490 results about "Peripheral nerve" patented technology

The invention relates to the technical field of artificial intelligence assisted medical rehabilitation, in particular to a peripheral nerve injury personalized rehabilitation system and method based on a multi-modal large model, and the method comprises the steps: a feature fusion module employs space-time attention to fuse multi-modal time series data, and constructs an evaluation map; the personalized generation module is combined with historical data and reinforcement learning to generate a scheme containing virtual scene parameters; the interaction feedback module collects data through mixed reality and calculates action deviation; and the adaptive adjustment module adopts a meta-learning optimization model and a distributed iterative output scheme. According to the method, the cross-modal association precision of the motion features and the mechanical parameters is improved, dynamic matching of the training scene and the motion ability of the user is achieved, the virtual environment and the mechanical feedback threshold are optimized by dynamically adjusting the rehabilitation scheme parameters, the scheme optimization period is shortened based on an online iterative optimization mechanism, and the training efficiency is improved. The core defects of personalized adaptation lagging and low utilization efficiency of multi-modal data are overcome.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator. Stimulation can be electrical, mechanical, or chemical. Stimulation can be delivered using either an open loop system or a closed loop system with feedback.

In some embodiments, systems and methods can include a wearable device with an electrically conductive skin interface that excites the underlying nerves from a transcutaneous surface stimulator. The device may be sized for a range of user sizes with stimulation electrodes positioned to target the appropriate nerves, such as the peroneal, femoral, saphenous and / or tibial nerves. The stimulation may include burst stimulation, and involve receiving an input relating to autonomic nervous system activity of the patient.

Systems, devices, and methods for electrically stimulating peripheral nerve(s) to treat various disorders are disclosed, as well as signal processing systems and methods for enhancing diagnostic and therapeutic protocols relating to the same. Personalized therapy based on algorithms and aggregated data are also provided.

A system and method for providing therapy to a patient can include a monitoring unit and a therapy unit. The monitoring unit can have a user interface and one or more sensors to measure patient data. The therapy unit can have a stimulator for generating electrical stimulation and a microcontroller for controlling the generation of the electrical stimulation based on the measured patient data.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulator can have electrodes that are placed circumferentially around the patient's wrist or arm. Specific nerves in the wrist or arm can be targeted by appropriate spacing of the electrodes. Positioning the electrodes on generally opposing sides of the target nerve can result in improved stimulation of the nerve. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate tremor feedback, external data, predictive adaptation, and long-term monitoring data.

The invention belongs to the technical field of medical electronic equipment, and discloses a control system for alternative electrical stimulation of idiopathic tremor, and the system comprises a signal collection module which is used for obtaining tremor motion data of a patient in real time; the signal processing module is used for analyzing tremor frequency, amplitude and phase characteristics; the dynamic parameter generation module is used for generating an alternate stimulation mode according to the tremor characteristics; and the electrode array module comprises at least two stimulating electrodes and a reference electrode. The invention provides a non-invasive and dynamically optimized alternate electrical stimulation control system which is used for inhibiting hand tremor of an idiopathic tremor patient, regulation and control of a tremor network can be enhanced by alternately stimulating different peripheral nerves, the curative effect can be improved through closed-loop feedback optimization parameters, long-acting and safe tremor inhibition is achieved, and the treatment effect is improved. The problems of insufficient curative effect, nerve adaptability, surgical risk and the like in the prior art are solved.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator. Stimulation can be electrical, mechanical, or chemical. Stimulation can be delivered using either an open loop system or a closed loop system with feedback.

The invention discloses an intelligent anesthesia depth monitoring system and method, and relates to the technical field of medical anesthesia, and the method is characterized in that through real-time data acquisition of an ultrasonic system and an electromyography instrument, nerve surrounding tissue data of shoulder and arm parts are accurately acquired. And inputting data of tissues around nerves into a real-time anesthesia depth calculation formula to calculate a real-time anesthesia depth Dreal, carrying out preliminary comparison on the real-time anesthesia depth Dreal and a target anesthesia depth Dtarget to obtain an anesthesia depth difference degree D, and evaluating a current anesthesia injection effect in real time. And based on the preliminary evaluation result, executing an anesthetic injection rate adjustment mechanism, and dynamically adjusting the anesthetic injection rate Radj (t) at the current time t to ensure that the anesthetic amount is accurately adjusted along with the change of the physiological state of the patient. Through the real-time dynamic adjustment mechanism, the anesthetic dosage control flexibility is improved, and continuous and stable anesthesia depth of a patient is ensured.

The invention provides a nervous tissue identification method based on artificial intelligence, and relates to the technical field of medical intelligent detection. According to the nervous tissue identification method, nervous tissue region annotation is carried out on 452 HE-dyed section images of bladder cancer, pancreatic cancer and porta-bile duct cancer by using QuPath software. 70% is used as a training set, 10% is used as a verification set of a training process, and 20% is used as an independent test set to train the nnUnet model. The whole training process is combined with an active learning strategy to enhance the specificity of the model. By using the algorithm and the deep learning technology, the nerve peripheral infiltration in the pathology is accurately and quickly evaluated, the workload of manual identification is greatly reduced, and the diagnosis accuracy is improved. The machine identification of tumor peripheral nerve invasion has obvious practicability, importance, clinical diversity and actual clinical value, and shows that the deep learning technology improves the potential of tumor detection and diagnosis.

Disclosed herein are systems, devices, and methods for stimulating nerves, including electrically stimulating peripheral nerve(s) to treat various diseases and disorders, as well as systems and methods for applying stimulation waveforms for improving the therapeutic benefit, outcomes, and / or experience relating to the same. Some systems and methods generate a biphasic stimulation waveform that includes a plurality of pulses with alternating leading phases. Some systems and methods vary one or more parameters of the stimulation waveform to correlate with a characteristic of the user. Example characteristic of the user include a phase of a tremor exhibited by the user and a respiratory cycle of the user. For some systems and methods, the stimulation waveform includes a plurality of burst with each burst ramping up in amplitude. For some systems and methods, the stimulation waveform is delivered during a time period that includes an on-cycle portion and an off-cycle portion with the stimulation waveform only being delivered during the on-cycle portion of the time period.

Systems, devices and methods are disclosed for the treatment of injured peripheral nerves or other tissue using electrical stimulation. The systems can be used either in intraoperative or peri-operative settings and incorporate the use of either a plurality of monopolar electrodes with a patch used as return or a plurality of bipolar electrodes such as a cuff. The systems can provide hands-free delivery of electrical stimulation therapy over a predetermined set of time.

Methods of treating a nerve injury are disclosed. The methods include administering to a target site of the nerve injury a thermally stable preparation having a purified amphiphilic peptide in an aqueous biocompatible solution, being configured to self-assemble into a hydrogel, and administering to the target site a buffer having an effective amount of an ionic salt and a biological buffering agent to form the hydrogel. The methods include administering to the target site a biological material suspension in an amount effective to treat the nerve injury. The methods include administering to the target site an anti-scarring agent in an amount effective to treat the nerve injury. The target site is associated with central nervous system tissue or peripheral nervous system tissue. The nerve injury includes spinal cord injury and peripheral nerve injury.

According to the flexible array type external field program control nerve stimulation device, the preparation method and the application thereof, the flexible array type external field program control nerve stimulation device comprises a flexible substrate layer and a stimulation response fiber array layer, and the stimulation response fiber array layer is prepared from a functional material capable of converting external field energy such as ultrasound, magnetism and light into electric energy; the flexible substrate layer with high flexibility is adopted, so that the flexible substrate layer can be matched with the surface of a nerve target tissue in a conformal manner; the stimulation response fiber array layer integrated on the flexible substrate layer in an array arrangement mode can meet the stimulation spatial resolution of neuron and even sub-neuron precision, has the characteristics of excellent flexibility, biocompatibility, passivity and wireless performance, can provide nerve electrical stimulation signals with high spatial resolution, and can be applied to the field of nerve electrical stimulation. The high-resolution nerve electrical stimulation device can be in conformal fit with the irregular surface of nerve soft tissue, and is suitable for high-resolution nerve electrical stimulation of different parts such as eyes, the brain and peripheral nerves.

The present invention relates to the technical field of ultrasonic diagnosis and treatment. The present invention provides an ultrasonic diagnosis and treatment device and a control method. The ultrasonic diagnosis and treatment device comprises: an ultrasonic transducer device, the ultrasonic transducer device comprises an ultrasonic imaging transducer and an ultrasonic stimulation transducer, the ultrasonic imaging transducer is used to perform ultrasonic imaging of a target area, and the ultrasonic stimulation transducer is used to perform ultrasonic stimulation on peripheral nerves or human epidermis; an ultrasonic electronic system connected to the ultrasonic transducer device, used to control the ultrasonic transducer device and realize ultrasonic imaging or ultrasonic stimulation regulation, the ultrasonic electronic system comprises an ultrasonic imaging circuit module and an ultrasonic stimulation circuit module, wherein the ultrasonic stimulation circuit module comprises a pulse generating circuit, a power amplifying circuit and a matching circuit, and the ultrasonic imaging circuit module comprises an imaging phased array transmitting unit, a receiving unit, an image processing unit and a system control unit; a mechanical arm is connected to the ultrasonic transducer device. Therefore, the present invention can realize the integrated design of peripheral ultrasonic diagnosis and treatment.

A peripheral nerve stimulator to stimulate a peripheral nerve to treat essential tremor and other movement disorders, as well as overactive bladder, cardiac dysfunction and neurotransmitter dysfunction is provided. The peripheral nerve stimulator can be a noninvasive surface stimulator to provide multi-modal optimized therapy. Stimulation can be vibrational, electromechanical, thermal, radiant, electrical, magnetic, electromagnetic, light, mechanical, chemical, thermal, ultrasonic, radiofrequency (RF), acoustic, infrared, ultraviolet, x-ray, and / or microwave. Stimulation can be delivered using an open loop system and / or a closed loop system with feedback. Stimulation can be to one site or multiple sites.

Systems, devices, and methods for electrically stimulating peripheral nerve(s) to treat various disorders are disclosed, as well as signal processing systems and methods for enhancing diagnostic and therapeutic protocols relating to the same.

Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a light source and a speaker. A visual neural stimulation system provides, via the light source, visual stimulation having a first value of a first parameter. An auditory neural stimulation system provides, via the speaker, audio stimulation having a second value of the second parameter. A stimuli orchestration component selects, for a first time interval, one of the visual stimulation or the audio stimulation to vary based on a policy, selects, for the first time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy, and provides causes the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation.

The embodiment of the invention discloses a peripheral nerve walking automatic generation method, device and equipment. The method comprises the steps that a to-be-processed CT image, obtained through CT scanning, of a specified examination part is obtained; acquiring CT scanning parameters corresponding to the CT image to be processed; obtaining a magnetic resonance image of the specified examination part through magnetic resonance imaging; performing peripheral nerve feature extraction on the magnetic resonance image to obtain peripheral nerve feature information of the specified examination part; marking peripheral nerves in the to-be-processed CT image based on the peripheral nerve feature information of the specified examination part to obtain a marked CT image; and inputting the marked CT image and the CT scanning parameters into a pre-trained peripheral nerve automatic generation model to obtain a peripheral nerve walking result image of the specified examination part. The result image about the peripheral nerve walking generated by the method can be applied to the field of radiotherapy, which has great benefits for illness state analysis in the radiotherapy process.

Systems, devices and methods are disclosed for the treatment of injured peripheral nerves or other tissue using electrical stimulation. The systems can be used either in intraoperative or peri-operative settings and incorporate the use of either a plurality of monopolar electrodes with a patch used as return or a plurality of bipolar electrodes such as a cuff. The systems can provide hands-free delivery of electrical stimulation therapy over a predetermined set of time.

The present application relates to an apparatus (100) for stimulating a peripheral nerve. The apparatus comprises: an implantable electrode assembly (102), which can be implanted in the body of a patient, and is configured to apply a stimulation signal to a nerve. The implantable electrode assembly (102) comprises: a stimulation electrode (102a), which is fixed to a predetermined position of the body of the patient and is adjacent to a nerve therein, and is configured to operably apply a stimulation signal to the nerve; and an electrode circuit (102b), which is coupled to the stimulation electrode (102a), and is configured to receive stimulation energy in the form of an electromagnetic field, convert the stimulation energy into the stimulation signal and provide the stimulation signal to the stimulation electrode (102a), wherein the stimulation energy is from the outside of the implantable electrode assembly (102). The apparatus further comprises: a stimulation energy generator (104), which can be worn outside the body of the patient, so as to provide stimulation energy to the implantable electrode assembly (102) by means of electromagnetic field coupling. The stimulation energy generator (104) comprises: a generator circuit (658), which is used for generating stimulation energy in the form of an electromagnetic field; and a power source (660), which is coupled to the generator circuit (658), and is configured to supply power to the generator circuit (658).

Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a light source and a speaker. A visual neural stimulation system provides, via the light source, visual stimulation having a first value of a first parameter. An auditory neural stimulation system provides, via the speaker, audio stimulation having a second value of the second parameter. A stimuli orchestration component selects, for a first time interval, one of the visual stimulation or the audio stimulation to vary based on a policy, selects, for the first time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy, and provides causes the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation.

The invention discloses a curative effect evaluation method of balance needle therapy in diabetic peripheral neuropathy, and relates to the technical field of curative effect evaluation. Constructing a medical history tree diagram of the diabetic patient, obtaining medical history influence factors of the diabetic patient, constructing a physical sign change curve of the diabetic patient, obtaining change coefficients of different time nodes, generating a change coefficient set, and inputting the change coefficient set into a curative effect judgment model to obtain effective interval duration of the balance needle therapy, acquiring fluctuation values of different real-time parameters to judge whether abnormal real-time parameters exist or not, generating a curative effect evaluation set, acquiring single evaluation coefficients of different physical sign parameters, and generating a comprehensive evaluation coefficient and a curative effect evaluation result thereof; through the technical scheme of the invention, the pertinence, accuracy and comprehensiveness of the balance needle therapy for evaluating the curative effect of the diabetic peripheral neuropathy can be obviously improved.

A peripheral nerve device can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The device may contain an interface separated, partially separated, or connected to a housing, and which may interact with the user. The interface may connect to the housing and be disposable after use for a period of time.

The invention discloses a diabetic foot management and control method for a diabetic patient and related equipment. The method comprises the following steps: periodically acquiring peripheral neuropathy examination data of a diabetic patient, wherein the period is dynamically determined based on historical diabetes data of the patient; generating a diabetic foot risk assessment problem table based on the peripheral neuropathy examination data and the diabetes historical data; and based on the peripheral neuropathy examination data and feedback data of the patient in response to the risk assessment problem table, predicting the diabetic foot disease risk level of the diabetic patient through a column diagram prediction model. The problem that a simple, feasible and easy-to-popularize diabetic foot prediction method is lacked at present can be solved.

The invention relates to the technical field of chemotherapy auxiliary medical instruments, and discloses a prevention and treatment device for peripheral neuropathy caused by chemotherapy drugs, which comprises a control device and a palm sleeve which is sequentially provided with an inner layer, a temperature control layer, a heat insulation layer and an inflation layer from inside to outside, the inner layer is used for wrapping hands and / or feet, detecting the temperature and pressure of the skin of a patient and applying medium-frequency electrical stimulation to the skin of the patient, the temperature control layer is used for controlling the temperature of the skin of the patient, the heat insulation layer is used for keeping the temperature of the temperature control layer, and the inflation layer is used for pressurizing the skin of the patient. By arranging the inner layer, the temperature control layer and the inflation layer, the hand or the foot can be wrapped, temperature control and pressure control can be carried out on the hand or the foot of a patient through control of the control device so as to prevent chemotherapy-induced peripheral neuropathy, or intermediate-frequency electrical stimulation can be carried out so as to recover the chemotherapy-induced peripheral neuropathy, and due to the fact that the temperature and the pressure are controllable, the temperature and the pressure of the patient can be controlled. The effect, comfort and safety of preventing and treating the peripheral neuropathy caused by chemotherapy are better.

Provided herein are methods for reducing the likelihood and / or severity of peripheral neuropathy, anemia, and / or neutropenia in an individual being treated with an antibody-drug conjugate (ADC). Also provided herein are methods for increasing dosing amount and / or frequency of an antibody-drug conjugate (ADC) in an individual. In some embodiments, the methods comprise administering to the individual an effective amount of an ADC that comprises an antibody conjugated to a drug moiety via a linker, wherein the antibody comprises a heavy chain comprising a human Fc region with reduced or eliminated effector function. Compositions, uses, and kits related thereto are also provided.

A system and method for locating and guiding a peripheral nerve evaluation (PNE) lead. The system comprising an X-ray system to capture images of the patient. The images are processed by the system and are provided to a user to utilize an augmented reality (AR) system for inserting a needle for placing leads for the PNE procedure.

The treatment system includes a limb sleeve containing a heating subsystem, a pressure subsystem, and a vibration subsystem. The heating subsystem provides controlled cyclic heating to the limb, leading to dilation of the microvasculature and improved blood flow to nerve receptors. The pressure subsystem provides progressively staged, cyclic pressure to the limb, thereby improving blood circulation to the limb, reducing edema buildup, and flushing waste out the lymphatic system. The vibration subsystem provides controlled vibrotactile sensation to the limb to promote neuronal stimulation and decrease pain sensation. The treatment system allows for a multi-faceted approach in disease stabilization and assistive, personalized treatment for peripheral neuropathy.

Provided are a polylactic acid and a use of a copolymer thereof in the preparation of a drug for promoting nerve growth and repair. The molecular weight of the polylactic acid and the copolymer thereof is 400-300 k Da. The drug has the following effects: 1) promoting the growth of nerve cells and nervous tissue; 2) promoting repair of nerve cells and nervous tissue; and 3) treating or preventing a peripheral nerve injury, a spinal cord injury, peripheral neuropathy, and neuritis. The molecular weight is preferably 5000-100 k Da. It is found for the first time that the polylactic acid and the copolymer thereof have a protective effect on nerves, and can promote nerve growth and a nerve injury repair.