424results about How to "Mask bad smell" patented technology

The invention relates to a Niuhuangshangqing soft capsule and a preparation method thereof, as well as a quality control method of capsule contents. The Niuhuangshangqing soft capsule comprises contents and capsule shell. The contents include an extent of Chinese medicinal materials in Niuhuangshangqing prescription and a dispersion medium with a weight ratio of 1:(1-2), wherein, the dispersion medium is vegetable oil. The soft capsule is prepared by extracting effective components from Chinese medicinal materials in Niuhuangshangqing prescription in accordance with the properties of the effective components by using different modern extraction techniques and making into soft capsule. The soft capsule has embedding and masking effects, and can prevent volatilization loss of oil components and oxygenation or photodecomposition of effective components. The soft capsule also has the advantages of rapid disintegration, uniform dispersion, high bioavailability, good stability of effective components, low liability of moisture absorption, good air tightness, direct intestinal absorption after disintegration, masking of unpleasant odors of effective components, convenience for administration and carrying, and so on.

The invention discloses a raticide, containing0.1-20 percent of rat-poison active ingredients extracted from plants, 0.1-30 percent of microcapsule embedding medium, 0.1-30 percent of odor sequestering agent, 18.7-98.6 percent of food-taking attractant, 0.1-0.3 percent of conserving agent and 1 percent of food color. The raticide is the mixture of one or more active ingredients extracted from poison hemlock, stramonium, honeylocust, Arisaema, raw pinellia ternate and scopine. The odor sequestering agent is soyabean protein or zein which is used to sequester the malodor of the extracts of the plant coating the microcapsule. Because the active gradients of the raticide are plant extracts, the raticide can decompose completely in the environment, as a result, environment pollution is avoided; besides, the plant extracts are made into microcapsules, thereby, the defect of oxygenolysis is avoided, and the effective period is extended; the raticide oriented in plants is not acute raticide, therefore, a rat which takes the raticide does not show the symptom of being poisoned, and alertness and food refusal of other rats do not occur; the raticide can be used to protect and kill rats in organic ecological agricultural zones, hotels, houses, etc..

The invention relates to the field of pharmaceutical preparations and particularly relates to a slow-release micropill preparation containing enrofloxacin and a preparation method of the preparation. The slow-release micropill provided by the invention is formed by coating an enrofloxacin micropill; the enrofloxacin micropill comprises enrofloxacin and auxiliary material and is formed through extruding and rounding; the auxiliary material is any one or more of microcrystalline cellulose, starch, cane sugar, artificial gum, lactose and sodium carboxymethyl starch; according to weight percent, the auxiliary material in the micropill accounts for 70% to 95%; and coating is made of high-molecular enteric material, film forming material, opaquer and the like. The slow-release micropill preparation has the characteristics of slow release and high bioavailability, can be used for treating bacteria and mycoplasma infection of livestocks, and has better curative effect on chronic respiratory diseases, colibacillosis and salmonellosis, and the frequency of medicine taking can be reduced; and in addition, the slow-release micropill provided by the invention has the advantages that the stability of medicine is improved, and peculiar bitter of enrofloxacin can be covered completely, so that feeding intake of the animals is not influenced, and the recovery rate is improved.

The invention discloses a dispersing agent for water non-soluble medicaments, which comprises, (1) 0.5-50 weight parts of active medicaments containing water non-soluble substance with a dissolvability of 0.001-10000mg/L of water at 25 deg C, (2) 0.5-1000 weight parts surface active agent or solubilizing agent with hydrophilyty and lipophilyty balance (HLB) >10.

The invention discloses an animal feed mold removal agent and a preparation method thereof and belongs to the technical field of husbandry veterinary drugs. According to a key point of the technical scheme, the animal feed mold removal agent is prepared from, by weight parts, 50-100 parts of live protection and kidney protection ingredient, 150-200 parts of mycotoxin adsorbent, 150-300 parts of probiotics, 100 parts of biological enzyme and 350-500 parts of nutritive additive. The invention further discloses the method for preparing the animal feed mold removal agent. The animal feed mold removal agent obtained according to the method can adsorb various mycotoxins in the intestinal tract, is high in adsorption capacity, wide in applied range and stable in form and can be completely and quickly decomposed and excreted by animal organisms.

The invention relates to a protein peptide composite nutrient fluid microsphere for anti-inebriation and a method for preparing the same. The protein peptide composite nutrient fluid microsphere and the method are characterized in that the method adopts vegetable protein peptide matched with water soluble extracts of hawthorn, radish, licorice and orange peel to prepare the protein peptide composite nutrient fluid according to the weight percentage that the protein peptide is between 60 and 80 percent and the extracts of the hawthorn, the radish, the licorice and the orange peel are between 5 and 10 percent respectively, and then a microcapsule forming technique is adopted to prepare the protein peptide composite nutrient fluid microsphere. The vegetable protein peptide comprises the protein peptide components generated by proteolysis extracted from one or more farm products including peanut, soybean, corn, and the like. The extracts of the hawthorn, the radish, the licorice and the orange peel can be hydrosolvent extracts, and also can be organic solvent extracts. The protein peptide composite nutrient fluid microsphere adopts green foods as raw materials for anti-inebriation, is environment-friendly and harmless to a human body, adopts microencapsulation technique so that the protein peptide is released slowly in the human body, has good anti-inebriation and sobering effects, and can properly improve the function of the human body and enhance the immunity.

The invention discloses a vegetable oil based insecticidal acaricide, which comprises (by weight percent) gum spirit of turpentine 5-75%, wintergreen oil 0-55%, elliptone 0.01-5%, and balancing adjuvant.

The invention discloses a chlorpyrifos-containing insect disinfestation composition, which is mainly characterized by comprising an effective active component chlorpyrifos and an effective component B, wherein the effective component B is selected from thiamethoxam, clothianidin and thiacloprid, a weight ratio of the chlorpyrifos to the effective component B is 20:1-1:5, and the composition can be prepared into a microcapsule suspension and a microcapsule suspension-suspending agent. The composition can be provided for prevention and control of a plurality of insect pests, has characteristics of significant synergy effect and prevention and control spectrum expanding, provides high activities for pests on grassy crops, tea trees, vegetables, cotton and fruit trees, and further has advantages of slow release, pesticide amount reduction, safety on human and animals, no pesticide injury, good environment compatibility, strong preparation adhesion, rain erosion resistance, long lasting period and the like.

The invention relates to a preparation method of Chailian oral preparation. The preparation method comprises the steps of: respectively extracting the volatile oils of the forsythia, the patchouli and the cinnamon to prepare a mixture A; then combining the residue after the forsythia is extracted for the volatile oil, the ephedra, the bupleurum and the balloonflower to extract the active components and spray drying to prepare powder B; then performing inclusion on the mixture A and beta-cyclodextrin to prepare volatile oil solid powder C; and finally mixing the powder B and the powder C evenly, and encapsulating to obtain the traditional Chinese medicine preparation. By the preparation method provided by the invention, the liquid medicament is prepared into solid powder, and preparation of the volatile oil components into capsule preparations and inclusion of the mixture of three kinds of volatile oils and the beta-cyclodextrin are realized.

The invention provides a dispersible tablet of maca. The dispersible tablet is prepared by the following components of: 48%-78% of maca powder, 3%-20% of crospolyvinylpyrrolidone, 0.1%-35% of maltodextrin, 5%-30% of microcrystalline cellulose, 0.03%-1% of sodium lauryl sulfate, 0.1%-3% of aspartame, 0.5%-3% of magnesium stearate and a proper amount of bonding agent. The prepared dispersible tablet of the maca has the advantages that the tablet is high in disintegration and high in dispersing uniformity, has obvious functions for relieving the physical fatigue and improving the sexual function, is good in drug compliance, and is especially applicable to old people and patients with difficulty in swallowing. A preparation method of the dispersible tablet of the maca has the advantages that the process is simple, the operation is controllable, new equipment does not need to be added, and the suitability for industrial and large-scale production is achieved.

The invention relates to the technical field of pharmaceutical preparation, in particular to an orally disintegrating tablet containing imatinib mesylate and a method for preparing the same, wherein the orally disintegrating tablet comprises effective amount of the imatinib mesylate and a pharmaceutic adjuvant which is acceptable in pharmacy and can rapidly collapse and release drugs in an oral cavity. The orally disintegrating tablet containing the imatinib mesylate has the advantages of faster action speed compared with the prior tablets and capsulated drugs, has convenient use and good taste in taking, and is more suitable for children, the elderly, and patients who can not swallow solid medicines.

The invention discloses valnemulin hydrochloride emulsion for animals. Each 100ml of emulsion mainly comprises the following components by weight: 5 to 10g of valnemulin hydrochloride, 1 to 5g of emulsifier, 20 to 40g of oil for injection, 5 to 15g of ethanol and the balance of water for injection. The valnemulin hydrochloride emulsion for animals has the advantages of quick in vivo distribution and good target, can reduce the medicament residue in vivo and the toxic or side effect on the animals, and also can mask the unpleasant odor of the medicament, and improve the stability of the medicament. The valnemulin hydrochloride emulsion for animals can effectively treat gram-positive bacteria and mycoplasma infection, particularly swine dysentery and porcine enzootic pneumonia, and can reduce the using amount of the medicament and avoid medicament tolerance.

The invention discloses special feed for improving the immunity of crabs. The special feed is prepared from the following raw materials: yellow mealworms, casing powder, fly maggot powder, grass carp meat, inkfish viscera powder, silvery pomfret meat, rice moth eggs, shrimp meal, sesame seed meal, potatoes, bagasse, corn protein powder, rapeseed meal, sweet potato powder, jujube powder, watergrass powder and a compound additive, wherein the compound additive is prepared from the following raw materials: Zhiqi fungal substances, candida utilis, phytase, mannase, acid proteinase, amylase, aloe polysaccharide, algal polysaccharide, xylo-oligosaccharide, corn protein peptide, soybean small peptide, garlic, lecithin, compound microelements and compound vitamins. The special feed for improving the immunity of the crabs, provided by the invention, has the functions of improving the immunity of the crabs, improving the survival rate of the crabs, and promoting the growth of the crabs.

The invention discloses a water-soluble florfenicol clathrate with high bioavailability. The water-soluble florfenicol clathrate is prepared from the following components in parts by weight: 5-15 parts of florfenicol or pharmaceutically acceptable salt of florfenicol, 20-60 parts of a florfenicol adsorption carrier, 1-2 parts of an absorption promoter, and 10-30 parts of a florfenicol cosolvent. For the florfenicol clathrate provided by the invention, the solubility of florfenicol is effectively improved, the bioavailability of florfenicol is improved, the hemolysis property of the medicine is alleviated, the release rate of the medicine is controlled, and the bad smell is masked. The preparation method provided by the invention comprises the following steps: firstly, mixing the florfenicol adsorption carrier, the absorption promoter and the florfenicol cosolvent, adding with florfenicol or the pharmaceutically acceptable salt of florfenicol under the water bath water control condition, carrying out stirring, carrying out heat preservation, and carrying out drying, thus obtaining the florfenicol clathrate. The technological operation is simple, the abundant time and manpower are saved, and during the preparation process, no organic solvents are used, so that the preparation method is safe and reliable and is free of pollution, and the process is simple and easy to realize.

The invention relates to a preparation method for oily and oil soluble drug nanocapsules, and aims at solving the problem that the existing nanocapsules prepared by the existing method have low packing efficiency and are large in grain size. The preparation method comprises the following steps of 1. preparing gelatin solution and chitosan solution; 2. preparing O/W emulsion with grain size of nanoscale; 3. adding the chitosan solution into the O/W emulsion with grain size of nanoscale so as to obtain mixed liquor; and 4. regulating pH value of the mixed liquor so as to obtain compound condensate, diluting the compound condensate and adding a curing agent, and then drying so as to complete the preparation of oily and oil soluble drug nanocapsules. The preparation method for oily and oil soluble drug nanocapsules is applicable to the technical field of medicines.

The invention discloses a water-soluble cannabidiol nano preparation based on a cyclodextrin carrier and a preparation method thereof. In terms of the amount of substances, the preparation is preparedfrom 1-50% of cannabidiol and 99-50% of cyclodextrin. The preparation has good water solubility, stability and bioavailability. In terms of the solubility of cannabidiol in water, the preparation hassolubility of 0.046-157.23mg/mL, and water-soluble cannabidiol nano-preparations with different concentrations can be prepared according to needs. The preparation method includes: adding cannabidiolor a suspension into a cyclodextrin solution, carrying out reaction under proper conditions, and performing filtering, freezing or vacuum drying. The preparation method is simple, mild in conditions and easy for industrial production, and can solve the problem that application of cannabidiol in drugs, foods, cosmetics and other fields is limited due to extremely low solubility of cannabidiol in water.

The invention relates to an anti-dental-ulcer allicin medicinal composition and a preparation method thereof. The allicin medicinal composition is divided into two layers, which are respectively a medicine-containing adhesive layer and a waterproof protective layer, wherein an allicin cyclodextrin inclusion compound is prepared from allicin and cyclodextrin or derivative thereof in the medicine-containing adhesive layer, so that the solubility and stability of allicin can be improved; the content of allicin is 0.1-2 percent of the weight of the composition. According to the two-layer composition, solution of the medicine to the opposite side of the oral mucosa and two-way adhesion of a tablet between the gum and the oral mucosa can be reduced, and the medicine is concentrated in the affected part, so that the drug effect is improved. The allicin medicinal composition prepared by the method has the advantages of reliable quality, stable property and good curative effect.

The invention relates to a euphausia superba oil soft capsule which is formed by a capsule shell and content with euphausia superba oil as a main ingredient in the capsule shell. The capsule shell comprises, by weight, 6-10 parts of chitosan, 1-3 parts of propyleneglycol alginate, 3-5 parts of plasticizer, 2-5 parts of organic weak acid and 85-92 parts of water. The content comprises, by weight, 50-100 parts of euphausia superba oil and 0-50 parts of vegetable oil. The euphausia superba oil soft capsule has the advantages that the capsule shell mainly made of the chitosan and the propyleneglycol alginate and the euphausia superba oil supplement each other and perform the health functions of reducing blood fat and blood sugar level and regulating cholesterol together; the soft capsule is prepared in a drop mode, and a capsule shell material and a capsule core material can be mixed well and perform a health protection function together; the euphausia superba oil soft capsule prepared in the method contains nutrient content in balanced proportion, the bioavailability is high, the appearance is attractive, and bad odor of components can be weakened.