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40 results about "Lyso-" patented technology
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Lyso- is a prefix applied to the various phospholipids to indicate the removal of one of the two fatty acids. For example, lysophosphatidylcholines are phosphatidylcholines with a single acyl group in either the 1- or 2-position.
Method of enhancing performance of cerium doped lutetium yttrium orthosilicate crystals and crystals produced thereby
ActiveUS7166845B1Improve performanceShorten production timePolycrystalline material growthMaterial analysis by optical meansLyso-Oxygen vacancy
A method for enhancing the light yield of a single crystal of cerium doped lutetium yttrium orthosilicate (LYSO) in response to irradiation with high energy radiation includes diffusing oxygen into the crystal by heating the crystal for a period of time in an ambient containing oxygen. This process of thermal oxygenation of the crystal effectively supplies oxygen to fill at least some of the oxygen vacancies in the body of monocrystalline LYSO. A scintillation detector comprises a monocrystalline body of LYSO enhanced by oxygen diffusion into the crystal.
Owner:CRYSTAL PHOTONICS
Process for the production of phospholipids
ActiveUS7034168B2High yieldHigh purityMicroorganism based processesPhosphatide foodstuff compositionsPhospholipaseCarboxylic acid
A new enzymatic process for preparing 1,2-diacylated phospholipids using an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced according to the esterification / transesterification process are obtainable in high yield and purity and carry identical desired carboxylic acid, preferably fatty acid, acyl groups at the sn-1 and sn-2 positions. The process involves esterification / transesterification (acylation) of a glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of the above mentioned appropriate enzyme preparation. The process of the invention further relates to a process for the production of 1-acyl-2-lyso-glycerophospholipid, preferably 2-lyso-PC by reacting glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of a sn-1 specific phospholipase (PLA1 or PLA1,2) and a solvent, in a microaqueous medium.
Owner:ENZYMOTEC
Process for growing cerium-doped LYSO scintillating crystals by using molybdenum crucible
ActiveCN104294365AImprove qualitySolve process problemsPolycrystalline material growthFrom frozen solutionsCrucibleCerium
The invention discloses a process for growing cerium-doped LYSO scintillating crystals by using a molybdenum crucible, which belongs to the technical field of scintillating crystal preparation. The process for growing scintillating crystals comprises the following steps: (a) putting a solid-phase reaction material into the molybdenum crucible; (b) putting the crucible into a vacuum furnace, and vacuumizing the vacuum furnace until the pressure of the inside of the furnace is less than or equal to 10 Pa; (c) filling flowing weak reductive protective gas in the furnace; (d) heating the inside of the furnace, and carrying out at least primary air exchange in the process of heating, wherein the air exchange includes vacuumizing the inside of the furnace until the pressure is less than or equal to 10 Pa, and then filling flowing weak reductive protective gas in the furnace again; and (e) further heating the inside of the furnace until the solid-phase reaction material is melted, and carrying out crystal growth. The process for growing LYSO scintillating crystals overcomes technical problems; and by using the process, the molybdenum crucible both can resist oxidation and erosion of molten LYSO raw materials, then high-quality LYSO scintillating crystals grow, and therefore, the production cost is greatly reduced, and the process is relatively simple and easy to control.
Owner:成都东骏激光股份有限公司
Generation of Triacylglycerols from Gums
ActiveUS20090173689A1Fatty oils/acids recovery from wasteFatty acid esterificationPhosphateFatty acid
A method is disclosed for the generation of triacylglycerols from gums that have been separated from an oil product. The gums are treated with an enzyme having PLC activity, which results in the formation of diacylglycerols and phosphates, and treated with an enzyme having PLA activity, which results in the formation of lyso-phospholipids and free fatty acids. The diacylglycerols and the free fatty acids from these two separate reactions then combine in the presence of the enzymes to generate new triacylglycerol molecules.
Owner:BUNGE OILS INC
Two-photon fluorescence dye, preparation method thereof and application
The invention discloses a two-photon fluorescence dye, a preparation method thereof and an application. The two-photon fluorescence dye takes carbazole as a parent body, and the structure of the two-photon fluorescence dye is as shown in the description. According to the two-photon fluorescence dye, in the wide concentration range, one-photon and two-photon fluorescence signals and the concentration of the fluorescence dye have good linear relationships. Two-photon confocal fluorescence micro-imaging experiments show that the fluorescence dyes Lyso-MCO and Lyso-NCO have good permeability for MCF (macrophage chemotactic factor) cells, lysosomes in the cells can be effectively positioned (positioning coefficients are 0.9475 and 0.9398), and the two-photon fluorescence dye is applicable to two-photon fluorescence imaging of the lysosomes in the cells. Compared with a commercial lysosome dye (Lysosome Tracker Red), the two-photon fluorescence dyes Lyso-MCO and Lyso-NCO are better in photo-stability.
Owner:ANHUI UNIVERSITY
Calcium fluoride crystal containing europium, preparation method and application
ActiveCN104357903APromote growthReduce contentPolycrystalline material growthBy pulling from meltHigh energyPhotomultiplier
The invention relates to the technical field of crystal growth, in particular to a calcium fluoride crystal containing europium, a preparation method and application. The calcium fluoride crystal containing europium, provided by the invention, can be irradiate with Co60; the light yield of the crystal is measured with an RCA8850 photomultiplier; the result shows that the calcium fluoride crystal containing europium, provided by the invention, has the excellent scintillating crystal property of emitting twinkling fluorescent light of a certain wave length after absorbing the energy of high-energy particles on the condition that the content of the crystal is low. Especially, the relative light output of the crystal is equal to that of an LYSO scintillating crystal. Besides, as the content is low, the calcium fluoride crystal containing europium is beneficial to growth of high optical mass crystals. The invention further provides the preparation method and the application of the calcium fluoride crystal containing europium.
Owner:BEIJING SCITLION TECH
Phosphoserine containing compositions for immune tolerance induction
ActiveUS20190151426A1More effectivenessInduction of immune toleranceOrganic active ingredientsSolution deliveryImmune toleranceLiposome
Compositions and methods for inducing immune tolerance to proteins and subsequence administration of the proteins are disclosed. Compositions comprise proteins complexed with liposomes comprising PS and PC, wherein at least part of the PS is present as lyso-PS.
Owner:THE RES FOUND OF STATE UNIV OF NEW YORK
Multifunctional scintillation crystal testing platform
InactiveCN106597569AThe result is accurateSolve the problem of difficulty in applying for radioactive sourcesGeological measurementsSilicon photomultiplierLight guide
The invention discloses a multifunctional scintillation crystal testing platform comprising a pedestal, a replaceable testing stand, and a hidden box. The pedestal is mainly used for providing power for the replaceable testing stand, obtaining data collected by the replaceable testing stand, processing the data and then sending the data to a computer through a USB data interface. The replaceable testing stand is formed by cooperation of a silicon photomultiplier array with different light guides by an optical coupling agent. Tested crystals are arranged above the light guides by on air coupling. A large LYSO support is embedded into the hidden box and is used for placing an LYSO crystal block needed by testing. On the basis of a new-generation solid photoelectric sensor SiPM technology, no radioactive source is needed and performances of crystals with different sizes and forms can be measured rapidly and precisely by replacing different light guides, wherein the crystals include a single crystal bar, single crystal arrays with different sizes, a plurality of crystal arrays with standard dimensions, and a plurality of crystal line arrays and the like. With the platform, the crystal product yield of crystal manufacturers can be improved substantially and the production cost and crystal products can be lowered.
Owner:无锡通透光电科技有限公司
Organelle targeting photosensitizer capable of activating pyroptosis of tumor cells and preparation method and application thereof
ActiveCN113956190AFew synthetic stepsRaw material economyOrganic chemistryPhotodynamic therapyReticulum cellLysosomal targeting
The invention discloses an organelle targeting photosensitizer capable of activating pyroptosis of tumor cells and a preparation method and application thereof. The Mito-ZS photosensitizer is a mitochondrial targeting photosensitizer; the Lyso-ZS photosensitizer is a lysosome targeting photosensitizer; the ER-ZS photosensitizer is an endoplasmic reticulum targeting photosensitizer. The photosensitizer activates a pyroptosis pathway by performing precise targeting therapy on organelles in tumor cells so that photodynamic therapy and immunotherapy strategies are perfectly combined, and the photosensitizer has a wide application prospect in the field of cancer therapy.
Owner:DALIAN UNIV OF TECH
Double-targeting fluorescent probe capable of simultaneously visualizing plasma membrane and lysosome and application of double-targeting fluorescent probe
ActiveCN114031549AFusion wellEasy to operateOrganic chemistryPreparing sample for investigationFluoProbesDisease
The invention belongs to the field of fluorescence detection, and relates to a double-targeting fluorescent probe capable of simultaneously visualizing plasma membranes and lysosomes and application of the double-targeting fluorescent probe, the probe is superior to the application of the conventional probe which can only display one observation substance, and the probe can simultaneously mark the plasma membranes and the lysosomes and enable the plasma membranes and the lysosomes to display different colors. Mem-Lyso can be used for marking plasma membranes and lysosomes with red and yellow respectively, so that the relative positions of two organelles of the zebra fish are displayed through real color imaging. More importantly, the Mem-Lyso has the capability of spatially distinguishing the content of cytomembrane cholesterol (CL) due to the double-targeting characteristic, and a potential detection tool is provided for biological research and diagnosis of related diseases, so that research on the relationship between the plasma membrane and the lysosome has important significance for related biological research.
Owner:QILU UNIV OF TECH
Flickering layered photography and ray measuring system and union image and ray measuring system
PendingCN103767724AHigh sensitivityRealize integrationComputerised tomographsDiagnostic recording/measuringPhotographic cameraRadiometer
The invention provides a flickering layered photography and ray measuring system and a union image and ray measuring system. A flickering layered photographic camera comprises a series of detectors and multiple radiometers for detecting target bodies, wherein BGO crystals or LYSO crystals, gamma-ray measuring software or SPECT, and X-ray determinators or CT are adopted in the series of detectors, and the series of detectors are used for detecting positive electrons, negative electrons and X-rays in the target bodies. The multiple radiometers can achieve the PET positive electron detection function and can detect and count residual gamma-rays and X-rays in a multi-probe and multilayer mode, wherein the residual X-rays are in the environment, and therefore the static and / or dynamic positive electron developing and SPECT function or the gamma-ray detection function or the X-ray quantitative analysis function or the CT function is achieved.
Owner:BEIJING TOP GRADE HEALTHCARE MEDICAL EQUIP CO LTD
Preparation method of human hair melanosomes derivative and application of human hair melanosomes derivative in antibiosis and tissue repair
PendingCN112516305AEfficient light-to-heat conversion efficiencyPromote degradationAntibacterial agentsPeptide/protein ingredientsTissue repairMedicine
The invention discloses a preparation method of human hair melanosomes derivatives (HHMs). The preparation method comprises the following steps of step 1, pretreatment: crushing, cleaning and drying human hair; step 2, hydrothermal reaction: carrying out hydrothermal reaction on the pretreated human hair in a NaOH solution; and 3, separation: carrying out centrifugal separation and vacuum drying on a solid sample material obtained after the hydrothermal reaction to obtain HHMs. The invention relates to a preparation method of a human hair melanosomes derivative-lysozyme (HHMs-Lyso) composite material. The preparation method comprises the following steps of uniformly dispersing prepared HHMs into deionized water to obtain a first feed liquid; dispersing lysozyme into deionized water to obtain second feed liquid; and mixing the first feed liquid and the second feed liquid in an isopyknic manner to obtain the HHMs-Lyso. According to the HHMs prepared through the method, MRSA can be efficiently killed by loading Lyso, and meanwhile tissue repair can be promoted through the HHMs.
Owner:TIANJIN UNIV
Experimental device for shortening flicker decay time of LYSO crystal, and experimental method thereof
PendingCN110646835AReduce flicker decay timePromote progressScintillation cellsPhotovoltaic detectorsPhotodetector
The invention discloses an experimental device for shortening flicker decay time of a LYSO crystal, and the experimental device comprises a vertically arranged thermal insulation sleeve, wherein the thermal insulation sleeve comprises a vertically arranged sample placing cylinder, the inner area of the sample placing cylinder is a heating cavity, the sample placing cylinder is made of a thermallyconductive insulating material, a crystal fixing mechanism is provided in the middle of the inner surface of the sample placing cylinder, and heating wires are evenly arranged on the outer surface ofthe sample placing cylinder to form a heating layer. The invention also discloses an experimental method of the above experimental device. The invention detects the flicker decay time of the heated sample crystal by setting a photodetector directly above the sample placing cylinder, and finds that the flicker decay time has changed from the original 36-42ns to 8-12ns, thereby overcoming the technical bias that the persons skilled in the art believe that LYSO crystal flicker cannot be used for high-repetition experiments.
Owner:INST OF FLUID PHYSICS CHINA ACAD OF ENG PHYSICS
Phosphoserine containing compositions for immune tolerance induction
ActiveUS10617640B2Induction of immune toleranceReducing existing antibody titersPeptide/protein ingredientsHydroxy compound active ingredientsLipofectamineLiposome
Owner:THE RES FOUND OF STATE UNIV OF NEW YORK
Medicine for detecting lipid components in vivo and vascular endoscope
InactiveUS20060062732A1Enabling diagnosisUltrasonic/sonic/infrasonic diagnosticsLuminescence/biological staining preparationLipid formationColor image
The present invention provides a medicine and an apparatus which can detect the sites and spreading of in vivo lipids by a two-dimensional image, thereby allowing diagnosis of diseases due to accumulation of lipids. According to the present invention, provided are a medicine for detecting in vivo lipids, comprising one or more components such as oxLDL and lyso PC, as an effective component, selected from a sulfonic acid blue dye having a radical —SO3−, a homidium, Metanyl yellow and Lissamin fast yellow, and an angioscopic system for obtaining a fluorescent image, which comprises a mercury-xenon lamp light source, a quartz fiberscope wherein the light guide part has 100 to 200 fibers and the image guide part has 7000 to 9000 fibers, a rotational exciting filter, an emitting filter, and a high-sensitive digital camera for picking up the fluorescence as a two-dimensional color image.
Owner:UCHIDA YASUMI
Method for measuring temperature change of organelle
ActiveCN112683417AAchieve acquisitionEasy to prepare ingredientsMaterial nanotechnologyNanoopticsLipofectamineIntracellular
The invention relates to a method for measuring the temperature change of an organelle. The method comprises the steps of preparing a temperature-sensitive water-soluble CdTe / CdS / ZnS quantum dot solution, and coating silicon dioxide on the temperature-sensitive water-soluble CdTe / CdS / ZnS quantum dot solution by using a reverse microemulsion method to obtain a CdTe / CdS / ZnS@SiO2 particle solution; then preparing a positioning probe CdTe / CdS / ZnS@SiO2-Cyto, a lysosome targeting positioning probe CdTe / CdS / ZnS@ SiO2-Lyso or a mitochondria targeting positioning probe CdTe / CdS / ZnS@SiO2-Mito for ingesting cytoplasm in cells; respectively taking positioning probes into cells through a liposome transfection method, carrying out targeted positioning in intracellular cytoplasm or on different organelles through different targeted modifications, combining with the temperature-sensitive characteristics of CdTe / CdS / ZnS quantum dots, and realizing acquisition of temperature-sensitive fluorescence information of quantum dots of a targeted organelle through the action of combining an inverted fluorescence microscope with slit locking of a spectrograph, so that temperature change information in cytoplasm or temperature change information of the targeted localized organelle is obtained. According to the invention, targeting cytoplasm and specific organelles (such as lysosome and mitochondria) and monitoring the temperature change of the cytoplasm and specific organelles are realized.
Owner:XI AN JIAOTONG UNIV
Polynucleotides encoding alpha-galactosidase a for the treatment of fabry disease
ActiveUS20200149052A1Minimize unwanted immune activationImprove translation efficiencyPeptide/protein ingredientsMetabolism disorderMetaboliteNanoparticle
The invention relates to mRNA therapy for the treatment of Fabry disease. mRNAs for use in the invention, when administered in vivo, encode human the α-galactosidase A (GLA), isoforms thereof, functional fragments thereof, and fusion proteins comprising GLA. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and / or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and / or restore deficient levels of GLA expression and / or activity in subjects. mRNA therapies of the invention further decrease levels of toxic metabolites associated with deficient GLA activity in subjects, namely Gb3 and lyso-Gb3.
Owner:MODERNATX INC
Device capable of converting high-energy X ray image into visible light image
InactiveCN101604118AAchieving Spatial ResolutionEasy to testX-ray/infra-red processesMaterial analysis by transmitting radiationNanosecondHigh energy
The invention discloses a device capable of converting a high-energy X ray image into a visible light image, which relates to a high-energy physical technique. The device comprises a plurality of parallel LYSO crystal columns to form an array, the incidence plane is parallel with the outgoing plane, and the incidence plane and the outgoing plane are vertical to the vertical direction of crystal columns. The device has the advantages of converting invisible high-energy X ray into visible light for the convenience of testing and achieving the spatial resolving power of sub-millimeter and the time resolving power of tens of nanoseconds.
Owner:INST OF FLUID PHYSICS CHINA ACAD OF ENG PHYSICS
Phosphoserine containing compositions for immune tolerance induction
ActiveUS11083782B2Induction of immune toleranceReducing existing antibody titersOrganic active ingredientsAntibody ingredientsLipofectamineLiposome
Owner:THE RES FOUND OF STATE UNIV OF NEW YORK
Lysosome fluorescent probe based on chalcone as well as preparation method and application of lysosome fluorescent probe
PendingCN114478435AWith push-pull electronic effectSimple structureOrganic chemistryFluorescence/phosphorescenceFluoProbesLysosome
The invention discloses a lysosome fluorescent probe of chalcone as well as a preparation method and application of the lysosome fluorescent probe, and belongs to the technical field of organic molecular fluorescent probes. The preparation method comprises the following steps: adding 2 '-hydroxychalcone HCA and 1, 3-dibromopropane into an organic solvent for reaction, carrying out silica gel column chromatography separation to obtain an intermediate Br-HCA, adding the intermediate Br-HCA and morpholine into the organic solvent for reaction, and carrying out silica gel column chromatography separation to obtain the lysosome fluorescent probe Lyso-HCA. The preparation method of the fluorescent probe is simple, rapid and low in cost, the prepared fluorescent probe is low in background interference, high in detection sensitivity and high in excitation capacity when being applied to cell fluorescence imaging, and the fluorescent probe is good in stability to an acid-base environment and good in specificity to lysosome fluorescence imaging. The probe provides a tool with a wide application prospect for cell lysosome fluorescence imaging research.
Owner:SHAANXI UNIV OF SCI & TECH
A kind of fluorescent dye for lysosome labeling and its synthesis method and application
ActiveCN111333623BRaw materials are cheap and easy to getThe synthesis method is simpleOrganic chemistryNaphthalimide/phthalimide dyesLysosomeBasic research
The invention provides a fluorescent dye for lysosome labeling and its synthesis method and application. The fluorescent dye uses naphthalimide as a fluorophore and introduces an N-(2-aminoethyl) at its N position. Phyloline substituents, two azetidine substituents were introduced at the 4,5-position, and a new type of lysosome fluorescent dye—Lyso-DAze was designed and synthesized. Its structural formula is shown in (1). The fluorescence of the dye The emission wavelength is 498nm, and it has very excellent fluorescence stability and high fluorescence intensity, and can realize the specific labeling of lysosomes in living cells under the condition of relatively low concentration (500nM). The Lyso-DAze dye satisfies the high stability and high brightness requirements of the current super-resolution technology for fluorescent dyes, making lysosome visualization have a very broad application prospect in basic research on the occurrence and development of diseases.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
A kind of preparation method of yttrium lutetium cerium oxide for scintillation crystal
ActiveCN111977680BUniform distribution of rare earth elementsMeet the requirements of scintillation crystalsRare earth metal oxides/hydroxidesOXALIC ACID DIHYDRATERare-earth element
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Phosphoserine containing compositions for immune tolerance induction
ActiveUS20200222322A1Induction of immune toleranceReducing existing antibody titersPeptide/protein ingredientsHydroxy compound active ingredientsLipofectamineLiposome
Owner:THE RES FOUND OF STATE UNIV OF NEW YORK
An intelligent daily quality control method and system for lyso crystal pet
ActiveCN110660464BSave time and costSave resource costMedical equipmentNeural learning methodsQuality controlEngineering
Owner:浙江明峰智能医疗科技有限公司
A silicon-based rhodamine nitric oxide fluorescent probe and its preparation method and application
InactiveCN105153214BReduce distractionsAvoid damageSilicon organic compoundsFluorescence/phosphorescenceBiological bodyLysosome localization
The invention relates to a silicon-based rhodamine nitric oxide fluorescent probe, the structure of which is as follows: the Lyso-SiRB-NO (formula II) has the function of lysosome localization. The advantages of the present invention: the excitation and emission wavelengths of the silicon-based rhodamine nitric oxide probe of the present invention are located in the near-infrared region, which can reduce the interference of the autofluorescent background of the organism when applied to biological imaging, and have strong penetrating ability. There is less damage to living tissues or cells; another advantage of the probe is that it can specifically detect nitric oxide molecules in lysosomes, providing a reliable research tool for studying the physiological effects of nitric oxide molecules.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Method for the Diagnosis of Gaucher's Disease
ActiveUS20180259538A1Strong specificityHigh sensitivityDisease diagnosisEnzymesDiseaseBiologic marker
Owner:CENTOGENE IP GMBH
Compositions and methods for treating atherosclerotic cardiovascular disease
PendingCN111194307AOrganic chemistryMetabolism disorderAtherosclerotic cardiovascular diseaseCardio vascular disease
The present invention relates to lyso-diacylglyceryltrimethylhomoserine (lyso- DGTS) or derivatives thereof for use in the treatment of atherosclerotic cardiovascular disease, and further provides particular such lyso-DGTS derivatives.
Owner:GAVISH GALILEE BIO APPL
Compositions and methods for treating atherosclerotic cardiovascular disease
ActiveUS20200308100A1Organic chemistryMetabolism disorderAtherosclerotic cardiovascular diseaseCardio vascular disease
The present invention relates to lyso-diacylglyceryltrimethylhomoserine (lyso-DGTS) or derivatives thereof for use in the treatment of atherosclerotic cardiovascular disease, and further provides particular such lyso-DGTS derivatives.
Owner:GAVISH GALILEE BIO APPL
A kind of two-photon fluorescent dye and its preparation method and application
Owner:ANHUI UNIVERSITY
Phosphoserine containing compositions for immune tolerance induction
ActiveUS20170209371A1Induction of immune toleranceReducing existing antibody titersOrganic active ingredientsPeptide/protein ingredientsImmune toleranceLiposome
Compositions and methods for inducing immune tolerance to proteins and subsequence administration of the proteins are disclosed. Compositions comprise proteins complexed with liposomes comprising PS and PC, wherein at least part of the PS is present as lyso-PS.
Owner:THE RES FOUND OF STATE UNIV OF NEW YORK
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