99 results about "Peripheral nerve" patented technology

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

A Peripheral Nerve Stimulation (PNS) system and method are disclosed. The system includes a headset with ear hooks and electrodes for placement on the mastoid processes. A stimulation device connected to the headset via lead wires delivers a pulsed electrical current to the electrodes. The device communicates with a computing device equipped with a mobile application that controls the stimulation characteristics. The mobile application allows users to adjust settings, monitor progress, and access treatment sessions. The system also includes snap ports for electrode attachment, self-adhesive hydrogel electrodes, and current control mechanisms using a digital potentiometer and waveform generator. The method includes pre- and post-session anxiety rating, personalized treatment based on user inputs, and tracking of physiological biomarkers. The application supports multiple operating systems, secure cloud data storage, and enables data sharing with healthcare providers. The invention provides a comprehensive, customizable, safe solution for managing anxiety and insomnia.

The present disclosure relates to the use of therapeutic ultrasound to non-invasively stimulate multiple peripheral nerve pathways that modulate energy homeostasis. An embodiment of the disclosed neuromodulation techniques includes neuromodulation techniques to treat a patient with a metabolic disorder. Certain embodiments of the disclosure are discussed in the context of blood glucose regulation.

The application belongs to the technical field of bone organ preparation, and relates to a bone organ for promoting nerve growth and a construction method and application thereof. The construction method comprises the following steps: S1, immersing a hydrogel mineralization scaffold with conductive polymer induction in an EDC / NHS crosslinking agent, and sterilizing and crosslinking; S2, immersing the crosslinked product in a culture medium and culturing, inoculating bone organ seed cells, and replacing the culture medium with a complete culture medium for adaptive culture; and S3, transferring to an osteogenic induction culture medium for osteogenic induction, so as to obtain the bone organ for promoting nerve growth. Compared with the prior art, the bone organ constructed by the application has good biological activity, osteogenic activity and bone conduction, can effectively promote the growth of peripheral nerves, provides a reliable in-vitro model for bone-nerve interaction research, and provides a new technical path and theoretical basis for bone-nerve integrated regeneration and repair.

1. Name of the product in this design: Electromyography Evoked Potential Instrument. 2. Purpose of this design: To determine the functional status and suspected lesions of the peripheral neuromuscular system and central nervous system, detect subclinical lesions, and accurately locate lesions. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model. 5. The bottom surface of this product is a part that is not easily seen or cannot be seen during use, so the bottom view is omitted.

The invention discloses a transdermal patch containing lidocaine, the transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises active ingredients lidocaine, an acrylic acid pressure-sensitive adhesive and a penetration enhancer, the weight content of the lidocaine is 21-33%, the weight content of the acrylic acid pressure-sensitive adhesive is 45-75%, the weight content of the penetration enhancer is 1-10%, and the weight content of the penetration enhancer is 1-10%. The weight content of the penetration enhancer is 3%-25%. The transdermal patch disclosed by the invention is simple in prescription and process, good in drug permeability and colloid application performance and high in stability, can be continuously used for a long time without causing skin irritation, and is suitable for treating peripheral nerve related pains, especially patients requiring long-term administration such as post-herpes zoster neuralgia.

The application provides a self-coiled flexible peripheral nerve electrode and a preparation method and application thereof, and the preparation method comprises the following steps: preparing a double-layer flexible liquid metal electrode with an exposed site; stretching the double-layer flexible liquid metal electrode, and then fixing two ends of the double-layer flexible liquid metal electrode to obtain a stretched electrode; coating a polymer prepolymer reaction solution on a surface of the stretched electrode which is opposite to the exposed site, and curing the polymer prepolymer reaction solution to form a fixing layer, so as to obtain a three-layer composite electrode; under the condition that the two ends are fixed, the fixing layer in the three-layer composite electrode faces downward, the fixing of one end of the three-layer composite electrode is released, and the three-layer composite electrode is self-coiled. The self-coiled flexible peripheral nerve electrode prepared by the preparation method of the self-coiled flexible peripheral nerve electrode has high conductivity, can realize self-coiling of the electrode, improves the detection quality and long-term stability of nerve signals, and avoids mechanical damage of nerve tissue caused by electrode implantation.

Embodiments described herein relate to restorative solutions for segmental peripheral nerve (PN) defects using allografted PNs for stimulating PN repair. More specifically, embodiments described herein provide for localized immunosuppression (LIS) surrounding PN allografts as an alternative to systemically suppressing a patient's entire immune system. Methods include localized release of immunosuppressive (ISV) agents are contemplated in one embodiment. Methods also include localized application of immunosuppressive (ISV) regulatory T-cells (Tregs) and / or mesenchymal stomal cells in other embodiments. Hydrogel carrier materials are also described herein.

The invention provides a wrist closed-loop peripheral nerve electrical stimulation method and system, and relates to the technical field of nerve regulation and wearable medical instruments.The method comprises the steps that physiological signals and wearing state information of the radial styloid process, the ulna styloid process and the wrist transverse grain midpoint of the wrist are obtained, and the reference range and the dynamic calibration boundary of stimulation parameters are obtained; based on the reference range and the dynamic calibration boundary, determining a structural relationship according to the position data of the radial styloid process, the ulna styloid process and the wrist cross grain midpoint of the wrist, and performing regional characteristic analysis on the structural relationship to obtain an analysis result; and calculating geometric characteristics in the regional characteristic analysis result to obtain a geometric moment quantification result of the region. According to the invention, an individual parameter setting, closed-loop online updating and long-term maintainable engineering system is realized.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulator can have electrodes that are placed circumferentially around the patient's wrist or arm. Specific nerves in the wrist or arm can be targeted by appropriate spacing of the electrodes. Positioning the electrodes on generally opposing sides of the target nerve can result in improved stimulation of the nerve. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate tremor feedback, external data, predictive adaptation, and long-term monitoring data.

The present invention provides a pharmaceutical composition for treating an acute-phase peripheral neuropathy induced by a chemotherapeutic agent, the pharmaceutical composition comprising an alkalizing agent. By administering this pharmaceutical composition, it is possible to treat an acute-phase peripheral neuropathy induced by a chemotherapeutic agent, in particular, a chemotherapeutic agent for cancer. The present invention also provides an anticancer pharmaceutical composition that contains an alkalizing agent and a chemotherapeutic agent for cancer and that is designed to suppress an acute-phase peripheral neuropathy induced by the chemotherapeutic agent or to suppress worsening of symptoms caused by the peripheral neuropathy. By administering this pharmaceutical composition, it is possible to provide a cancer treatment in which an acute-phase peripheral neuropathy or worsening of symptoms caused by the peripheral neuropathy is suppressed.

An endovascular system for targeted photothermal ablation of perivascular nerves is disclosed. A catheter includes a fluid lumen communicating with outlet orifices, and an electromagnetic radiation emitter positioned within a support structure that apposes the array against a vessel wall. A proximal console independently controls irradiation and injection parameters. In use, a nanofluid comprising plasmonic nanoparticles, such as gold nanorods tuned for near-infrared absorption, is injected into or through the vascular wall and subsequently irradiated intraluminally; the nanofluid absorbs energy and converts it to heat to ablate adjacent nerve fibers while reducing non-target tissue heating.

The invention belongs to the technical field of biomedical detection, and discloses a biomarker for predicting or diagnosing diabetic peripheral neuropathy and application of the biomarker, and the biomarker comprises GREM2 and HPD. The biomarker disclosed by the invention is high in sensitivity, strong in specificity, capable of accurately identifying DPN and reliable in detection result, the AUC value of combined diagnosis of two differential proteins reaches 0.86, and the biomarker is remarkably superior to an existing clinical marker. When the biomarker is combined with clinical markers Age, BMI, T2DM daughter and HbA1c for use, the AUC value of the biomarker can reach 0.95. When the biomarker is applied, only a small number of blood samples of a patient are needed, the detection method is simple, convenient and rapid, the professional requirement is not high, and the biomarker is suitable for clinical popularization.

This invention relates to the field of natural language processing technology, specifically to a triage method and system for neurological diseases, comprising the following steps: segmenting the syntactic structure of the patient's chief complaint text sequence and identifying nodes; calculating and quantifying the nesting degree of the patient's linguistic organization logic; and obtaining a syntactic potential depth value. This invention can filter out noise interference from complex clinical expressions and extract neurological syndrome features by comparing them with a preset internal capsule lesion pattern. By jointly analyzing feature tensors pointing to limb paralysis with syntactic potential depth values ​​below the normal threshold, dual cross-validation of somatic motor disorders and central cognitive impairment is achieved. Furthermore, by comparing with feature thresholds of peripheral nerve or spinal cord lesions, the specificity of identifying central acute and severe illnesses such as ischemic stroke is improved, optimizing the accuracy of emergency triage.

Described herein are various implementations of systems and methods for accessing and modulating tissue (for example, systems and methods for accessing and ablating nerves or other tissue within or surrounding a vertebral body to treat chronic lower back pain). Assessment of vertebral endplate degeneration or defects (e.g., pre-Modic changes) to facilitate identification of treatment sites and protocols are also provided in several embodiments. Several embodiments comprise the use of biomarkers to confirm or otherwise assess ablation, pain relief, efficacy of treatment, etc. Some embodiments include robotic elements for, as an example, facilitating robotically controlled access, navigation, imaging, and / or treatment.

The embodiment of the invention discloses implantable peripheral nerve electrical stimulation equipment. The implantable peripheral nerve electrical stimulation equipment comprises a main body part, a battery part and a stimulation part, a controller is arranged in the main body part, the battery part comprises a power supply, a coating film, a charging coil and a first shell, the charging coil sleeves the outer side of the power supply, and the coating film is made of a flexible permanent magnet material and coats the outer surface of the power supply to form a magnetic core of the charging coil. According to the embodiment of the invention, the overall structure of the battery part can be supported and protected through the first shell made of an insulating material, and the efficiency of wireless energy and information transmission between the charging coil and the outside can be improved due to the self-insulating characteristic of the first shell, so that the situation that eddy current is generated on the first shell to cause temperature rise is avoided; through the arrangement of the coating film, the charging coil can be matched with a power supply, a magnetic core structure is formed in the center of the charging coil, the charging efficiency is further improved, a charging magnetic field can be shielded, and eddy current is prevented from being generated on a shell of the power supply.

This invention relates to the field of electromagnetic field control technology, specifically to a control system for pulsed electromagnetic fields used in the repair of peripheral nerve injuries. The system acquires the action potential voltage amplitude of each spatial node within the coil's coverage area, calculates the pre-stimulation conduction blockage coefficient based on the voltage distribution and time delay correlation of adjacent nodes, identifies blockage nodes, determines the principal normal direction of the blockage region through principal component analysis, and generates a theoretical output current value by combining the coil's projected area in that direction with the blockage coefficient. Subsequently, a low-frequency test pulse is applied, the post-stimulation conduction blockage coefficient is acquired, and a stimulation intensity correction coefficient is calculated. Finally, the corrected actual output intensity is used as the execution parameter for the next round of test pulses, forming a closed-loop adaptive control. This invention overcomes the problem that traditional uniform stimulation parameters cannot match the electrophysiological heterogeneity of nerve injury regions, achieving spatially precise and functionally adaptable electromagnetic control.

The invention relates to a self-energized flexible nerve conduit and a preparation method thereof.The self-energized flexible nerve conduit comprises a PCL spiral skeleton and a PVDF / PCL mixed nanofiber membrane wrapping the outer side of the PCL spiral skeleton, and the preparation method comprises the following steps that a PCL solution with the mass concentration being 10-15% is prepared and added into printing equipment to be printed and formed, and the PCL spiral skeleton is obtained after drying; the preparation method comprises the following steps: preparing a PVDF / PCL mixed solution with the mass fraction of 26%, adding the PVDF / PCL mixed solution into electrostatic spinning equipment, and drying after spinning, so that the PVDF / PCL mixed nanofiber membrane is formed outside a PCL spiral framework. Through the structural design of the PCL spiral skeleton and the PVDF / PCL nanofiber membrane and the cooperation of EHD printing and electrostatic spinning processes, compared with a traditional nerve conduit, the nerve conduit has the advantages that the mechanical stability, the electrical stimulation self-energizing capacity, the cytocompatibility, the production and processing technology and the like of the conduit are comprehensively improved, and the nerve conduit has a good application prospect. Therefore, the method better meets the actual needs of peripheral nerve injury repair, and is suitable for various nerve defect scenes.

The application belongs to the technical field of medical imaging, and particularly discloses a peripheral nerve imaging method and system based on ultrasonic tomography and a storage medium. A plurality of tomographic images of a to-be-measured part are collected by an ultrasonic tomography system; a YOLO target detection network is used to locate a nerve tissue of each tomographic image; then a U-Net segmentation network is used for pixel-level segmentation to obtain a pixel-level probability map of the nerve tissue; an uncertainty of a pixel in the pixel-level probability map is modeled by using a membership modeling mechanism to adaptively weight a membership degree of the nerve tissue, so that an accurate segmentation result is obtained; the accurate segmentation result is taken as an observation of Kalman filtering, prediction and updating are performed based on the Kalman filtering, and an optimal state estimation of the nerve tissue is obtained; and a three-dimensional model of the peripheral nerve tissue is reconstructed by using the optimal state estimation of each tomographic image. The application can significantly improve the segmentation accuracy and structural integrity of the nerve tissue.

A system and method for locating and guiding a peripheral nerve assessment (PNE) lead. The system includes an X-ray system for capturing an image of a patient. The image is processed by the system and provided to the user to use a measurement device to insert a needle for placement of a lead to perform the PNE process.

Systems and methods for selectively blocking neural conduction in fibers in a nerve are disclosed. The methods include (a) associating an intraneural electrode with a fascicle of the nerve and (b) utilizing a stimulator in electrical communication with the intraneural electrode to provide electrical stimulation to the fascicle. The electrical stimulation blocks conduction in the nerve. The systems include (a) an intraneural electrode operational to associate with a fascicle of the nerve and (b) a stimulator in electrical communication with the intraneural electrode. The stimulator is operational to provide electrical stimulation to the fascicle. The electrical stimulation is operable to block neural conduction in neural fibers in the nerve.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator. Stimulation can be electrical, mechanical, or chemical. Stimulation can be delivered using either an open loop system or a closed loop system with feedback.

The present invention provides novel near-infrared fluorophore compounds of Formula (I), formulations comprising them, and methods for their use in imaging peripheral and central nerves.

An electrode array for peripheral nerve stimulation, in particular for auricular punctual stimulation of the vagus nerve, including a planar carrier and a plurality of needle-shaped electrodes protruding from the carrier and at least one electrical terminal, which is electrically conductively connected to the electrodes or to a subgroup of electrodes, for electrical connection to a stimulation device, the electrodes having a maximum length of 0.6 mm, preferably 0.4 mm

Systems, devices, and methods for electrically stimulating peripheral nerve(s) to treat various disorders are disclosed, as well as signal processing systems and methods for enhancing diagnostic and therapeutic protocols relating to the same.

Methods and devices for the administration of compositions comprising glutathione trisulfide (GSSSG), pantethine trisulfide (PTN-SSS), or lipoic acid trisulfide (LA-SSS) to treat peripheral neuropathy, e.g., chemotherapy-induced peripheral neuropathy (CIPN), e.g., by oral or nasal administration. The methods can be used, e.g., to reduce pain associated with CIPN, or reduce the risk of development of CIPN.

This invention discloses a non-invasive targeted electrical stimulation device for peripheral nerve injury based on coherent electrical signals, comprising: a flexible electrode array module, an impedance monitoring and sensing module, a flexible fixation adapter module, a coherent electrical signal generation module, a main control chip processing module, and a human-computer interaction control module. Each module is wirelessly connected via medical-grade flexible wires or Bluetooth, forming a wearable stimulation unit and a control and analysis unit. The flexible fixation adapter module adapts to different limbs, the coherent electrical signal generation module generates multiple synchronous carrier signals, and the main control chip processing module realizes functions such as targeted positioning and impedance feedback. This device locks the nerve target site using external imaging data, utilizes the superposition of coherent electrical signals to form a targeted difference frequency signal, and combines impedance monitoring data with dynamic adjustment signals based on multi-dimensional environmental and device-related parameters to achieve non-invasive, precise, and stable targeted electrical stimulation of peripheral nerve injury, improving stimulation specificity and safety.

This invention discloses a screw-installing device suitable for angled sacroiliac screws. The device includes a torque-applying section for installing the sacroiliac screw. The distal angle of the tubular torque-applying section matches the proximal angle of the sacroiliac screw, ensuring complete alignment of their axes. Each end of the torque-applying section is provided with an elastic locking element and a driving element. The elastic locking element is used to lock or unlock the sacroiliac screw, and the driving element controls the movement of the elastic locking element, thereby enabling the installation and removal of the torque-applying section and the sacroiliac screw. This screw-installing device is used for placing angled sacroiliac screws. Angled sacroiliac screws cannot be directly rotated in a minimally invasive environment after insertion. This device is suitable for both pre- and post-screw placement of sacroiliac screws, significantly reducing damage to surrounding nerves and blood vessels and significantly improving surgical efficiency.