to a lithium-ion battery electrolyte additive, its preparation method, and its application. The invention provides a lithium-ion battery electrolyte additive, characterized in that the chemical formula of the additive is as shown in formula (D): wherein R1 and R2 are each independently H, a C1-C4 alkyl group, a fluoroalkane, a benzene ring, or a fluorobenzene ring. The compounds included in the lithium-ion battery electrolyte additive provided by this invention, by introducing electron-donating N atoms, facilitate reduction at the negative electrode and can polymerize on the electrode to form a polymer film. These characteristics allow the additive to form a dense and stable solid electrolyte interface film on the surface of the positive and negative electrode active materials after application to the battery electrolyte, thereby blocking direct contact between the electrolyte and the active materials, avoiding side reactions, and improving the cycle performance of the lithium-ion battery.

The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl) phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.

This invention discloses a method for preparing a diarylcarbazole material, relating to the field of organic light-emitting device technology. The method includes: obtaining intermediate A through a nitration reaction of 4-bromo-2-chloro-1-fluorobenzene; obtaining coupling intermediate B through a Suzuki coupling reaction of intermediate A and 1-naphthoboric acid; preparing intermediate C through a nitro cyclization reaction of intermediate B; coupling intermediate C with iodobenzene or iodobenzene derivative D to form intermediate E; preparing pinacol borate intermediate F using intermediate E; obtaining intermediate H through a Suzuki coupling reaction of intermediate F and o-bromoaniline or o-bromoaniline derivative G; cyclizing intermediate H under alkaline conditions to obtain intermediate I; and coupling intermediate I with a haloaryl derivative J to obtain the diarylcarbazole material. The preparation route provided by this invention has high reaction selectivity, produces a single product, has no obvious reaction defects, and avoids the problems of isomers in cyclization reactions and polybromination in bromination reactions.

This invention discloses a 2-hydroxy-3-pinene-difluoroborane complex-based fluorescent probe for detecting H2S, its preparation method, and its application. The invention uses 2-hydroxy-3-pinene as a raw material and reacts it with 6-hydroxy-2-naphthaldehyde via an aldol condensation reaction to obtain compound DQ; compound DQ undergoes a complexation reaction with boron trifluoride-diethyl ether to obtain compound DQTY; compound DQTY undergoes a substitution reaction with 2,4-dinitrofluorobenzene to obtain the fluorescent probe DQTY-HS. Probe DQTY-HS specifically recognizes H2S. Upon addition of H2S to a DMSO / PBS (1:9, v / v) solution of DQTY-HS, the fluorescence color of the solution changes from colorless to yellow under 365 nm ultraviolet light irradiation, with a response time of 30 s and a detection limit of 50 nM. This probe has many advantages, such as simple synthesis, good selectivity, high sensitivity, good biocompatibility, and low toxicity, and has good application prospects in environmental analysis and food fields.

This disclosure relates to crystalline forms of nitrogen-containing tetracyclic compounds and methods for preparing them. Specifically, this disclosure provides C-type, F-type, G-type, H-type, L-type, M-type, N-type, R-type, and S-type crystals of (S)-4-((S)-10-acryloyl-4-chloro-2-fluoro-14-oxo-8,8a,9,10,11,12-hexahydro-7H,14H-pyrazino[1',2':5,6][1,5]diazosino[3,2,1-hi]indazole-3-yl)-2-amino-7-fluorobenzo[b]thiophene-3-carbonitrile (formula 1), which have good stability and can be used more effectively in clinical treatment. [Formula 1] JPEG2026516635000071.jpg56137

The application discloses a synthesis method of lumerizine and intermediates thereof, and belongs to the technical field of medicine synthesis. The application takes 1-(4-fluorophenyl)-4-(4-piperidone-1-yl) butan-1-one with 2-(methylamino) phenylhydrazine as starting materials, and efficiently prepares medical-grade lumerizine p-toluenesulfonate through four core reactions of Fischer indole condensation, intramolecular double SN2 ring closure, normal-pressure metal-free asymmetric transfer hydrogenation and salt formation and refinement. Three kinds of key intermediates and preparation processes thereof are completely protected, a non-metal normal-pressure catalytic system is used throughout the process, and a noble metal high-pressure hydrogenation process is abandoned, so that metal residues are avoided, chiral selectivity is high, the process is simple, three-waste quantity is small, the problems of low yield, high cost, many impurities and difficulty in industrialization of the existing process are effectively solved, and the application has extremely high industrialization popularization value and patent protection value.

This invention relates to the field of insecticide technology in the agrochemical industry, specifically to a method for synthesizing brofenoxam and an insecticide thereof. The method for synthesizing brofenoxam includes: mixing ethyl 2-fluoro-3-nitrobenzoate, paraformaldehyde, a Pd / C catalyst, an acidic compound, and an ionic liquid under pressure for a reductive hydrogenation methylation reaction. Then, intermediate II undergoes acylation and hydrolysis, and finally, it is mixed with 2-trifluoromethyl-4-perfluoroisopropyl-6-bromoaniline and continuously condensed under ultrasonic irradiation to obtain brofenoxam. This synthesis method uses a one-pot process for reductive methylation and continuously produces the brofenoxam technical material under ultrasonic irradiation, thus achieving energy saving, environmental friendliness, and stable product quality. This synthesis method has mild reaction conditions, short synthesis steps, and can improve the yield of brofenoxam.

This invention discloses a color-changing polyimide ether ketone polymer, its preparation method, and its applications, belonging to the technical field of color-changing material preparation. The preparation method involves: reacting 4,4'-dimethoxydiphenylamine with boron tribromide to synthesize 4,4'-dihydroxydiphenylamine; reacting p-bromobenzoyl chloride, anhydrous aluminum chloride, and fluorobenzene to synthesize 4-bromo-4'-fluorobenzophenone; reacting 4-bromo-4'-fluorobenzophenone, p-phenylenediamine, sodium tert-butoxide, Pd2(dba)3 catalyst, and BINAP under heat to obtain bis(4-fluorophenylbenzophenone)-4,4'-iminodiphenylamine; and reacting 4,4'-dihydroxydiphenylamine, bis(4-fluorophenylbenzophenone)-4,4'-iminodiphenylamine, and anhydrous potassium carbonate under heat to obtain the polyimide ether ketone polymer. This color-changing material exhibits excellent thermal stability, and the synthesis route is simple and easy to operate, effectively solving the problems existing in the prior art.

A mixture for killing pests, comprising, as the active compound, A) an ethyl sulfone compound having formula (I) and B) At least one additional compound B, selected from fipronil, λ-cyhalothrin, bifenthrin, heptafluthrin, α-cyhalothrin, thiamethoxam, thiamethoxam, acetamiprid, imidacloprid, dinotefuran, trifluralin, dithiamethoxam, spinosad, ethyl spinosad, abamectin, bispyribac-methyl, indoxacarb; cyfluthrin, methoxypiperazine ethyl ester, dispirenil, chlorantraniliprole, brofenoxuronamide, tetrazolium acetonitrile, cyclobromhizobium acetonitrile, brofenoxuron dimethoate; pyrimethanil, M.UN.1: 1-[6-(2,2-difluoro-7-methyl-[1,3]m-dioxacyclopenten[4,5-f]benzimidazol-6-yl)-5-ethylsulfonyl-3-pyridyl]cyclopropaneformonium, M.UN.2: 6-(5-cyclopropyl-3-ethylsulfonyl- 2-pyridyl)-2,2-difluoro-7-methyl-[1,3]m-dioxacyclopenten[4,5-f]benzimidazole; and difenoconazole, prothioconazole, fenbendazole, tebuconazole, chlorfluazuron, cymoxanil, fluopyram, tetrazoxystrobin, azoxystrobin, oxadiazon, azoxystrobin, fluopyram, fluopyram, fluopyram, fluopyram, fluopyram, isopropoxystrobin, trifluoropyridamole, fluthiazolinone, flusaprolin, metalaxyl, tetrazoxystrobin, fludioxonil, thiophanate-methyl; these mixtures are used to combat invertebrate pests such as insects, arachnoides or nematodes inside and on the surface of plants, and for the protection of such plants, especially for the protection of plant propagation material such as seeds from pest infestation.

The present invention relates to a method of controlling, limiting or preventing the infestation of plants by Ascomycota plant pathogens, which comprises applying to the plant propagation material a pesticidal combination comprising as active ingredient A a phosphorus-based compound and as active ingredient B a fungicide selected from the group consisting of acibenzolar-S-methyl, fludioxonil, fluazinam, fluindapyr, metconazole, prothioconazole, silthiofam, triticonazole, flutianil, fluorofuram, azoxystrobin, difenoconazole, pyridylcarbamate, ipconazole, tetraconazole, silthiofam, dimethomorph, thiophanate-methyl, natamycin, benzene enofluorocarbostyril, fluazinam, triflupyrrole, high efficiency metalaxyl (metamitron), tetraconazole, isoxazoles, bromofluoride, thiamethoxam, imidacloprid, clothianidin, cyantraniliprole, tioxazofen, flufenoxuron and any mixtures thereof.

The application discloses a method for synthesizing 1,4-di(4-fluorobenzoyl)benzene by using ultrasonic waves, and belongs to the technical field of Friedel-Craft reaction. In the method, trifluoromethanesulfonic acid compounds are used as catalysts, fluorobenzene and terephthaloyl chloride are catalyzed to synthesize 1,4-di(4-fluorobenzoyl)benzene under the action of ultrasonic waves; the trifluoromethanesulfonic acid compounds are selected from any one of Bi(OTf)3, La(OTf)3, Sn(OTf)2 and TfOH. In the method, trifluoromethanesulfonic acid compounds are used as catalysts, the catalysts are separated by filtering and rectifying, and a large amount of acidic waste liquid is avoided; meanwhile, the reaction time is shortened, the reaction yield is improved, and the production cost is reduced by combining with ultrasonic wave intensification.