21results about How to "Reduce depression" patented technology

The invention belongs to the field of neurobiology and drug research and development, and discloses application of NR3A as a protein target in screening or preparing drugs for preventing and / or treating depression-like behaviors. According to the invention, the expression of NR3A in hippocampus is enhanced by stereotactic injection of adeno-associated virus containing Grin3a gene. A chronic constraint stress (CRS) is adopted to induce a depressive mouse, and a sucrose preference test (SPT), a forced swimming test (FST) and an open field test (OFT) are adopted for identification. The expression of proteins such as NR3A, calpain 2 (Calpain2), neuron nitric oxide synthase (nNOS), 3-nitrotyrosine (3-NT), an NLRP3 inflammation complex and the like is detected by WesternBlot; and performing DHE staining to detect reactive oxygen species (ROS). By enhancing hippocampus NR3A expression, depression-like behaviors induced by CRS can be improved, signal cascade activated by calcium is inhibited, ROS generation and 3-NT expression are reduced, and neuroinflammation driven by NLRP3 inflammasomes is inhibited. The NR3A participates in depression-like behaviors induced by CRS, and the mechanism of the NR3A is related to calcium homeostasis regulation, ROS generation and inflammatory response driven by NLRP3 inflammasomes.

The invention discloses a magnesium boride nanosheet / inulin composite hydrogel and application thereof in treating inflammatory bowel diseases and complicated mental diseases, and the composite hydrogel is synthesized by doping magnesium boride nanosheets into inulin and carrying out hot melting and cooling to form gel. The composite hydrogel has good oxidation resistance and biocompatibility, reducing hydrogen can be generated through a hydrolysis reaction to be used for reducing active oxygen and inflammatory factors of the enteritis part, intestinal flora can be adjusted, meanwhile, the composite hydrogel can be prevented from being affected by gastric acid and reach the intestinal part through the addition of inulin, and the enteritis treatment effect is improved. Therefore, the inflammatory bowel disease and related anxiety and depression symptoms thereof are effectively treated.

The present invention relates to the field of nutritional supplements, and discloses a composition for preventing Parkinson's disease and its application, wherein the composition comprises 30 to 44 parts of probiotics, 5 to 7 parts of plant extracts, and 0 to 1 part of nutritional supplements. The probiotics include Lactobacillus helveticus R0052 and Bifidobacterium longum R0175, and the total viable bacterial concentration of the probiotics is not less than 8×10 8 CFU / g. The plant extracts include cranberry extract, ashwagandha extract, and saffron extract. The anthocyanin content of the cranberry extract is 30-50 mg / g, and the proanthocyanidin content is 23-35 mg / g. The composition for preventing Parkinson's disease of the present invention can improve the ability of the intestine to resist oxidative stress, improve anxiety, depression and sleep conditions in the prodromal stage of PD, alleviate constipation and anosmia symptoms in the prodromal stage of PD, and can prevent and delay the continuous development of symptoms in the prodromal stage before Parkinson's disease is diagnosed.

The present invention provides a dedicated tunnel for pedestrians and non-motor vehicles and a method for determining the inner contour thereof. The dedicated tunnel includes a non-motor vehicle lane, a separation zone and a sidewalk. The separation zone includes a conventional section, a fire-fighting facility section and a fire door section. The conventional section includes a structural column and a fire-proof roller shutter. The fire-fighting facility section includes a fire-proof isolation wall and a fire-fighting box room. The fire door section includes a fire-proof isolation wall and a fire door. Under normal working conditions, the fire-proof roller shutter is retracted, the fire door is closed, the sidewalk and the non-motor vehicle lane are connected, the field of vision in the tunnel is wide, and the sense of oppression is reduced. Under fire working conditions, the fire-proof roller shutter is lowered, the fire door is opened, and the sidewalk and the non-motor vehicle lane are separated into two separate compartments, each of which is an escape passage for personnel when a fire occurs in another space. The present invention reasonably utilizes the tunnel section, divides the tunnel into compartments by setting a separation zone, and solves the problem of personnel escape and evacuation in a single-hole dedicated tunnel for pedestrians and non-motor vehicles during a fire without increasing the project investment.

This invention provides a milk powder-based processed cheese rich in γ-aminobutyric acid (GABA) and its preparation method. It is prepared from the following raw materials in the indicated weight percentages: 50-60% natural cheese, 1-3% emulsifying salt, 1-3% thickener, 0.1-0.5% preservative, 6-8% granulated sugar, and the balance being water. The natural cheese is made from reconstituted milk with the following components added according to the weight percentage of the reconstituted milk: 4-8% starter culture, 0.3-0.6% monosodium glutamate, 0.01-0.05% rennet, and 1-4% edible salt. The reconstituted milk is obtained by reconstituted whole milk powder and water at a ratio of 1:6. The starter culture is *Lactobacillus plantarum* NDC75017. The resulting product has moderate hardness, good viscoelasticity, mild flavor, good stability, and a delicate texture. Furthermore, it is high in GABA, which can exert positive effects such as relieving depression, anxiety, insomnia, and lowering blood pressure.

The utility model relates to a lighting lamp mounting structure of a range hood, which comprises a smoke collecting hood, a smoke baffle and an oil cup, the oil cup and a lamp body which are detachable are simultaneously arranged at the bottom of the smoke collecting hood, and a groove for embedding and matching the lamp body is formed on the side part of the oil cup, so that the lamp body and the oil cup can be connected with each other to form a whole. When the smoke barrier on the smoke collecting hood is closed, the lamp body is exposed at the bottom of the oil cup, so that the purpose of external lighting can be achieved without opening the smoke barrier, the defect that the smoke barrier needs to be opened firstly when a lamp is turned on in the prior art is overcome, danger caused by the fact that a user touches the smoke barrier when operating on a kitchen table top is avoided, and the user experience is improved. And meanwhile, the sense of repression brought to people when the smoke barrier is opened is reduced, and the use experience of a user is improved. Besides, the oil cup is the lowest point of the product, the lamp body is arranged at the bottom of the oil cup and can be closer to the lower end space needing lighting, and the brightness of the bottom cooking bench area is greatly improved under the condition of the same power. In addition, the oil cup and the lamp body can be mutually connected to form a whole, so that the lamp has the advantages of compact structure, attractive appearance and the like.

The invention relates to a construction method and application of a chronic codisease depression mouse model. According to the invention, mice to which viruses required by chemical genetic regulation are applied are constructed into the chronic pain co-disease depression mouse model, so that D1MSN and D2MSN existing in NAcMed are specifically infected by the chemical genetic viruses, and then the D1MSN and D2MSN in the NAcMed of the constructed chronic pain co-disease depression mouse model are activated in a chemical genetic control manner; further, the pain can be relieved by activating the D2MSN in the NAcMed, the depression can be relieved by activating the D1MSN, and a new therapeutic target is provided for the treatment of the chronic pain co-disease depression.

The utility model provides a range hood which comprises a fan box and a lower cavity, and the top of the lower cavity is communicated with the fan box; the lower cavity is provided with a front panel and a rear panel which are oppositely arranged and do not exceed a first preset spacing distance, and a left side plate and a right side plate which are oppositely arranged and do not exceed a second preset spacing distance, one end of the front panel is connected with the left side plate, and the other end of the front panel is connected with the right side plate; one end of the rear panel is connected with the left side plate, and the other end of the rear panel is connected with the right side plate; the front panel is provided with an upper smoke inlet and a lower smoke inlet which are arranged at an interval, and the lower edge of the upper smoke inlet is higher than the upper edge of the lower smoke inlet; and the area of the upper smoke inlet is larger than that of the lower smoke inlet. The anti-pressure range hood can not only play an anti-pressure effect, but also improve the smoke suction effect of the range hood.

The present invention discloses a rehabilitation training system based on dynamic regulation, which belongs to the technical field of medical rehabilitation training, and includes a medical assessment module, a mirror simulation training module, a language and cognitive training module, a personalized pain perception regulation module, a progress prediction module, a dynamic regulation module, a social interaction module, and an emotional interaction promotion module. The present invention discloses a rehabilitation training system based on dynamic regulation, and the entire rehabilitation training system based on dynamic regulation can realize medical assessment patient classification, mirror simulation training, language and cognitive training, progress prediction and dynamic regulation, social interaction, emotional interaction promotion, and personalized pain perception regulation, which is helpful to carry out full-time companionship, encouragement and personalized regulation during the rehabilitation training of patients, improve the intrinsic drive of patients during rehabilitation training, improve the enthusiasm of patients during rehabilitation training and help patients build confidence, and improve the therapeutic effect of rehabilitation training.

This invention belongs to the field of biomedical technology, specifically relating to an isoliquiritigenin composition for improving depression and its preparation method. The isoliquiritigenin composition for improving depression comprises the following raw materials in parts by weight: 22-40 parts isoliquiritigenin, 10-17 parts N-acetyl-D-glucosamine, and 15-20 parts β-lapaquinone. Isoliquiritigenin, N-acetyl-D-glucosamine, and β-lapaquinone constitute a multi-target synergistic isoliquiritigenin composition for improving depression. Experimental results show that by taking the isoliquiritigenin composition prepared according to this invention, it can systematically exert its effects and comprehensively improve the pathological state of depression, showing broad application prospects.

The utility model belongs to elevator field discloses a kind of no upper beam elevator, including car frame and the car of being set on car frame, the car frame includes lower beam assembly and two straight beam assemblies respectively being set on the left and right sides of lower beam assembly, the car includes car bottom assembly, car wall assembly being set on car bottom assembly and car roof assembly being set on the upper end of car wall assembly, straight beam guiding assembly is respectively set on the left and right sides of the upper end of car roof assembly, straight beam guiding assembly is slidably inserted on the straight beam assembly of same side, alternatively, straight beam guiding assembly is slidably sleeved on the straight beam guiding assembly of same side.The utility model cancels upper beam, reduces top layer height, improves hoistway utilization.

The utility model relates to the technical field of door and window protective fences, and particularly discloses a protective fence for building doors and windows, which comprises an outer frame, the two ends of the outer frame are fixedly connected with receiving boxes, and the upper side and the lower side between the outer frame and the two receiving boxes are fixedly connected with sliding rails. Two symmetrically-arranged folding hurdles are slidably connected between the two sliding rails, each folding hurdle comprises a main frame body and a plurality of branch frame bodies, a plurality of shear type supports are hinged between the main frame body and the branch frame bodies, a locking mechanism is arranged in the main frame body, the locking mechanism comprises a sliding groove and a lock head, and the lock head is hinged to the main frame body. And the lock head is fixedly connected with one main frame body and is inserted into the other main frame body. According to the folding guardrail, the folding barrier frame serving as the guardrail can be folded and stored in the storage box, and the guardrail can be selectively opened when the folding guardrail is used, so that the folding barrier frame is prevented from blocking the indoor sight, and the indoor repression feeling after the guardrail is installed is reduced.

The invention discloses an application of antrodia camphorata total triterpenes in treating depression. The antrodia camphorata total triterpenes are obtained by extracting antrodia camphorata sporocarp or mycelium. The antrodia camphorata total triterpenes are the main active substance in the antrodia camphorata sporocarp, and the content of the triterpenes in the antrodia camphorata is far higher than that of the ganoderma lucidum. The antrodia camphorata triterpenes in the invention can significantly improve depressive symptoms and restore neurotransmitter and inflammatory factor levels. In addition, the antrodia camphorata triterpene also has the effects of dispelling the effects of alcohol, protecting the liver, resisting hepatic fibrosis, tumor, fatigue, cancer, inflammation and virus, reducing blood pressure, regulating immunity, regulating intestinal flora and the like. The antrodia camphorata triterpene is wide in source, remarkable in effect, free of side effects and diversified in function, and has great development value and good application prospects in treating or relieving depression.

The device for controlling the oil quantity of the aluminum foil tape comprises an oiling machine, a stabilizing device and a fixing device, a control panel is arranged on the surface of the oiling machine, a discharging port is formed in the side, facing the stabilizing device and the fixing device, of the oiling machine, a winding frame is fixed to the discharging port side of the oiling machine, a winding rod is rotationally connected to the interior of the winding frame, and the oil quantity of the aluminum foil tape is controlled through the winding rod. A servo motor is fixedly connected to the outer side of the winding frame, the output end of the servo motor is fixedly connected with the winding rod, and the stabilizing device is installed on the surface of the winding frame through a fixing device. The servo motor drives the winding rod to rotate, so that uniform oiling operation on the surface of the aluminum foil can be achieved while the oiled aluminum foil is wound, and the possibility that in the prior art, the surface of the aluminum foil which is not oiled uniformly is possibly damaged when oil attached to the surface of the oiled aluminum foil is scraped away through scraping tools such as a scraper is replaced.

The invention discloses a tea bag capable of soothing liver-qi stagnation, and relates to the related technical field of tea products, and the tea bag comprises the following components (by mass): 10-20 parts of hypericum perforatum, 10-20 parts of spina date seed, 8-12 parts of longan aril, 8-12 parts of wine-processed cornel, and 8-12 parts of jujube. The invention also discloses a preparation method of the tea bag for soothing liver-qi stagnation. The preparation method comprises the following steps: drying, crushing, sterilizing, quantitatively mixing and packaging. The beverage disclosed by the invention has the effects of soothing liver-qi stagnation and tranquilizing and allaying excitement, effectively relieves the depressive mood of a patient, has a curative effect similar to that of fluoxetine, is better in safety, and is prepared into an instant tea bag product through scientific compatibility of traditional Chinese medicinal materials with the effects of soothing liver-qi stagnation and combining a modern tea making process; effective components of the traditional Chinese medicinal materials are reserved, the tea is convenient to carry and drink, and the health requirements of modern people in fast-paced life are met.

The present invention provides, for example, a molded diffusion laminated film which is excellent in shieldability and designability and which is according to a new design concept. A molded diffusion laminated film 100 of one embodiment of the present invention includes a laminated product including at least a substrate film 11, a molded diffusion layer 21 provided on one surface 11a of the substrate film 11, and a colored layer 31 provided on other surface 11b of the substrate film 11, in which the molded diffusion layer 21 includes at least a first resin binder 22 and a light diffusing particle 23 dispersed in the first resin binder 22, and has a void V in the layer, and the ratio (T / t) of the average thickness T of the molded diffusion layer 21 to the average particle size t of the light diffusing particle 23 is 3.0 or more, and the colored layer 31 includes at least a second resin binder and a colorant dispersed in the second resin binder.

The invention relates to the technical field of medicines, and discloses a medicine for treating periodic psychosis, which comprises the following components: pinellia ternate, pericarpium citri reticulatae, poria cocos, immature bitter orange, bamboo shavings, liquorice, ginger, Chinese date, theanine and a cortex albiziae extract. Through the rapid sedation effect of the theanine and the long-acting emotion regulation effect of the cortex albiziae extract, the multi-target synergistic effect is achieved, and the anxiety, depression, emotion fluctuation and sleep disorder symptoms of a patient are effectively improved; according to the composition, a modern extraction and processing technology is adopted, the bioavailability of the medicine is improved, multiple dosage forms such as granules, capsules and tablets are developed, and the compliance of patients is improved. The traditional Chinese medicine composition has the advantages of high efficiency, safety, low side effect and the like, not only can be used for treating periodic psychosis such as bipolar affective disorder and periodic depression, but also is suitable for adjuvant therapy of other affective disorders, and the dependence of patients on traditional western medicines is reduced.

The invention belongs to the technical field of tea leaves and the field of food technologies, and particularly relates to a preparation method of agilawood white tea, application of the agilawood white tea prepared by the method, a preparation method of a composite agilawood tea beverage and the composite agilawood tea beverage. The agilawood white tea prepared by the agilawood white tea preparation method provided by the invention is savoury, mellow and lingering in taste, fully combines the dual effects of agilawood and white tea, and has the effects of clearing heat and moistening lung, calming liver and benefiting blood, reducing blood pressure and fat and the like. In addition, the prepared compound agilawood tea beverage has the faint scent of the agilawood white tea and the scented tea, has strong antioxidant activity, is a slow-release health-care beverage, and has the effects of regulating nerves, improving the functions of central nervous system, calming nerves, relieving anxiety and depression, promoting gastrointestinal digestion, resisting oxidation, resisting tumors and the like.

The invention discloses a steering column shield lighting assembly, a steering column and a vehicle. The steering column shield lighting assembly comprises a steering column shield and a lighting assembly, a protruding part is formed on the steering column shield in the direction opposite to a steering column, a containing cavity is formed in the side, facing the steering column, of the protruding part, and a light through hole is formed in the surface of the side, facing an instrument panel, of the protruding part in a penetrating mode; and the lighting assembly is fixed in the containing cavity, and at least part of the lighting assembly faces the light through hole. By the adoption of the steering column protecting cover, light emitted by the lighting assembly is transmitted to the original liquid crystal instrument area on the instrument panel through the light through hole formed in the protruding part of the steering column protecting cover, so that the light lighting effect is achieved in the area, the problem that the eyes are black is solved, and the visual uncomfortableness and oppression sense of a driver caused by the darkness of the area are relieved.