7 results about "Nerve agent" patented technology

The present invention relates to a compound of formula (I). It also relates to a pharmaceutical composition comprising at least one compound of formula (I) and at least one pharmaceutically acceptable support. Finally, it relates to the use of such a compound as a medicine, preferably in the treatment of a nervous and / or respiratory failure due to intoxication with at least one organophosphorous nerve agent; in the treatment of neurological diseases such as Alzheimer's disease; and / or in the treatment of cancer.

The invention relates to a paper spray ionization sampling device, further relates to a kit comprising the device, further relates to application of the device and the kit to detection of a Bitz or nerve agent hydrolysate, and further relates to a method for detecting the Bitz or nerve agent hydrolysate by using the device.

The present application provides a biological product and a method and an application thereof. The biological product is used for the preparation of a therapeutic agent for cancer treatment, and it includes at least one of the recombinant butyrylcholinesterase-albumin (rBChE-albumin) fusion protein and the recombinant butyrylcholinesterase-Fc (rBChE-Fc) fusion protein. The biological product adjusts the balance of acetylcholine and other related metabolic pathways by supplementing at least one of the exogenous rBChE-albumin fusion protein and rBChE-Fc fusion protein to treat cancer. The present invention solves the problem that the extraction and purification of BChE from human serum may not meet the huge demand for cancer treatment. The present application further provides a biological product for neutralizing and degrading nerve agents and organophosphate compounds, hydrolyzing ghrelin, and anti-wrinkle.

The present invention relates to a compound of formulas (II) to (V). It also relates to a pharmaceutical composition comprising at least one compound of formulas (II) to (V) and at least one pharmaceutically acceptable support. Finally, it relates to the use of such a compound as a medicine, preferably in the treatment of a nervous and / or respiratory failure due to intoxication with at least one organophosphorus nerve agent by reactivation of hAChE; in the treatment of neurological diseases such as Alzheimer's disease; and / or in the treatment of cancer.

A respiratory and eye protection device having at least one filter and at least one axial fan. The least one filter is configured to achieve an aerosolized particle contamination filtration efficiency of 50% or greater for particles having a size of about 0.3 pm and configured to achieve a vapor contamination filtration efficiency of 50% or greater for one or more of Novichok nerve agent (A232), thickened venomous nerve agent (TVX), sulfur mustard agent (HD), thickened sulfur mustard agent (THD), soman nerve agent (GD), and sarin nerve agent (GB). During the operation and monitoring of the respiratory and eye protection device, at least one fan is activated when concentrations of select aerosolized chemical, biological, radiological, and nuclear (CBRN) agents are detected.

The invention provides a fluorescent single-particle membrane device for detecting nerve agent simulant diethyl chlorophosphate and a preparation method of the fluorescent single-particle membrane device. According to the single-particle film device, a lattice structure is formed on a glass substrate by utilizing photoresist or an ultraviolet curing adhesive material through mask exposure, and a tetraphenylethylene covalent organic framework material is loaded by means of a rubber substrate; and then the two are attached, positive pressure is applied, heating is conducted, the photo-curing material in the molten state is made to adhere to the frame material, and finally the single-particle film is formed. After the device is in contact with a diethyl chlorophosphate atmosphere and a methanol solution thereof, the fluorescence of the device at 543 nm is specifically quenched, so that high-sensitivity, high-selectivity, on-site rapid and visual detection of diethyl chlorophosphate is realized.

This invention relates to an organic fluorescent sensor array for the sensitive and selective detection of sarin using fluorescence methods, and its preparation method. The organic fluorescent sensor material is assembled with compounds of formula (B) and formula (C), which are insensitive to nerve agents, along with the compound of formula (A), to form an organic fluorescent sensor array consisting of material 1 and material 2. This improves upon the poor stability and susceptibility to interference when using compound (A) alone for sarin detection, while maintaining the sensitivity for sarin detection, thus improving the fluorescence stability and anti-interference capability of the detection.