The invention relates to a photoelectrode biomolecular sensor, in particular to a broadband interference type photoelectrode biomolecular sensor and method of a graphene oxide fiber bragg grating. Thesensor comprises an optical fiber core, an optical fiber cladding, an optical fiber coating layer, and a large-angle inclined fiber bragg grating arranged in the middle of the optical fiber core; coating layers of the middle section and the rear section of an optical fiber are completely removed, the tail end surface of the rear section of the optical fiber is plated with a silver reflecting film, the distance between the rear end of the large-angle inclined optical fiber grating and the silver reflecting film at the tail end of the optical fiber ranges from 30 mm to 60 mm, and an optical fiber micro Michelson interference cavity is formed. A silane layer, a nano gold shell particle layer, a graphene oxide layer and a biomolecule sensitive layer are arranged on the cladding surface from the starting end of the large-angle tilted fiber bragg grating to the tail end of the optical fiber. The photoelectrode biomolecular sensor structure can be used to increase the action distance betweenLSPR excited by a light wave evanescent place and biomolecules, is convenient to integrate and apply, has very high robustness, and can be applied to the fields of biomedicine, life science, environmental monitoring and the like.