37 results about "Axonal action potential" patented technology

The invention relates to the technical field of medical rehabilitation treatment, and discloses a self-adaptive functional electrical stimulation system based on bimodal feedback and a control method. The system comprises a main control module, a stimulation output module, an electroneurographic signal detection module, a biological impedance test module and a safety isolation module. The main control module comprises a safety current determination unit, a stimulation control unit and a dynamic calibration unit which are respectively used for determining an individualized initial safety current based on neural action potential feedback, controlling treatment stimulation output and dynamically calibrating a safety current upper limit according to biological impedance change before and after stimulation. According to the invention, through bimodal feedback of electroneurographic signals and biological impedance, individualized calibration and real-time dynamic optimization of stimulation parameters are realized, and the problem that the treatment effect and safety are difficult to guarantee due to the fact that traditional functional electrical stimulation depends on experience setting and lacks physiological feedback is solved; and the accuracy, safety and adaptability of rehabilitation treatment are remarkably improved.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a computing device includes a therapy-management application configured to assist a user to: capture a representative evoked compound action potential (ECAP) signal from a patient based; apply one or more filters to the representative ECAP signal to select one or more parameters of the representative ECAP signal; and control electrical stimulation therapy based at least in part on the one or more parameters.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

Devices, systems and methods are provided for treating target tissue with pulsed electric field energy in a manner that does not induce cardiac arrhythmias such as fibrillation of the heart and therefore negates any need for cardiac synchronization of energy delivery. Cardiac synchronization is typically employed to avoid delivering energy during portions of the cardiac cycle that are vulnerable to inducing fibrillation. Thus, herein parameters are manipulated to reduce the probability of inducing an arrhythmia. Typically, high voltage energy can trigger a premature action potential within the cardiac muscle as the delivered energy increases the cardiac muscle cell membrane permeability allowing ion transport, which can induce cardiac arrhythmias, especially ventricular fibrillation. However, both shorter pulse durations (i.e. higher frequencies such as 100-600 kHz) and biphasic waveform shapes theoretically and practically reduce the probability of inducing an arrhythmia.

Disclosed herein are of systems, methods, and computer-program products for determining if a response is an electrically evoked compound action potential (eCAP), refining raw data of an eCAP amplitude growth function (AGF) and utilizing maximum (i.e., steepest) slope from moving linear regression to effectively estimate cochlear nerve function, and determining quality of an electrode-neuron interface (ENI) using a model developed from eCAP attributes.

The present invention addresses the problem of providing a device for simultaneously measuring an electrical signal and a contractile force using a highly mature cardiac muscle tissue having a 3D / oriented structure close to a cardiac muscle structure in a living body. As a solution, provided is a device for measuring the contractility of a cardiac muscle tissue, which is provided with a contractile part that includes a rod-like artificial cardiac muscle tissue that has a three-dimensional structure and in which cardiac muscle cells are oriented in the longitudinal direction, and which is used to measure the contractility of the contractile part.

An apparatus for delivering stimulation energy to a patient is provided. The apparatus comprises an algorithm for determining a stimulation paradigm comprising one or more stimulation parameter settings, and an implantable system comprising an implantable device. The implantable device comprises at least one sensor for measuring evoked compound action potentials (eCAPs), muscle responses, and / or other neural responses, and multiple stimulation elements configured to deliver the stimulation energy to tissue based on the stimulation paradigm. The algorithm is configured to determine the stimulation paradigm based on the measured neural responses. Methods of delivering stimulation energy are also provided.

A computational system and method for digital modeling of cardiac cell membrane electrophysiology is disclosed. The system generates a digital model representing the cell membrane as a dielectric lipid bilayer comprising a capacitor element and a resistor element, where the resistor element is emulated by a plurality of ion channels. The system calculates cell membrane potential based on intracellular and extracellular concentrations of key ions, such as Na+, K+, Ca2+, and Cl-, using the Goldman-Hodgkin-Katz equation. Generation of cellular membrane action potentials is simulated by modeling the opening and closing of voltage-gated ion channels in response to triggering events. The model provides dynamic visualizations of the distinct phases of the action potential, including depolarization and repolarization, offering a high-fidelity tool for research and for enhancing the realism of training simulations in electrophysiology procedures.

Methods and systems for using sensed neural responses for informing aspects of stimulation therapy are disclosed. For example, features of evoked neural responses, such as evoked compound action potentials (ECAPs) can be used for closed-loop feedback control of stimulation parameters. Aspects of the disclosed methods and systems can differentiate between changes in the sensed neural responses that are caused by the environment at stimulating electrodes and changes in the neural responses that are caused by the environment at sensing electrodes. Embodiments determine changes in the morphology of the neural responses, which morphology changes indicate a degree of change in the stimulating environment. Algorithms and systems for assigning and tracking likelihoods for underlying electrode-tissue changes based on sensed neural responses are disclosed. The feedback control modality may be updated based on such likelihoods. Also disclosed are methods and systems for determining which features of evoked neural responses are more sensitive to changes in the stimulating environment and less sensitive to changes in the sensing environment.

Therapy can be determined using evoked compound action potentials (ECAPs). For example, a medical device includes stimulation generation circuitry and processing circuitry. The processing circuitry is configured to determine whether a characteristic of a first ECAP is greater than a threshold ECAP characteristic value. Based on the characteristic of the first ECAP being greater than the threshold ECAP characteristic value, the processing circuitry is configured to decrease a parameter of a first set of pulses delivered by the stimulation generation circuitry after the first ECAP. Additionally, the processing circuitry is configured to determine whether a characteristic of a second ECAP is less than the threshold ECAP characteristic value, and based on the characteristic of the second ECAP being less than the threshold ECAP characteristic value, increase a parameter of a second set of pulses delivered by the stimulation generation circuitry after the second ECAP.

The invention discloses a progressive risk prevention and control system and method for an electrical stimulation physiotherapy instrument, and belongs to the technical field of medical equipment. The system integrates a central control unit, and an electrode contact quality detection module, a nerve excitation threshold detection module, an electromagnetic environment interference detection module, a risk grade evaluation module and a strategy generation module which are electrically connected with the central control unit. The system evaluates the risks of electrode poor contact, nerve over-excitation and electromagnetic interference respectively by detecting a micro-current contact impedance dynamic spectrum, a myoelectricity composite action potential incubation period change rate and a stimulation waveform distortion entropy. The system adopts a progressive detection method, divides risks into three levels according to key indexes such as a contact quality index, a latency drift index and waveform distortion entropy, and automatically generates corresponding prevention and control strategies for different risk levels, such as automatic deoxidation pulse, adaptive reduction of stimulation parameters or emergency termination of treatment. Accurate risk identification and dynamic prevention and control in the electrical stimulation physiotherapy process are realized, and the safety is improved.

Systems, devices, and techniques for analyzing evoked compound action potentials (ECAP)signals to evaluate and select an electrode combination. A method includes controlling, by processing circuitry, deliver of a plurality of stimulation pulses via at least one stimulation electrode combination, receiving, by the processing circuitry, evoked compound action potential (ECAP) signal information representing different ECAP signals evoked from respective stimulation pulses of the plurality of stimulation pulses and obtained from respective different sensing electrode combinations, selecting by the processing circuitry and based on the ECAP signal information, one electrode combination from the different sensing electrode combinations.

The invention discloses an external field generator, a probe based on external field driving and a neural electrode system. Wherein the neural electrode system comprises an external field generator and a probe which are in signal connection; the probe is used for being fixed in a designated brain area and collecting action potentials of neurons in the brain, and the probe is provided with a composite coating containing an external field response material and a conductive material. The external field generator is used for driving the external field response material in the composite coating to drive the conductive material to perform gradient migration along the short axis of the scar so as to form a continuous conductive micro-channel. The external field response conductive material is used between the glial cells to construct the conductive micro-channel, so that the insulated glial scar is converted into the artificial neural pathway, the total impedance of an electrode-tissue interface is reduced by a plurality of orders of magnitude, the fidelity of electroencephalogram signals is remarkably improved, and the service life of the electrode is prolonged.

This invention relates to the field of electromagnetic field control technology, specifically to a control system for pulsed electromagnetic fields used in the repair of peripheral nerve injuries. The system acquires the action potential voltage amplitude of each spatial node within the coil's coverage area, calculates the pre-stimulation conduction blockage coefficient based on the voltage distribution and time delay correlation of adjacent nodes, identifies blockage nodes, determines the principal normal direction of the blockage region through principal component analysis, and generates a theoretical output current value by combining the coil's projected area in that direction with the blockage coefficient. Subsequently, a low-frequency test pulse is applied, the post-stimulation conduction blockage coefficient is acquired, and a stimulation intensity correction coefficient is calculated. Finally, the corrected actual output intensity is used as the execution parameter for the next round of test pulses, forming a closed-loop adaptive control. This invention overcomes the problem that traditional uniform stimulation parameters cannot match the electrophysiological heterogeneity of nerve injury regions, achieving spatially precise and functionally adaptable electromagnetic control.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a computing device includes a therapy-management application configured to assist a user to: capture a representative evoked compound action potential (ECAP) signal from a patient based; apply one or more filters to the representative ECAP signal to select one or more parameters of the representative ECAP signal; and control electrical stimulation therapy based at least in part on the one or more parameters.

Controlling a neural stimulus comprises applying the neural stimulus to a neural pathway in order to give rise to an evoked action potential on the neural pathway, the stimulus being defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured, and from the measured evoked response a feedback variable is derived. Loop backoff behaviour is adjusted by applying a non-identity function to the feedback variable to produce a revised feedback variable, and completing a feedback loop by using the revised feedback variable to control the at least one stimulus parameter so as to maintain the feedback variable at a setpoint. Additionally, or alternatively, loop gain can be adjusted in response to a change in the loop setpoint, and / or a logarithm of the stimulus parameter can be controlled.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a computing device includes a therapy-management application configured to assist a user to: capture a representative evoked compound action potential (ECAP) signal from a patient based; apply one or more filters to the representative ECAP signal to select one or more parameters of the representative ECAP signal; and control electrical stimulation therapy based at least in part on the one or more parameters.

The application relates to the technical field of electric massage, and discloses an acupoint positioning electric stimulation massage method and system based on a flexible electrode array, which comprises the following steps: pasting the flexible electrode array on a skin stimulation area, injecting a composite electric detection signal of superimposed low-frequency sine waves and high-frequency pulse sequences into the subcutaneous tissue through the electrode, collecting and extracting low-frequency impedance spectrum and high-frequency transient response waveform, determining the subcutaneous extracellular fluid resistance and fitting the capacitance charging and discharging time, combining into an acupoint electrophysiological characteristic vector, positioning the active acupoint to be stimulated through spatial clustering analysis, and then applying a biphasic asymmetric electric stimulation pulse according to the electric characteristics of the tissue, capturing an induced composite response signal in real time, fitting the density to obtain an action potential emission density trend, reducing the pulse repetition frequency and pulse width when the trend reaches a decay inflection point, and restoring the trend to a resting state level until the trend is restored to a resting state level; and the application can improve the effectiveness of electric stimulation massage.

The present invention discloses a high-throughput in vitro cardiotoxicity assessment platform, integrating human cardiac organoids (hCOs) with an advanced 3D-cell culture plate featuring embedded electrodes and batteries for electrical stimulation. The inclusion of batteries allows the platform to provide electrical stimulation without the need for external stimulators, enabling seamless, autonomous operation. The platform replicates heart electrophysiology, allowing precise control and real-time monitoring of cardiac parameters such as calcium dynamics and action potential waveforms, improving predictive accuracy for acute and chronic cardiotoxicity.

Methods and systems for spinal cord stimulation (SCS) are disclosed. The methods and systems involve using electrode leads implanted within the patient's spinal column to record neural responses evoked by the stimulation. The disclosed neural responses are different in several respects from electrical responses that have previously been measured in the context of SCS, such as stimulation artifacts and evoked compound action potentials (ECAPs). The disclosed neural responses typically occur later in time following the evoking stimulation pulse. Another distinguishing feature is that disclosed neural responses are generally most prominently observed with consistent, relatively unchanging amplitudes when the evoking stimulation frequency is ultra-low, for example, about 10 Hz or less. The disclosed methods and systems may use these neural responses as indications of pain, therapy, and / or another clinically relevant dimension, to direct / confirm stimulation placement, and for feedback control of stimulation parameters.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

A magnetographic method. The method of the invention allows for the characterization of individual membranous or cytosolic ion currents, for example, ion currents in connection with the action potential of myocardial cells.

Disclosed are methods and systems for characterizing intracellular electrophysiology supported by artificial intelligence (AI). The disclosed techniques and systems capitalize on large amounts of intracellular action potential (iAP) and extracellular action potential (eAP) recordings, with high throughput collected from cells, using microelectrode arrays (MEAs) and / or nanoelectrode arrays (NEAs). In some aspects, an AI-supported method for characterizing an intracellular electrophysiological response of cells includes receiving, at a data processing module operating on a computing device, a data set comprising electrophysiological signals obtained from one or more cardiomyocyte cells on a sensor device; providing, to an artificial intelligence (AI) system comprising a trained machine learning (ML) model operating on a computer system, the data set; and reconstructing, by the trained ML model, an intracellular action potential (iAP) data set from the data set that predictively determines iAP waveforms or iAP characteristics of the one or more cardiomyocytes.

Disclosed herein are systems and methods for action potential-based object detection. Received signals corresponding to multiple chirps can be grouped based on temporal or spatial attributes. Within these groups, successful detections can be identified when at least one signal satisfies an action potential threshold. The presence of a valid object is confirmed when the number of groups with successful detections satisfies a predetermined detection threshold.

In embodiments, devices, methods and systems to analyze the different mediums of brain function in a mathematically uniform manner may be provided. For example, in an embodiment, a computer-implemented method for determining structure of living neural tissue may comprise receiving at least one signal from at least one read modality, the signal representing at least one physical condition of the living neural tissue, determining action potentials based on the signals received from the read modalities, determining frequency oscillations based on the signals received from the read modalities and the action potentials, determining neuron network structures based on the photonic signals received from the read modalities, the action potentials, and the frequency oscillations, wherein the neuron network structures are determined using a Maximum Entropy model, and mapping brain region activation by S+ / R− events to observable linguistic events using the Maximum Entropy model.

Disclosed in the present invention is a pacing device for preventing occurrence of atrial fibrillation following premature atrial contraction, including: adjusting values of the number M of atrial events and the number N of premature atrial contraction events to control a pacing control process for preventing the occurrence of atrial fibrillation following premature atrial contraction to take place after a single or more than one premature atrial contraction events, and on the basis of a current p-p′ interval, an atrial safe pacing interval and an average atrial interval, setting a smooth transition pacing sequence. The smooth transition pacing sequence avoids atrial compensation intervals caused by the premature atrial contraction and avoids occurrence of a “short-long-short” sequence. Meanwhile, the number of pacing intervals in the smooth transition pacing sequence is controllably set, and the pacing intervals included sequentially increase and are gradually in transition to the average atrial interval representing a normal atrial interval prior to the occurrence of the premature atrial contraction events, so that the occurrence of the alternation of action potential durations is avoided, and the occurrence of atrial fibrillation caused by the premature atrial contraction is prevented at multiple levels.

Medical device systems and methods for providing spinal cord stimulation (SCS) are disclosed. The SCS systems and methods provide therapy below the perception threshold of the patient. The methods and systems are configured to measure neurological responses to stimulation and use the neurological responses as biomarkers to maintain and adjust therapy. An example of neurological responses includes an evoked compound action potential (ECAP).

There is a need for technology that can acquire information about the activity of living organisms or nerves connected to living organisms, as well as information transmitted from living organisms to nerves, from various action potentials, including those of muscles. [Solution] The disclosed technology may be an action potential generation location detection device. The disclosed device measures biopotentials with multiple electrodes, obtains multiple digital signals by sampling each of the multiple biopotential signals obtained from the measurement at a sampling frequency higher than the frequency of the action potential, and can determine the generation location of the action potential from the multiple digital signals.

The present application relates to the technical field of feedback regulation, and particularly relates to an electric field stimulation feedback regulation system based on organoid micro-reaction observation, comprising: obtaining an electric stimulation period between two adjacent electric stimulation parameter adjustment time points, determining fatigue influence sensitivity according to the numerical change of the electric stimulation parameter and the morphological similarity analysis of the action potential; determining the fatigue superposition performance degree of the organoid in each electric stimulation period according to the lactic acid concentration distribution and the change of the action potential amplitude, combining the fatigue superposition performance degree of the current electric stimulation period and the fatigue influence sensitivity of the time period set to obtain a fatigue early warning coefficient; and adjusting and warning the electric field stimulation according to the fatigue early warning coefficient of the current electric stimulation period. The present application can accurately judge the fatigue state and timely perform fatigue early warning by combining the change of the electric stimulation parameter and the superposition performance, thereby reducing the possibility of irreversible damage of the organoid caused by continuous electric stimulation.