Anari series mongolian drug intragastric floating sustained release preparation and preparation method thereof
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A technology of floating and sustained-release preparations in the stomach, applied in the directions of pharmaceutical formulations, digestive system, pill delivery, etc., can solve the problems of reduced patient compliance, easy moisture absorption of powder, loss of drug efficacy, etc., to improve bioavailability, appearance, etc. Smooth and uniform, reducing adverse reactions
Inactive Publication Date: 2018-03-30
张慧文
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Problems solved by technology
[0004] 1. The specific surface area of powder medicine powder is large, and the powder is easy to absorb moisture, stick and agglomerate during storage, or the active ingredient of the medicine is easy to oxidize and hydrolyze, and lose the efficacy. inconvenient;
[0005] 2. The active ingredients of the medicine in the powder have not been enriched, resulting in the disadvantages of high impurity content, large dosage and inconvenience in taking medicine;
[0006] 3. Due to the multi-flavored medicinal materials in Anari, such as longan, cinnamon, and dried ginger, etc., the taste is pungent, and the medicine has a strong odor, which reduces the patient's compliance; Clinical application
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Embodiment 1
[0040] Embodiment 1: the preparation of Anari-4 extract
[0041] Take 100g of pomegranate, 100g of cinnamon bark, 100g of white cardamom, and 100g of Piper piscifolia as the prescription medicinal materials and grind them, add 8-12 times the volume of 50%-90% ethanol, heat and reflux at 80°C-100°C for 3 times, each time for 60-90min , the extract was cooled to room temperature, suction filtered and combined, and the ethanol was recovered by rotary evaporation until there was no alcohol smell, concentrated to a clear paste with a density of 1.10, freeze-dried for 12-24 hours, and the dried extract was obtained, which was crushed through a 100-mesh sieve to obtain Ana Day-4 extract powder.
[0042] The preparation method of the following Anari series is exactly the same as that of the above Anari-4.
Embodiment 2
[0043] Embodiment 2: the preparation of Anari-5 extract
[0044] Take 250g of pomegranate, 15g of cinnamon, 150g of white cardamom, 100g of longan and 100g of dried ginger and grind them into pieces, add 8-12 times the volume of 50%-90% ethanol, heat and reflux at 80°C-100°C for 3 times, each time After 60-90 minutes, the extract was cooled to room temperature, suction filtered, combined, and the ethanol was recovered by rotary evaporation until it had no alcohol smell, concentrated to a clear paste with a density of 1.10, freeze-dried for 12-24 hours, and the dried extract was obtained, crushed through a 100-mesh sieve, Vested Anari-5 extract powder.
Embodiment 3
[0045] Embodiment 3: the preparation of Anari-6 extract
[0046] Take 100g of pomegranate, 100g of cinnamon, 100g of white cardamom, 100g of longan, 100g of dried ginger, and 100g of bright salt, which are prescribed medicines, and grind them, add 8-12 times the volume of 50%-90% ethanol, and heat and reflux at 80°C-100°C for extraction3 Each time, 60-90min each time, the extract was cooled to room temperature, suction filtered, combined, and the ethanol was recovered by rotary evaporation until there was no alcohol smell, concentrated to a clear paste with a density of 1.10, freeze-dried for 12-24h, and the dried extract was obtained, crushed 100-mesh sieve, acquired Anari-6 extract powder.
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Abstract
The invention relates to an Anari series mongolian drug intragastric floating sustained release preparation and a preparation method thereof, and belongs to the technical field of manufacturing of drugs. At present, most Anari compounds are powder, and are easy in moisture absorption, adhesion and caking, larger in administration dosage, pungent in flavor and poor in compliance. The Anari series mongolian drug intragastric floating sustained release preparation comprises a main drug and a pharmaceutic adjuvant, wherein the main drug comprises Anari or extract thereof; a sustained release adjuvant is used for constructing a skeleton structure of the drug and controlling the dissolving-out speed of the drug; an often release adjuvant is used for enabling the drug to float and the preparationto be formed; the often release adjuvant comprises a floating auxiliary and / or a filling agent and / or a binding agent and / or a lubricating agent. By adopting a positioning sustained release dosing system, the Anari series mongolian drug intragastric floating sustained release preparation is steady and lasting in drug release and can float sustainably, so that intragastric positioning dosing is achieved, the bioavailability of oral administration of the Anari, the defects of the powder of large dose and frequent dosing can be overcome, bad flavor of the drug can be covered, and the complianceof patients is improved. Therefore, a more ideal treatment effect is achieved.
Description
technical field [0001] The invention relates to an oral medicine for treating stomach diseases, which belongs to the technical field of medicine manufacture, in particular to an intragastric floating slow-release preparation of Mongolian medicine of Anari series and a preparation method thereof. Background technique [0002] Anari series Mongolian medicine (hereinafter referred to as Anari) is a classic clinical prescription of Mongolian medicine. " and other Mongolian medicine works are recorded, and the Anari series of Mongolian medicines based on Anari-4 include Anari-5, Anari-6, Anari-7, Anari-8, Anari That day-9, Ana day-10, Ana day-11, Ana day-12, Ana day-13, Ana day-14, Ana day-15, Ana day-17, Ana day -20, Anari-24 and Anari-25, etc., can be used to dispel "Badaganxieri", have the functions of appetizing and helping digestion, and mainly treat indigestion, gray "Badaganheyi", and stomach dullness , Stomach-fire decay and other diseases, and has a good clinical effec...
Claims
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Application Information
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