The invention discloses non-resistant dust-free piglet creep formula feed and a preparation method thereof. The feed is prepared from the following components: corns, fermented corns, soybean meal, fermented soybean meal, expanded soybean flour, expanded corn flour, imported fish meal, spray-dried plasma proteins, dried porcine solubles, powdered whey, soybean oil, sucrose, molasses, sodium glutamate, a feeding promoting agent, Yibao phospholipid, yeast autolysate, an acidifying agent, stone powder, calcium hydrogen phosphate, table salt, 98.5 percent of lysine, 98.5 percent of threonine, 10 percent of tryptophan, special compound enzyme for early-weaned piglets, phytase enzyme, a micro-ecological preparation, a Chinese herbal medicine heath preserver, antibacterial peptide, immunopotentiator, 50 percent of choline chloride and a premix. The preparation method comprises the following steps: firstly, separately preparing granulated feed products and powdery feed products; and then mixing the granulated feed products with the powdery feed products to obtain the non-resistant dust-free piglet creep formula feed. According to the feed disclosed by the invention, antibiotics are not added, a formula is scientific, the dust of the product is low, the palatability and the immunity are improved, and a diarrhea ratio of piglets is reduced.