292 results about "Peripheral nerve" patented technology

The invention relates to the technical field of artificial intelligence assisted medical rehabilitation, in particular to a peripheral nerve injury personalized rehabilitation system and method based on a multi-modal large model, and the method comprises the steps: a feature fusion module employs space-time attention to fuse multi-modal time series data, and constructs an evaluation map; the personalized generation module is combined with historical data and reinforcement learning to generate a scheme containing virtual scene parameters; the interaction feedback module collects data through mixed reality and calculates action deviation; and the adaptive adjustment module adopts a meta-learning optimization model and a distributed iterative output scheme. According to the method, the cross-modal association precision of the motion features and the mechanical parameters is improved, dynamic matching of the training scene and the motion ability of the user is achieved, the virtual environment and the mechanical feedback threshold are optimized by dynamically adjusting the rehabilitation scheme parameters, the scheme optimization period is shortened based on an online iterative optimization mechanism, and the training efficiency is improved. The core defects of personalized adaptation lagging and low utilization efficiency of multi-modal data are overcome.

Systems, devices, and methods for electrically stimulating peripheral nerve(s) to treat various disorders are disclosed, as well as signal processing systems and methods for enhancing diagnostic and therapeutic protocols relating to the same. Personalized therapy based on algorithms and aggregated data are also provided.

The invention belongs to the technical field of medical electronic equipment, and discloses a control system for alternative electrical stimulation of idiopathic tremor, and the system comprises a signal collection module which is used for obtaining tremor motion data of a patient in real time; the signal processing module is used for analyzing tremor frequency, amplitude and phase characteristics; the dynamic parameter generation module is used for generating an alternate stimulation mode according to the tremor characteristics; and the electrode array module comprises at least two stimulating electrodes and a reference electrode. The invention provides a non-invasive and dynamically optimized alternate electrical stimulation control system which is used for inhibiting hand tremor of an idiopathic tremor patient, regulation and control of a tremor network can be enhanced by alternately stimulating different peripheral nerves, the curative effect can be improved through closed-loop feedback optimization parameters, long-acting and safe tremor inhibition is achieved, and the treatment effect is improved. The problems of insufficient curative effect, nerve adaptability, surgical risk and the like in the prior art are solved.

Disclosed herein are systems, devices, and methods for stimulating nerves, including electrically stimulating peripheral nerve(s) to treat various diseases and disorders, as well as systems and methods for applying stimulation waveforms for improving the therapeutic benefit, outcomes, and / or experience relating to the same. Some systems and methods generate a biphasic stimulation waveform that includes a plurality of pulses with alternating leading phases. Some systems and methods vary one or more parameters of the stimulation waveform to correlate with a characteristic of the user. Example characteristic of the user include a phase of a tremor exhibited by the user and a respiratory cycle of the user. For some systems and methods, the stimulation waveform includes a plurality of burst with each burst ramping up in amplitude. For some systems and methods, the stimulation waveform is delivered during a time period that includes an on-cycle portion and an off-cycle portion with the stimulation waveform only being delivered during the on-cycle portion of the time period.

According to the flexible array type external field program control nerve stimulation device, the preparation method and the application thereof, the flexible array type external field program control nerve stimulation device comprises a flexible substrate layer and a stimulation response fiber array layer, and the stimulation response fiber array layer is prepared from a functional material capable of converting external field energy such as ultrasound, magnetism and light into electric energy; the flexible substrate layer with high flexibility is adopted, so that the flexible substrate layer can be matched with the surface of a nerve target tissue in a conformal manner; the stimulation response fiber array layer integrated on the flexible substrate layer in an array arrangement mode can meet the stimulation spatial resolution of neuron and even sub-neuron precision, has the characteristics of excellent flexibility, biocompatibility, passivity and wireless performance, can provide nerve electrical stimulation signals with high spatial resolution, and can be applied to the field of nerve electrical stimulation. The high-resolution nerve electrical stimulation device can be in conformal fit with the irregular surface of nerve soft tissue, and is suitable for high-resolution nerve electrical stimulation of different parts such as eyes, the brain and peripheral nerves.

A peripheral nerve stimulator to stimulate a peripheral nerve to treat essential tremor and other movement disorders, as well as overactive bladder, cardiac dysfunction and neurotransmitter dysfunction is provided. The peripheral nerve stimulator can be a noninvasive surface stimulator to provide multi-modal optimized therapy. Stimulation can be vibrational, electromechanical, thermal, radiant, electrical, magnetic, electromagnetic, light, mechanical, chemical, thermal, ultrasonic, radiofrequency (RF), acoustic, infrared, ultraviolet, x-ray, and / or microwave. Stimulation can be delivered using an open loop system and / or a closed loop system with feedback. Stimulation can be to one site or multiple sites.

Systems, devices, and methods for electrically stimulating peripheral nerve(s) to treat various disorders are disclosed, as well as signal processing systems and methods for enhancing diagnostic and therapeutic protocols relating to the same.

Systems, devices and methods are disclosed for the treatment of injured peripheral nerves or other tissue using electrical stimulation. The systems can be used either in intraoperative or peri-operative settings and incorporate the use of either a plurality of monopolar electrodes with a patch used as return or a plurality of bipolar electrodes such as a cuff. The systems can provide hands-free delivery of electrical stimulation therapy over a predetermined set of time.

Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a light source and a speaker. A visual neural stimulation system provides, via the light source, visual stimulation having a first value of a first parameter. An auditory neural stimulation system provides, via the speaker, audio stimulation having a second value of the second parameter. A stimuli orchestration component selects, for a first time interval, one of the visual stimulation or the audio stimulation to vary based on a policy, selects, for the first time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy, and provides causes the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation.

A peripheral nerve device can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The device may contain an interface separated, partially separated, or connected to a housing, and which may interact with the user. The interface may connect to the housing and be disposable after use for a period of time.

Provided herein are methods for reducing the likelihood and / or severity of peripheral neuropathy, anemia, and / or neutropenia in an individual being treated with an antibody-drug conjugate (ADC). Also provided herein are methods for increasing dosing amount and / or frequency of an antibody-drug conjugate (ADC) in an individual. In some embodiments, the methods comprise administering to the individual an effective amount of an ADC that comprises an antibody conjugated to a drug moiety via a linker, wherein the antibody comprises a heavy chain comprising a human Fc region with reduced or eliminated effector function. Compositions, uses, and kits related thereto are also provided.

A system and method for locating and guiding a peripheral nerve evaluation (PNE) lead. The system comprising an X-ray system to capture images of the patient. The images are processed by the system and are provided to a user to utilize an augmented reality (AR) system for inserting a needle for placing leads for the PNE procedure.

The treatment system includes a limb sleeve containing a heating subsystem, a pressure subsystem, and a vibration subsystem. The heating subsystem provides controlled cyclic heating to the limb, leading to dilation of the microvasculature and improved blood flow to nerve receptors. The pressure subsystem provides progressively staged, cyclic pressure to the limb, thereby improving blood circulation to the limb, reducing edema buildup, and flushing waste out the lymphatic system. The vibration subsystem provides controlled vibrotactile sensation to the limb to promote neuronal stimulation and decrease pain sensation. The treatment system allows for a multi-faceted approach in disease stabilization and assistive, personalized treatment for peripheral neuropathy.

The present disclosure relates to a muscle or nerve function rehabilitation assistance device using electrically conductive hydrogel. The electrically conductive hydrogel (IT-IC) provides an electrophysiological interface function between electrically active tissues, enabling the filling of lost muscle or nerve tissue for immediate rehabilitation in the early stages. It facilitates electrophysiological signal transmission between tissues and accelerates myofiber regeneration during the recovery phase. Particularly, when the electrically conductive hydrogel (IT-IC) is applied, the transmission of electrical signals generated in the muscle can be precisely controlled by a closed-loop device capable of being feedback in conjunction with peripheral nerve stimulation and electromyogram (EMG) monitoring.

The novel flexible electrodes disclosed herein utilize the low bending stiffness of electrospun nanofiber mats to achieve the material properties required for surgical implantation and sustained bidirectional communication with peripheral nerves without compromising electronic functionality. According to certain embodiments disclosed herein, implantable neural electrode probes are provided which comprise a polymeric substrate having proximal and distal ends, an electrode interface at the proximal end of the substrate; at least one neural contact at the distal end of the substrate; and electrically conductive traces formed on the fibrous substrate providing electrical communication between the at least one neural contact and the electrode interface, wherein the substrate comprises a nonwoven mass of polymeric nanofibers.

The invention provides a peripheral nerve precise regulation and control method and system based on a multi-channel flexible electrode, and is applied to the technical field of data processing. Physiological parameter information of a target user is processed based on a target peripheral nerve stimulation model, muscle contraction characteristic comprehensive indexes are generated, the muscle contraction characteristic comprehensive indexes comprise muscle contraction amplitude and contraction frequency, and the contraction frequency is clearly distinguished according to fast muscles, slow muscles and different motion modes; processing the training purpose information and the muscle contraction characteristic comprehensive index of the target user based on the target peripheral nerve stimulation model, and generating a preliminarily adjusted muscle contraction signal; processing the preliminarily adjusted muscle contraction signal based on the physiological feature information of the target organ to generate a secondarily adjusted muscle contraction signal; and processing the muscle contraction signal after secondary adjustment based on the motion intensity interval information of the target organ, and generating a target peripheral nerve stimulation signal.

There is provided a transvenous cryoneurolysis system and method for accessing and targeting neural treatment sites to relieve a variety of clinical indications, including peripheral neuropathy. A neurosome approach is described that includes one or more target nerves to receive selective cryoneurolysis via a target vein. The system performs a variety of freeze-thaw cycles via the target vein to induce a desired axial cryolesion along a target nerve. The target nerves and veins are selected to combine the treatment of the identified neurosome for pain relief in addition to the regenerative properties of cryoneurolysis.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor. Parkinson tremor, and other forms of tremor. For example, a stimulation device can record and transmit data to a cloud-based server in certain aspects.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. In one aspect, the stimulation algorithm is designed to optimize the therapy. The algorithm may be a learning algorithm to tailor the stimulation over time to adjust in real-time to a user's tremor user-defined needs. Stimulation can be delivered using open and / or closed loop systems.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor. Parkinson tremor, and other forms of tremor. Stimulation of nerves using machine learning algorithms are provided in certain aspects.

Systems, devices, and methods for stimulating peripheral nerves in the fingers or hand to treat tremor are described. For example, a wearable ring device for delivering electrical stimulation to sensory nerves in a patient's finger can include an annular ring having a plurality of electrodes and a detachable unit having a power source and a pulse generator.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate at least one of tremor feedback, external data, predictive adaptation, or long-term monitoring data. The device may be configured as a wrist worn device to stimulate three nerves to provide tremor reduction.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

A Peripheral Nerve Stimulation (PNS) system and method are disclosed. The system includes a headset with ear hooks and electrodes for placement on the mastoid processes. A stimulation device connected to the headset via lead wires delivers a pulsed electrical current to the electrodes. The device communicates with a computing device equipped with a mobile application that controls the stimulation characteristics. The mobile application allows users to adjust settings, monitor progress, and access treatment sessions. The system also includes snap ports for electrode attachment, self-adhesive hydrogel electrodes, and current control mechanisms using a digital potentiometer and waveform generator. The method includes pre- and post-session anxiety rating, personalized treatment based on user inputs, and tracking of physiological biomarkers. The application supports multiple operating systems, secure cloud data storage, and enables data sharing with healthcare providers. The invention provides a comprehensive, customizable, safe solution for managing anxiety and insomnia.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulator may be inductively charged in certain aspects. The stimulation device can be configured to be worn on the wrist of a user.

The application provides a peripheral nerve precise regulation method and system based on a multi-channel flexible electrode, and is applied to the technical field of data processing. The physiological parameter information of a target user is processed based on a target peripheral nerve stimulation model to generate a muscle contraction characteristic comprehensive index, wherein the muscle contraction characteristic comprehensive index includes a muscle contraction amplitude, a contraction frequency, and the contraction frequency is clearly distinguished according to fast muscle, slow muscle and different movement modes. The training purpose information and the muscle contraction characteristic comprehensive index of the target user are processed based on the target peripheral nerve stimulation model to generate a preliminarily adjusted muscle contraction signal. The preliminarily adjusted muscle contraction signal is processed based on the physiological characteristic information of a target organ to generate a secondarily adjusted muscle contraction signal. The secondarily adjusted muscle contraction signal is processed based on the movement intensity interval information of the target organ to generate a target peripheral nerve stimulation signal.

The invention discloses a nursing test method and system based on surgical glove pressurization, and the method comprises the steps: obtaining a plurality of test groups, each test group comprises a test group and a control group; pressurizing the test group based on a preset nursing mode to obtain test data of different time nodes; on the basis of the same environment, the control group is not subjected to any nursing, and control data of different time nodes are obtained; based on the same test group, performing comparative analysis on the test data and the contrast data of different time nodes to obtain an initial test result of the corresponding test group; traversing all the test groups to obtain an initial test result set, and comparing and analyzing initial test results in the initial test result set to obtain a test result. According to the method, non-drug intervention is adopted, through risk factor evaluation, personnel homogenization training and a surgical glove compression method, the accuracy of peripheral neuropathy testing is improved, and a scientific basis is provided for whether the surgical glove can replace a frozen glove or not.

Embodiments of the disclosure provide a device. The device comprises a body and a hook coupled to the body. The hook can be configured to receive a collar. The device comprises an arm coupled to the body. The collar can be positioned between the arm and the hook. The device comprises an actuator coupled with the hook. When the collar is in an open configuration, the collar can be positioned between and engaged by the hook and the arm. The collar can surround a peripheral nerve. From the open configuration, the actuator can be configured to pull the hook towards the body thereby forcing the collar to close around the peripheral nerve and force the collar into a closed configuration.

Systems and methods of applying electrical stimulation to achieve sustained relief of chronic pain that comprise a coiled wire percutaneous lead configured for insertion into a portion of a body that is proximal to a region of pain and an electrode formed integrally on the coiled wire percutaneous lead, wherein the electrode is configured to be positioned inside the body and at a therapeutically effective distance from a portion of at least one peripheral nerve that innervates the region of pain. The systems and method may also include an electrical stimulation device operatively coupled to the lead to apply electrical stimulation through the at least one electrode to at least one peripheral nerve that innervates the region of pain, to activate target peripheral nerve fibers while preventing activation of non-target peripheral nerve fibers and avoiding changing or blocking neural activity in off-target peripheral nerve fibers in the at least one peripheral nerve to create comfortable sensations in the region of pain and produce pain relief by modulating central nervous system plasticity associated with the pain.

The invention discloses siRNA capable of knocking down Pr18a9 gene expression and application of the siRNA, and relates to the technical field of biological medicine. The invention provides a positive-sense strand sequence and an antisense strand sequence of the siRNA, and the siRNA is used for preparing a preparation for promoting Schwann cell survival. According to the invention, the Prl8a9 gene of SCs is knocked down by virtue of a small interfering RNA technology; by improving the proliferation and migration capabilities of the Schwann cells, the apoptosis rate of the Schwann cells is reduced, and the survival rate of the Schwann cells is further improved. Meanwhile, a transcriptome sequencing technology is applied, key genes and pathways of Schwann cells treated by siPr18a9 are deeply excavated, and a theoretical support is provided for research on a repair mechanism after peripheral nerve injury.