Process for preparing novel medicine for breviscapine having function of promoting blood circulation and removing blood stasis

A technology for breviscapine and pharmaceutical preparations, which is applied in the field of sustained-release preparations containing traditional Chinese medicine breviscapine extract, can solve problems such as treatment of unfavorable diseases, sunk costs for patients, waste of resources, etc., so as to ensure effectiveness and safety, and reduce sunk Cost, benefit for long-term use

Inactive Publication Date: 2002-12-18
SICHUAN YIBIN WULIANGYE GROUP YIBIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In these preparations, there are many deficiencies, such as ordinary tablets, capsules, and granules, which are used for a long time for the treatment of patients, and the natural herbal medicine extracts all have the characteristics of slow onset, so It is unfavorable for patients with hemiplegia and elderly patients with coronary heart disease to take medicine too many times a day; in addition, the way of taking medicine three times a day makes the blood drug con

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Scutellarin Sustained-release Tablets: 30mg / tablet

[0039] Scutellarin 30.0g

[0040] Hydroxypropylmethylcellulose (HPMC K15M) 35.5g

[0041] Lactose 15.0g

[0042] Sodium alginate 20.0g

[0043] Carbomer 1.0g

[0044] Appropriate amount of PVP ethanol solution is made into 1000 tablets in total. Mix the above materials evenly, wet granulate, granulate, dry, and press into tablets to make 1000 scutellarin sustained-release tablets.

Embodiment 2

[0045] Example 2 scutellarin sustained-release capsules: 60mg / capsule

[0046] Scutellarin 60.0g

[0047] Hydroxypropylmethylcellulose (HPMC K15M) 50.0g

[0048] Lactose 30.0g

[0049] Sodium alginate 40.0g

[0050]Carbomer 2.0g

[0051] Appropriate amount of PVP ethanol solution

[0052] A total of 1000 tablets were made, the above materials were mixed, wet granulated, and the whole grain was dried and packed into No. 1 hard gelatin capsules.

Embodiment 3

[0053] Example 3 Scutellarin Sustained-release Tablets: 30mg / tablet

[0054] Breviscapine 30.0g

[0055] Hydroxypropylmethylcellulose (HPMC K15M) 35.5g

[0056] Lactose 15.0g

[0057] Sodium alginate 20.0g

[0058] Carbomer 1.0g

[0059] Appropriate amount of PVP ethanol solution

[0060] A total of 1000 tablets were made. The above materials were mixed uniformly, wet granulated, granulated, dried, and tableted to make 1000 tablets.

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PUM

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Abstract

The present invention discloses a slow-released medicine preparation with the function of promoting blood circulation, removing staiss, removing obstruction in the channels to relieve pain. In particular it is a slow-released medicine preparation containing breviscapine. The described breviscapine is scutellarin or 4-hydroxy ba icalein-7-O-beta-D-pyrangluconate methyl ester.

Description

Field of invention: [0001] The invention relates to a sustained-release preparation of traditional Chinese medicine, in particular to a sustained-release preparation containing the extract of the traditional Chinese medicine scutellaria breviscapus. Background of the invention: [0002] Breviscapine is a flavonoid component extracted from the herb breviscapine, and is divided into scutellarin and scutellarin. It was first used in the 1970s, mainly in the form of granules, tablets, capsules, and injections for the clinical treatment of stroke sequelae, coronary heart disease, angina pectoris and other diseases. In these preparations, there are many deficiencies, such as ordinary tablets, capsules, and granules, which are used for a long time for the treatment of patients, and the natural herbal medicine extracts all have the characteristics of slow onset, so It is unfavorable for patients with hemiplegia and elderly patients with coronary heart disease to take medicine too m...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/22A61K31/7048A61P9/10
Inventor 王建蓉
Owner SICHUAN YIBIN WULIANGYE GROUP YIBIN PHARMA
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