123 results about "Molecular composition" patented technology

A separation membrane for hydrogen and a gas L (excepting hydrogen), wherein the activation energy Ep(S) (kJ / mol) for a hydrogen permeance P(S) (mol / (m2∙s∙Pa)) through the separation membrane, as derived within a temperature Tam (°C) range satisfying the following expression (1-I), and the activation energy Ep(L) (kJ / mol) for a gas L permeance P(L) (mol / (m2∙s∙Pa)) through the separation membrane, as derived within the same temperature range, satisfy the following expression (1-II).　(1-I): 5(°C)≤Tam(°C)≤200(°C)　(1-II): |Ep(L)|<|Ep(S)|　The present invention can provide a separation membrane, a separation membrane layered body, a separation module or separation tower, a hydrogen recovery system, and a hydrogen separation and recovery method that are for separating and recovering hydrogen and in which hydrogen can be separated and recovered in a safe and highly efficient manner, even with a relatively low-pressure supply, from a mixed gas comprising molecules that are relatively close in kinetic diameter, one example being the separation and recovery of hydrogen from a hydrogen-oxygen mixed gas.

A method and apparatus for the rapid analysis of the molecular components of naphtha. The method comprises: receiving scanning spectrum data of target naphtha (S201); using a calibration spectrogram data set to calibrate the scanning spectrum data, wherein the calibration spectrogram data set is obtained by means of scanning a plurality of naphtha samples under preset detection conditions by using a plurality of spectrometers, and the scanning spectrum data is obtained by means of scanning the target naphtha on the basis of a first scanner among the plurality of spectrometers (S202); and performing, from a preset naphtha molecular composition library, matching to obtain a molecular composition corresponding to the calibrated scanning spectrum data, and obtaining predicted molecular properties of the target naphtha on the basis of the molecular composition, so as to determine macroscopic properties of the target naphtha, wherein the naphtha molecular composition library is obtained by using comprehensive two-dimensional gas chromatography technology (S203). The analysis of fraction molecular components of naphtha fractions and the characterization of macroscopic physical properties of petroleum fractions can be accurately and efficiently implemented.

The invention relates to the field of bioconjugation of functional entities, such as payloads and targeting agents, mediated by novel trans-cyclooctene (TCO) compounds. More particularly the present invention relates to novel trans-cyclooctene compounds, unnatural amino acids comprising such trans-cyclooctene compounds and preparation thereof. Said novel trans-cyclooctene compounds and unnatural amino acids comprising such trans-cyclooctene compounds are characterized by high structural stability and hydrophilicity and thus instrumental to ease the conjugation of said functional entities. The invention further relates to respective trans-cyclooctene-functionalized construct obtainable by, in particular covalently, binding said novel trans-cyclooctene compounds to a targeting agent or payload molecule, said functionalized construct containing at least one functionalizing residue comprising a mono-unsaturated trans-cyclooctene entity. The invention further relates to conjugates obtainable by covalently linking, in particular, via biorthogonal bioconjugation via a Diels-Alder-type cycloaddition, a first functionalized molecule, particularly selected from said trans-cyclooctene-functionalized constructs with a second functionalized molecule comprising a docking group (DG) capable of reacting with the trans-cyclooctene-type functional group of the first functionalized molecule. The present invention further relates to preparation methods of said constructs and conjugates. The invention also relates to the use of such conjugates of the present invention for use in medicine, to corresponding pharmaceutical compositions as well as to corresponding diagnostic and analytical kits.

The invention provides a simulation calculation method for the electron blocking capability of a complex compound, which comprises the following steps: S1, according to the molecular composition of a compound target material, simulating and constructing a microscopic all-atomic molecular structure of the target material by using a computer; s2, randomly generating more than ten thousands of ion movement tracks, and counting a distribution function group of closest distances between the ions and various atoms in the target material when the ions pass through the target material; s3, 10-100 short tracks capable of enabling the comprehensive overlap index to reach 95% or above are screened out from the ion movement tracks; and S4, simulating the process that the ions pass through the target material along the selected trajectories by using a time-dependent density functional method, wherein the ratio of the sum of energy changes of each simulation system to the sum of the lengths of the ion trajectories is the electron blocking capability of the compound on the ions. According to the scheme provided by the invention, the electron blocking capability of a complex compound on ions can be quickly and accurately calculated, and complex and high-cost experimental measurement is avoided. Wherein the calculation cost is reduced to 10% of the calculation cost of the random incidence method through the screening track method.

The invention discloses a method for identifying duck palm weight and related molecular marker application thereof, and relates to the technical field of molecular marker-assisted selection, a primer pair is used for amplifying a DNA fragment containing a 63823029th base polymorphic site from the 5'terminal on a fourth chromosome of a duck reference genome IASAASPekinDuckT2T, and the primer pair is used for amplifying a DNA fragment containing the 63823029th base polymorphic site from the 5 '-terminal on the fourth chromosome of the duck reference genome IASAASPekinDuckT2T. The duck reference genome IAASAASPekinDuckT2T is a duck reference genome sequence in a GenBank database, and the duck reference genome sequence is a duck reference genome sequence in the GenBank database; the duck is a Chinese and new white feather meat duck, and the primer pair consists of a DNA (deoxyribonucleic acid) molecule as shown in SEQ ID No.2 and a DNA molecule as shown in SEQ ID No.3. According to the method for identifying the duck foot weight and the application of the related molecular marker, the genotype of the duck can be judged by detecting the genome DNA of the duck, early living screening of the duck foot weight character is achieved, phenotype determination after slaughtering is not needed, the breeding period is remarkably shortened, and the breeding cost is reduced.

The invention relates to the technical field of mass spectrum imaging, in particular to a non-targeted cascade mass spectrum imaging method and device, and the method comprises the steps: obtaining a second-level mass spectrum of each pixel point, and carrying out the spectrum peak recognition and peak extraction, so as to obtain a first intensity matrix, and performing first-order deconvolution calculation to obtain a plurality of parent ion secondary mass spectrums and a corresponding relation between the parent ion secondary mass spectrums and fragment ions, generating a second intensity matrix in combination with adjacent pixel molecule composition information, performing second-order deconvolution calculation to obtain relative ion intensity of characteristic fragments generated by each parent ion in each pixel, and generating a multi-target mass spectrum imaging result. Therefore, the problems that in related technologies, mass spectrum imaging cannot be combined with a chromatographic separation technology generally, so that the analysis dimension is limited, and the data analysis difficulty is increased; the problems that the complexity and the cost of an instrument are increased, the application scene is limited and the stability and the usability are influenced due to the fact that data do not depend on acquisition and spectrum diagram deconvolution depends on a molecular composition modulation technology are solved.

The present disclosure provides a method, device, electronic device and storage medium for molecular screening, and relates to the fields of deep learning technology, graph theory technology and biological and information technology in the field of artificial intelligence technology. The method is as follows: obtain a first label map of the molecule to be screened and a second label map of the reference molecule, each molecule to be screened and the reference molecule form a molecule pair, for each molecule pair, obtain the mapping between the vertices of the first label map and the second label map and the conflict information between the mappings to generate a mapping map of the molecule pair, sample the mapping map, obtain the maximum weight fully connected subgraph of the molecule pair, and according to the maximum weight fully connected subgraph of each molecule pair, screen out the molecule to be screened with the greatest similarity to the reference molecule as the target molecule. A framework for molecular screening based on Gaussian boson sampling is proposed, so that Gaussian boson sampling can be used to efficiently implement the problem of ligand-based drug virtual screening and improve the efficiency of molecular screening.

The invention relates to the field of biological medicine, in particular to a water-soluble alginate microcarrier as well as a preparation method and application thereof. The alginate microcarrier comprises a carrier core structure and a shell surface modifier, the micro-carrier core layer is formed by carrying out plasma crosslinking on water-soluble alginate, ethylenediamine tetraacetic acid salt, nitrilotriacetic acid salt, diethylene triamine pentaacetic acid and water-soluble divalent metal salt, and light-sensitive alginate and a photoinitiator can also be added, so that the micro-carrier core layer has two crosslinking networks; the shell layer is composed of one of gelatin, collagen, fibrinogen, albumin and fibrin, or the gelatin, the collagen, the fibrinogen, the albumin and the fibrin and other biocompatible polymers; the obtained microcarrier has the characteristics of high transparency and rapid degradation, and adherent cells can be amplified in vitro; the microcarrier obtained in the invention can be used for mesenchymal stem cell culture, and can be rapidly degraded under a mild cell condition to harvest cells.

This invention is a smart ring with spectroscopic sensors. Changes in the spectrum of light which are caused by interaction with (e.g. reflection by or transmission through) matter are analyzed to get information about the composition of that matter. In an example, light emitters can direct light outward toward an environmental object to get information concerning the molecular composition of the object. In an example, light emitters can direct light inward toward the surface of a person's finger to measure one or more biometric parameters.

Laser absorption spectroscopy using multipass absorption based on multi-plane light conversion is a very sensitive chemical sensing technique to determine the molecular composition and concentration of a sample, especially a gas sample. To achieve a long optical path length while keeping the detector small, many trace gas sensors rely on multipass absorption cells in which the beam is reflected multiple times. The novel approach of the present invention consists in using multi-plane light conversion (MPLC) phase plates as reflectors in such multipass absorption cells.

The invention provides low-molecular-weight araboxylan as well as a preparation method and application thereof, and belongs to the technical field of biological extraction and purification. The method comprises the following steps: by taking wheat bran as a raw material, pretreating, further fully exposing arabinoxylan in wheat bran by adopting an extrusion expansion coupling steam explosion technology, hydrolyzing by xylanase, decoloring, carrying out ion exchange refining treatment, and separating and purifying components by adopting a multi-stage membrane technology, so as to obtain the arabinoxylan. And finally, preparing araboxylan with different molecular weights. Through the process, on one hand, arabinoxylan with different molecular weights is obtained, the molecular composition is optimized, on the other hand, the content and purity of arabinoxylan with small molecular weight are further improved, and the adaptability of the product is improved.

The invention relates to a multi-model-based petrochemical production stream molecular-level composition prediction method and system, and relates to the technical field of oil refining chemical molecule management, and the method comprises the steps: measuring the molecular composition of a raw material, splicing structural units based on a structural unit-bond electric matrix frame, and constructing a molecular digital structure topology; constructing a molecular composition model by combining a preset molecular database, a probability density function and a molecular property predictor; establishing a molecular-level reaction network based on a catalytic reforming reaction mechanism, and constructing a molecular-level reaction kinetic model in combination with a reaction rate expression; constructing a reactor model according to mass, energy and momentum transfer equations; inactivation and separation unit models are constructed, multiple models are coupled in sequence, a whole-process reaction-separation molecular level prediction model is generated, and any stream molecular level composition is predicted. The method solves the problem that traditional petrochemical production depends on measurement results to adjust process parameters and has operation lag, and can eliminate lag and improve production control precision by predicting stream molecular composition.

The determination of chemical mixture components is vital to a multitude of scientific fields. Oftentimes various spectroscopic methods are employed to decipher the molecular composition of these complex mixtures. The sheer density of spectral features of different molecules present in such observations may make unambiguous assignment to individual species using these methods challenging. Yet, components of a mixture are commonly chemically related due to environmental processes or shared precursor molecules. Therefore, along with investigating the spectroscopic signals, analysis of the structural and chemical relevance of a molecule is an important consideration when determining which species are present in a mixture. Machine-learning molecular embedding methods are used with a relevance module to determine the likelihood of a molecule being present in a mixture based on the other known species, chemical priors, and spectroscopic information. By incorporating this metric, the mixture components can be identified with extremely high accuracy (∼ 97%).

An embodiment represents composition of molecules in a feedstock as a combination of individual molecule representations and molecular attribute representations. A representation of chemistry of a chemical reaction of the feedstock in a chemical reactor is then formulated based on the representations. Then, a simulation of the chemical reaction of the feedstock in the reactor is performed using the representations to determine composition of products of the reaction. A first subset of the products are represented as individual molecule represented products, and a second subset of the products are represented as attribute represented products. In turn, the attribute represented products of the second subset are sampled to determine individual molecule representations of the attribute represented products. As a consequence of the sampling, individual molecule representations of the first and second subsets of the products of the chemical reaction of the feedstock in the chemical reactor result.

The invention relates to the field of oil reservoir exploration and development, and discloses a heavy oil micromechanism characterization method and device, a storage medium and a processor, and the method comprises the following steps: determining the molecular composition of a heavy oil sample and the content of each molecule; classifying the molecules based on the features of the molecules to obtain a classification result, and selecting at least one target molecule from each category of the classification result; establishing a heavy oil system molecular model based on a heavy oil simulation system composed of the target molecules; based on the thickened oil system molecular model and a pre-established mineral pore molecular model, establishing a thickened oil system flow model; and determining the thickened oil micromechanism according to the simulation result of the thickened oil system flow model. Based on the scheme of the application, the similarity degree of properties between the thick oil simulation system and the real thick oil system can be improved, so that the accuracy of the subsequent micro simulation result of the thick oil can be improved, and the accuracy of the obtained thick oil micro mechanism can be improved.

The invention belongs to the field of soil dissolved organic matter analysis, and provides a multispectral-based DOM detection and reclamation influence evaluation method, which comprises the following steps: step 1, collecting dry farmland soil samples of different reclamation years, and obtaining soil column samples of a plough layer, a plow pan and subsoil; 2, extracting, centrifuging and filtering the soil sample to obtain a DOM solution; 3, detecting the DOM solution by adopting an ultraviolet-visible absorption spectrum; step 4, adopting a three-dimensional fluorescence spectrum and combining parallel factor analysis to obtain fluorescence components and source characteristics of the DOM solution; step 5, analyzing molecular composition and characteristic parameters of the DOM solution by adopting solid-phase extraction in combination with Fourier transform ion cyclotron resonance mass spectrometry; and step 6, based on the detection data in the steps 3-5, evaluating the influence of reclamation years on the composition, structure and degradation characteristics of the DOM. According to the method, multi-dimensional detection of soil DOM is realized through a multi-spectrum and mass spectrum combined technology, and DOM is comprehensively analyzed from a macrostructure to molecular composition.

The present application relates to a kind of hydrolysis targeting chimera based on artificial antibody and its preparation method and application.The hydrolysis targeting chimera is composed of artificial gold antibody and molecule that can activate cell degradation mechanism, the artificial gold antibody is composed of gold nanoparticle and polypeptide coupled on the surface of gold nanoparticle, the molecule that can activate cell degradation mechanism is coupled on the surface of gold nanoparticle.The hydrolysis targeting chimera can simultaneously bind target protein and activate cell degradation mechanism, with the performance of strong specific recognition target protein, and high stability, orientation controllable.At the same time, the hydrolysis targeting chimera can also play the molecule of activation cell degradation mechanism, such as lysosome sorting signal motif, coupled on the surface, induce clathrin-mediated endocytosis, transport the complex of target protein and chimera to lysosome and degrade.The hydrolysis targeting chimera can play multi-mode cancer treatment effect by synergistic inhibition of tumor cell proliferation, invasion pathway and apoptosis activation.

The present invention provides a Zn-MOF material for high-sensitivity and high-selectivity detection of ATP / ADP, and a preparation method therefor and a use thereof. The Zn-MOF material uses zinc as a metal center and H2PDBA as a ligand. The chemical molecular formula of the Zn-MOF material is [C34H30N2O4Zn]n, wherein n represents an infinite alternating arrangement of the simplest molecular formula in the internal molecular composition of the material. The present invention further provides a preparation method for the Zn-MOF material. The preparation method comprises adding H2PDBA and an inorganic zinc compound to a first organic mixed solution and placing the mixture in a reaction kettle for a reaction to obtain the Zn-MOF material. The Zn-MOF material of the present invention can realize high-selectivity detection of ATP / ADP in water. In addition, a new fluorescent material is provided for the detection of ATP / ADP, and new ideas are provided for rationally constructing more stable MOFs in terms of structural design.

The application provides a method and system for identifying molecular composition and predicting physical properties based on a graph, and belongs to the technical field of material analysis and testing. The method comprises: performing infrared spectrum detection and gas chromatography detection on the gasoline to be detected respectively to obtain infrared spectrum data and gas chromatography data; obtaining a first predicted molecular composition according to the infrared spectrum data; identifying a second predicted molecular composition based on the gas chromatography data; performing linear addition on the first predicted molecular composition and the second predicted molecular composition to obtain an overall predicted molecular composition; and taking the overall predicted molecular composition and predicted molecular attribute information as the molecular detection result of the gasoline to be detected. The application solves the technical problems of low accuracy of gasoline molecular composition identification, great limitation of a single detection method and inaccurate physical property prediction in the prior art, achieves the technical effect of improving the accuracy of molecular composition identification through double spectrum data fusion, and realizes reliable physical property prediction based on accurate molecular composition.

The invention relates to the technical field of petrochemical production, and discloses a molecular-level method and system for predicting the quality of any stream in petrochemical production. The method comprises the following steps: carrying out online spectral analysis on a feed stream to obtain carbon number distribution and hydrocarbon composition data, and establishing a dynamic molecular library through structural unit coding; establishing a reaction rule library according to a reaction mechanism, and matching with the molecular library to generate a reaction network; establishing a reaction kinetics equation set in which the feed composition correction factor is introduced, and optimizing parameters; and performing gas-liquid phase equilibrium calculation on the reaction product to obtain stream molecular composition, extracting a structure descriptor, inputting the structure descriptor into a neural network model, introducing a component interaction item, and outputting a stream quality prediction result. The problems that stream quality prediction lags behind, precision is low, and feeding fluctuation cannot be adapted in real time in the prior art are solved.

The invention relates to preparation and application of a nano material for targeting and enhancing nervous tumor ferroptosis, and belongs to the field of medicines. The nano-scale polypeptide-gold complex cluster NG formed by gold and sulfydryl-containing targeting polypeptide is characterized in that NG molecules form AuxPy, x is equal to 1-35, y is equal to 1-30, and P is corresponding nervous system tumor targeting polypeptide, preferably Au17P7. The preparation method comprises the following steps: mixing a gold salt solution with nervous system tumor targeting polypeptide to form a mixed solution, and adding a reducing agent under certain temperature and pH conditions, so that Au interacts with a sulfydryl phase of the polypeptide to form the complex cluster NG. The compound is used for preparing a targeted drug for improving the tumor treatment effect of the ferroptosis inducer, and has a specific synergistic treatment effect on nervous system tumors when being used together with the ferroptosis inducer.

The application discloses a preparation method of a solid-phase extraction filler special for carboxylic acid herbicides, and the method comprises the following steps: firstly, modifying a template molecular composition into a polymerizable monomer through esterification, then bonding the polymerizable monomer into a cross-linked polymer, and finally hydrolyzing and removing the template molecular composition to obtain the solid-phase extraction filler special for carboxylic acid herbicides. The solid-phase extraction filler special for carboxylic acid herbicides provided by the application has the advantages of good specificity adsorption for carboxylic acid herbicides, high detection sensitivity, complete impurity removal, good stability of the filler, high strength, strong chemical resistance, and the like. Meanwhile, the template molecular composition does not belong to the detected molecules, and a small amount of residual template molecular composition does not affect the detection, so that the problems of low purification efficiency and easy pollution of the sample inlet of a chromatograph in the prior art, which affect the detection effect, are solved.

The invention relates to a novel chemical compound - a diagnostic marker - for use in medicine, more specifically in cancer diagnosis, in particular the diagnosis of brain tumour. The invention thus provides a compound having formula 1: Xl-Lys-Asp-Gly-Gln-X2, wherein XI comprises or consists of molecule Cl, and X2 comprises or consists of molecule C2, wherein a pair of molecules Cl and C2 is a pair of fluorescence donor and fluorescence acceptor, and wherein the compound undergoes enzymatic cleavage into the fragments Xl-Lys- Asp-Gly-GIn-OH (Fragment 1) and X2 (Fragment 2) with a generation of a measurable optical signal upon spatial separation of molecules Cl and C2. The invention also relates to an in vitro method for detecting enzymatic activity present in a subject's body fluid, in particular derived from brain tumour cells, using the compound. The invention further relates to an in vitro method for diagnosing brain tumour using the compound, a kit comprising the compound and use of the compound for the detection of enzymatic activity specific to brain tumour and use of the compound for the diagnosis of brain tumour. The invention also relates to the compound for use as a diagnostic marker of brain tumour and a method for the treatment of brain tumour comprising a step of carrying out the method for the diagnosis of brain tumour as defined above using the compound.

The invention discloses a Q-TOF mass spectrum database system and a Q-TOF mass spectrum database method for analyzing unknown substances of medical equipment. According to the system and the method, the traditional positive matching logic of quasi-molecule ion priority is abandoned, and a reverse analysis strategy from a structural unit to a molecular structure is creatively adopted. The core of the method is that: a candidate structural unit is locked preferentially through characteristic fragment ions in a secondary mass spectrum and mass difference matching between the ions; and carrying out intelligent combination calculation by combining information of primary excimer ions (essentially adduct ions), and finally deducing the molecular composition of an unknown compound. The method effectively solves the problems that a traditional method is low in unknown derivative identification success rate and excessively depends on expert experience, minute-level efficient identification is achieved, and the efficiency, accuracy and coverage range of medical instrument leached matter identification are remarkably improved.

The invention provides a double-base pichia pastoris base editor aiming at pichia pastoris, the double-base pichia pastoris base editor is a DNA molecular composition, the DNA molecular composition comprises a first expression plasmid containing a coding gene of nCas9 protein, a coding gene of pyrimidine deaminase and a coding gene of adenosine deaminase, and a second expression plasmid containing a coding gene of nCas9 protein, a coding gene of pyrimidine deaminase and a coding gene of adenosine deaminase, and a second expression plasmid containing gRNA, wherein the gRNA is a spacer sequence of a targeted target gene, and the length of the spacer sequence is 20 nt. The double-base editor can edit the base A and the base C at the same time, and an efficient and accurate tool basis is provided for the research fields of pichia pastoris-based recombinant protein evolution or chassis cell transformation and the like.

The present disclosure relates to systems and methods for real-time analysis and classification of tangible products based on predefined quality parameters using artificial intelligence (AI). It incorporates one or more sensors to monitor various product properties such as molecular composition, moisture content, and structural integrity. Sensor data is processed by a server, which identifies relevant characteristics like spectral peaks and dielectric constants, then generates a comprehensive aggregate signature using feature-level fusion techniques. An Al model, trained on tangible datasets, analyzes the fused data to detect deviations in quality, such as foreign particles, improper moisture, or structural defects. The system provides real-time feedback for corrective action, allowing adjustments in production parameters or sorting of defective products. In some embodiments, a handheld version of the system enables manufacturers to perform in process checks and immediately address quality issues during production.

A separation membrane for separating hydrogen and a gas L, in which an activation energy Ep(S) (kJ / mol) of a permeance P(S) (mol / (m2·s·Pa)) of hydrogen through the separation membrane derived within a range of a temperature Tam (° C.) satisfying Formula (1-I) described below and an activation energy Ep(L) (kJ / mol) of a permeance P(L) (mol / (m2·s·Pa)) of a gas L (provided that hydrogen is excluded) through the separation membrane derived within the same temperature range satisfy Formula (1-II) described below: 5 (° C.)≤Tam (° C.)≤200 (° C.) (1-I)|Ep(L)|<|Ep(S)| (1-II). There can be provided a separation membrane for separating and recovering hydrogen, a separation membrane laminated body, a separation module or separation tower, a hydrogen recovery system, and a method for separating and recovering hydrogen, which enable safe and highly efficient separation and recovery of hydrogen from a mixed gas composed of molecules having relatively close dynamic molecular diameters even when a supply pressure is relatively low, including separation and recovery of hydrogen from a hydrogen-oxygen mixed gas.

This application relates to the field of mass spectrometry imaging technology, and particularly to a non-targeted cascade mass spectrometry imaging method and apparatus. The method includes: acquiring the secondary mass spectrum of each pixel, performing peak identification and extraction to obtain a first intensity matrix; obtaining multiple parent ion secondary mass spectra and their correspondence with fragment ions through first-order deconvolution calculation; generating a second intensity matrix by combining the molecular composition information of neighboring pixels; performing second-order deconvolution calculation to obtain the relative ion intensities of characteristic fragments generated by each parent ion within each pixel; and generating multi-target mass spectrometry imaging results. This solves the problems in related technologies where mass spectrometry imaging cannot be coupled with chromatographic separation techniques, resulting in limited analytical dimensions and increased data analysis difficulty; and where data acquisition and spectral deconvolution rely on molecular composition modulation techniques, leading to increased instrument complexity and cost, limited application scenarios, and impacts on stability and ease of use.

The invention relates to the technical field of veterinary drugs, and particularly provides a polynucleotide molecule composition for preventing cat infectious peritonitis, a chimeric polynucleotide molecule and an mRNA vaccine. In order to overcome the ADE effect caused by S protein full-length antigen in the prior art, FIPV N protein without ADE risk is adopted and is combined with screened S protein specific T cell and B cell epitopes. Core schemes include two classes: one is a separate polynucleotide composition comprising epitope peptides encoding N and S proteins; and 2, a single chimeric polynucleotide encoding N protein and S protein epitope peptides. The polynucleotides are optimized by codons and encapsulated in lipid nanoparticles (LNP) to prepare vaccines. Experiments prove that the vaccine can synergistically stimulate powerful immune response, the survival rate of immune cats is remarkably increased to 80%-100% from standard 40% on the premise that ADE is not caused, and FIP is effectively prevented.

The application discloses a generation method and a prediction method and device of an oil product molecular composition prediction network. The generation method comprises the following steps: obtaining an original data set; training a pre-constructed generator based on the original data set to obtain first network parameters of the generator; inputting macroscopic physical property data of a randomly generated to-be-tested oil product into the generator to obtain molecular composition data of the to-be-tested oil product generated by the generator; keeping the first network parameters of the generator unchanged, training a pre-constructed discriminator connected with the generator based on the molecular composition data of the known oil product in the original data set and the molecular composition data of the to-be-tested oil product generated by the generator to obtain second network parameters of the discriminator; keeping the second network parameters of the discriminator unchanged, and jointly training the trained generator and the discriminator based on the original data set to obtain an oil product molecular composition prediction network. The prediction network can predict the full molecular composition of the oil product.