The invention provides a
mechanics analysis device for piezomodulated and sensed single
cell, comprising a piezoelectric
chip, a detecting tank, and a controlling and detecting
system. The
mechanics analysis device is characterized in that the piezoelectric
chip is encapsulated in the detecting tank; the mechanic dynamic analysis on the piezomodulated and sensed single
cell is carried out by controlling an detecting
system; the piezoelectric
chip consists of a piezoelectric sheet and at least one group of electrodes arranged on the surface of the piezoelectric sheet; one group of
electrode pairs and the piezoelectric sheet form a piezoelectric
resonator; the
electrode pair comprises at least one micro-
electrode with the area matched with that of the single
cell and surface decorated chemically; the single cell is naturally fixed on the chemically decorated micro-electrode in a bonding way; the
microelectrode can generate vibration by the controlling and detecting
system and can interact with the bonding cell, thus synchronously realizing the
dynamic modulation and real-time induction of the single
cell mechanics. The device and the method aim at solving the problem of difficulty on modulation and monitoring of the
cell mechanics in the single
cell mechanics technology and have the characteristics of no existence of non-mechanic interference, high simpleness and flexibility,
high flux and the like; the bio-mechanic characteristics of the cell can be discovered on
cell layer, time and space; and the
mechanics analysis device can be suitable for application in the wide fieldssuch as
biomechanics,
tissue engineering,
drug screening, clinical
medicine, and the like.