The invention discloses a preparation method and application of
magnolol derivatives, and belongs to the technical field of
organic synthesis. The invention relates to an application of lignite residues as a catalyst to generate
magnolol derivatives, which comprises the following steps: S1, mixing
magnolol with a
diazo ester compound, adding
acetonitrile, and continuously stirring; s2, adding lignite residues as a catalyst, reacting at
room temperature for 1 hour, heating to 70 DEG C, and continuously reacting for 10-12 hours; s3, stopping the reaction when the reaction of the raw materials is detected to be complete by TLC; and S4, filtering the reaction material, washing the
filter cake with
dichloromethane until the
filter cake is colorless, carrying out reduced pressure concentration on the filtrate to remove volatile components, and carrying out
silica gel column chromatography separation to obtain the magnolol derivative. According to the method, the lignite residues are adopted as the catalyst, the problem that the lignite residues are difficult to treat can be solved, a new thought can be provided for selection of the catalyst in the
organic synthesis reaction, recycling of waste resources is achieved, and the method is suitable for the purposes of
green chemistry and
environmental protection.