26 results about "Peripheral nerve" patented technology

This invention relates to the field of natural language processing technology, specifically to a triage method and system for neurological diseases, comprising the following steps: segmenting the syntactic structure of the patient's chief complaint text sequence and identifying nodes; calculating and quantifying the nesting degree of the patient's linguistic organization logic; and obtaining a syntactic potential depth value. This invention can filter out noise interference from complex clinical expressions and extract neurological syndrome features by comparing them with a preset internal capsule lesion pattern. By jointly analyzing feature tensors pointing to limb paralysis with syntactic potential depth values ​​below the normal threshold, dual cross-validation of somatic motor disorders and central cognitive impairment is achieved. Furthermore, by comparing with feature thresholds of peripheral nerve or spinal cord lesions, the specificity of identifying central acute and severe illnesses such as ischemic stroke is improved, optimizing the accuracy of emergency triage.

Described herein are various implementations of systems and methods for accessing and modulating tissue (for example, systems and methods for accessing and ablating nerves or other tissue within or surrounding a vertebral body to treat chronic lower back pain). Assessment of vertebral endplate degeneration or defects (e.g., pre-Modic changes) to facilitate identification of treatment sites and protocols are also provided in several embodiments. Several embodiments comprise the use of biomarkers to confirm or otherwise assess ablation, pain relief, efficacy of treatment, etc. Some embodiments include robotic elements for, as an example, facilitating robotically controlled access, navigation, imaging, and / or treatment.

This invention relates to the field of electromagnetic field control technology, specifically to a control system for pulsed electromagnetic fields used in the repair of peripheral nerve injuries. The system acquires the action potential voltage amplitude of each spatial node within the coil's coverage area, calculates the pre-stimulation conduction blockage coefficient based on the voltage distribution and time delay correlation of adjacent nodes, identifies blockage nodes, determines the principal normal direction of the blockage region through principal component analysis, and generates a theoretical output current value by combining the coil's projected area in that direction with the blockage coefficient. Subsequently, a low-frequency test pulse is applied, the post-stimulation conduction blockage coefficient is acquired, and a stimulation intensity correction coefficient is calculated. Finally, the corrected actual output intensity is used as the execution parameter for the next round of test pulses, forming a closed-loop adaptive control. This invention overcomes the problem that traditional uniform stimulation parameters cannot match the electrophysiological heterogeneity of nerve injury regions, achieving spatially precise and functionally adaptable electromagnetic control.

This invention discloses a non-invasive targeted electrical stimulation device for peripheral nerve injury based on coherent electrical signals, comprising: a flexible electrode array module, an impedance monitoring and sensing module, a flexible fixation adapter module, a coherent electrical signal generation module, a main control chip processing module, and a human-computer interaction control module. Each module is wirelessly connected via medical-grade flexible wires or Bluetooth, forming a wearable stimulation unit and a control and analysis unit. The flexible fixation adapter module adapts to different limbs, the coherent electrical signal generation module generates multiple synchronous carrier signals, and the main control chip processing module realizes functions such as targeted positioning and impedance feedback. This device locks the nerve target site using external imaging data, utilizes the superposition of coherent electrical signals to form a targeted difference frequency signal, and combines impedance monitoring data with dynamic adjustment signals based on multi-dimensional environmental and device-related parameters to achieve non-invasive, precise, and stable targeted electrical stimulation of peripheral nerve injury, improving stimulation specificity and safety.

This invention discloses a screw-installing device suitable for angled sacroiliac screws. The device includes a torque-applying section for installing the sacroiliac screw. The distal angle of the tubular torque-applying section matches the proximal angle of the sacroiliac screw, ensuring complete alignment of their axes. Each end of the torque-applying section is provided with an elastic locking element and a driving element. The elastic locking element is used to lock or unlock the sacroiliac screw, and the driving element controls the movement of the elastic locking element, thereby enabling the installation and removal of the torque-applying section and the sacroiliac screw. This screw-installing device is used for placing angled sacroiliac screws. Angled sacroiliac screws cannot be directly rotated in a minimally invasive environment after insertion. This device is suitable for both pre- and post-screw placement of sacroiliac screws, significantly reducing damage to surrounding nerves and blood vessels and significantly improving surgical efficiency.

A system and method for treating patients with symptoms of restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) using high-frequency stimulation by applying high-frequency pulsed electrical stimulation therapy signals to the peroneal nerve or its branches, where the therapy signals exceed the motor threshold of muscles stimulated by the peroneal nerve or its branches. Surface electromyography (sEMG) responses to the nerve stimulation can be used to assess patient responsiveness to the nerve stimulation or to assess nerve stimulation efficacy, for example, to compare various nerve stimulation parameter settings and select between such settings to address or balance one or more goals. The sEMG responses can be obtained with the muscle at rest or during muscle activation.

This invention discloses a system and method for treating patients with symptoms of restless legs syndrome (RLS) or periodic limb movement disorder (PLMD) using high-frequency stimulation by applying a high-frequency pulsed electrical stimulation therapeutic signal to the peroneal nerve or its branches, wherein the therapeutic signal is above the motor threshold of the muscles innervated by the peroneal nerve or its branches. Surface EMG (sEMG) responses to nerve stimulation can be used to assess a patient's response to nerve stimulation or to evaluate the efficacy of nerve stimulation, such as comparing various nerve stimulation parameter settings and selecting between these settings to achieve or balance one or more goals. The sEMG response can be obtained during muscle rest or during muscle activation.

Peripheral nerve field stimulation (PNFS) may be controlled based on detected physiological effects of the PNFS, which may be an efferent response to the PNFS. In some examples, a closed-loop therapy system may include a sensing module that senses a physiological parameter of the patient, which may be indicative of the patient's response to the PNFS. Based on a signal generated by the sensing module, the PNFS may be activated, deactivated or modified. Example physiological parameters of the patient include heart rate, respiratory rate, electrodermal activity, muscle activity, blood flow rate, sweat gland activity, pilomotor reflex, or thermal activity of the patient's body. In some examples, a patient pain state may be detected based on a signal generated by the sensing module, and therapy may be controlled based on the detection of the pain state.

Disclosed is a complex including: cellulose nanocrystals; at least one β-cyclodextrin molecule; and at least one curcumin molecule, suitable for use in the treatment of any kind of peripheral neuropathies. Further disclosed is a pharmaceutical composition including at least the complex and at least one pharmaceutically acceptable excipient. Also disclosed is the use of the complex or the pharmaceutical composition, in particular in the form of a hydrogel, a subcutaneous implant, an implantable pump, an implanted biofunctionalized nerve conduit, to improve the treatment compliance, to allow an extended release of the complex and to obtain better pharmacokinetics.

A fixation device for the treatment of diabetic peripheral neuropathy, belonging to the field of fixation technology, aims to address the problem that prolonged pressure on the same location during long-term treatment can easily lead to pressure marks, ischemic injuries, or even pressure sores. The invention includes a bed frame with two placement plates fixedly installed on one side. A lifting seat is fixedly installed on the surface of each placement plate. Three moving parts are evenly distributed below the lifting seats. A driving component is fixedly installed on one side of the lifting seats. Three adjusting seats are slidably connected to the surfaces of the three moving parts. A first rolling pressure plate is fixedly installed at one end of the adjusting seat in the middle position, and a second rolling pressure plate is rotatably connected to one end of the adjusting seats on either side. This invention allows for switching between different pressure points, avoiding prolonged pressure on the same location and preventing the risk of local tissue ischemia and necrosis. Furthermore, it maintains the fixation of the lower leg while switching between different pressure points, improving the stability of the lower leg during treatment.

Provided is a peripheral nerve stimulation system comprising: a device for electrically stimulating a peripheral nerve and measuring an evoked compound action potential (ECAP) from the peripheral nerve; a control unit for receiving feedback of the ECAP measured after stimulating the peripheral nerve and determining a threshold value of the ECAP; and a stimulation determination unit for determining, according to the threshold value, a stimulation intensity of an electrode that stimulates the peripheral nerve.

This invention belongs to the field of biomedical technology and specifically relates to the use of divalent metal lactates in the manufacture of products for the prevention, improvement, repair, and treatment of nerve damage. Preferably, the divalent metal lactate includes one or more of the following: calcium lactate, magnesium lactate, zinc lactate, and ferrous lactate. This invention provides a novel treatment method for repairing damage to the central and peripheral nervous systems and has broad potential applications in the treatment and repair of central nervous system damage caused by trauma or other causes, or peripheral neuritis or peripheral nerve sensory abnormalities caused by viruses, diabetes, chemotherapy drugs, etc.

A topical cream or ointment is provided that provides for the binding to CB1 and / or CB2 receptors for the soothing of pain, inflammation of smooth muscle, tendons, ligaments, skeletal muscle, endothelial cell, synovial cell, peripheral nerve fibers, reduction of endothelial bruising, promotion of healing of endothelial bruising, and dermatological itch sensation wherein the improvement comprises providing the effect of cannabinoid using plant extracts. A topically administered formulation is also provided for treating anal mucosal inflammation, soothing of pain, inflammation of anal mucosal inflammation; reducing keratinocyte apoptosis; treating viral-associated epithelial damage, treating radiation dermatitis; and treating chemotherapy-induced dermatitis.

Devices, systems, or methods include generating, by stimulation generation circuitry, a first train of electrical stimulation pulses at a first frequency to a first target tissue; and generating, by the stimulation generation circuitry, a second train of electrical stimulation pulses at a second frequency to a second target tissue different from the first target tissue, wherein at least some electrical stimulation pulses of the first train of electrical stimulation pulses are interleaved with at least some electrical stimulation pulses of the second tram of electrical stimulation pulses. At least the first target tissue is associated with a spinal cord of a patient, and the second target tissue is associated with at least one of a peripheral nerve or a nerve root of the patient.

This invention relates to the field of electromyography (EMG) signal technology, specifically to a method for analyzing and evaluating EMG signals in peripheral nerve injury. The method includes the following steps: acquiring raw EMG signals and environmental noise reference signals. This invention discretizes the intrinsic mode function (IMF) components and the environmental noise reference signal, calculates the length of the discrete signal; calculates the cross-correlation coefficient based on the length, sorts the components to obtain the correlation coefficient of the largest component and determines a threshold, filters effective IMF components according to the threshold, and then integrates them into a set of effective components; processes the IMF components within the set to obtain denoised components, and superimposes the denoised components to obtain a pure EMG signal, effectively removing power frequency interference and patient jitter artifacts, avoiding the accidental deletion of weak EMG signals from early, minor nerve injuries by traditional fixed thresholds, improving the purity of EMG signals with low signal-to-noise ratios, and preserving effective component characteristics even at low signal-to-noise ratios, thus improving the integrity of preserved effective features.

The present disclosure belongs to the technical field of biomedicine, and specifically relates to a lipid compound for therapeutic delivery, an oligonucleotide delivery system, and a preparation method therefor and the use thereof. The present disclosure has the following advantage: the lipid compound for therapeutic delivery or a pharmaceutically acceptable salt, isomer, solvate or prodrug thereof of the present disclosure can be used in the preparation of an siRNA delivery system, thereby further improving the ability of siRNA to knock down target genes in tissues such as muscle, adipose tissue, and peripheral nerves. The lipid compound for therapeutic delivery or the pharmaceutically acceptable salt, isomer, solvate or prodrug thereof provided in the present disclosure is expected to provide a new strategy for siRNA delivery to muscle, adipose tissue, nervous system, etc.

This invention discloses a wearable device integrating epilepsy prodrome recognition and non-invasive physical intervention, belonging to the field of medical wearable technology. The device includes a flexible wearable body (80), a physiological signal monitoring module (10), an analog front-end AFE (20), a hardware processing unit (30), a transcutaneous physical intervention module (40), an alarm module (50), a communication module (60), and a power supply module (70). The physiological signal monitoring module (10) collects multimodal physiological signals including EEG, which are processed by the analog front-end AFE (20) and then sent to the hardware processing unit (30). The hardware processing unit (30) uses a hardware interrupt mechanism to quickly identify epilepsy prodromes and generate trigger signals, controlling the transcutaneous physical intervention module (40) to output inhibitory electrical pulses to peripheral nerve targets that can be touched on the body surface. The core is that the hardware processing unit (30) is configured to collect EEG signals during the interval of electrical pulse output, and monitor the intervention effect in real time while shielding strong stimulation artifacts, thus solving the industry's technical bias that electrical stimulation and EEG monitoring cannot be synchronized. The device supports modular activation of monitoring and intervention, independent offline operation, end-to-end encrypted cloud synchronization, and adopts medical biocompatibility and electromagnetic compatibility design. It features low latency, high anti-interference, safety and compliance, and easy implementation, and can be effectively used for pre-hospital protection and clinical auxiliary intervention for epilepsy patients.

The application discloses application of a compound INF195 in treatment of diseases related to nerve axon injury. 17 H 22 ClNO3.The application proves through research that the compound INF195 can significantly promote axon regeneration of DRG neurons at a concentration of 5 muM, and has no significant effect on neuron activity at the concentration.Further based on an axon injury model of Xona microfluidic chip, it is proved that the INF195 can promote regeneration and extension of axons after injury.Therefore, the compound INF195 can inhibit NLRP3 inflammasome activity, and is an important compound molecule for promoting axon regeneration and repair after nerve injury, and has a good application prospect in preparation of drugs for treating diseases related to nerve axon injury, including peripheral nerve injury and central nerve injury.

The invention relates to the technical field of biological materials, in particular to a bionic nerve conduit and a preparation method and application thereof. Through layered functional design, the multifunctional nerve conduit which sequentially comprises an inner layer, a middle layer and an outer layer from inside to outside is prepared. Wherein the inner layer is used for constructing parallel oriented nanofibers through an electrostatic spinning technology, and is connected with divalent metal ions after being modified by connecting molecules, so as to regulate and control the behaviors of endothelial cells and blood vigor cells; the middle layer adopts a melt spinning technology to form micron fibers which are arranged in a crossed manner, so that sufficient radial and circumferential mechanical support is provided to enhance the deformation resistance; the outer layer utilizes an electrostatic spinning technology to construct compact and randomly arranged nanofibers, so that on one hand, fibrosis infiltration can be prevented; on the other hand, the structural integrity can be effectively ensured. The bionic nerve conduit provides a new material and a new strategy with clinical transformation potential for peripheral nerve defect repair in a complex environment.

This invention relates to the fields of artificial intelligence and biomedical technology, specifically to a robotic automated patching method and system for peripheral nerve conduction detection, as follows: After the doctor selects the examination items on the electromyography instrument, the robot receives instructions and executes the operation; it extracts the patient's limb contour image through a binocular industrial camera system, and calls the nerve-electrode position mapping database to determine the relative positions of standard anatomical feature points; it uses probabilistic Hough transform to filter the lines corresponding to the joints, calculates the intersection points to obtain the feature point image coordinates, combines the relative positions to calculate the target patch position, and then solves the transformation matrix to obtain the three-dimensional coordinates of the robotic arm end; after determining that the electrode inventory is sufficient, it plans a path to grasp the electrodes, aligns and applies them with pressure, verifies the adhesion and contact resistance, and makes fine adjustments if they are unqualified or the impedance drifts; after completing the patching at multiple positioning points, it records the status to form a log, ensuring electrode stability before testing, achieving precise, stable and intelligent patching, reducing medical care intensity and improving diagnostic efficiency.

Neural stimulator systems with an external magnetic coil to produce changing magnetic fields is applied on the neck, in conjunction with one or more tiny injectable objects that concentrates the induced electric or magnetic field to the hypoglossal nerve and protects the user by limiting and charge-balancing the output. Additional and non-invasive neural stimulator systems apply alternating current at one skin electrode and receive oppositely rectified currents at two other skin electrodes.