A
dual electrode arrangement, is provided, wherein two, preferably unidirectional,
electrode configurations flank a nerve junction from which a preselected nerve
branch issues, proximally and distally to the junction, with respect to the brain. The arrangement is conducive to the following: generating
efferent action-potential propagations, substantially restricted to the preselected nerve
branch, inhibiting
afferent action-potential propagations, from the preselected nerve
branch, selectively generating action-potential propagations, in a subset of nerve fibers of a predetermined
diameter range, substantially restricted to the preselected nerve branch, and selectively inhibiting action-potential propagations, in a subset of nerve fibers of a predetermined
diameter range, substantially restricted to the preselected nerve branch. The
dual electrode arrangement is further conducive to monitoring naturally-occurring,
efferent action-potential propagations, heading towards the preselected nerve branch, and monitoring naturally-occurring,
afferent action-potential propagations, from the preselected nerve branch. The unidirectional
electrode configurations may be monopolar, bipolar, tripolar, or multipolar. Communication with
extracorporeal stations, and
closed loop operations are also provided.