107 results about "Olfactory receptor" patented technology

A subgenus of olfactory receptors (ORs) that are activated by isovaleric acid (IVA) are identified as well as assays that utilize one or more of these ORs. These assays are useful for identifying potential anti-odorants which may be used in deodorants, air and carpet fresheners, fabric deodorizers, and other compositions for camouflaging odor attributable to IVA and related carboxylic acids.

The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

The present invention comprises compositions methods and cell lines related to controlling insects. An embodiment of a composition comprises a plant essential oil and targets at least one receptor of insects chosen from tyramine receptor, Or83b olfactory receptor, and Or43a olfactory receptor, resulting in a change in the intracellular levels of cAMP, Ca2+, or both.

A method of modifying perception of a malodor, such as the stench associated with putrefying flesh, by selectively affecting specific olfactory receptors in an individual is disclosed. Disclosed are articles of manufacture and especially innovative compositions effective in implementing the method of the present invention including at least three plant extracts.

The present invention comprises compositions, methods and cell lines related to controlling insects. An embodiment of a composition comprises a plant essential oil and targets at least one receptor of insects chosen from tyramine receptor, Or83b olfactory receptor, and Or43a olfactory receptor, resulting in a change in the intracellular levels of cAMP, Ca2+, or both in the insects.

The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the OR classification. The invention encompasses the use of the interaction of OR polypeptides and carboxylic acids as the basis of screening assays for agents that specifically modulate the activity of the seven ORs of the invention.

The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

The invention relates to a plutella xylostella attractant and a preparation method of the plutella xylostella attractant. The plutella xylostella attractant is prepared by the steps of: dissolving alpha-pinene, beta-pinene, geraniolene, cineole, cis-3-hexenyl acetate, isothiocyanate, cis-11-hexadecene aldehyde, cis-11-hexadecene acetate, cis-11-hexadecene alcohol and cis-9-tetradecene acetate in acetic ether and ethanol in formula ratio; and mixing the mixture with sodium dodecyl benzene sulfonate and water in formula ratio. The attractant which is efficient for plutella xylostella is researched and developed by combining the latest research result that the olfactory receptor system of plutella xylostella receives external information according to characteristics that plutella xylostella positions host plants by volatile substances derived from the host plants and positions heterosexual mates by sex pheromone. The attractant is put on the market, and a plutella xylostella preventing and treating product which is safe, environment-friendly and efficient can be provided for farmers.

A subgenus of olfactory receptors (ORs) that are activated by isovaleric acid (IVA) are identified as well as assays that utilize one or more of these ORs. These assays are useful for identifying potential anti-odorants which may be used in deodorants, air and carpet fresheners, fabric deodorizers, and other compositions for camouflaging odor attributable to IVA and related carboxylic acids.

Newly identified Olfactory G protein-coupled receptors (ORs), and the genes and cDNA encoding said receptors are described. Specifically, G protein-coupled receptors active in olfactory signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing olfactory perception of a particular odorant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined odor perception in a mammal, and methods for simulating one or more odors. Further, methods for stimulating or blocking odor perception in a mammal are also disclosed.

The invention relates to an electronic nose recognition method based on a bionic olfactory bulb model and a convolutional neural network. The electronic nose recognition method comprises: sampling to-be-recognized object by using an electronic nose platform to obtain an electronic nose sample data set S; constructing a bionic olfactory bulb model, wherein the bionic olfactory bulb model is formedby connecting a plurality of olfactory glomerulus models, the number of the olfactory glomerulus models in the bionic olfactory bulb model is the same as the number of electronic nose sensors, each olfactory glomerulus model is formed by connecting four basic neuron models, and the four basic neuron models respectively are an olfactory receptor, a mitral cell, a granulosa cell and a olfactory glomerulus pericyte; inputting the ample data set S into the bionic olfactory bulb model by using the olfactory receptor, and processing to obtain a new multivariate pulse time series data set S'; carrying out data normalization processing; obtaining a corresponding grayscale data set M; determining a convolutional neural network model; and training. With the electronic nose recognition method of thepresent invention, the automatic feature extraction and the end-to-end learning can be achieved, and the versatility of the electronic nose recognition algorithm can be improved.

The present invention comprises compositions, methods and cell lines related to controlling insects. An embodiment of a composition comprises a plant essential oil and targets at least one receptor of insects chosen from tyramine receptor, Or83b olfactory receptor, and Or43a olfactory receptor, resulting in a change in the intracellular levels of cAMP, Ca2+, or both in the insects.

Provided is a method for identifying a malodor inhibitor based on a response of an olfactory receptor. The present invention provides a method for identifying a malodor inhibitor including: adding a test substance and a malodor-causing substance to at least one olfactory receptor selected from the group consisting of OR5P3, OR5K1, OR2W1, OR8H1, and a polypeptide which has 80% or more identity in amino acid sequence to any one of the aforementioned polypeptides; measuring the response of the olfactory receptor to the malodor-causing substance; identifying the test substance which can suppress the response of the olfactory receptor based on the measured response; and selecting, as a malodor inhibitor, the test substance which can suppress the response of the olfactory receptor.

A method of modifying perception of a malodor, such as the stench associated with putrefying flesh, by selectively affecting specific olfactory receptors in an individual is disclosed. Disclosed are articles of manufacture and especially innovative compositions effective in implementing the method of the present invention including at least three plant extracts.

A subgenus of olfactory receptors (ORs) that are activated by isovaleric acid (IVA) are identified as well as assays that utilize one or more of these ORs. These assays are useful for identifying potential anti-odorants which may be used in deodorants, air and carpet fresheners, fabric deodorizers, and other compositions for camouflaging odor attributable to IVA and related carboxylic acids.

A medium is analysed for the search for an odorous biological molecule characteristic of a specific substance in an environment to be studied comprising the steps of: exposing a component containing at least one olfactory biological receptor, capable of selectively attaching the type of odorous molecule sought, to an atmosphere taken from the environment to be studied; irradiating that component by means of an incident laser radiation having a wavelength chosen in the ultraviolet close to the absorption wavelength for the olfactory receptor, to cause the excitation of a resonance Raman scattering in the irradiated component; and analysing the Raman spectrum obtained to determine whether or not it corresponds to the Raman spectrum of the olfactory receptor having attached an odorous molecule of the type sought in the atmosphere sampled, so as to identify any presence of the specific substance mentioned in the environment to be studied. The method applies particularly to the identification of toxic or hazardous substances in packaged products or objects or where access to them is difficult, for example during transit.

The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

The invention belongs to the technical field of semiconductor devices and integrated systems and discloses a quantum dot-based electronic nose chip and a design method thereof. The design method includes the following steps that: (1) a gas sensor array on the electronic nose chip is designed; and (2) a signal processing unit and a micro control unit are designed. The step (1) further includes thefollowing steps that: (1-1) with a quantum dot material adopted as an olfactory acceptor material, a quantum dot gas sensor unit is designed, specifically, a resistive or field effect transistor typesensor unit on a substrate is designed; and (1-2) a quantum dot sensor array of an MEMS or TFT device structure is designed based on the quantum dot gas sensor unit. According to the quantum dot-basedelectronic nose chip and the design method thereof of the invention adopted, the quantum dot material is adopted as the olfactory receptor material; the micro-nano gas sensor is designed and prepared; the sensor array is obtained on the basis of the MEMS and TFT device structure; and the MCU containing a pattern recognition algorithm, and the signal processing unit are integrated on the chip, andtherefore, the quantum dot-based electronic nose chip which has the advantages of high sensitivity , small size and low power consumption can be obtained.

The invention discloses a medicine for accelerating brain recovery after anesthesia and improving cognition through the nose through the olfactory pathway. Mixture, which can also add other natural spices and native plant essential oils such as lemon essential oil, rosemary essential oil, clove essential oil and neroli essential oil, etc. The medicine, aromatic smell substance or plant essential oil of the present invention stimulates the olfactory nerve through the nose or mouth, regulates the olfactory center of the brain through the olfactory pathway and then affects the secondary olfactory center, so as to refresh the brain, improve the cognitive function of the brain and improve the brain function; moreover These important natural aromatic substances or essential oils directly regulate the instinctive olfactory nerves and play a regulatory role through specific olfactory receptors without any side effects.

Provided is a substance inhibiting an odor caused by 2,5-dimethyl-4-hydroxy-3(2H)-furanone. An inhibitor of an odor caused by 2,5-dimethyl-4-hydroxy-3(2H)-furanone, comprising a substance inhibiting the response of an olfactory receptor OR5K1 as an active ingredient.

Suggested is a method for evaluating the scent performance of perfumes or perfume mixtures, wherein at least one odorant is brought into contact with an olfactory receptor selected from the group consisting of OR1B1, OR2L8, OR4X2, OR4C16, OR5L1, OR8B4, OR8D2, OR10A6, OR10C1, OR12D2, OR524, OR4E2, OR4P4, OR4K2, OR4C3, OR5I1, OR10Q1 and measuring the response of the receptor.

The present invention provide chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit host targeting functions in insects such as mosquitoes. Method of employing such agents, and articles incorporating the same, are also provided.

The invention discloses a method for detecting an odor substance butanedione based on an olfactory receptor sensor. The method comprises the following steps of: at first, expressing olfactory receptor protein ODR-10 with a His6-tag on an HEK-293 cell surface, extracting and effectively immobilizing the olfactory receptor protein ODR-10 on a quartz crystal microbalance surface through an aptamer so as to form the olfactory receptor sensor; testing a series of odor material butanedione with different set concentrations, thus obtaining a butanedione-resonance frequency variation standard curve; and then, testing a gas which has unknown concentration and needs to be tested, thereby obtaining the concentration of the odor substance-butanedione in the gas to be tested according to the quartz crystal microbalance resonant frequency and the butanedione-resonance frequency variation standard curve. The method is simple in required instrument and convenient to operate, a problem that the olfactory receptor protein ODR-10a of a sensitive element and a quartz crystal microbalance are stably coupled with each other is solved, and the odor substance butanedione is quickly and specially detected.

An object of the present invention is to provide an artificial olfactory sensing system capable of sniffing out various odors highly sensitively.The artificial olfactory sensing system includes: plural sensor cells on a lipid membrane of each of which olfactory receptors have developed; and plural ion-sensitive field-effect transistors (ISFETs) that correspondingly exist to the sensor cells on a one-on-one basis. A response signal showing that each of the olfactory receptors of each of the sensor cells has recognized an odor molecule is converted into an electric signal by an ISFET corresponding to each of the sensor cells.

It is intended to provide a substance inhibiting an odor caused by sotolone. The present invention provides an inhibitor of an odor caused by sotolone, comprising an antagonist of an olfactory receptor OR8D1 as an active ingredient.

The present invention concerns determination of risk for an early age of onset for Alzheimer's Disease in an individual. In specific embodiments, it concerns identification of copy number at chromosome 14q11.2 or a region thereof and associating a high copy number with an earlier age of onset of Alzheimer's Disease.

The invention relates to application of an olfactory receptor in identification of 3-methylthiopropionaldehyde and a method for detecting the 3-methylthiopropionaldehyde. The invention relates to an application of an olfactory receptor in identification of 3-methylthiopropionaldehyde. The olfactory receptor comprises at least one selected from the group consisting of MOR244-3, MOR256-17, MOR180-1 and OR2C1, and the 3-methylthiopropionaldehyde is selected from the group consisting of MOR244-3, MOR256-17, MOR180-1 and OR2C1. The method comprises the steps that a to-be-detected sample makes contact with an olfactory receptor, the response value of the olfactory receptor is determined, whether the to-be-detected sample contains 3-methylthiopropionaldehyde or not is determined based on the response value, and the olfactory receptor comprises at least one selected from MOR244-3, MOR256-17, MOR180-1 and OR2C1. The olfaction receptor disclosed by the invention can be used for rapidly identifying the 3-methylthio-propionaldehyde and can be used for detecting the 3-methylthio-propionaldehyde in drinks, fruits or fruit products and other products so as to determine the freshness degree of the products or the types of the fruits contained in the products.