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65 results about "Patient classification" patented technology

The Patient classification system (PCS), also known as patient acuity system, is a tool used for managing and planning the allocation of nursing staff in accordance with the nursing care needs. Thus, PCS is used to assist nurse leaders determine workload requirements and staffing needs.

Alzheimer's disease rehabilitation auxiliary system based on artificial intelligence

The invention discloses an Alzheimer's disease rehabilitation assistance system based on artificial intelligence. The Alzheimer's disease rehabilitation assistance system comprises a data collection module, a cognitive evaluation module, a patient classification module, a rehabilitation planning module and a comprehensive assistance module. The invention belongs to the technical field of Alzheimer's disease rehabilitation management, and particularly relates to an Alzheimer's disease rehabilitation auxiliary system based on artificial intelligence, which realizes cognitive risk level judgment by acquiring multi-modal data of voice, writing, behavior and nursing evaluation, extracting structural features and constructing a cognitive evaluation method fusing rules and a lightweight model; performing multi-dimensional symptom grading in combination with patient behaviors and living abilities, screening personalized intervention tasks through an adaptive scoring mechanism, and generating a dynamic rehabilitation path and plan; closed-loop linkage among cognitive assessment, hierarchical classification and rehabilitation intervention is realized, and the accuracy and practicability of rehabilitation assistance are improved.
Owner:HUNAN MAITAI MEDICAL EQUIP CO LTD

Emergency medical system and method for vehicle for guiding emergency patient classification, treatment, and hospital transport

An emergency medical method for a vehicle for guiding emergency patient classification, treatment, and hospital transport, according to the present invention, comprises the steps in which: a patient information registration unit receives essential information on a patient before boarding a vehicle or inside the vehicle after boarding; a patient symptom input unit receives the patient's current symptoms in various formats; an emergency treatment guideline provision unit presents emergency treatment methods suitable for the patient on the basis of the collected information; and a remote medical support unit provides support for real-time communication with remote medical staff inside the vehicle so that the patient or paramedics can receive direct advice and guidance from an emergency medical specialist.
Owner:COSMOS MEDIC INC

Patient care plan determination system, and patient care plan determination method

To recommend inspection having high validity, according to a result at each timing of inspection, diagnosis, treatment and progress observation, in a whole workflow of a patient management.SOLUTION: A patient care plan determination system includes: a medical information server for holding attribute information and inspection results of a plurality of patients; an information terminal for providing a patient management policy indicating a classification of a target patient; and a calculator for acquiring predetermined information from the medical information server and the information terminal and determining a test item candidate related to a disease of the target patient. The calculator acquires the attribute information of the target patient and the patient management policy of the target patient from the medical information server, and applies patient attribute information of the target patient, a test result of the target patient, and the patient management policy of the target patient, to a test plan learned model for calculating a test value of each test item for specifying the disease according to the patient management policy, and executes estimation processing of a test value of a future test item candidate of the target patient and output processing of the test item candidate and the test value of the target patient.SELECTED DRAWING: Figure 1
Owner:HITACHI HIGH TECH CORP

Intelligent drug purchase quantity prediction method based on medical insurance consumption data

The invention relates to the technical field of drug purchase quantity prediction, in particular to an intelligent drug purchase quantity prediction method using medical insurance consumption data, comprising the following steps: S1, acquiring historical medical insurance consumption data including drug names, sales quantity, sales time, medical institution information and patient classification information; s2, preprocessing the medical insurance consumption data, including data cleaning, missing value filling and abnormal value correction, to form a standardized data set; and S3, based on the standardized data set, a drug demand feature matrix X is constructed, and each row represents a drug consumption record of one time period. According to the intelligent drug purchase quantity prediction method based on the medical insurance consumption data, trend, seasonal and random fluctuations are decomposed and separated through a time sequence, and noise interference is reduced; and combining an XGBoost and LSTM integrated model, comprehensively capturing a linear and nonlinear relationship, reducing a final prediction error rate, dynamically calculating a safe inventory threshold value, and avoiding excessive stockpiling of drugs.
Owner:SICHUAN KAICHENG CLOUD TECHNOLOGY DEVELOPMENT CO LTD

Cancer classifier models, machine learning systems and methods of use

Disclosed herein are classifier models, computer implemented systems, machine learning systems and methods thereof for classifying asymptomatic patients into a risk category for having or developing cancer and / or classifying a patient with an increased risk of having or developing cancer into an organ system-based malignancy class membership and / or into a specific cancer class membership.
Owner:COHEN JONATHAN +2

Systems and methods for machine learning approaches to management of healthcare populations

A method for providing treatment recommendations for a patient to a physician is disclosed. The method includes receiving health information associated with the patient, determining a first risk score for the patient based on the health information using a trained predictor model, determining a second risk score for the patient based on the health information and at least one artificially closed care gap included in the health information using the predictor model, determining a predicted risk reduction score based on the first risk score and the second risk score, determining a patient classification based on the predicted risk reduction score, and outputting a report based on at least one of the first risk score, the second risk score, or the predicted risk reduction score.
Owner:GEISINGER CLINIC

Artificial intelligence applications to alert a data safety monitory board to adverse events in clinical-trial data

Provided is a process including: accessing clinical trial data of an ongoing clinical trial that is not yet complete, the clinical trial having a plurality of treatment groups and a plurality of patients in the treatment groups; detecting, with an anomaly detection model, an anomaly in the clinical trial data for a first patient, the anomaly corresponding to a first patient among the plurality of patients; in response to detecting the anomaly classifying the first patient as anomalous in the trial; generating, with the computer system, by an artificial intelligence model, a candidate explanation for the detected anomaly by designating data in a record for the first patient as potentially correlated with the anomaly; and causing the anomaly and the candidate explanation to be presented to a data safety monitoring board (“DSMB”) of the clinical trial.
Owner:TELPERIAN INC

Ai based computing system and method for prediciting continuous cardiac output (CCO) of patients

A system and method for predicting the Continuous Cardiac Output (CCO) of patients is disclosed. The method includes receiving a request from one or more patients and one or medical professionals and determining a set of recovery patterns of the one or more patients. The method further classifying the one or more patients into one or more predefined profiles and predicting the CCO of the one or more patients based on the request, the set of recovery patterns and result of classification using health management based AI model. Further, the method includes generating recommendations corresponding to the predicted CCO and outputting the predicted CCO of the one or more patients and the generated recommendations along with insights on user interface screen of electronic devices associated with the one or more patients and the one or more medical professionals, to take corrective actions in real time and future.
Owner:IQGATEWAY LLC

Mobile tent hospital medical information management system and method based on wechat applet

This invention relates to the field of medical information management technology, specifically to a mobile tent hospital medical information management system and method based on WeChat mini-programs. The system includes the following steps: a mini-program login verification module, a treatment process recording module, a patient classification and bed allocation module, a network topology management module, and a rapid medical record export module. In this invention, abnormal behavior is identified by analyzing user login behavior data, and the identity verification process is adjusted to raise the security threshold for data access and strengthen the defense against data leakage incidents. RFID tags are used to achieve automatic identification of patient information and real-time updates of electronic medical records, improving the response efficiency of temporary medical facilities and ensuring the continuity and efficiency of medical services in disaster response scenarios. Real-time monitoring and optimization of the network topology ensures smooth data transmission within the medical network. Combined with the analysis and formatting of electronic medical record text content, rapid export of electronic medical records is achieved.
Owner:CHINA JAPAN FRIENDSHIP HOSPITAL

Patient classification method, apparatus, device, medium based on magnetic resonance parameters

ActiveCN120804919BMedical data miningSensorsGadolinium contrastLeft ventricular size
The application discloses a patient classification method and device based on magnetic resonance parameters, equipment, medium, the method comprises the following steps: obtaining the target magnetic resonance parameter of the target patient; the target magnetic resonance parameter is selected from a plurality of preset magnetic resonance parameters based on the cardiac resynchronization label of the sample patient and the true result of the occurrence of the preset endpoint event; the target magnetic resonance parameter comprises a myocardial strain parameter, a gadolinium contrast agent delayed enhancement result and a left ventricular torsion parameter; the target classification tree is input into the target patient, and the target patient is classified by using the target classification tree, and the target classification result corresponding to the target patient is obtained; the target classification tree is obtained by extending the preset classification tree based on the cut-off value of each target magnetic resonance parameter and the influence of meeting each cut-off value on cardiac resynchronization; and the target classification result is output. The application can classify patients more accurately.
Owner:FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE

Health care information system providing additional data fields in patient data

Health care information for multiple patients is processed to classify patients into categories. Additional data fields related to a category in which a patient is classified are added to the patient record. These data fields are populated in part by automatically processing the existing patient data. Such automatic processing can result in a probability that the underlying data supports having a particular value stored in one of the added data fields, and this probability also can be stored. Over time, additional data can be obtained from patients, caregivers and other sources, for structured data fields based on data entry forms for patient reported outcomes, caregiver reported outcomes, events of interest, survival and resource utilization. A set of factor scores is computed for each patient, for each category in which the patient is classified. An outcome score is computed for each patient for each category in which the patient is classified, using an outcome function defined for that category, as a weighted function of one or more of the factor scores. The outcome function for a category is standardized across all patients classified in that category.
Owner:OM1 INC

Gastric cancer patient classification and methods of treatment

PCT designated stage expiredWO2025034898A1Drug and medicationsMicrobiological testing/measurementGastric tumorsOncology
The present disclosure provides methods for classifying genomic subtypes of gastric tumor using digital gene expression profiles. The methods include selecting a therapeutic modality for treating patients based on their genomic subtype of gastric tumor. Also provided herein are kits including primers or probes directed to one or more genes associated with a gastric tumor subtype.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST

Vehicle-based emergency medical system and method for guiding emergency patient classification, treatment, and hospital transfer

The vehicle first-aid medical method for guiding first-aid patient classification, treatment and hospital transfer according to the present application includes the following steps: a patient information registration unit receives necessary information about a patient in advance before getting on a vehicle or in the vehicle after getting on the vehicle; a patient symptom input unit receives the current symptoms of the patient in multiple ways; a first-aid treatment guideline providing unit provides a first-aid treatment method suitable for the patient based on the collected information; and a remote medical support unit supports real-time communication with a remote medical staff in the vehicle, so that the patient or a first-aid team member can obtain direct advice and guidance from a first-aid medical specialist.
Owner:KANGSIMEI MEDICAL CO LTD

Method of stratifying haematuria patients

PCT designated stageWO2025228813A1Disease diagnosisData setMarker analysis
Identifying the causes of haematuria requires detailed clinical investigations. Unbalanced patient populations (mostly male) and diverse causes complicate patient classification and biomarker identification. Multi-marker analysis with advanced methods can improve diagnosis even in unbalanced datasets. We used k-means clustering, decision trees, random forest with LIME explainer, and CACTUS algorithm to classify patients as healthy (with no clear cause of haematuria) or sick (with an identified cause of haematuria e.g., bladder cancer, or infection). The CACTUS algorithm was more robust to dataset imbalance, achieving balanced accuracy of 0.747 for both genders, 0.718 for females, and 0.803 for males. Key biomarkers identified included microalbumin, male gender, and tPSA for the whole dataset; age, microalbumin, tPSA, cystatin C, BTA, HAD, and S100A4 for males; and microalbumin, IL-8, pERK, and CXCL16 for females. CACTUS outperformed decision trees and random forest, highlighting potential novel biomarkers for future diagnosis.
Owner:RANDOX LAB LTD

AI blood collection decompression handgrip system and application method

The application provides an AI blood collection decompression grip ware system and an application method, and the system comprises a sensor matrix module, a main control processing module connected with the sensor matrix module, a voice interaction module connected with the main control processing module, and a feedback module connected with the main control processing module. The main control processing module constructs a three-dimensional grip curve surface model based on a pressure signal, calculates a blood vessel exposure index, dynamically adjusts a sensor weight according to patient classification, and forms a closed-loop control from signal collection to individualized intervention. The application reduces the workload of nurses through an automatic process, reduces the puncture failure rate through accurate grip evaluation, realizes accurate decompression guidance through clustering typing, and relieves psychological stress through multi-modal interaction. The standardized voice prompt and intelligent guidance reduce noise pollution in the blood collection area, improve the environmental comfort, and liberate nurses from repeated guidance, so that the nurses can pay more attention to core links such as sterile operation and improve the blood collection efficiency of the hospital.
Owner:THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL

Methods, systems, and devices for detecting sleep and apnea events

Described herein are apparatuses and methods for classifying a patient as being asleep or awake. Such an apparatus can include an accelerometer and a processor. The accelerometer, alone or in combination with the processor, is used to determine an activity level of the patient and a posture of the patient. The processor is configured to classify the patient as being asleep in response to both (i) the posture of the patient being recumbent or reclined for at least a sleep latency duration, and (ii) the activity level of the patient not exceeding an activity threshold for at least the sleep latency duration; and classify the patient as being awake in response to at least one of (iii) the posture of the patient being upright for at least an awake latency duration, or (iv) the activity level of the patient exceeding the activity threshold for at least the awake latency duration.
Owner:PACESETTER INC

Nursing auxiliary system in first-aid transfer process

The invention relates to the field of medical equipment based on the digital information technology, in particular to a nursing auxiliary system in the first-aid transfer process. According to the invention, big data is utilized to analyze the patient condition in the first-aid transfer process and provide auxiliary suggestions. A neural network model based on image processing is constructed, patient information is converted into an image in a specific format, patients are classified according to an image classification mode, and the system comprises an inquiry prompt module, an information acquisition module, an auxiliary diagnosis module, a first-aid database and a display unit. A trained neural network model used for image classification is built in the auxiliary diagnosis module, and after information of a current patient is mapped to a template image to obtain an information image of the current patient, the patient information image of the current patient is classified by using the trained neural network model. And finding the existing patient information closest to the classification of the patient information image of the current patient and the first-aid treatment information of the existing patient.
Owner:THE FIRST HOSPITAL OF HUNAN UNIV OF CHINESE MEDICINE (CLINICAL RES INST OF TRADITIONAL CHINESE MEDICINE)

Index for risk of non-adherence in geographic region with patient-level projection

Methods and systems to train and use an ensemble of artificial intelligence / machine learning (AI / ML) models to extract information from social determinants of health (SDoH), including training each of multiple dimensionality reduction models to reduce dimensionality of socio-demographic variables associated with a respective one of multiple SDoH categories, training a predictive model to predict a patient behavior for a geographic region (e.g., risk of non-adherence to treatment regimens) based on dimensionally reduced SDoH (alone or in combination with selected socio-demographic variables and / or other data), training a patient classification model to classify patients based on prescription transactions, and / or training a regional similarity model to determine a measure of similarity between geographic regions based on SDoH and / or dimensionally reduced SDoH. Also disclosed are techniques to visually represent outputs of the models on a user-interactive display.
Owner:IQVIA INC

A rehabilitation training system based on dynamic regulation

The present invention discloses a rehabilitation training system based on dynamic regulation, which belongs to the technical field of medical rehabilitation training, and includes a medical assessment module, a mirror simulation training module, a language and cognitive training module, a personalized pain perception regulation module, a progress prediction module, a dynamic regulation module, a social interaction module, and an emotional interaction promotion module. The present invention discloses a rehabilitation training system based on dynamic regulation, and the entire rehabilitation training system based on dynamic regulation can realize medical assessment patient classification, mirror simulation training, language and cognitive training, progress prediction and dynamic regulation, social interaction, emotional interaction promotion, and personalized pain perception regulation, which is helpful to carry out full-time companionship, encouragement and personalized regulation during the rehabilitation training of patients, improve the intrinsic drive of patients during rehabilitation training, improve the enthusiasm of patients during rehabilitation training and help patients build confidence, and improve the therapeutic effect of rehabilitation training.
Owner:LELING JIADA HEALTH TECH CO LTD

Blood glucose monitoring alarm reminding system

The invention discloses a blood glucose monitoring alarm reminding system, which belongs to the technical field of blood glucose monitoring and is characterized in that various blood glucose patients are subjected to reserve analysis to obtain various patient classifications, and corresponding dynamic condition models are set according to the patient classifications; analyzing the user, determining a patient classification corresponding to the user, configuring a corresponding blood glucose background recognition scheme for the user according to the patient classification, and configuring a dynamic condition model in a user side of the user; performing blood sugar monitoring on the user to obtain blood sugar monitoring data; the blood sugar background of the user is recognized in real time, and a blood sugar background label is marked on the blood sugar monitoring data according to the blood sugar background; performing real-time alarm analysis on the blood glucose of the user to obtain blood glucose monitoring data, and analyzing a blood glucose background corresponding to the blood glucose monitoring data through a dynamic condition model to obtain an alarm condition; analyzing the blood glucose monitoring data according to the alarm condition to obtain an alarm analysis result, and performing corresponding processing according to the alarm analysis result.
Owner:THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV

Multidisciplinary cooperative treatment commanding and dispatching platform

The invention relates to the technical field of multidisciplinary cooperative treatment, and discloses a multidisciplinary cooperative treatment commanding and dispatching platform, which comprises a patient information acquisition unit for acquiring patient information and storing the patient information into a patient library, and a patient classification unit for summarizing the patient information into a patient label combination, each patient label combination comprises a plurality of disease state labels with weights; the doctor information acquisition unit is used for acquiring doctor information and storing the doctor information into a doctor library; the MDT grouping module is used for calculating the complex value of each illness state label, the complex value is the sum of all weight values of the illness state labels in all patient label combinations, and the maximum illness state label combination with the accumulated complex value not exceeding a treatment label grouping threshold value serves as a treatment label combination; the patient group screening module is used for matching a corresponding patient group from a patient library through the treatment label combination, and the matched patient group is treated by a single MDT team in the same period; the technical problem that the resource utilization rate is reduced due to an MDT treatment mode is solved.
Owner:SECOND AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE

Machine vision skin detection and treatment method and system

The invention discloses a machine vision skin detection and treatment method and system. The system is composed of a machine vision device, a vision calculation system, a training system, a storage system, a reasoning calculation system and an automatic distribution device. The main working method of the system comprises the following steps: 1) the machine vision device collects a skin image of a patient; 2) generating a plurality of feature images from the acquired images by the visual computing system; 3) the training system determines classification levels of the patients for the plurality of feature images; 4) the storage system stores a classification level sample library; 5) the inference calculation system determines the patient classification levels of the current multiple feature images in combination with the level sample library of the storage system; (6) the automatic distribution device automatically provides medicines for the patients according to the classification grades of the patients; the traditional Chinese medicine composition has the advantage that the cure rate of patients can be effectively increased.
Owner:SMARTEYE TECH LTD +1

Stressor management method for hypertensive patients based on meticulous nursing

This invention relates to the field of medical data management technology, specifically to a method for managing stressors in hypertensive patients based on meticulous nursing care. After identifying blood pressure stress points, this method quantifies the conformity of short-term stress stimuli to identify both short-term and chronic blood pressure stress points. The impact of short-term blood pressure stress on the patient is then obtained through the rate of change in systolic blood pressure. Complete chronic stress phases are determined through splitting and merging methods, and the similarity between different time periods is analyzed to obtain the chronic blood pressure stress impact on each patient. Patients can be classified based on these two stress characteristics. In the results of the first classification, the similarity of the complete chronic stress phases is further considered for further classification. This invention determines the short-term and long-term blood pressure stress characteristics of patients based on the trends in systolic and diastolic blood pressure, enabling meticulous patient classification and facilitating effective management and targeted nursing care for hypertensive patients.
Owner:ORDNANCE IND HYGIENIC INST

Method and apparatus for identifying high risk patients for protective percutaneous coronary intervention therapy

Methods and devices are provided for identifying whether a patient meets a protective percutaneous coronary intervention # imgabs0 # condition. The method comprises the following steps: receiving medical information of a patient; extracting one or more features from the received medical information; classifying the patient with respect to an eligibility of the patient for protective # imgabs1 # based at least in part on the extracted one or more features to produce a patient classification; and outputting an indication of the patient classification.
Owner:ABIOMED INC

Biological status classification

There is provided a method of classifying a biological status of an individual. The method comprising: obtaining a biological sample from a patient; obtaining health-related information from the patient, said information including patient gender; analysing the sample to identify a quantity of each of 2 or more endogenous analytes in the sample; comparing the analyte quantities to reference data from healthy individuals to classify the patient as healthy, pre-diseased, at risk of disease or diseased for at least one health-related condition. The reference data includes data derived from a group of biological samples of individuals having the same gender as the patient and not having a need for medical treatment for a disease or illness, each biological sample of the group of biological samples having been analysed by the same process as used to analyse the patient sample, the process being monitored to maintain a predetermined level of consistency.
Owner:RANDOX LAB LTD

AI-powered system for predicting and managing eye health risks in diabetes

A system for predicting and managing eye health risks in diabetes, consisting of a data acquisition interface for receiving ophthalmic images and longitudinal health data of a diabetes patient, a feature extraction module for deriving imaging and clinical features, a trained risk assessment engine for classifying the patient into risk or stable categories and generating alerts according to predefined thresholds, and a communication module for providing personalized recommendations and notifications to patient and physician interfaces.
Owner:SR UNIVERSITY WARANGAL

Vision based detection of breastfeeding related conditions

An artificial intelligent (AI) mediated patient management system is described in this disclosure. This patient management system includes a patient interface configured to collect breastfeeding-related information from a patient, the breastfeeding-related information being stored in images and / or videos, and a semi-independent system connected to the patient interface and configured to propose actionable feedback to the patient. The semi-independent system includes a data pre-processing module connected with the patient interface and configured to resize and normalize the images and / or videos forwarded by the patient interface, and a convolutional neural network (CNN) engine having a final layer and a softmax activation function that classify the processed images into one or more possible issues of a plurality of possible issues, comprising normal, mastitis, and nipple damage. The patient management system also includes a patient triage module and a provider interface connected to the patient triage module and a lactation consultant.
Owner:RGT UNIV OF CALIFORNIA

Method and apparatus for identifying high-risk patients with respect to percutaneous coronary intervention

A method and apparatus are provided for identifying whether a patient is eligible for protected percutaneous coronary intervention (protected PCI). The method includes receiving medical information regarding the patient, extracting one or more features from the received medical information, classifying the patient with respect to eligibility for protected PCI based at least in part on the one or more extracted features, generating a patient classification, and outputting an indication of the patient classification.
Owner:ABIOMED INC

An intelligent medical system for respiratory monitoring in clinical nursing

The present invention relates to the field of respiratory monitoring technology, and specifically to an intelligent medical system for clinical nursing respiratory monitoring. The present invention first obtains the basic medical record information of all patients under respiratory monitoring, and the monitoring curves under each monitoring indicator; according to the similarity of the basic medical record information, all patient groups are obtained; the periodic characteristics of each monitoring curve are analyzed to obtain its degree of instability; and then the fluctuation period and fluctuation range of the respiratory monitoring data under each monitoring indicator in each patient group are obtained in combination with the autocorrelation and fluctuation amplitude of all monitoring curves; finally, respiratory monitoring warning is performed on the patients under respiratory monitoring. Based on the idea that the fluctuation changes of the respiratory monitoring data of patients with similar basic signs are also similar, the present invention classifies all patients, and combines the periodic characteristics of normal breathing to determine the monitoring warning reference of the respiratory monitoring data under each monitoring indicator in each patient category, thereby improving the respiratory monitoring effect for patients with different physical signs.
Owner:DALIAN QINGDONG TECH CO LTD

Diabetes adjuvant therapy cloud platform system based on artificial intelligence model

The invention relates to a diabetes adjuvant therapy cloud platform system based on an artificial intelligence model, and relates to the technical field of health-related information systems and cloud platforms, and the diabetes adjuvant therapy cloud platform system comprises a correlation analysis module which is used for determining a plurality of patient classification factors based on medical records of a plurality of historical diabetic patients, determining a plurality of diabetic patient types and the complication risk of each diabetic patient type; the feature extraction module is used for determining the type of the diabetic patient of the current patient according to the medical record of the current patient and the plurality of patient classification factors, and extracting complication risk features from the medical record of the current patient; the auxiliary treatment module is used for determining similar historical diabetic patients according to the complication risk characteristics of the current patient and determining an auxiliary treatment scheme of the current patient based on the auxiliary treatment scheme of the similar historical diabetic patients and the complication risk characteristics of the current patient, and the diabetes diagnosis and treatment efficiency and the treatment effect are improved.
Owner:JINHUA PEOPLES HOSPITAL (AFFILIATED HOSPITAL OF JINHUA VOCATIONAL & TECH COLLEGE) +1