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265results about How to "Highly specific" patented technology
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Methods and devices for optical stimulation of neural tissues
InactiveUS6921413B2Increasing electrical field sizeHighly specificElectrotherapySurgeryPHYSICAL MANIPULATIONSOptical stimulation
The present invention provides methods of directly stimulating neural tissue with optical energy. By stimulating neural tissue at wavelengths, laser pulses, and spot sizes disclosed herein, nerve stimulation may be used to uniquely stimulate neural tissue in way not afforded by other means of stimulation. It can allow basic scientists to study the properties of individual neurons or populations of neurons without piercing tissue with fragile microelectrodes. Furthermore, responses of neural tissue can be studied in a pure fashion without contamination by electrical artifact commonly seen with electrical stimulation. With respect to clinical uses, optical stimulation can be used to map function in subsections of peripheral nerves as an aid to operative repair. Finally, stimulation with optical energy does not require physical contact with the nerve which may be an advantage clinically when physical manipulation of neural tissue is not desired.
Owner:VANDERBILT UNIV
Applications of the stimulation of neural tissue using light
InactiveUS20060155348A1Increase electrical field sizeHigh specificityLight therapyLIGHT STIMULATIONLight source
The present invention comprises systems and methods for stimulating target tissue comprising a light source; an implantable light conducting lead coupled to said light source; and an implantable light-emitter. The light source, lead and emitter are used to provide a light stimulation to a target tissue
Owner:DECHARMS RICHARD CHRISTOPHER
Applications of the stimulation of neural tissue using light
The present invention comprises systems and methods for stimulating target tissue comprising a light source; an implantable light conducting lead coupled to said light source; and an implantable light-emitter. The light source, lead and emitter are used to provide a light stimulation to a target tissue
Owner:DECHARMS R CHRISTOPHER
Fan with magnetic blades
InactiveUS6194798B1MiniaturizationReduce manufacturing costMagnetic circuit rotating partsPump componentsStator coilEngineering
A DC driven fan with blades made of magnetized material and permanently magnetized in the radial direction and cooperating with a plurality of electromagnetic stator coils mounted external to the outer fan edges. Adjacent blades have alternate N-S, S-N radial magnetic orientations. In one embodiment, the blades are mounted in a non-ferrous hub and in an alternate embodiment they are mounted in a ferrous hub so that adjacent blades function like a U or V-shaped magnet. Blades can be made of magnetized ferrous, ferromagnetic, or magnetized plastic depending upon the application and blade strength specifications.
Owner:AIR CONCEPTS
Compositions and methods for systemic inhibition of cartilage degradation
InactiveUS7067144B2Limit their usefulnessLow costPowder deliveryOrganic active ingredientsMedicineWhole body
Methods and compositions for inhibiting articular cartilage degradation. The compositions preferably include multiple chondroprotective agents, including at least one agent that promotes cartilage anabolic activity and at least one agent that inhibits cartilage catabolism. The compositions may also include one or more pain and inflammation inhibitory agents. The compositions may be administered systemically, such as to treat patients at risk of cartilage degradation at multiple joints, and suitably may be formulated in a carrier or delivery vehicle that is targeted to the joints. Alternatively the compositions may be injected or infused directly into the joint.
Owner:OMEROS CORP
Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
InactiveUS20030087962A1Control inflammationPain controlBiocideKallidin/bradykinin ingredientsArteriolar VasoconstrictionInflammation Process
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes during arthroscopic procedures. The solution preferably includes a vasoconstrictor that demonstrates substantial agonist activity at alpha adrenergic receptors and that is selected for peripheral (local) vasoconstriction and one or more additional pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for peripheral vasoconstriction and inhibition of pain and / or inflammation while avoiding undesirable side effects associated with systemic application of larger doses of the agents.
Owner:OMEROS CORP
Device and method for investigating analytes in liquid suspension or solution
InactiveUS7245379B2Small sizeEasy to adaptBioreactor/fermenter combinationsBiological substance pretreatmentsAnalytePlanar substrate
Owner:PROIMMUNE
Device and method for investigating analytes in liquid suspension or solution
InactiveUS20050068536A1Small sizeEasy to adaptBioreactor/fermenter combinationsBiological substance pretreatmentsAnalytePlanar substrate
An optical detection device is provided for analysing analytes in a liquid suspension or solution that can detect and process a large number of wavelengths of incident and fluorescent light simultaneously, which is small in size and can be easily adapted to different investigation requirements. In one embodiment an optical detection device comprises a light supplying means (45), an analyte handling means (78), a light directing means (19), and detection means, integrated on planar substrate devices (40), (20), and (30), (30′), respectively. A plurality of optical waveguides are integrated in the substrate devices to direct light emitted by the light supplying means (45) through the different sections of the optical detection device to the detection means. The analyte handling means (78) comprises an analyte channel (70) for the liquid flow of the analyte suspension or solution and an analyte sorting means (72) comprising several sorting channels (72′).
Owner:PROIMMUNE
Synthetic Nano-Sized Crystalline Calcium Phosphate and Method of Production
ActiveUS20080220233A1Easy to depositMaximize adherence to surfaceMaterial nanotechnologyNanostructure manufactureLiquid crystallineSolvent
Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2 / g to 300 m2 / g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described. The method comprises formation of a liquid crystalline phase in a water solution of calcium, phosphor and a surfactant, placing the phase in an ammonia atmosphere so that nano-sized crystals are formed, followed by either removal of the surfactant with a solvent and recovering the nano-sized crystals to obtain the powder, or diluting the ammonia-treated liquid crystalline phase with a hydrophobic organic solvent to create a microemulsion of the nano-sized crystals in water, dipping an oxide layer-coated surface of an object into the microemulsion, or alternatively saving the step of ammonia treatment of the liquid crystalline phase until after the dipping of the surface of an object into the microemulsion, followed by removal of the organic solvent and the surfactant from the surface to obtain the coating.
Owner:PROMIMIC
Irrigation solution and method for inhibition of pain, inflammation, spasm and restenosis
InactiveUS6413961B1Limit their usefulnessLow costBiocideNervous disorderPercent Diameter StenosisMuscle spasm
A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general surgical, therapeutic and diagnostic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents, including at least one local anesthetic agent, and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. Specific preferred embodiments of the solution of the present invention for use in cardiovascular and general vascular procedures also include anti-restenosis agents.
Owner:OMEROS CORP
Compositions and methods for systemic inhibition of cartilage degradation
InactiveUS20060210552A1Control degradationControl inflammationOrganic active ingredientsPowder deliveryMedicineWhole body
Methods and compositions for inhibiting articular cartilage degradation. The compositions preferably include multiple chondroprotective agents, including at least one agent that promotes cartilage anabolic activity and at least one agent that inhibits cartilage catabolism. The compositions may also include one or more pain and inflammation inhibitory agents. The compositions may be administered systemically, such as to treat patients at risk of cartilage degradation at multiple joints, and suitably may be formulated in a carrier or delivery vehicle that is targeted to the joints. Alternatively the compositions may be injected or infused directly into the joint.
Owner:OMEROS CORP
Affinity chromatography matrices and methods of making and using the same
ActiveUS20070207500A1Highly specificFast and economicalPeptide/protein ingredientsOther chemical processesAntibody Affinity ChromatographyChromatography
The invention provides methods of coupling protein ligands to a solid support. The invention also provides affinity chromatography matrices and methods of using affinity chromatography matrices to purify a target molecule.
Owner:MILLIPORE CORP
Rationally designed antibodies
InactiveUS7396917B2Highly specificImprove biological activityAntibacterial agentsBacteriaDiagnostic modalitiesBioactive peptide
Antibodies or fragments thereof having at least two CDR regions replaced or fused with biologically active peptides are described. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities.
Owner:ALEXION PHARMA INC
Method and system for detecting and/or classifying cancerous cells in a cell sample
ActiveUS20140139625A1Fast and inexpensiveIncrease riskTelevision system detailsPhase-affecting property measurementsCancer cellDigital holographic microscopy
The current invention concerns a method for detecting cancerous cells and / or classifying cells in a cell sample comprising the following steps: providing a cell sample; obtaining holographic information from said cell sample by digital holographic microscopy (DHM); deriving at least one cellular parameter from said holographic information, and; classifying said cells of cells sample; characterized in that said classification occurs by appointing a Scoring Factor to said cells of cell sample, based on said cellular parameters. In a second aspect, a system for the detection of cancerous cells and / or classification of cells in a cell sample is provided, employing the method as disclosed in the invention. In a final aspect, a method for updating and / or improving a database comprising thresholds linked to holographic information and the database related thereof is equally disclosed.
Owner:OVIZIO IMAGING SYST NV SA
Pharmaceutical compositions
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral / dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a mu-opioid agonist.
Owner:OMEROS CORP
Surgical irrigation solution and method for inhibition of pain and inflammation
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral / dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a mu -opioid agonist.
Owner:OMEROS CORP
Detecting variants in sequencing data and benchmarking
InactiveUS20150178445A1Easily measureAccurately detectProteomicsBiological testingSequencing dataSomatic cell
Owner:BROAD INSTITUTE
Methods for monitoring pathological conditions in a female subject
InactiveUS20100136707A1Readily and accurately detectedHighly specificChemical analysis using titrationMicrobiological testing/measurementAbsorbent materialFluid volume
A method for identifying physiological conditions associated with the pH or the buffer capacities of biological fluid secreted from a person, by providing a secretion-monitoring article of a body that includes an absorbent material for absorbing a biological fluid secreted from a person and an indicator system having a hydrophobic chemical composition that includes an indicator agent and an ion-balance reagent, at specific relative amounts. Optionally, a competitive agent for establishing a pre-set threshold of an analyte of interest in a tested bodily fluid, is added to the indicator system, wherein the indicator reagent being charged oppositely to the analyte of interest and the competitive reagent having the same charge as the indicator reagent.
Owner:COMMON SENSE
Methods for monitoring pathological conditions in a female subject
InactiveUS7947467B2Readily and accurately detectedHighly specificMicrobiological testing/measurementVaccination/ovulation diagnosticsAbsorbent materialFluid volume
A method for identifying physiological conditions associated with the pH or the buffer capacities of biological fluid secreted from a person, by providing a secretion-monitoring article of a body that includes an absorbent material for absorbing a biological fluid secreted from a person and an indicator system having a hydrophobic chemical composition that includes an indicator agent and an ion-balance reagent, at specific relative amounts. Optionally, a competitive agent for establishing a pre-set threshold of an analyte of interest in a tested bodily fluid, is added to the indicator system, wherein the indicator reagent being charged oppositely to the analyte of interest and the competitive reagent having the same charge as the indicator reagent.
Owner:COMMON SENSE
Human antibodies against tissue factor
ActiveUS20110300156A1Improved treatment of cancerConvenient treatmentFungiBacteriaMonoclonal antibodyTissue factor antibody
Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
Owner:GENMAB AS
Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
InactiveUS7091181B2Limit their usefulnessLow costHormone peptidesPeptide/protein ingredientsInflammation ProcessVein
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral / dental procedures. The solution preferably includes at least one tumor necrosis factor (TNF) soluble receptor at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied locally and perioperatively to a surgical site during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents.
Owner:OMEROS CORP
Front Electronic Equipment System
InactiveUS20060274467A1Easily dealing with change in functionReduce noiseVehicle testingRegistering/indicating working of vehiclesElectricityControl signal
A front electronic equipment system includes a load electrical parts provided at a front portion of a vehicle, a front electrical control unit which receives a control signal for controlling the drive of the load electrical parts through a main bus line of the vehicle, and a drive control unit connected to the front electrical control unit through a sub bus line, converting the control signal into a drive signal, and driving the load electrical parts based on the drive signal. The front electrical control unit converts a communication protocol of the control signal from a communication protocol of the main bus line into a communication protocol of the sub bus line, and transmits the converted control signal received through the main bus line to the drive control unit through the sub bus line.
Owner:YAZAKI CORP
Integrated Method for Enriching and Detecting Rare Cells from Biological Body Fluid Sample
InactiveUS20110195413A1Good cell shapeHigh recovery rateBioreactor/fermenter combinationsBiological substance pretreatmentsStainingSorbent
The present invention relates to an integrated method for enriching and detecting rare cells in biological body fluid sample. The enriching method comprises: (a) removing plasma protein by centrifugation; (b) optionally adding a red cell lysis solution to carry out red cell lysis so as to remove the red blood cells; (c) adding immunomicrospheres or immunoadsorbent to incubate; and (d) carrying out density centrifugation based on a special cell separation medium for separating the circulating rare cells, residual red blood cells after removing red blood cells and the white blood cells combined on the immunomicrospheres. The method for detecting the enriched rare cells according to the present invention comprises combining immunohistochemistry based staining with immunofluorescence, or bicolor, tricolor or multicolor staining based on immunohistochemistry, and observing and identifying by fluorescence or ordinary optical microscope or a scanner based on microscope principle. The novel and unique method for enriching and staining has been proved to have low cost and can rapidly, effectively and high specifically enrich and quantitatively detect the rare cells in blood.
Owner:CYTTEL BIOSCI BEIJING
Dental prosthesis and method of its production utilizing standardized framework keys and matching premanufactured teeth
ActiveUS8875398B2Rapid and precisely accurate methodHighly repeatableDental implantsFastening prosthesisDenturesMethods of production
A system including a method and associated structures creates efficiencies in the manufacture of prosthetic tooth support frameworks. Pre-manufactured teeth with matching internal keys are used in the setup of a patient prototype. Each key includes a shaft, a cervical platform, a retention knob and preferably at least one channel for the expulsion of excess adhesive fluid. The cervical platforms are shaped to provide intimate contact with a base of their respective tooth. The same tooth / key pairs are then used to make a framework pattern from the setup positioning. The pattern can be cast or scanned for direct machining to produce the finished framework.
Owner:GLOBAL DENTAL SCI
Methods and Compositions for Identifying Sulfur and Iron Modifying Bacteria
ActiveUS20110104684A1Easy to controlSave moneySugar derivativesMicrobiological testing/measurementAmplification dnaSulfur
The invention relates to methods and compositions for identifying specific bacterial species, which are sulfur and iron oxidizers and / or reducers, from wall board (e.g., dry wall) and / or a patient tissue or body fluid. The method comprises the steps of extracting and recovering DNA of the bacterial species from the wall board and / or the patient tissue or body fluid, amplifying the DNA, hybridizing a probe to the DNA to specifically identify the bacterial species, and specifically identifying the bacterial species. Kits and nucleic acids for use in the methods are also provided. Methods for eliminating the sulfur and iron oxidizing and / or reducing bacteria from wall board using a zeolite are also provided.
Owner:ADVATECT DIAGNOSTICS LLC
Monoclonal antibodies against her2
ActiveUS20130189271A1Improve efficiencyImproved internalizationAnimal cellsImmunoglobulins against cell receptors/antigens/surface-determinantsMonoclonal antibodyHuman Epidermal Growth Factor Receptor 2
Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related anti-body-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
Owner:GENMAB AS
Method and system for detecting and/or classifying cancerous cells in a cell sample
ActiveUS9684281B2Increased riskFast and inexpensivePhase-affecting property measurementsStill image data indexingCancer cellDigital holographic microscopy
The current invention concerns a method for detecting cancerous cells and / or classifying cells in a cell sample comprising the following steps: providing a cell sample; obtaining holographic information from said cell sample by digital holographic microscopy (DHM); deriving at least one cellular parameter from said holographic information, and; classifying said cells of cells sample; characterized in that said classification occurs by appointing a Scoring Factor to said cells of cell sample, based on said cellular parameters. In a second aspect, a system for the detection of cancerous cells and / or classification of cells in a cell sample is provided, employing the method as disclosed in the invention. In a final aspect, a method for updating and / or improving a database comprising thresholds linked to holographic information and the database related thereof is equally disclosed.
Owner:OVIZIO IMAGING SYST NV SA
Rationally designed antibodies
InactiveUS7482435B2Highly specificImprove biological activityBacteriaAntibody mimetics/scaffoldsDiagnostic modalitiesBioactive peptide
Antibodies or fragments thereof having CDR regions replaced or fused with biologically active peptides are described. Flanking sequences may optionally be attached at one or both the carboxy-terminal and amino-terminal ends of the peptide in covalent association with adjacent framework regions. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities.
Owner:ALEXION PHARMA INC
Device and method for invetigating analytes in liquid suspension or solution
InactiveUS20070268489A1Small sizeEasy to adaptBioreactor/fermenter combinationsBiological substance pretreatmentsAnalytePlanar substrate
Owner:PROIMMUNE
Catalytic antibodies
ActiveUS7205136B1Strong specificityConstant and inexpensiveMicrobiological testing/measurementBiological material analysisChemical reactionReaction rate
A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal antibody under conditions permitting the formation of a complex between the antibody and the reactant. The complexed reactant is converted to the product which is then released from the complex. The monoclonal antibody may employ a cofactor and may be directed to a known substrate of an enzyme. Methods for preparing such monoclonal antibodies are also disclosed.
Owner:WELLSTAT BIOCATALYSIS
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