27 results about "Essential tremor" patented technology

A peripheral nerve stimulator to stimulate a peripheral nerve to treat essential tremor and other movement disorders, as well as overactive bladder, cardiac dysfunction and neurotransmitter dysfunction is provided. The peripheral nerve stimulator can be a noninvasive surface stimulator to provide multi-modal optimized therapy. Stimulation can be vibrational, electromechanical, thermal, radiant, electrical, magnetic, electromagnetic, light, mechanical, chemical, thermal, ultrasonic, radiofrequency (RF), acoustic, infrared, ultraviolet, x-ray, and / or microwave. Stimulation can be delivered using an open loop system and / or a closed loop system with feedback. Stimulation can be to one site or multiple sites.

1. Name of the product in this design: Watch. 2. Purpose of this design: A watch to suppress essential tremor or hand tremor. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulator can have electrodes that are placed circumferentially around the patient's wrist or arm. Specific nerves in the wrist or arm can be targeted by appropriate spacing of the electrodes. Positioning the electrodes on generally opposing sides of the target nerve can result in improved stimulation of the nerve. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate tremor feedback, external data, predictive adaptation, and long-term monitoring data.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator. Stimulation can be electrical, mechanical, or chemical. Stimulation can be delivered using either an open loop system or a closed loop system with feedback.

Described herein, in part, are dosage forms and compositions useful for the prevention and / or treatment of diseases or conditions associated with aberrant T-type calcium channel function, such as epilepsy and epileptic syndromes (e.g., absent seizures, teenager myospastic epilepsy or genetic epilepsy), tremor (e.g., epilepsy seizures, spasmodic epilepsy, or hereditary epilepsy), or tremor (e.g., epilepsy seizures). Idiopathic tremor (e.g., idiopathic tremor) and psychiatric disorders (e.g., mood disorders (e.g., severe depressive disorder)). The invention also includes methods for modulating the function of T-type calcium channels.

Described is a low voltage, pulsed electrical stimulation device for controlling expression of growth differentiation factor 10 (“GDF10”), a useful protein, by tissues. Also described are methods of enhancing expression of GDF10 in cells, particularly a method of stimulating the expression and / or release of GDF10 in a cell having a gene encoding GDF10, wherein the method includes applying a bioelectric signal produces, as measured at the level of the target cells or tissues being stimulated 2 mA to 4 mA direct current positive to the cell (e.g., directly, indirectly, or wirelessly). Applications in the treatment of cerebral strokes, brain injuries, paralysis, brain cancer, Alzheimer's disease, dementia, anxiety, Parkinson's disease, and / or essential tremors are also disclosed.

Described herein, in part, are dosage forms and compositions useful for preventing and / or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)). The present invention further comprises methods for modulating the function of a T-type calcium channel.

Wearable devices can be used to stimulate one or more nerves or proprioceptors to reduce essential tremor, Parkinson tremor, and other forms of tremor. Wearable devices for vibrotactile stimulation of proprioceptors are provided in certain aspects.

Described herein, in part, are dosage forms and compositions useful for the prevention and / or treatment of diseases or conditions associated with aberrant T-type calcium channel function, such as epilepsy and epileptic syndromes (e.g., absent seizures, teenager myospastic epilepsy or genetic epilepsy), tremor (e.g., epilepsy seizures, spasmodic epilepsy, or hereditary epilepsy), or tremor (e.g., epilepsy seizures). Idiopathic tremor (e.g., idiopathic tremor) and psychiatric disorders (e.g., mood disorders (e.g., severe depressive disorder)). The invention also includes methods for modulating the function of T-type calcium channels.

This invention relates to the fields of intelligent agents and computer vision technology, specifically to a method and system for guiding Parkinson's disease hand rehabilitation training based on visual features and intelligent agents. It integrates hand movement videos captured by high frame rate event cameras, physiological sensor data, and prior medical knowledge to construct a closed-loop rehabilitation guidance system centered on a medical intelligent agent. This system utilizes deep neural networks to extract spatiotemporal features of key hand points, combines Euclidean distance error and joint angle error to construct a two-dimensional comprehensive evaluation index, and dynamically adjusts the evaluation weights according to the patient's UPDRS stage. Through a medical intelligent agent based on the Transformer architecture, combined with a multi-objective reinforcement learning strategy, personalized, multimodal rehabilitation feedback instructions are generated. This invention achieves precise quantitative assessment and personalized guidance of hand movements in Parkinson's disease patients, effectively distinguishing between Parkinson's tremor and essential tremor, and significantly improving the accuracy, compliance, and individual adaptability of rehabilitation training.

Described herein, in part, are crystalline and salt forms of N-((1-(2-(tert-butylamino)-2-oxoethyl)piperidin-4-yl)methyl)-3-chloro-5-fluorobenzamide useful for preventing and / or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)).

The present disclosure relates to methods of treating essential tremor that comprise administering to a subject in need thereof compound of formula (I):or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I), or a pharmaceutically acceptable salt thereof, is administered to the subject once daily at a dose of about 20 mg to about 60 mg; such that The Essential Tremor Rating Assessment Scale (TETRAS) performance score of said subject is decreased by at least 3 points following administration of the compound of formula (I), or a pharmaceutically acceptable salt thereof, as compared to the TETRAS performance score of said subject prior to the administration of the compound of formula (I), or a pharmaceutically acceptable salt thereof.

The present invention amalgamates the domains of deep brain stimulation, wearable and wireless inertial sensor systems, machine learning, and multidisciplinary design optimization to achieve an optimal parameter configuration. This present invention's respective amalgamation attains a means to automate the acquisition of an optimal parameter configuration for deep brain stimulation for movement disorders, such as essential tremor and Parkinson's disease, in a closed loop context. Wearable inertial sensors provide quantified feedback of movement disorder response to a deep brain stimulation parameter configuration. Using multidisciplinary design optimization, a minimal effective power, which is derived from tremor power and deep brain stimulation power, is acquired constituting an optimal parameter configuration.

The present disclosure relates to devices and methods for controlling tremor. A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The peripheral nerve stimulator can be a non-invasive surface stimulator or an implantable stimulator. The stimulation can be electrical, mechanical, or chemical. An open loop system with feedback or a closed loop system can be used to deliver the stimulation.

Described herein, in part, are dosage forms and compositions useful for the prevention and / or treatment of diseases or conditions associated with aberrant T-type calcium channel function, such as epilepsy and epileptic syndromes (e.g., absent seizures, teenager myospastic epilepsy or genetic epilepsy), tremor (e.g., epilepsy seizures, spasmodic epilepsy, or hereditary epilepsy), or tremor (e.g., epilepsy seizures). Idiopathic tremor (e.g., idiopathic tremor) and psychiatric disorders (e.g., mood disorders (e.g., severe depressive disorder)). The invention also includes methods for modulating the function of T-type calcium channels.

Described herein, in part, are dosage forms and compositions useful for preventing and / or treating diseases or disorders associated with aberrant function of T-type calcium channels, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or genetic epilepsy), tremors (e.g., essential tremor), and psychiatric disorders (e.g., mood disorders (e.g., major depressive disorder)). The present invention also includes methods for modulating the function of T-type calcium channels.

The invention provides an anti-noise 3D hand motion estimation method applied to idiopathic tremor assessment, the core of the method is a motion perception hierarchical grouping Mama (Motion-aware Hierarchical Grouping Mama, MHG-Mama) network, and a set of complete hand tremor automatic assessment system is integrally formed. According to the method, firstly, high-degree-of-freedom finger joint movement and stable palm joint movement are separated through feature extraction, and accurate finger posture estimation is achieved; the method comprises the following steps of: firstly, acquiring a skeleton sequence, then combining with a layered space-time scanning mechanism in a selective state space model (SSM) of Mama, capturing global motion features and retaining anatomical constraints, and obtaining a skeleton sequence which is smooth and reasonable in time; and finally, objective indexes are introduced based on the predicted skeleton sequence to quantify motion features, and a classifier is applied to perform accurate objective severity rating. Experiments show that the 3D hand posture estimation precision is remarkably improved, the motion sequence noise is reduced, the evaluation variability of clinicians can be reduced, and the method has very high clinical value.

Described herein, in part, are single-unit dosage forms, comprising the compound of Formula (I) or a pharmaceutically acceptable salt thereof (e.g., the compound of Formula (II), e.g., PRAX-944 HCl), wherein the composition is bioequivalent to a reference composition of the same dosage strength administered as multiple small, round tablets. The present invention further comprises methods useful for treating a disease or condition relating to aberrant function or activity of a T-type calcium channel, such as tremor (e.g., essential tremor).

The invention relates to multi-modal stimulation for treating tremor. A peripheral nerve stimulator is provided that stimulates the peripheral nerve to treat idiopathic tremor and other dyskinesia as well as overactive bladder, cardiac dysfunction, and neurotransmitter dysfunction. The peripheral nerve stimulator may be a non-invasive surface stimulator that provides multi-modal optimized therapy. The stimulation may be vibratory, electromechanical, thermal, radiant, electrical, magnetic, electromagnetic, optical, mechanical, chemical, thermal, ultrasonic, radio frequency (RF), acoustic, infrared, ultraviolet, X-ray, and / or microwave. Stimulation may be delivered using an open loop system and / or a closed loop system with feedback. Stimulation may be for one site or several sites.

The present disclosure relates to a method of treating essential tremor, the method comprising administering to a subject in need thereof a compound of formula (I): JPEG2026507197000027.jpg2578 or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I) or a pharmaceutically acceptable salt thereof is administered to the subject once daily at a dose of about 60 mg to about 100 mg, whereby the subject's Essential Tremor Rating Scale (TETRAS) performance score is reduced after administration of the compound of formula (I) or a pharmaceutically acceptable salt thereof, compared to the subject's TETRAS performance score before administration of the compound of formula (I) or a pharmaceutically acceptable salt thereof.

The present disclosure relates to methods of treating essential tremor that comprise administering to a subject in need thereof compound of formula (I):or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I), or a pharmaceutically acceptable salt thereof, is administered to the subject once daily at a dose of about 60 mg to about 100 mg; such that The Essential Tremor Rating Assessment Scale (TETRAS) performance score of said subject is decreased following administration of the compound of formula (I), or a pharmaceutically acceptable salt thereof, as compared to the TETRAS performance score of said subject prior to the administration of the compound of formula (I), or a pharmaceutically acceptable salt thereof.

Disclosed is a method of using D3 partial agonists for treating or inhibiting the restless leg syndrome, binge eating, essential tremor and neurodegenerative diseases, in particular D3 partial agonists / D2 antagonists.

Described herein, in part, are single-dose dosage forms comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof (e.g., a compound of Formula (II), e.g., PRAX-944 HCl), which compositions are bioequivalent to an identical dose of a reference composition administered as multiple small, round tablets. The invention further includes methods useful for treating diseases or conditions associated with abnormal function or activity of T-type calcium channels, such as tremor (e.g., essential tremor).

The present disclosure relates to methods of treating essential tremor that comprise administering to a subject in need thereof compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the compound of formula (I), or a pharmaceutically acceptable salt thereof, is administered to the subject once daily at a dose of about 60 mg to about 100 mg; such that The Essential Tremor Rating Assessment Scale (TETRAS) performance score of said subject is decreased following administration of the compound of formula (I), or a pharmaceutically acceptable salt thereof, as compared to the TETRAS performance score of said subject prior to the administration of the compound of formula (I), or a pharmaceutically acceptable salt thereof.

A transcutaneous stimulation system can be used to stimulate one or more nerves or proprioceptors to reduce essential tremor, Parkinson tremor, and other forms of tremor. Vibrotactile stimulation of proprioceptors is provided in certain aspects.

Provided herein are methods for treating and / or preventing tremor, as well as diseases and disorders associated with tremor, such as essential tremor.

The present invention relates to a wearable anti-shaking device designed to improve the quality of life of people suffering from Parkinson's disease and essential tremor. The device consists of a smart bracelet that incorporates sensors for detecting tremor, measuring heart rate and estimating blood pressure. The system uses IMU (Inertial Measurement Units) sensors to analyze wrist movements, a PPG (Photoplethysmography) sensor for heart rate and specific algorithms for blood pressure estimation. The device's microcontroller processes the collected data and generates precise electrical impulses applied to the radial and median nerves via electrodes, helping to reduce tremors. The aim is to provide personalized, adaptive treatment, enhancing patients' autonomy and comfort in their daily activities.