49 results about "Essential tremor" patented technology

A peripheral nerve stimulator to stimulate a peripheral nerve to treat essential tremor and other movement disorders, as well as overactive bladder, cardiac dysfunction and neurotransmitter dysfunction is provided. The peripheral nerve stimulator can be a noninvasive surface stimulator to provide multi-modal optimized therapy. Stimulation can be vibrational, electromechanical, thermal, radiant, electrical, magnetic, electromagnetic, light, mechanical, chemical, thermal, ultrasonic, radiofrequency (RF), acoustic, infrared, ultraviolet, x-ray, and / or microwave. Stimulation can be delivered using an open loop system and / or a closed loop system with feedback. Stimulation can be to one site or multiple sites.

Described herein, in part, are methods useful for preventing and / or treating a disease or condition relating to aberrant function or activity of a T-type calcium channel, such as psychiatric disorders (e.g., mood disorder (e.g., major depressive disorder)), pain, tremor (e.g., essential tremor), seizures (e.g., absence seizures), epilepsy, or an epilepsy syndrome (e.g., juvenile myoclonic epilepsy). The present invention further comprises methods for modulating the function of a T-type calcium channel and methods of administering a titrated dosage of a T-type calcium channel antagonist.

A peripheral nerve device can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The device may contain an interface separated, partially separated, or connected to a housing, and which may interact with the user. The interface may connect to the housing and be disposable after use for a period of time.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor. Parkinson tremor, and other forms of tremor. For example, a stimulation device can record and transmit data to a cloud-based server in certain aspects.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. In one aspect, the stimulation algorithm is designed to optimize the therapy. The algorithm may be a learning algorithm to tailor the stimulation over time to adjust in real-time to a user's tremor user-defined needs. Stimulation can be delivered using open and / or closed loop systems.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor. Parkinson tremor, and other forms of tremor. Stimulation of nerves using machine learning algorithms are provided in certain aspects.

Described herein, in part, are methods useful for preventing and / or treating a disease or condition relating to aberrant function or activity of a T-type calcium channel, such as Parkinson's disease, psychiatric disorders (e.g., mood disorder (e.g., major depressive disorder)), pain, tremor (e.g., essential tremor), seizures (e.g., absence seizures), epilepsy, or an epilepsy syndrome (e.g., juvenile myoclonic epilepsy). The present invention further comprises methods for modulating the function of a T-type calcium channel and methods of administering a titrated dosage of a T-type calcium channel antagonist.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate at least one of tremor feedback, external data, predictive adaptation, or long-term monitoring data. The device may be configured as a wrist worn device to stimulate three nerves to provide tremor reduction.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulator may be inductively charged in certain aspects. The stimulation device can be configured to be worn on the wrist of a user.

A peripheral nerve stimulator to stimulate a peripheral nerve to treat essential tremor and other movement disorders, as well as overactive bladder, cardiac dysfunction and neurotransmitter dysfunction is provided. The peripheral nerve stimulator can be a noninvasive surface stimulator to provide multi-modal optimized therapy. Stimulation can be vibrational, electromechanical, thermal, radiant, electrical, magnetic, electromagnetic, light, mechanical, chemical, thermal, ultrasonic, radiofrequency (RF), acoustic, infrared, ultraviolet, x-ray, and / or microwave. Stimulation can be delivered using an open loop system and / or a closed loop system with feedback. Stimulation can be to one site or multiple sites.

1. Name of the product in this design: Watch. 2. Purpose of this design: A watch to suppress essential tremor or hand tremor. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulator can have electrodes that are placed circumferentially around the patient's wrist or arm. Specific nerves in the wrist or arm can be targeted by appropriate spacing of the electrodes. Positioning the electrodes on generally opposing sides of the target nerve can result in improved stimulation of the nerve. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate tremor feedback, external data, predictive adaptation, and long-term monitoring data.

Described herein, in part, are single-unit dosage forms, comprising the compound of Formula (I) or a pharmaceutically acceptable salt thereof (e.g., the compound of Formula (II), e.g., PRAX-944 HCl), wherein the composition is bioequivalent to a reference composition of the same dosage strength administered as multiple small, round tablets. The present invention further comprises methods useful for treating a disease or condition relating to aberrant function or activity of a T-type calcium channel, such as tremor (e.g., essential tremor).

To provide dosage forms and compositions useful for preventing and / or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)).SOLUTION: Provided is an oral dosage form comprising: a compound of the following formula or a pharmaceutically acceptable salt thereof; and a modified-release polymer.SELECTED DRAWING: None

Described herein, in part, are single unit dosage forms comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof (e.g., a compound of Formula (II), e.g., PRAX-944 HCl) wherein the composition is bioequivalent to a reference composition of the same dose intensity administered as a plurality of small round tablets. The invention further comprises methods useful for treating diseases or conditions associated with abnormal function or activity of T-type calcium channels, such as tremor (e.g., idiopathic tremor).

The present invention provides a multifunctional telescopic support staff adaptable for diverse indoor and outdoor activities. It significantly improves upon conventional support devices in terms of stability, adjustability, and versatility. The steady staff is particularly beneficial for individuals requiring stable support due to conditions such as essential tremor, facilitating enhanced mobility and steady support for optical devices, and serving as a structural component in temporary shelters.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator. Stimulation can be electrical, mechanical, or chemical. Stimulation can be delivered using either an open loop system or a closed loop system with feedback.

Described herein, in part, are dosage forms and compositions useful for the prevention and / or treatment of diseases or conditions associated with aberrant T-type calcium channel function, such as epilepsy and epileptic syndromes (e.g., absent seizures, teenager myospastic epilepsy or genetic epilepsy), tremor (e.g., epilepsy seizures, spasmodic epilepsy, or hereditary epilepsy), or tremor (e.g., epilepsy seizures). Idiopathic tremor (e.g., idiopathic tremor) and psychiatric disorders (e.g., mood disorders (e.g., severe depressive disorder)). The invention also includes methods for modulating the function of T-type calcium channels.

Described is a low voltage, pulsed electrical stimulation device for controlling expression of growth differentiation factor 10 (“GDF10”), a useful protein, by tissues. Also described are methods of enhancing expression of GDF10 in cells, particularly a method of stimulating the expression and / or release of GDF10 in a cell having a gene encoding GDF10, wherein the method includes applying a bioelectric signal produces, as measured at the level of the target cells or tissues being stimulated 2 mA to 4 mA direct current positive to the cell (e.g., directly, indirectly, or wirelessly). Applications in the treatment of cerebral strokes, brain injuries, paralysis, brain cancer, Alzheimer's disease, dementia, anxiety, Parkinson's disease, and / or essential tremors are also disclosed.

The present invention relates to methods for tuning treatment parameters in movement disorder therapy systems. The present invention further relates to a system for screening patients to determine viability as candidates for certain therapy modalities, such as deep brain stimulation (DBS). The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not limited to, Parkinson's disease and Parkinsonism, Dystonia, Chorea, and Huntington's disease, Ataxia, Tremor and Essential Tremor, Tourette syndrome, stroke, and the like. The present invention yet further relates to methods of tuning a therapy device using objective quantified movement disorder symptom data acquired by a movement disorder diagnostic device to determine the therapy setting or parameters to be provided to the subject via his or her therapy device. The present invention also provides treatment and tuning remotely, allowing for home monitoring of subjects.

Described herein, in part, are dosage forms and compositions useful for preventing and / or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)). The present invention further comprises methods for modulating the function of a T-type calcium channel.

This invention relates to methods and materials for treating mammals having, or at risk of developing, one or more movement disorders (e.g., essential tremor, epilepsy, and / or Parkinson's disease). For example, compositions including one or more T-type calcium channel antagonists (e.g., one or more Cav3 antagonists such as CX-8998) are provided, as well as methods for administering such compositions to a mammal having, or at risk of developing, one or more movement disorders (e.g., essential tremor, epilepsy, and / or Parkinson's disease) to treat the mammal.

A system that amalgamates the domains of deep brain stimulation, wearable and wireless inertial sensor systems, machine learning, and multidisciplinary design optimization to achieve an optimal parameter configuration by automating the acquisition of an optimal parameter configuration for deep brain stimulation for movement disorders, such as essential tremor and Parkinson's disease, in a closed loop context. Wearable inertial sensors provide quantified feedback of movement disorder response to a deep brain stimulation parameter configuration. Using multidisciplinary design optimization, a minimal effective power, which is derived from tremor power and deep brain stimulation power, is acquired constituting an optimal parameter configuration.

Wearable devices can be used to stimulate one or more nerves or proprioceptors to reduce essential tremor, Parkinson tremor, and other forms of tremor. Wearable devices for vibrotactile stimulation of proprioceptors are provided in certain aspects.

Described herein, in part, are dosage forms and compositions useful for the prevention and / or treatment of diseases or conditions associated with aberrant T-type calcium channel function, such as epilepsy and epileptic syndromes (e.g., absent seizures, teenager myospastic epilepsy or genetic epilepsy), tremor (e.g., epilepsy seizures, spasmodic epilepsy, or hereditary epilepsy), or tremor (e.g., epilepsy seizures). Idiopathic tremor (e.g., idiopathic tremor) and psychiatric disorders (e.g., mood disorders (e.g., severe depressive disorder)). The invention also includes methods for modulating the function of T-type calcium channels.

This invention relates to the fields of intelligent agents and computer vision technology, specifically to a method and system for guiding Parkinson's disease hand rehabilitation training based on visual features and intelligent agents. It integrates hand movement videos captured by high frame rate event cameras, physiological sensor data, and prior medical knowledge to construct a closed-loop rehabilitation guidance system centered on a medical intelligent agent. This system utilizes deep neural networks to extract spatiotemporal features of key hand points, combines Euclidean distance error and joint angle error to construct a two-dimensional comprehensive evaluation index, and dynamically adjusts the evaluation weights according to the patient's UPDRS stage. Through a medical intelligent agent based on the Transformer architecture, combined with a multi-objective reinforcement learning strategy, personalized, multimodal rehabilitation feedback instructions are generated. This invention achieves precise quantitative assessment and personalized guidance of hand movements in Parkinson's disease patients, effectively distinguishing between Parkinson's tremor and essential tremor, and significantly improving the accuracy, compliance, and individual adaptability of rehabilitation training.

Described herein, in part, are crystalline and salt forms of N-((1-(2-(tert-butylamino)-2-oxoethyl)piperidin-4-yl)methyl)-3-chloro-5-fluorobenzamide useful for preventing and / or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)).

A system and method for scoring movement disorder symptoms comprises a movement measurement data acquisition system and processing comprising an algorithm trained on standardized scores. The movement measuring apparatus may comprise sensors such as accelerometers or gyroscopes or may utilize motion capture and / or machine vision technology or various other methods to measure tremor, bradykinesia, gait and balance disturbances, dyskinesia, or other movement disorders in a subject afflicted with Parkinson's disease, essential tremor or the like. The system outputs a score having an inclusive 0-4 scale that correlates to the UPDRS and MDS-UPDRS, or to a particular component of the movement disorder such as speed, amplitude or rhythm, but has greater resolution and lower variability. In some embodiments, the system is used to provide recommendations for treatment and / or to provide treatment in the form of pharmaceutical drugs and / or electric stimulus as part of a closed-loop system.

The present disclosure relates to methods of treating essential tremor that comprise administering to a subject in need thereof compound of formula (I):or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I), or a pharmaceutically acceptable salt thereof, is administered to the subject once daily at a dose of about 20 mg to about 60 mg; such that The Essential Tremor Rating Assessment Scale (TETRAS) performance score of said subject is decreased by at least 3 points following administration of the compound of formula (I), or a pharmaceutically acceptable salt thereof, as compared to the TETRAS performance score of said subject prior to the administration of the compound of formula (I), or a pharmaceutically acceptable salt thereof.

The present invention amalgamates the domains of deep brain stimulation, wearable and wireless inertial sensor systems, machine learning, and multidisciplinary design optimization to achieve an optimal parameter configuration. This present invention's respective amalgamation attains a means to automate the acquisition of an optimal parameter configuration for deep brain stimulation for movement disorders, such as essential tremor and Parkinson's disease, in a closed loop context. Wearable inertial sensors provide quantified feedback of movement disorder response to a deep brain stimulation parameter configuration. Using multidisciplinary design optimization, a minimal effective power, which is derived from tremor power and deep brain stimulation power, is acquired constituting an optimal parameter configuration.