71 results about "Axonal action potential" patented technology

The invention relates to the technical field of medical rehabilitation treatment, and discloses a self-adaptive functional electrical stimulation system based on bimodal feedback and a control method. The system comprises a main control module, a stimulation output module, an electroneurographic signal detection module, a biological impedance test module and a safety isolation module. The main control module comprises a safety current determination unit, a stimulation control unit and a dynamic calibration unit which are respectively used for determining an individualized initial safety current based on neural action potential feedback, controlling treatment stimulation output and dynamically calibrating a safety current upper limit according to biological impedance change before and after stimulation. According to the invention, through bimodal feedback of electroneurographic signals and biological impedance, individualized calibration and real-time dynamic optimization of stimulation parameters are realized, and the problem that the treatment effect and safety are difficult to guarantee due to the fact that traditional functional electrical stimulation depends on experience setting and lacks physiological feedback is solved; and the accuracy, safety and adaptability of rehabilitation treatment are remarkably improved.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a computing device includes a therapy-management application configured to assist a user to: capture a representative evoked compound action potential (ECAP) signal from a patient based; apply one or more filters to the representative ECAP signal to select one or more parameters of the representative ECAP signal; and control electrical stimulation therapy based at least in part on the one or more parameters.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

Devices, systems and methods are provided for treating target tissue with pulsed electric field energy in a manner that does not induce cardiac arrhythmias such as fibrillation of the heart and therefore negates any need for cardiac synchronization of energy delivery. Cardiac synchronization is typically employed to avoid delivering energy during portions of the cardiac cycle that are vulnerable to inducing fibrillation. Thus, herein parameters are manipulated to reduce the probability of inducing an arrhythmia. Typically, high voltage energy can trigger a premature action potential within the cardiac muscle as the delivered energy increases the cardiac muscle cell membrane permeability allowing ion transport, which can induce cardiac arrhythmias, especially ventricular fibrillation. However, both shorter pulse durations (i.e. higher frequencies such as 100-600 kHz) and biphasic waveform shapes theoretically and practically reduce the probability of inducing an arrhythmia.

Disclosed herein are of systems, methods, and computer-program products for determining if a response is an electrically evoked compound action potential (eCAP), refining raw data of an eCAP amplitude growth function (AGF) and utilizing maximum (i.e., steepest) slope from moving linear regression to effectively estimate cochlear nerve function, and determining quality of an electrode-neuron interface (ENI) using a model developed from eCAP attributes.

The present invention addresses the problem of providing a device for simultaneously measuring an electrical signal and a contractile force using a highly mature cardiac muscle tissue having a 3D / oriented structure close to a cardiac muscle structure in a living body. As a solution, provided is a device for measuring the contractility of a cardiac muscle tissue, which is provided with a contractile part that includes a rod-like artificial cardiac muscle tissue that has a three-dimensional structure and in which cardiac muscle cells are oriented in the longitudinal direction, and which is used to measure the contractility of the contractile part.

An apparatus for delivering stimulation energy to a patient is provided. The apparatus comprises an algorithm for determining a stimulation paradigm comprising one or more stimulation parameter settings, and an implantable system comprising an implantable device. The implantable device comprises at least one sensor for measuring evoked compound action potentials (eCAPs), muscle responses, and / or other neural responses, and multiple stimulation elements configured to deliver the stimulation energy to tissue based on the stimulation paradigm. The algorithm is configured to determine the stimulation paradigm based on the measured neural responses. Methods of delivering stimulation energy are also provided.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a system includes a user interface and processing circuitry. The processing circuitry is configured to output, for display by the user interface, a message requesting the patient perform a set of actions, receive, from the user interface, user input indicative of a patient response associated with the set of actions, and determine, based on the user input, one or more adjustments to a control policy which controls electrical stimulation delivered by a medical device based on a plurality of evoked compound action potentials (ECAPs) sensed by the medical device.

The invention provides a method for removing noise signals in a brain-computer interface through a force-electric decoupling method, and the method comprises the steps: collecting signals generated in the brain-computer interface, including electric signals transmitted by nerve fibers, interference electric signals and electric signals caused by force signals of various loads in the brain; electric signals caused by action potential are removed through the force-electricity constitutive relation of the liquid-containing porous material, electric signals caused by force signals of various loads in the brain are decoupled, and electric signals conducted by nerve fibers are reserved. According to the method, noise signals generated due to the electrokinetic effect in the brain-computer interface can be effectively removed, and electric signals conducted by nerve fibers can be accurately obtained.

A computational system and method for digital modeling of cardiac cell membrane electrophysiology is disclosed. The system generates a digital model representing the cell membrane as a dielectric lipid bilayer comprising a capacitor element and a resistor element, where the resistor element is emulated by a plurality of ion channels. The system calculates cell membrane potential based on intracellular and extracellular concentrations of key ions, such as Na+, K+, Ca2+, and Cl-, using the Goldman-Hodgkin-Katz equation. Generation of cellular membrane action potentials is simulated by modeling the opening and closing of voltage-gated ion channels in response to triggering events. The model provides dynamic visualizations of the distinct phases of the action potential, including depolarization and repolarization, offering a high-fidelity tool for research and for enhancing the realism of training simulations in electrophysiology procedures.

A spinal cord machine interface (SCMI) device is described. The SCMI includes an intraspinal probe, composed of at least one implantable shank. The implantable shank include a sensing electrode array and a stimulating electrode array. The SCMI also includes an application specific integrated circuit (ASIC). The ASIC is configured to detect action potentials from a patient's spine using the sensing electrode array and to stimulate a target action of the patent using the stimulating electrode array according to a location of the action potentials in a spinal cord and a learned mapping of the location of the action potentials to the target action.

Compounds having a 3,4,6-substituted benzocyclobuten-1-yl-methylamine structure, pharmaceutical compositions and methods employing use thereof for treating acute or chronic bipolar disorders, neuropsychiatric disorders, neurodegenerative conditions and other health conditions associated with neuronal excitability or dysregulated synaptic neurotransmission. The disclosed compounds selectively and rapidly reduce the frequency of action potentials in cortical pyramidal neurons by modulating presynaptic glutamate release while preserving GABAergic neurotransmission and single action potential properties. Selective modulation of excitatory neurotransmission achieves rapid therapeutic effects within minutes to hours after ingestion without disrupting inhibitory transmission, presenting a therapeutic approach for neurological conditions characterized by neuronal hyperexcitability and other pathological excitatory-inhibitory neurotransmission imbalance.

In some embodiments, a method of providing a neurostimulation therapy to a patient, comprises: generating electrical pulses, by an implantable pulse generator (IPG), comprising respective bursts of a plurality of anodic pulses with each anodic pulse being separated by a time gap, wherein (1) the plurality of anodic pulses comprise successively increasing charge; (2) the plurality of anodic pulses are charge limited to be sub-threshold; (3) each burst of anodic pulses is followed by a discharge phase of intermittent time periods to discharge charge build up from the anodic pulses; and (4) each successive intermittent time period increases in time through the discharge phase to avoid action potential (AP) generation; and applying the generated electrical pulses to neural tissue of the patient to inhibit neural activity of the patient.

Methods and systems for using sensed neural responses for informing aspects of stimulation therapy are disclosed. For example, features of evoked neural responses, such as evoked compound action potentials (ECAPs) can be used for closed-loop feedback control of stimulation parameters. Aspects of the disclosed methods and systems can differentiate between changes in the sensed neural responses that are caused by the environment at stimulating electrodes and changes in the neural responses that are caused by the environment at sensing electrodes. Embodiments determine changes in the morphology of the neural responses, which morphology changes indicate a degree of change in the stimulating environment. Algorithms and systems for assigning and tracking likelihoods for underlying electrode-tissue changes based on sensed neural responses are disclosed. The feedback control modality may be updated based on such likelihoods. Also disclosed are methods and systems for determining which features of evoked neural responses are more sensitive to changes in the stimulating environment and less sensitive to changes in the sensing environment.

Devices, systems, and methods are provided for treating target tissue with pulsed electric field energy in a manner that does not induce arrhythmia, such as tremor of the heart, and thus eliminates any need for cardiac synchronization of energy delivery. Cardiac synchronization is typically used to avoid delivery of energy during portions of the cardiac cycle that are susceptible to effect to induce fibrillation. Thus, parameters are manipulated herein to reduce the probability of inducing an arrhythmia. Typically, high voltage energy may trigger premature action potentials within the myocardium because the delivered energy increases myocardial cell membrane permeability, allowing ion transport, which may induce arrhythmias, especially ventricular fibrillation. However, shorter pulse durations (i.e., higher frequencies, e.g., 100 kHz to 600 kHz) and biphasic waveform shapes both theoretically and practically reduce the probability of inducing an arrhythmia.

The invention provides an efficient enrichment and purification method of adipose-derived stem cell exosomes. According to the invention, the sex determining gene is used for distinguishing and identifying the adipose-derived mesenchymal stem cells from different sources for the first time, and then the culture medium containing specific sex hormone and regulatory factors is used for realizing in-vitro amplification of the adipose-derived mesenchymal stem cells, so that convenience is provided for preparation of the adipose-derived mesenchymal stem cell exosome. According to different sources of adipose-derived stem cell exosomes, different effects of the adipose-derived stem cell exosomes are respectively verified, and the male adipose-derived stem cell exosomes can realize skin injury repair by effectively promoting fibroblast proliferation; the female adipose-derived stem cell exosome can realize nerve injury protection by regulating the nerve conduction velocity and action potential incubation period of an injured part.

Therapy can be determined using evoked compound action potentials (ECAPs). For example, a medical device includes stimulation generation circuitry and processing circuitry. The processing circuitry is configured to determine whether a characteristic of a first ECAP is greater than a threshold ECAP characteristic value. Based on the characteristic of the first ECAP being greater than the threshold ECAP characteristic value, the processing circuitry is configured to decrease a parameter of a first set of pulses delivered by the stimulation generation circuitry after the first ECAP. Additionally, the processing circuitry is configured to determine whether a characteristic of a second ECAP is less than the threshold ECAP characteristic value, and based on the characteristic of the second ECAP being less than the threshold ECAP characteristic value, increase a parameter of a second set of pulses delivered by the stimulation generation circuitry after the second ECAP.

This document discusses, among other things, systems and methods for providing pain relief to a patient. Recording circuitry may receive electrical signals corresponding to evoked compound action potentials in the patient that may be produced in response to external stimulation of a location where the patient is experiencing pain. The received electrical signals may be stored in a memory. Internal stimulation may then be applied to the patient and control circuitry may receive electrical signals corresponding to evoked compound action potentials in the patient that may be produced in response to the internal stimulation. The control circuitry may then adjust electrical parameters of the internal stimulation, such as to reduce a difference between the electrical signals corresponding to evoked compound action potentials produced in response to the internal stimulation and electrical signals corresponding to evoked compound action potentials produced in response to the external stimulation.

The invention discloses a progressive risk prevention and control system and method for an electrical stimulation physiotherapy instrument, and belongs to the technical field of medical equipment. The system integrates a central control unit, and an electrode contact quality detection module, a nerve excitation threshold detection module, an electromagnetic environment interference detection module, a risk grade evaluation module and a strategy generation module which are electrically connected with the central control unit. The system evaluates the risks of electrode poor contact, nerve over-excitation and electromagnetic interference respectively by detecting a micro-current contact impedance dynamic spectrum, a myoelectricity composite action potential incubation period change rate and a stimulation waveform distortion entropy. The system adopts a progressive detection method, divides risks into three levels according to key indexes such as a contact quality index, a latency drift index and waveform distortion entropy, and automatically generates corresponding prevention and control strategies for different risk levels, such as automatic deoxidation pulse, adaptive reduction of stimulation parameters or emergency termination of treatment. Accurate risk identification and dynamic prevention and control in the electrical stimulation physiotherapy process are realized, and the safety is improved.

A pulse generator system that facilitates asynchronous ignition of recruited neurons includes an implantable pulse generator (IPG) that is capable of sensing a degree of synchronous ignition of recruited neurons in tissue of a patient and modifying a stimulation procedure to facilitate asynchronism and reduce sensory abnormalities. An evoked composite action potential (ECAP) of the recruited neurons is sensed by the at least one non-active electrode as a measure of synchronism. An ECAP algorithm operable in the IPG evaluates the shape of the ECAP and determines one or more ECAP shape parameters that indicate whether the recruited neurons are a synchronous fire or a non-synchronous fire. If the shape parameter indicates significant synchronism, the ECAP algorithm may adjust the stimulation procedure to facilitate non-synchronous firing.

Compounds having a 3,4,6-substituted benzocyclobuten-1-yl-methylamine structure, pharmaceutical compositions and methods employing use thereof for treating acute or chronic bipolar disorders, neuropsychiatric disorders, neurodegenerative conditions and other health conditions associated with neuronal excitability or dysregulated synaptic neurotransmission. The disclosed compounds selectively and rapidly reduce the frequency of action potentials in cortical pyramidal neurons by modulating presynaptic glutamate release while preserving GABAergic neurotransmission and single action potential properties. Selective modulation of excitatory neurotransmission achieves rapid therapeutic effects within minutes to hours after ingestion without disrupting inhibitory transmission, presenting a therapeutic approach for neurological conditions characterized by neuronal hyperexcitability and other pathological excitatory-inhibitory neurotransmission imbalance.

Systems, devices, and techniques for analyzing evoked compound action potentials (ECAP)signals to evaluate and select an electrode combination. A method includes controlling, by processing circuitry, deliver of a plurality of stimulation pulses via at least one stimulation electrode combination, receiving, by the processing circuitry, evoked compound action potential (ECAP) signal information representing different ECAP signals evoked from respective stimulation pulses of the plurality of stimulation pulses and obtained from respective different sensing electrode combinations, selecting by the processing circuitry and based on the ECAP signal information, one electrode combination from the different sensing electrode combinations.

The invention discloses an external field generator, a probe based on external field driving and a neural electrode system. Wherein the neural electrode system comprises an external field generator and a probe which are in signal connection; the probe is used for being fixed in a designated brain area and collecting action potentials of neurons in the brain, and the probe is provided with a composite coating containing an external field response material and a conductive material. The external field generator is used for driving the external field response material in the composite coating to drive the conductive material to perform gradient migration along the short axis of the scar so as to form a continuous conductive micro-channel. The external field response conductive material is used between the glial cells to construct the conductive micro-channel, so that the insulated glial scar is converted into the artificial neural pathway, the total impedance of an electrode-tissue interface is reduced by a plurality of orders of magnitude, the fidelity of electroencephalogram signals is remarkably improved, and the service life of the electrode is prolonged.

An implantable device is configured to control application of a neural stimulus as defined by a stimulus parameter; measure via the measurement circuitry a characteristic of a neural compound action potential response evoked by the stimulus; and compute, using the stimulus parameter and the measured characteristic of the evoked neural compound action potential response, a characteristic of an evoked response that would be obtained from the neural stimulus if the patient were in a reference posture. A posture of the patient can be estimated from the computed characteristic and / or the computed characteristic can be used as a feedback variable of a feedback loop. Multidimensional histograms of datasets comprising at least one of the stimulus parameter and a feedback variable can be stored.

This invention relates to the field of electromagnetic field control technology, specifically to a control system for pulsed electromagnetic fields used in the repair of peripheral nerve injuries. The system acquires the action potential voltage amplitude of each spatial node within the coil's coverage area, calculates the pre-stimulation conduction blockage coefficient based on the voltage distribution and time delay correlation of adjacent nodes, identifies blockage nodes, determines the principal normal direction of the blockage region through principal component analysis, and generates a theoretical output current value by combining the coil's projected area in that direction with the blockage coefficient. Subsequently, a low-frequency test pulse is applied, the post-stimulation conduction blockage coefficient is acquired, and a stimulation intensity correction coefficient is calculated. Finally, the corrected actual output intensity is used as the execution parameter for the next round of test pulses, forming a closed-loop adaptive control. This invention overcomes the problem that traditional uniform stimulation parameters cannot match the electrophysiological heterogeneity of nerve injury regions, achieving spatially precise and functionally adaptable electromagnetic control.

The present disclosure relates to systems and methods for analyzing extracellular electrophysiological recordings are disclosed. Extracellular electrophysiological recordings captured by at least one recording device are received, and for each of a plurality of neurons, a waveform feature representing a shape of an extracellular action potential and an interspike-interval feature representing a temporal distribution of intervals between successive action potentials are extracted. One or more conditional variational autoencoders, conditioned on a recording source descriptor associated with the recording device, generate a waveform latent code and a timing latent code from the respective features. The waveform latent code and the timing latent code are fused to produce a multimodal latent embedding for each neuron. One or more analysis operations are performed on the multimodal latent embeddings to generate an analysis result characterizing the plurality of neurons, including batch harmonization to reduce source-dependent variation and classification of neurons into neuronal categories.

The invention discloses a method for up-regulating L-type calcium channels of myocardial cells, and belongs to the technical field of molecular biology. In order to solve the problem that a method for up-regulating the L-type calcium channel of the myocardial cell with high safety and high efficiency is lacked in the prior art, the invention provides a method for up-regulating the L-type calcium channel of the myocardial cell by combining in-vivo intravenous injection or in-vitro direct incubation of a sound-sensitive agent with low-frequency and low-intensity ultrasonic irradiation treatment. According to the method for up-regulating the L-type calcium channel of the myocardial cell, the L-type calcium channel of the myocardial cell can be up-regulated, the percentage and frequency of spontaneous atrial fibrillation of a rabbit with atrial fibrillation can be reduced, the atrial fibrillation induction rate can be reduced, the effective atrial refractory period can be prolonged, the action potential time history of acute separation rabbit atrial muscle cells can be prolonged, and the current density of the L-type calcium channel of the atrial muscle cells can be increased; and mRNA and protein expression of the L-type calcium channel pore forming subunit CACNA1C are increased.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a computing device includes a therapy-management application configured to assist a user to: capture a representative evoked compound action potential (ECAP) signal from a patient based; apply one or more filters to the representative ECAP signal to select one or more parameters of the representative ECAP signal; and control electrical stimulation therapy based at least in part on the one or more parameters.

The embodiment of the invention provides a self-adaptive compression method based on difference filtering neural signal action potential detection and related equipment, and belongs to the technical field of biological signal detection. The method comprises the steps that high-throughput neural signals are obtained, the high-throughput neural signals comprise at least one potential signal, and the potential signals comprise action potentials and local field potentials; performing difference operation detection on the high-throughput neural signal based on high-frequency narrow pulse mutation characteristics to obtain action position information of the action potential in the high-throughput neural signal; and performing event-driven adaptive variable rate compression on the high-throughput neural signal according to the action position information to obtain compressed data. According to the embodiment of the invention, the action potential can be accurately detected, and meanwhile, resource occupation is greatly reduced.

The invention belongs to the technical field of biological medicine, and particularly relates to composite hydrogel for promoting hiPSC-CMs in-situ maturation and a preparation method and application thereof. According to the preparation method disclosed by the invention, a compound liposome modified by quaternary ammonium chitosan and loaded with Torrin 1 is constructed, a unique three-dimensional network structure (PDN) is constructed by compounding different chitosan, and the compound liposome and the PDN are combined to obtain the composite hydrogel for embedding and delivering hiPSC-CMs. Wherein residual amine of the quaternary ammonium chitosan can slowly release drugs in an acidic microenvironment after myocardial infarction, and the cell cycle is inhibited; the PDN structure enhances the retention rate of cell transplantation; the loaded hiPSC-CMs can restore the contraction function, reduce spontaneous depolarization and action potential, reduce the risk of lethal arrhythmia and promote in-situ maturation of transplanted cells. Experiments show that the gel loaded with the hiPSC-CMs can significantly promote myocardial tissue maturation after myocardial infarction, effectively slow down ventricular remodeling and improve heart functions.