The invention discloses
receptor-modified and
receptor-free
titanium dioxide nano
metal film Raman chips and a manufacturing method. Each
chip is composed of a surface enhanced
Raman scattering (SERS) film and a carrier thereof, the carriers comprise the capillary type carrier, the small box type carrier and the
microfluidic channel type carrier, the SERS-films comprise the
receptor-modified SERS-film and the receptor-free SERS-film, and six types of the Raman chips are obtained. Control standards are set in the manufacturing method, and the controllable SERS-film manufacturing method comprises the steps that 1, a
titanium dioxide film is pulled through a
sol-
gel method, and scattered particles are crystallized; 2, a second-layer nano silver foil / silver particle SERS-film grows through
photocatalysis; 3, the second-layer SERS-film is modified with specifically coordinated and combined receptor molecules through
hydrogen bonding force or immune bonding force according to the needs of detected object donor molecules, and then a third-layer SERS-film is formed. The Raman chips can be applied to environmental
pollution treatment and detection, hard
drug and warfare
agent detection,
pesticide residue detection, harmful
food additive screening, large-scale early-stage
cancer Raman screening and the like.