The invention provides a Fano resonance sensing apparatus based on an axisymmetric optical micro-cavity. The Fano resonance sensing apparatus comprises an axisymmetric optical micro-cavity and a coupled waveguide, wherein the axisymmetric optical micro-cavity has a columnar shape and comprises a straight cylinder type solid cylinder micro-cavity, a straight cylinder type hollow cylinder micro-cavity, a microbubble-like solid cylindrical micro-cavity, a microbubble-like hollow cylindrical micro-cavity, a micro ring cavity, a metal-coated cylindrical micro-cavity and the like, the material of the micro-cavity is silicon dioxide, a macromolecule polymer, an optic crystal, a semiconductor material and the like, and the coupled waveguide is optical fibers with a diameter of 0.5-1.5 [mu]m, a coupled prism having high refractive index, an on-chip integrated waveguide and the like. According to the present invention, the discrete high-order echo wall mode in the micro-cavity and the continuous background light are subjected to offset interference, such that the dynamically-changing Fano resonance spectrum can be stably and effectively produced.