22 results about "Nerve agent" patented technology

The present invention relates to a compound of formula (I). It also relates to a pharmaceutical composition comprising at least one compound of formula (I) and at least one pharmaceutically acceptable support. Finally, it relates to the use of such a compound as a medicine, preferably in the treatment of a nervous and / or respiratory failure due to intoxication with at least one organophosphorous nerve agent; in the treatment of neurological diseases such as Alzheimer's disease; and / or in the treatment of cancer.

The present invention discloses a fluorescence probe based on naphthalimide for detecting nerve agent simulants, which relates to the technical field of fluorescence probes. To further expand the detection means of fluorescence probes based on naphthalimide for nerve agent simulants; the structural formula of the organic probe 1 of the present invention is synthesized with naphthalimide as the fluorophore and piperazine as the recognition site; the synthesis method of the organic probe 1 of the present invention is simple, and the organic probe 1 has good fluorescence responses to DCP and DCNP, can visually detect DCP and DCNP, can well recognize DCP and DCNP, and has a low detection limit; it provides a new detection means for fluorescence probes based on naphthalimide for nerve agent simulants, which is conducive to the further development of nerve agent detection technology based on fluorescence probes.

The invention relates to a paper spray ionization sampling device, further relates to a kit comprising the device, further relates to application of the device and the kit to detection of a Bitz or nerve agent hydrolysate, and further relates to a method for detecting the Bitz or nerve agent hydrolysate by using the device.

Aryl-substituted acetamide and pyrrolidin-2-one (γ-butyrolactam) derivatives have useful activity in the inhibition, prevention, or treatment of seizures. The derivatives may be useful in the treatment of epilepsy, including medically refractory epilepsy, and nerve agent poisoning.

The present application provides a biological product and a method and an application thereof. The biological product is used for the preparation of a therapeutic agent for cancer treatment, and it includes at least one of the recombinant butyrylcholinesterase-albumin (rBChE-albumin) fusion protein and the recombinant butyrylcholinesterase-Fc (rBChE-Fc) fusion protein. The biological product adjusts the balance of acetylcholine and other related metabolic pathways by supplementing at least one of the exogenous rBChE-albumin fusion protein and rBChE-Fc fusion protein to treat cancer. The present invention solves the problem that the extraction and purification of BChE from human serum may not meet the huge demand for cancer treatment. The present application further provides a biological product for neutralizing and degrading nerve agents and organophosphate compounds, hydrolyzing ghrelin, and anti-wrinkle.

The invention relates to a method for detecting sarin simulant diethyl chlorophosphate by using a europium-based metal organic framework nano material, and nano particles are the europium-based metal organic framework material of double ligands (1, 3, 5-tri (4-carboxyl phenyl) benzene and o-phenylenediamine tripolymer) uniformly grown on the surface of nano cellulose. The europium-based metal organic framework material taking o-phenylenediamine tripolymer as the ligand can weaken red fluorescence due to the fact that the antenna effect is hindered. Amino groups in the ligand can be subjected to nucleophilic addition reaction with diethyl chlorophosphate, so that an addition ligand with unstable coordination is generated, the addition ligand is separated from a material framework, red fluorescence is recovered, rapid and high-sensitivity fluorescence enhancement detection on sarin toxic agent simulant diethyl chlorophosphate atmosphere is realized, the detection limit is 2.88 ppb, and the response time is about 1 s. Meanwhile, the film material overcomes the interference of acid, realizes the specific detection of diethyl chlorophosphate, and provides an extensive design thought for the detection of functional metal organic framework materials and nerve toxic agents.

The present invention relates to a compound of formulas (II) to (V). It also relates to a pharmaceutical composition comprising at least one compound of formulas (II) to (V) and at least one pharmaceutically acceptable support. Finally, it relates to the use of such a compound as a medicine, preferably in the treatment of a nervous and / or respiratory failure due to intoxication with at least one organophosphorus nerve agent by reactivation of hAChE; in the treatment of neurological diseases such as Alzheimer's disease; and / or in the treatment of cancer.

A respiratory and eye protection device having at least one filter and at least one axial fan. The least one filter is configured to achieve an aerosolized particle contamination filtration efficiency of 50% or greater for particles having a size of about 0.3 μm and configured to achieve a vapor contamination filtration efficiency of 50% or greater for one or more of Novichok nerve agent (A232), thickened venomous nerve agent (TVX), sulfur mustard agent (HD), thickened sulfur mustard agent (THD), soman nerve agent (GD), and sarin nerve agent (GB). During the operation and monitoring of the respiratory and eye protection device, at least one fan is activated when concentrations of select aerosolized chemical, biological, radiological, and nuclear (CBRN) agents are detected.

The invention discloses a fluorescent compound with double excited state characteristics and a preparation method and application thereof, and belongs to the field of fluorescence sensing. The invention aims to solve the problem of insufficient sensitivity of the existing fluorescence detection mechanism in detection of the organophosphorus nerve poison. The structural general formula of the fluorescent compound is shown in the specification. The preparation method comprises the following steps: mixing a brominated precursor, a donor and other raw materials, reacting, and finally filtering and purifying. The preparation method is used for preparing the nerve poison detection film.

The present invention provides a tetraphenylethylene-based covalent organic framework material with a high fluorescence quantum yield, as well as a preparation method and uses. Due to the introduction of the aggregation-induced emission unit tetraphenylethylene, the conjugated interaction between the tetraphenylethylene moiety and the linking group is weakened, thereby changing the exciton dynamics between other linking groups, resulting in a photoluminescence quantum yield of 73%. This material exhibits excellent luminescence performance and is suitable for use in the field of optoelectronic materials, providing insights for the design of similar materials. Furthermore, this material possesses regular pores and abundant active sites. The highly reactive imine linking sites can nucleophilically attack the phosphorus-chlorine bond in the nerve agent simulant diethyl chlorophosphate, altering the conjugated relationship of its linking groups. This material exhibits excellent detection efficiency for the nerve agent simulant diethyl chlorophosphate. The material is characterized by simple and rapid operation, sensitive response, ease of use, and low cost, providing an effective technical means for relevant departments to detect potentially hazardous substances.

Aryl-substituted acetamide and pyrrolidin-2-one (γ-butyrolactam) derivatives have useful activity in the inhibition, prevention, or treatment of seizures. The derivatives may be useful in the treatment of epilepsy, including medically refractory epilepsy, and nerve agent poisoning.

A respiratory and eye protection device having at least one filter and at least one axial fan. The least one filter is configured to achieve an aerosolized particle contamination filtration efficiency of 50% or greater for particles having a size of about 0.3 pm and configured to achieve a vapor contamination filtration efficiency of 50% or greater for one or more of Novichok nerve agent (A232), thickened venomous nerve agent (TVX), sulfur mustard agent (HD), thickened sulfur mustard agent (THD), soman nerve agent (GD), and sarin nerve agent (GB). During the operation and monitoring of the respiratory and eye protection device, at least one fan is activated when concentrations of select aerosolized chemical, biological, radiological, and nuclear (CBRN) agents are detected.

The invention provides a fluorescent single-particle membrane device for detecting nerve agent simulant diethyl chlorophosphate and a preparation method of the fluorescent single-particle membrane device. According to the single-particle film device, a lattice structure is formed on a glass substrate by utilizing photoresist or an ultraviolet curing adhesive material through mask exposure, and a tetraphenylethylene covalent organic framework material is loaded by means of a rubber substrate; and then the two are attached, positive pressure is applied, heating is conducted, the photo-curing material in the molten state is made to adhere to the frame material, and finally the single-particle film is formed. After the device is in contact with a diethyl chlorophosphate atmosphere and a methanol solution thereof, the fluorescence of the device at 543 nm is specifically quenched, so that high-sensitivity, high-selectivity, on-site rapid and visual detection of diethyl chlorophosphate is realized.

The invention belongs to the technical field of medicines, and particularly discloses an application of IEM-1925 and pharmaceutically acceptable salts thereof in preparation of medicines for treating epileptic status and brain injury caused by nerve toxic agents. In-vivo animal experiments prove that the IEM-1925 is applied after soman poisoning, behavioral epilepsy and electroencephalogram epilepsy can be effectively terminated, neuronal death and neuroinflammation in a hippocampal region can be remarkably relieved, and the long-term cognitive function and anxiety-like behaviors of poisoned living animals can be improved. The curative effect of the medicine is obviously superior to that of the existing standard medicine diazepam in the aspects of epilepsy control, brain injury protection and sequelae improvement. The application range of the IEM-1925 is expanded, the provided medicine is simple in preparation process and low in cost, has good clinical application prospects and market value, provides a brand-new and efficient neuroprotective medicine for treating nerve poison poisoning, and has great medical and public safety value.

This invention relates to an organic fluorescent sensor array for the sensitive and selective detection of sarin using fluorescence methods, and its preparation method. The organic fluorescent sensor material is assembled with compounds of formula (B) and formula (C), which are insensitive to nerve agents, along with the compound of formula (A), to form an organic fluorescent sensor array consisting of material 1 and material 2. This improves upon the poor stability and susceptibility to interference when using compound (A) alone for sarin detection, while maintaining the sensitivity for sarin detection, thus improving the fluorescence stability and anti-interference capability of the detection.

The invention discloses a Ga-based metal organic framework material for detecting sarin simulants and a preparation method and application thereof, the material takes N, N '-di-(isophthalic acid)-1, 2, 6, 7-tetrachloroperylene-3, 4, 9, 10-tetracarboxylic diimine as an organic ligand, the organic ligand and metal Ga < 3 + > are synthesized under solvothermal conditions, and the Ga-based metal organic framework material shows excellent thermal stability and chemical stability. The material shows different degrees of fluorescence opening response to a nerve agent sarin simulant-diethyl chlorophosphate in solvents with different polarities, the response time is extremely short (less than 10 s), the fluorescence detection limit can reach 4.44 ppb, and the material has extremely high sensitivity and shows remarkable selective recognition capability and cyclic test capability to diethyl chlorophosphate. According to the material, detection and analysis of trace diethyl chlorophosphate are achieved, the application range of the metal organic framework material based on the perylene bisimide derivative in the field of nerve poison detection is widened, and a new design thought and theoretical basis are provided for development of efficient and sensitive fluorescent sensing materials.

The invention discloses a nano-film based on an azetidine hydrazide derivative and a preparation method and fluorescence sensing application thereof, and the nano-film is prepared by taking the azetidine hydrazide derivative and tetraformyl tetraphenylethylene as construction units through a dynamic confinement self-assembly reaction of a gas-liquid interface. By introducing azetidine into hydrazide, the molecular structure can be changed, the electronic configuration can be regulated and controlled, and meanwhile, the system is endowed with specific sensing recognition capability. The preparation method of the nano-film is simple and easy to implement and mild in condition, the size of the film can be accurately regulated and controlled by changing the size of the glass substrate, and convenience is provided for application of the nano-film in large-scale production. The nano-film not only has a flat and smooth surface and good flexibility and self-supporting capability, but also has excellent sensing performance of gaseous nerve poison simulants diethyl chlorophosphate (DCP) and thionyl chloride (SOCl2), shows fluorescence color change from dark to bright, and can realize field detection and distinguishing identification of DCP and SOCl2.

This paper discloses a method for preparing an electrochemical sensing glove based on screen-printed electrodes (SPEs) modified with Cu-BTC and Au@Cu-BTC materials. A layered Cu-BTC MOF material with a large specific surface area, strong surface reactivity, and strong electron transfer ability was prepared for the hydrolysis products of nerve agents, ethyl methyl phosphate (EMPA) and isopropyl methyl phosphate (IMPA), which have high chemical stability and limited electrochemical activity. Gold nanoparticles (Au NPs) obtained by plasma reduction were loaded on the layered Cu-BTC material to prepare the Au@Cu-BTC material. The strong affinity of the Au-S bond formed between the Au@Cu-BTC material and thiodiglycol (TDG), a hydrolysis product of mustard gas, was utilized to construct an electrochemical sensing glove for efficiently detecting TDG. The detection device is simple to operate, convenient, time-saving, and low-cost, and can be used for online detection in the field.

The present invention discloses a quinoxalinone containing styrylpyridine and its preparation method, belonging to the field of chemical analysis and detection. This compound is first obtained by condensing 2-amino-4-nitrodiphenyl with pyruvic acid to get phenylquinoxalinone, and then condensing with pyridylbenzaldehyde to obtain the final product. The reaction conditions are mild and the steps are simple to operate. At the same time, this compound has good fluorescence emission performance and reaction activity, and can be used as a fluorescent probe to achieve rapid and sensitive detection of the nerve agent simulant diethyl chlorophosphate DCP.

The invention relates to a preparation method of an antidote zeolite imidazate skeleton for central nervous agent poisoning, which comprises the following steps: S100, weighing 2.6 mg of Mal-PEG2000-COOH, dissolving in 5ml of PBS (Phosphate Buffer Solution) with the pH value of 7.4, and carrying out ultrasonic full dissolution to form a first reaction solution; s200, 2 mg of RVG15 is weighed and dissolved in 5 ml of a PBS solution, the PH value of the PBS solution is 7.4, and a second reaction solution is formed after sufficient ultrasonic dissolution; s300, adding the first reaction solution in the step S100 and the second reaction solution in the step S200 into a reaction bottle, reacting for 20-28 hours in a dark place under the condition of nitrogen protection, dialyzing through a 3000Da dialysis bag, removing unreacted substances, and freeze-drying the obtained product for 20-28 hours to prepare RVG15-PEG2000-COOH; s400, weighing HI-6, dissolving HI-6 in a blank ZIF-8 suspension, uniformly stirring to form drug-loaded ZIF-8, centrifuging the drug-loaded ZIF-8 to remove free drugs, and alternately washing the drug-loaded ZIF-8 with methanol and water to prepare HI-6 ZIF-8; and S500, adding the RVG-PEG2000-COOH prepared in the step S300 into the HI-6 (at) ZIF-8 prepared in the step S400, so as to prepare the HI-6 loaded brain targeting ZIF-8.

The invention provides a D-A-D type organic fluorescent small molecule based on 2, 2 '-dipyridyl, a preparation method and application of the D-A-D type organic fluorescent small molecule in detection of chemical warfare agents, and belongs to the technical field of fluorescent sensing. The D-A-D type organic fluorescent small molecule is composed of 2, 2 '-dipyridyl and an electron donating group, the 2, 2'-dipyridyl serves as an electron acceptor group and a recognition group, after the electron donating group is introduced to different binding sites of the 2, 2 '-dipyridyl, an intramolecular charge transfer state can be formed, and the D-A-D type organic fluorescent small molecule is constructed; meanwhile, 2, 2 '-bipyridine serving as a recognition site of a sensing reaction and nerve poison molecules are subjected to protonation, the purpose of detecting the nerve poison is achieved, efficient fluorescence detection of trace nerve poison molecules in a liquid phase and a gas phase can be achieved, and the sensor has the advantages of being high in sensitivity, good in selectivity, high in anti-interference capacity and the like.

The invention entails methods to detect and at least partially decontaminate an intact skin surface of a person suspected of exposure to harmful substance, such as cholinesterase inhibitors (i.e., nerve agents, carbamate pesticides), vesicants or synthetic opioids. The method uses a two-step film-forming composition, which indicates dermal contact of harmful substances, and at least partially decontaminate the skin surface if needed.