99 results about "Axonal action potential" patented technology

Methods and systems for spinal cord stimulation (SCS) are disclosed. The methods and systems involve the use of electrode leads implanted within the spine of a patient to record nerve responses induced by a stimulus. The disclosed neural responses differ in various aspects from the electrical responses previously measured in the SCS context, such as stimulation artifacts and evoked compound action potentials (ECAPs). The disclosed neural responses typically occur at a later time after inducing the stimulation pulse. Another significant feature is that when the frequency of evoked stimulation is ultra-low, such as about 10 Hz or less, the disclosed neural response is most significantly observed at a consistent, relatively constant amplitude as a whole. The disclosed methods and systems may use these neural responses as indications of pain, treatment, and / or another clinically relevant dimension to guide / confirm stimulation placement, as well as feedback control for stimulation parameters.

The invention relates to the use of cannabidiol (CBD), at a dose of greater than 300 mg / day, in combination with a standard anti-epileptic drug (SAED) which acts via sodium or calcium channels, for use in the treatment of epilepsy. The SAED is preferably one which •modities low-threshold or transient neuronal calcium currents, or •reduces high-frequency neuronal firing and sodium-dependent action potentials and enhances GABA effects. Preferred SAEDs are ethosuximide and valproate.

The invention relates to the technical field of medical health data information decoding analysis and processing, and particularly discloses a dynamic pain nerve decoding and intervention system based on a prefrontal lobe time sequence characteristic window, which comprises a signal acquisition module, a dynamic window control module, a phase prediction module, an intervention execution module and an event driving controller. The dynamic window control module intelligently adjusts the duration of a signal analysis window through real-time calculation of the energy ratio of a # imgabs 0 # frequency band to a # imgabs 1 # frequency band, and accurately locks a transient characteristic window in a pain outbreak period; the phase prediction module realizes millisecond-level synchronization of stimulation pulse and a rising edge of action potential of a neural cluster based on a two-factor mapping mechanism of an individualized conduction velocity level and an oscillation frequency; the event-driven controller reduces the power consumption to a wearable device level while maintaining 10 ms-level real-time response through a dynamic resource allocation strategy.

The invention relates to the technical field of medical rehabilitation treatment, and discloses a self-adaptive functional electrical stimulation system based on bimodal feedback and a control method. The system comprises a main control module, a stimulation output module, an electroneurographic signal detection module, a biological impedance test module and a safety isolation module. The main control module comprises a safety current determination unit, a stimulation control unit and a dynamic calibration unit which are respectively used for determining an individualized initial safety current based on neural action potential feedback, controlling treatment stimulation output and dynamically calibrating a safety current upper limit according to biological impedance change before and after stimulation. According to the invention, through bimodal feedback of electroneurographic signals and biological impedance, individualized calibration and real-time dynamic optimization of stimulation parameters are realized, and the problem that the treatment effect and safety are difficult to guarantee due to the fact that traditional functional electrical stimulation depends on experience setting and lacks physiological feedback is solved; and the accuracy, safety and adaptability of rehabilitation treatment are remarkably improved.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a computing device includes a therapy-management application configured to assist a user to: capture a representative evoked compound action potential (ECAP) signal from a patient based; apply one or more filters to the representative ECAP signal to select one or more parameters of the representative ECAP signal; and control electrical stimulation therapy based at least in part on the one or more parameters.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

Devices, systems and methods are provided for treating target tissue with pulsed electric field energy in a manner that does not induce cardiac arrhythmias such as fibrillation of the heart and therefore negates any need for cardiac synchronization of energy delivery. Cardiac synchronization is typically employed to avoid delivering energy during portions of the cardiac cycle that are vulnerable to inducing fibrillation. Thus, herein parameters are manipulated to reduce the probability of inducing an arrhythmia. Typically, high voltage energy can trigger a premature action potential within the cardiac muscle as the delivered energy increases the cardiac muscle cell membrane permeability allowing ion transport, which can induce cardiac arrhythmias, especially ventricular fibrillation. However, both shorter pulse durations (i.e. higher frequencies such as 100-600 kHz) and biphasic waveform shapes theoretically and practically reduce the probability of inducing an arrhythmia.

Disclosed herein are of systems, methods, and computer-program products for determining if a response is an electrically evoked compound action potential (eCAP), refining raw data of an eCAP amplitude growth function (AGF) and utilizing maximum (i.e., steepest) slope from moving linear regression to effectively estimate cochlear nerve function, and determining quality of an electrode-neuron interface (ENI) using a model developed from eCAP attributes.

The present invention addresses the problem of providing a device for simultaneously measuring an electrical signal and a contractile force using a highly mature cardiac muscle tissue having a 3D / oriented structure close to a cardiac muscle structure in a living body. As a solution, provided is a device for measuring the contractility of a cardiac muscle tissue, which is provided with a contractile part that includes a rod-like artificial cardiac muscle tissue that has a three-dimensional structure and in which cardiac muscle cells are oriented in the longitudinal direction, and which is used to measure the contractility of the contractile part.

The present invention relates to the technical field of microbial pharmaceutical chemistry, specifically to a method for preparing a Penicillium fungus ( Penicillium daleae The present invention relates to the medical use of a polyketide compound with a unique cage-like structure isolated from the fermentation product of a strain of the bacterium Mycobacterium spp. Using patch-clamp techniques to measure the action potential discharge frequency and spontaneous excitatory post-synaptic currents (sEPSCs) of hippocampal basket cells, the present invention confirmed that the compound has significant inhibitory activity on neuronal excitability and is non-toxic to N2a neurons at active concentrations. The compound can be used to prepare new drugs for treating diseases associated with neuronal hyperexcitability.

An example apparatus for electro-medical stimulation includes a current generator to generate a sine wave output treatment signal, and a processor coupled to the current generator to modulate a frequency and a power of the sine wave output treatment signal over a cycle of stimulation treatment to produce periods of action potential for a stimulatory treatment phase and periods of non-action potential for a rest treatment phase. The cycle of stimulation treatment includes a first time period followed by a second time period, and during the first time period, the cycle of stimulation treatment is in a period of action potential for the stimulatory treatment phase, and during the second time period, the cycle of stimulation treatment is in a period of non-action potential for the rest treatment phase.

An apparatus for delivering stimulation energy to a patient is provided. The apparatus comprises an algorithm for determining a stimulation paradigm comprising one or more stimulation parameter settings, and an implantable system comprising an implantable device. The implantable device comprises at least one sensor for measuring evoked compound action potentials (eCAPs), muscle responses, and / or other neural responses, and multiple stimulation elements configured to deliver the stimulation energy to tissue based on the stimulation paradigm. The algorithm is configured to determine the stimulation paradigm based on the measured neural responses. Methods of delivering stimulation energy are also provided.

This disclosure is directed to devices, systems, and techniques for controlling electrical stimulation. In some examples, a system includes a user interface and processing circuitry. The processing circuitry is configured to output, for display by the user interface, a message requesting the patient perform a set of actions, receive, from the user interface, user input indicative of a patient response associated with the set of actions, and determine, based on the user input, one or more adjustments to a control policy which controls electrical stimulation delivered by a medical device based on a plurality of evoked compound action potentials (ECAPs) sensed by the medical device.

The invention provides a method for removing noise signals in a brain-computer interface through a force-electric decoupling method, and the method comprises the steps: collecting signals generated in the brain-computer interface, including electric signals transmitted by nerve fibers, interference electric signals and electric signals caused by force signals of various loads in the brain; electric signals caused by action potential are removed through the force-electricity constitutive relation of the liquid-containing porous material, electric signals caused by force signals of various loads in the brain are decoupled, and electric signals conducted by nerve fibers are reserved. According to the method, noise signals generated due to the electrokinetic effect in the brain-computer interface can be effectively removed, and electric signals conducted by nerve fibers can be accurately obtained.

A computational system and method for digital modeling of cardiac cell membrane electrophysiology is disclosed. The system generates a digital model representing the cell membrane as a dielectric lipid bilayer comprising a capacitor element and a resistor element, where the resistor element is emulated by a plurality of ion channels. The system calculates cell membrane potential based on intracellular and extracellular concentrations of key ions, such as Na+, K+, Ca2+, and Cl-, using the Goldman-Hodgkin-Katz equation. Generation of cellular membrane action potentials is simulated by modeling the opening and closing of voltage-gated ion channels in response to triggering events. The model provides dynamic visualizations of the distinct phases of the action potential, including depolarization and repolarization, offering a high-fidelity tool for research and for enhancing the realism of training simulations in electrophysiology procedures.

A spinal cord machine interface (SCMI) device is described. The SCMI includes an intraspinal probe, composed of at least one implantable shank. The implantable shank include a sensing electrode array and a stimulating electrode array. The SCMI also includes an application specific integrated circuit (ASIC). The ASIC is configured to detect action potentials from a patient's spine using the sensing electrode array and to stimulate a target action of the patent using the stimulating electrode array according to a location of the action potentials in a spinal cord and a learned mapping of the location of the action potentials to the target action.

Compounds having a 3,4,6-substituted benzocyclobuten-1-yl-methylamine structure, pharmaceutical compositions and methods employing use thereof for treating acute or chronic bipolar disorders, neuropsychiatric disorders, neurodegenerative conditions and other health conditions associated with neuronal excitability or dysregulated synaptic neurotransmission. The disclosed compounds selectively and rapidly reduce the frequency of action potentials in cortical pyramidal neurons by modulating presynaptic glutamate release while preserving GABAergic neurotransmission and single action potential properties. Selective modulation of excitatory neurotransmission achieves rapid therapeutic effects within minutes to hours after ingestion without disrupting inhibitory transmission, presenting a therapeutic approach for neurological conditions characterized by neuronal hyperexcitability and other pathological excitatory-inhibitory neurotransmission imbalance.

In some embodiments, a method of providing a neurostimulation therapy to a patient, comprises: generating electrical pulses, by an implantable pulse generator (IPG), comprising respective bursts of a plurality of anodic pulses with each anodic pulse being separated by a time gap, wherein (1) the plurality of anodic pulses comprise successively increasing charge; (2) the plurality of anodic pulses are charge limited to be sub-threshold; (3) each burst of anodic pulses is followed by a discharge phase of intermittent time periods to discharge charge build up from the anodic pulses; and (4) each successive intermittent time period increases in time through the discharge phase to avoid action potential (AP) generation; and applying the generated electrical pulses to neural tissue of the patient to inhibit neural activity of the patient.

Methods and systems for using sensed neural responses for informing aspects of stimulation therapy are disclosed. For example, features of evoked neural responses, such as evoked compound action potentials (ECAPs) can be used for closed-loop feedback control of stimulation parameters. Aspects of the disclosed methods and systems can differentiate between changes in the sensed neural responses that are caused by the environment at stimulating electrodes and changes in the neural responses that are caused by the environment at sensing electrodes. Embodiments determine changes in the morphology of the neural responses, which morphology changes indicate a degree of change in the stimulating environment. Algorithms and systems for assigning and tracking likelihoods for underlying electrode-tissue changes based on sensed neural responses are disclosed. The feedback control modality may be updated based on such likelihoods. Also disclosed are methods and systems for determining which features of evoked neural responses are more sensitive to changes in the stimulating environment and less sensitive to changes in the sensing environment.

Devices, systems, and methods are provided for treating target tissue with pulsed electric field energy in a manner that does not induce arrhythmia, such as tremor of the heart, and thus eliminates any need for cardiac synchronization of energy delivery. Cardiac synchronization is typically used to avoid delivery of energy during portions of the cardiac cycle that are susceptible to effect to induce fibrillation. Thus, parameters are manipulated herein to reduce the probability of inducing an arrhythmia. Typically, high voltage energy may trigger premature action potentials within the myocardium because the delivered energy increases myocardial cell membrane permeability, allowing ion transport, which may induce arrhythmias, especially ventricular fibrillation. However, shorter pulse durations (i.e., higher frequencies, e.g., 100 kHz to 600 kHz) and biphasic waveform shapes both theoretically and practically reduce the probability of inducing an arrhythmia.

The invention provides an efficient enrichment and purification method of adipose-derived stem cell exosomes. According to the invention, the sex determining gene is used for distinguishing and identifying the adipose-derived mesenchymal stem cells from different sources for the first time, and then the culture medium containing specific sex hormone and regulatory factors is used for realizing in-vitro amplification of the adipose-derived mesenchymal stem cells, so that convenience is provided for preparation of the adipose-derived mesenchymal stem cell exosome. According to different sources of adipose-derived stem cell exosomes, different effects of the adipose-derived stem cell exosomes are respectively verified, and the male adipose-derived stem cell exosomes can realize skin injury repair by effectively promoting fibroblast proliferation; the female adipose-derived stem cell exosome can realize nerve injury protection by regulating the nerve conduction velocity and action potential incubation period of an injured part.

Therapy can be determined using evoked compound action potentials (ECAPs). For example, a medical device includes stimulation generation circuitry and processing circuitry. The processing circuitry is configured to determine whether a characteristic of a first ECAP is greater than a threshold ECAP characteristic value. Based on the characteristic of the first ECAP being greater than the threshold ECAP characteristic value, the processing circuitry is configured to decrease a parameter of a first set of pulses delivered by the stimulation generation circuitry after the first ECAP. Additionally, the processing circuitry is configured to determine whether a characteristic of a second ECAP is less than the threshold ECAP characteristic value, and based on the characteristic of the second ECAP being less than the threshold ECAP characteristic value, increase a parameter of a second set of pulses delivered by the stimulation generation circuitry after the second ECAP.

This document discusses, among other things, systems and methods for providing pain relief to a patient. Recording circuitry may receive electrical signals corresponding to evoked compound action potentials in the patient that may be produced in response to external stimulation of a location where the patient is experiencing pain. The received electrical signals may be stored in a memory. Internal stimulation may then be applied to the patient and control circuitry may receive electrical signals corresponding to evoked compound action potentials in the patient that may be produced in response to the internal stimulation. The control circuitry may then adjust electrical parameters of the internal stimulation, such as to reduce a difference between the electrical signals corresponding to evoked compound action potentials produced in response to the internal stimulation and electrical signals corresponding to evoked compound action potentials produced in response to the external stimulation.

The invention discloses a progressive risk prevention and control system and method for an electrical stimulation physiotherapy instrument, and belongs to the technical field of medical equipment. The system integrates a central control unit, and an electrode contact quality detection module, a nerve excitation threshold detection module, an electromagnetic environment interference detection module, a risk grade evaluation module and a strategy generation module which are electrically connected with the central control unit. The system evaluates the risks of electrode poor contact, nerve over-excitation and electromagnetic interference respectively by detecting a micro-current contact impedance dynamic spectrum, a myoelectricity composite action potential incubation period change rate and a stimulation waveform distortion entropy. The system adopts a progressive detection method, divides risks into three levels according to key indexes such as a contact quality index, a latency drift index and waveform distortion entropy, and automatically generates corresponding prevention and control strategies for different risk levels, such as automatic deoxidation pulse, adaptive reduction of stimulation parameters or emergency termination of treatment. Accurate risk identification and dynamic prevention and control in the electrical stimulation physiotherapy process are realized, and the safety is improved.

Systems and methods provide interface to a patient's autonomic nerves via an interior lumen wall of a blood vessel. Systems can include a probe having at least one electrode for receiving electrical signals from the interior of the lumen wall. The system can include processing components for extracting the signals from noise within the patient's body. Systems can include stimulation electrodes for providing stimulation and eliciting action potentials within the patient and destructive processes for destroying nervous function. The effect of nerve destruction on the propagation of action potentials can be effectively used as a feedback mechanism for determining the amount of nervous function destruction in the patient.

In some aspects, the disclosure relates methods for treating ventricular tachycardia in a subject. In some embodiments, methods of the disclosure comprise measuring action potential durations and / or expression levels of KCNE3 and / or KCNE4 in a subject. In some aspects, the disclosure relates to methods and compositions for reducing or inhibiting the activity of KCNE3 and / or KCNE4, for example, in subjects having ventricular tachycardia.

A pulse generator system that facilitates asynchronous ignition of recruited neurons includes an implantable pulse generator (IPG) that is capable of sensing a degree of synchronous ignition of recruited neurons in tissue of a patient and modifying a stimulation procedure to facilitate asynchronism and reduce sensory abnormalities. An evoked composite action potential (ECAP) of the recruited neurons is sensed by the at least one non-active electrode as a measure of synchronism. An ECAP algorithm operable in the IPG evaluates the shape of the ECAP and determines one or more ECAP shape parameters that indicate whether the recruited neurons are a synchronous fire or a non-synchronous fire. If the shape parameter indicates significant synchronism, the ECAP algorithm may adjust the stimulation procedure to facilitate non-synchronous firing.

The invention relates to the technical field of bio-electricity signal processing, in particular to a motion intention recognition method for single-channel surface electromyogram (sEMG) decomposition. Single-channel sEMG preprocessing: processing the acquired sEMG in sequence by adopting a mode of combining band-pass filtering and second-order differential filtering; single-channel sEMG signal decomposition: extracting a plurality of motion unit action potential sequences (MUAPT) from the mixed signal, then accurately classifying the sequences, and finally performing peak extraction; and motion intention recognition based on MUAPT: key features are extracted based on a motion unit action potential sequence (MUAPT), and after feature processing is performed by using an LSTM layer and a Softmax layer of an LSTM network, an accurate recognition result is output, so that recognition of different muscle actions is realized.

Compounds having a 3,4,6-substituted benzocyclobuten-1-yl-methylamine structure, pharmaceutical compositions and methods employing use thereof for treating acute or chronic bipolar disorders, neuropsychiatric disorders, neurodegenerative conditions and other health conditions associated with neuronal excitability or dysregulated synaptic neurotransmission. The disclosed compounds selectively and rapidly reduce the frequency of action potentials in cortical pyramidal neurons by modulating presynaptic glutamate release while preserving GABAergic neurotransmission and single action potential properties. Selective modulation of excitatory neurotransmission achieves rapid therapeutic effects within minutes to hours after ingestion without disrupting inhibitory transmission, presenting a therapeutic approach for neurological conditions characterized by neuronal hyperexcitability and other pathological excitatory-inhibitory neurotransmission imbalance.

Systems, devices, and techniques for analyzing evoked compound action potentials (ECAP)signals to evaluate and select an electrode combination. A method includes controlling, by processing circuitry, deliver of a plurality of stimulation pulses via at least one stimulation electrode combination, receiving, by the processing circuitry, evoked compound action potential (ECAP) signal information representing different ECAP signals evoked from respective stimulation pulses of the plurality of stimulation pulses and obtained from respective different sensing electrode combinations, selecting by the processing circuitry and based on the ECAP signal information, one electrode combination from the different sensing electrode combinations.