394 results about "Slow release drug" patented technology

Stable, biologically compatible pharmaceutical compositions in the form of water-in-oil microemulsions (w / o), for the sustained release by parenteral administration of active ingredients which are hydrophilic or are made hydrophilic by suitable derivatization, a process for the preparation of said microemulsions and the use thereof.

A formulation to treat ocular conditions such as dry eye disease, as well as other conditions, is disclosed. Rapamycin and / or ascomycin is administered intraocularly, such as by topical application, injection into the eye, or implantation in or on the eye. For example, a topical administration may contain between about 50 pg / ml drug to about 50 μg / ml drug in a formulation which may be applied at bedtime or throughout the day. For injection, a dose of about 50 pg / ml to about 200 μg / ml may be used. Rapamycin and / or ascomycin may also be administered in milligram quantities as a surgical implant, for example, in a diffusible walled reservoir sutured to the wall of the sclera, or may be contained within an inert carrier such as microspheres or liposomes to provide a slow-release drug delivery system.

A formulation to treat ocular conditions such as dry eye disease, as well as other conditions, is disclosed. Rapamycin and / or ascomycin is administered intraocularly, such as by topical application, injection into the eye, or implantation in or on the eye. For example, a topical administration may contain between about 50 pg / ml drug to about 50 μg / ml drug in a formulation which may be applied at bedtime or throughout the day. For injection, a dose of about 50 pg / ml to about 200 μg / ml may be used. Rapamycin and / or ascomycin may also be administered in milligram quantities as a surgical implant, for example, in a diffusible walled reservoir sutured to the wall of the sclera, or may be contained within an inert carrier such as microspheres or liposomes to provide a slow-release drug delivery system.

The invention belongs to the field of polymer material and biomedical engineering, particularly relates to drug-loaded silica embolism microsphere and a preparation method thereof. Through technical improvement, silica microsphere is prepared into micron microsphere, hydrophilic polyethylene glycol coupling agent is coupled onto the surface of silica microsphere by efficient Huisgen cycloaddition reaction to form a neutral hydrophilic layer, so that the microspheres can be stably and uniformly dispersed in an aqueous medium to facilitate operation of arterial embolization; meanwhile, silica embolism microsphere has a nano porous structure which can adsorb chemicals, so as to reach the purpose of slow release of drug for treatment while achieving arterial embolization, which further improves the therapeutic effect. The embolism microsphere provided by the invention has good histocompatibility, is mainly used for arterial embolization treatment of diseases, especially suitable for arterial embolization treatment of hepatic tumor, and has broad application prospect.

The present disclosure provides extended release pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state.