Lonicerae and Forsythiae detoxication soft capsule medicine and preparation method and quality detection method thereof

A technology of soft capsules and pharmaceutical preparations, which is applied in the field of traditional Chinese medicine preparations and its preparation, and can solve the problems of large doses, affecting drug efficacy, and poor drug dissolution

Active Publication Date: 2011-03-30
JIANGSU KANION PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Yinqiaojiedu preparations are mainly used for the treatment of wind-heat cold, fever and headache, cough, dry mouth, sore throat and other diseases. The existing Yinqiaojiedu pills, Yinqiaojiedu tablets, Yinqiaojiedu capsules, Yinqiaojiedu granules and other drugs are all There is a defect that the dosage is relatively large. For example, Yinqiao Jiedu pills weigh 3g per pill, take 1 pill once orally, 2 to 3 times a day, and the daily dosage is between 6g and 9g; 0.52g, take 4 tablets orally once, 2-3 times a day, the daily dosage is between 4g-6g; Yinqiao Jiedu Capsules weigh 0.4g, take 4 capsules orally once, 2-3 times a day, the daily dosage Between 3g and 5g; the dosage of Yinqiao Jiedu Granules is larger, and the daily dosage reaches between 15g and 45g
[0004] In addition, Yinqiaojiedu pills, Yinqiaojiedu tablets, Yinqiaojiedu capsules, Yinqiaojiedu granules and other medicines all have the problem of poor drug dissolution, which affects the efficacy of the medicine.

Method used

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  • Lonicerae and Forsythiae detoxication soft capsule medicine and preparation method and quality detection method thereof
  • Lonicerae and Forsythiae detoxication soft capsule medicine and preparation method and quality detection method thereof
  • Lonicerae and Forsythiae detoxication soft capsule medicine and preparation method and quality detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0184] Prescription: Honeysuckle 400g, Forsythia 400g, Mint 240g

[0185] Nepeta 160g Light tempeh 200g Burdock (fried) 240g

[0186] Bellflower 240g, light bamboo leaves 160g, licorice 200g

[0187] Preparation method: Take honeysuckle and add 80% ethanol to reflux twice, each time for 1 hour, combine the extracts, recover ethanol, concentrate to a thick paste with a relative density of 1.28-1.30, and obtain the honeysuckle thick paste;

[0188] Take the fermented soya bean, add water to boil, soak twice at 80°C for 2 hours each time, combine the extracts, and filter to obtain the fermented soya bean extract;

[0189] Extract volatile oil from peppermint, nepeta, and forsythia, set aside, and collect the distilled aqueous solution in another device to obtain mixed extract Ⅰ; decoct the distilled medicinal dregs with burdock fruit (stir-fried), light bamboo leaves, licorice, and bellflower times, 2 hours each time, combine the decoctions and filter to obtain the ...

Embodiment 2

[0208] Prescription: Honeysuckle 400g, Forsythia 400g, Mint 240g

[0209] Nepeta 160g Light tempeh 200g Burdock (fried) 240g

[0210] Bellflower 240g, light bamboo leaves 160g, licorice 200g

[0211] Preparation method: Take honeysuckle and add ethanol to reflux to extract, recover ethanol, concentrate to thick paste, and obtain honeysuckle thick paste;

[0212] Take fermented soya bean, add water to boil, soak in warm, and filter to obtain fermented soya bean extract;

[0213] Take peppermint, Nepeta, and forsythia to extract volatile oil, get volatile oil, set aside, and collect the distilled aqueous solution in another device to obtain mixed extract Ⅰ; add water to the distilled medicinal residue and burdock fruit (stir-fried), light bamboo leaves, licorice, and bellflower Boil and filter the decoction to obtain the mixed extract II;

[0214] Combine the above light tempeh extract, mixed extract I, and mixed extract II, concentrate to extract, and centrifuge ...

Embodiment 3

[0232] Prescription: Honeysuckle 400g, Forsythia 400g, Mint 240g

[0233] Nepeta 160g Light tempeh 200g Burdock (fried) 240g

[0234] Bellflower 240g, light bamboo leaves 160g, licorice 200g

[0235] Preparation method: take honeysuckle and add 70% to 90% ethanol to reflux and extract once, for 2 hours, recover ethanol from the extract, concentrate it into a thick paste, and obtain honeysuckle thick paste;

[0236] Take the fermented soya bean, add water to boil, soak once at 70°C for 3 hours each time, combine the extracts, filter, and obtain the fermented soya bean extract;

[0237] Take peppermint, Nepeta, and forsythia to extract volatile oil, get volatile oil, set aside, and collect the distilled aqueous solution in another device to obtain mixed extract Ⅰ; add water to the distilled medicinal residue and burdock fruit (stir-fried), light bamboo leaves, licorice, and bellflower Decoct once for 3 hours each time, filter the decoction to obtain the mixed extra...

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Abstract

The invention relates to a Lonicerae and Forsythiae detoxication soft capsule medicine and a preparation method and a quality detection method thereof, belonging to the field of traditional Chinese medicines. The Lonicerae and Forsythiae detoxication soft capsule comprises the following raw materials in parts by weight: 5 parts of Lonicerae, 5 parts of Forsythiae, 3 parts of mint, 2 parts of Schizonepeta, 2.5 parts of fermented soya beans, 3 parts of burdock (fried), 3 parts of Platycodon grandiflorum, 2 parts of lophatherum gracile and 2.5 parts of liquorice. The invention provides the preparation method of the medicine and also provides the quality detection method, wherein the quality detection method comprises five identification methods and a method for carrying out content determination by adopting a high performance liquid chromatography, and the methods can effectively control the quality of the Lonicerae and Forsythiae detoxication soft capsule.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, a preparation method thereof, and a quality inspection method, in particular to a pharmaceutical preparation of Yinqiaojiedu soft capsules, a preparation method thereof, and a quality inspection method. technical background [0002] "The Pharmacopoeia of the People's Republic of China" (2005 edition) records some technical contents of Yinqiaojiedu pills, Yinqiaojiedu tablets, Yinqiaojiedu capsules, Yinqiaojiedu granules, etc., such as prescription, preparation method, identification, content Determination, function and indications, usage and dosage, etc. [0003] Yinqiaojiedu preparations are mainly used for the treatment of wind-heat cold, fever and headache, cough, dry mouth, sore throat and other diseases. The existing Yinqiaojiedu pills, Yinqiaojiedu tablets, Yinqiaojiedu capsules, Yinqiaojiedu granules and other drugs are all There is a defect that the dosage is relatively large...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/48A61P29/00A61P25/04A61P11/04A61P11/14G01N30/90G01N30/30G01N30/02
Inventor 萧伟王振中毕宇安刘涛胡军华章晨峰陈凤龙
Owner JIANGSU KANION PHARMA CO LTD
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