280 results about "Molecular composition" patented technology

The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.), cholesterol, hormones, antivirals, peptides, proteins, chemotherapeutics, small molecules, vitamins, co-factors, nucleosides, nucleotides, oligonucleotides, enzymatic nucleic acids, antisense nucleic acids, triplex forming oligonucleotides, 2,5-A chimeras, dsRNA, allozymes, aptamers, decoys and analogs thereof, and small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), short hairpin RNA (shRNA), and RNAi inhibitor molecules, to relevant cells and/or tissues, such as in a subject or organism. Such novel cationic lipids, microparticles, nanoparticles and transfection agents are useful, for example, in providing compositions to prevent, inhibit, or treat diseases, conditions, or traits in a cell, subject or organism. The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP).

The invention discloses a multiplex composite engineering scaffold material capable of gradually decomposing bone tissue and a preparation method thereof. The composite scaffold material consists of calcium phosphate bone cement, biological compatible degradable synthetic high polymer and biological compatible degradable natural high polymer, has better mechanical property and gradient degradation characteristic, and can achieve the aim of regenerating and repairing bone tissue defect by implanting a bone growth factor to induce in-vivo stem cells to be differentiated into bone cells, thereby obviously improving initial strength and toughness of the scaffold material, and ensuring enough strength and toughness of the scaffold material during operating and implanting. After compounded with the high polymer material, the scaffold has excellent flexibility, so that the scaffold can be subjected to certain machining, such as cutting and the like.

A quaternary ammonium salt ionic liquid of the present invention and its preparation and application methods belong to quaternary ammonium compounds, and its molecular composition is N, N, N-trimethyl-N-sulfobutyl-ammonium bisulfate, and its molecular formula is [HSO3-b -N(CH3)3]HSO4, the structural formula is as follows: the quaternary ammonium salt ionic liquid of the present invention is non-corrosive equipment and environment-friendly, and the quaternary ammonium salt ionic liquid catalyst of the present invention is used for nitrobenzene catalytic hydrogenation to synthesize p-amino The phenol reaction is a liquid phase method, the reaction temperature is 60-130° C., and the PAP yield reaches 19.5-88%.

A photochromic composition comprising (A) a polyrotaxane having a composite molecular structure composed of an axial molecule and a plurality of cyclic molecules clathrating the axial molecule and (B) a photochromic compound.

The invention discloses a minimally invasive blood glucose monitoring microneedle which comprises a needle handle, a needle body and a needle point which are sequentially connected, wherein after one of an amino group, an aldehyde group, a hydroxide radical and a carboxyl group is modified on the surfaces of the needle body and needle point of the microneedle, and the microneedle can be covered by a metal nano material layer modified by a Ph response molecule, the microneedle is inserted in a solution consisting a water-soluble polymer and a water-insoluble polymer, a porous polymer material layer is coated on the metal nano material layer, and then the microneedle is inserted in a glucose oxidase solution, so that the water-soluble polymer is dissolved and a plurality of pores are formed in a polymer layer; and glucose oxidase is absorbed on the surface of the porous polymer layer or in the holes, and the metal nano material has a grain size of 20-1000nm. By using the characteristic that the minimally invasive blood glucose monitoring microneedle has different intensities of Raman signals for different concentrations of glucose, the purpose of minimally invasively detecting the glucose in vivo and in vitro can be achieved.

The present invention generally provides systems and methods for the detection, identification, or characterization of differences between properties or behavior of corresponding species in two or more mixtures comprised of molecules, including biomolecules and/or molecules able to interact with biomolecules, using techniques such as partitioning. The experimental conditions established as distinguishing between the mixtures of the molecules using the systems and methods of the invention can also be used, in some cases, for further fractionation and/or characterization of the biomolecules and/or other molecules, using techniques such as single-step or multiple-step extraction, and/or by liquid-liquid partition chromatography. The methods could also be used for discovering and identifying markers associated with specific diagnostics, and can be used for screening for such markers once discovered and identified during diagnostics screening.

The invention discloses a molecular-level RTO method for an oil refining and petrochemical device. The method mainly comprises the steps that molecular composition and physicochemical properties of a product are predicted according to molecular compositions of raw materials, a model is optimized, and a production scheme is optimized. The method can be used to optimize the oil refining and petrochemical device in real time, maintain the device in the optimal state always, improve economic benefits, and reduce energy consumption.

The invention relates to a superhydrophobic coating. The superhydrophobic coating comprises the following ingredients by mass percent: 5-15% of fluorine-containing segmented copolymer, 65-85% of an amino nanometer or micron material, and 10-20% of resin, wherein the fluorine-containing segmented copolymer is a copolymer containing a monomer and a fluorine-containing acrylic acid monomer; the monomer is a mixture of an epoxy acrylate monomer or an epoxy acrylate monomer and an acrylate monomer. The invention further relates to a preparation method of the superhydrophobic coating. The preparation method comprises the steps of preparing the fluorine-containing segmented copolymer, preparing the amino nanometer or micron material, and preparing the superhydrophobic coating. The superhydrophobic coating and the preparation method disclosed by the invention have the following benefits: (1) the molecular weight of the fluorine-containing segmented copolymer is controllable, the molecular weight is narrow in distribution, and the molecular structure and the molecular composition are controllable; (2) the chemical bond interaction between the polymer and the nanoparticles is provided, so that the superhydrophobic coating has the advantages of the nanoparticles and the high molecular compound, and the dispersibility and the stability in the organic solvent are high; (3) the superhydrophobic coating is good in hydrophobicity, and high in comprehensive paint film property.

The invention discloses a method used for determining molecular composition of crude oil based on crude oil macroscopic properties. The method comprises following steps: a database of crude oil macroscopic properties and molecular composition data is established, the macroscopic properties of crude oil to be detected are measured and similar data retrieval in the database is carried out, and the detailed molecular composition of the crude oil to be detected is determined based on similar crude oil molecular composition.

The invention discloses polypeptide derivatives for generating stable micro-molecular hydrogel and relates to a compound library containing polypeptides. The molecular composition and structure are represented by a compound structural formula below, wherein in the formula, R1 represents aromatic ring derivatives, R2 represents one side chain group of 20 natural amino acids, R3 may be any of H and halogen, R4 may be OMe group or NHMe group, and n is 0 to 3. The micro-molecular hydrogel generated by the polypeptide derivatives can exist stably in a large amount of an aqueous solution, the shape can be well maintained, the micro-molecular hydrogel has high biocompatibility and is widely applied in the fields of tissue engineering, cosmetic, and the like.

The invention relates to a bionic artificial skin. The artificial skin comprises a protective layer, an epidermal layer, and a corium layer, and is characterized in that the protective layer is composed of polymer films, which contain micro pores, are non-degradable, or have a low degrading speed; the epidermal layer is composed of biopolymer, which contains a micro pore structure and can be degraded and absorbed; and the corium layer is composed of biopolymer sponge that can be degraded and absorbed. The protective layer has a waterproof and moisture permeable function; the material of the epidermal layer is the same as the human epidermis and has a micro pore structure, thus the artificial skin has a similar oxygen and moisture permeable function as that of human skin, the artificial skin is enabled to have a breathable function, the epidermal layer and corium layer of the artificial skin can be degraded, and moreover, because the components of the epidermal layer and corium layer are similar to human skin, and degradation products can promote the regeneration of epidermal cells and fibroblast. The invention also provides a preparation method of the bionic artificial skin.

The invention relates to the building material field, and especially relates to a high-molecular composition used for plastic building template and its preparation method. The high-molecular composition used for plastic building template comprises the following ingredients by weight: 100 parts of polyolefin feed back, 0.01-2 parts of cross-linking agent, 0.01-10 parts of auxiliary cross-linking agent, 5-200 parts of fiber, 0-100 parts of filling material and 0-20 parts of auxiliary agent. Compared with a prior art, the addition of the cross-linking agent and the auxiliary cross-linking agent in the high-molecular composition raw material can greatly increase the mechanical property of the building template, so that the building template has high strength and good shock resistance, the building template is not damaged while falling off from high altitude, and is difficultly scratched by hard objects, and the usage efficiency and life of the building template can be obviously increased.

The invention belongs to the technical field of medicines, and particularly discloses a composition and a preparation method of cyclic dinucleotide cGAMP (cyclic Guanosine Adenosine Monophosphate) encapsulated by a targeting liposome and application of the cyclic dinucleotide cGAMP to anti-tumor. The targeting liposome consists of lecithin, cholesterol, polyethylene glycol and the like as well as a link targeting molecule of the targeting liposome; a cGAMP slow release drug encapsulated by the targeting liposome can be used for enhancing the intensifying cell osmosis action, enhancing an immune reaction, effectively targeting drug delivery and intensifying the inhibition on the growth of multiple tumor cells. Therefore, the cGAMP encapsulated by the targeting liposome can be used for preparing an anti-tumor targeting slow release drug, and has important potential application in the field of targeting immune anti-tumor.

The invention relates to a thermoplastic high-molecular composition interpenetrated network structure and a preparation method thereof. More particularly, the invention relates to the thermoplastic high-molecular composition interpenetrated network structure obtained by adopting a supercritical process to process a thermoplastic high-molecular composition.