Niuhuangshangqing soft capsule and preparation method thereof

A soft and bezoar technology, applied in the field of medicine, can solve the problems of affecting the curative effect and easy dissipation of volatile components, and achieve the effect of preventing oxidation or photolysis, good drug stability and fast absorption.

Active Publication Date: 2009-06-03
TAIJI GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since this dosage form is a solid preparation, and the prescription contains mostly volatile medicinal materials, the volatile ingredients in the medicinal materials are easily lost after long-term storage, which affects the curative effect.

Method used

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  • Niuhuangshangqing soft capsule and preparation method thereof
  • Niuhuangshangqing soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Embodiment 1: Preparation of Niuhuang Shangqing Soft Capsules

[0060] According to the prescription, 2 parts of bezoar, 30 parts of mint, 40 parts of chrysanthemum, 16 parts of Nepeta panicle, 16 parts of Angelica dahurica, 16 parts of Chuanxiong, 50 parts of gardenia, 16 parts of coptis, 10 parts of cortex phellodendri, 50 parts of skullcap, 80 parts of rhubarb, 50 parts of rhubarb, 16 parts of red peony, 50 parts of angelica, 64 parts of rehmannia, 16 parts of bellflower, 10 parts of licorice, 80 parts of gypsum, and 10 parts of borneol. Weigh the medicinal materials, grind artificial bezoar and borneol into fine powder; powder; forsythia, nepeta, peppermint extract volatile oil, decoct the dregs with water once, filter; add water to decoct scutellaria baicalensis, gardenia, bellflower, red peony root, rehmannia glutinosa, gypsum, licorice twice, add water 8 for the first time Double the amount, add 8 times the amount of water for the second time, 2 hours each time, ...

Embodiment 2

[0061] Embodiment 2: Preparation of Niuhuang Shangqing Soft Capsules

[0062] Grind artificial bezoar and borneol into fine powder according to the prescription ratio of Example 1; grind rhubarb and rhubarb into fine powder; Add red peony root, rehmannia glutinosa, gypsum, and licorice to decoct twice, add 10 times the amount of water each time, 1 hour, combine the decoction, and filter; add chrysanthemum to hot soak twice, add 5 times the amount of water each time, 1 hour, filter , combined the filtrate, the filtrate was combined with the above-mentioned medicinal solutions, concentrated under reduced pressure to an extract with a relative density of 1.05 to 1.08 (60°C), and dried into a dry extract; The percolation method under the item (Chinese Pharmacopoeia version one appendix 10 in 2005), carries out percolation with 60% ethanol as solvent, speed 15kg / hour, collects filtrate, reclaims ethanol, concentrates under reduced pressure into thick paste, adds Coptis Rhizoma, R...

Embodiment 3

[0063] Embodiment 3: the preparation of Niuhuangshangqing Soft Capsules

[0064] Grind artificial bezoar and borneol into fine powder according to the prescription ratio of Example 1; grind rhubarb and rhubarb into fine powder; Add red peony root, rehmannia glutinosa, gypsum, and licorice to decoct twice, add 6 times the amount of water for 3 hours each time, combine the decoction, and filter; add chrysanthemum to hot soak twice, add 3 times the amount of water each time, 3 hours, filter , combined the filtrate, the filtrate was combined with the above-mentioned medicinal solutions, concentrated under reduced pressure to an extract with a relative density of 1.05 to 1.08 (60°C), and dried into a dry extract; The percolation method under the item (Chinese Pharmacopoeia version one appendix 10 in 2005), carries out percolation with 80% ethanol as solvent, speed 20kg / hour, collects filtrate, reclaims ethanol, concentrates under reduced pressure into thick paste, adds Coptidis Rh...

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Abstract

The invention relates to a Niuhuangshangqing soft capsule and a preparation method thereof, as well as a quality control method of capsule contents. The Niuhuangshangqing soft capsule comprises contents and capsule shell. The contents include an extent of Chinese medicinal materials in Niuhuangshangqing prescription and a dispersion medium with a weight ratio of 1:(1-2), wherein, the dispersion medium is vegetable oil. The soft capsule is prepared by extracting effective components from Chinese medicinal materials in Niuhuangshangqing prescription in accordance with the properties of the effective components by using different modern extraction techniques and making into soft capsule. The soft capsule has embedding and masking effects, and can prevent volatilization loss of oil components and oxygenation or photodecomposition of effective components. The soft capsule also has the advantages of rapid disintegration, uniform dispersion, high bioavailability, good stability of effective components, low liability of moisture absorption, good air tightness, direct intestinal absorption after disintegration, masking of unpleasant odors of effective components, convenience for administration and carrying, and so on.

Description

【Technical field】 [0001] The invention relates to the technical field of medicine, in particular to Niuhuangshangqing Soft Capsules for treating headache, dizziness, red eyes and tinnitus, sore throat, sore mouth and tongue, gingival swelling and dry stool, and its preparation method and quality control method . 【Background technique】 [0002] Included in the Ministry of Health Ministerial Standards (WS 3 -B-1509-93) "Niuhuang Shangqing Tablet" has the functions of clearing away heat and purging fire, dispersing wind and relieving pain. The prescription is: Calculus Calculus 2g, Mint 30g, Chrysanthemum 40g, Nepeta 16g, Angelica 16g, Chuanxiong 16g, Gardenia 50g, Coptis 16g, Phellodendron 10g, Scutellaria baicalensis 50g, Rhubarb 80g, Forsythia 50g, Radix Paeoniae Rubra 16g, Angelica 50g , Rehmannia glutinosa 64g, bellflower 16g, licorice 10g, gypsum 80g, borneol 10g. Its preparation method: grind artificial bezoar and borneol into fine powder for the above nineteen flavor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/48A61K47/44A61P1/02A61P1/10A61P11/04G01N30/90A61K31/045A61K33/06A61K35/413
Inventor 杨军彭涛王静秦郁文王晓华刘世琪
Owner TAIJI GROUP
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