95 results about "Sleep Latencies" patented technology

A method for treating a patient via high-frequency (HF) electrostimulation therapy at an external target body location comprises generating a tonic motor activation (TOMAC) electrostimulation waveform using a power source supplying less than 100 volts zero-to-peak voltage amplitude per phase. The waveform has a frequency of 1,000 Hz to 5,000 Hz, a zero-to-peak current amplitude of 10-50 mA, and a duty cycle greater than 25%. The waveform is configured to overcome skin capacitance, induce proprioceptive afferent activity, and induce sustained tonic motor activation of a muscle. The method involves delivering the waveform to the external target body location over a specified duration during the patient's sleep period and receiving at least one TOMAC efficacy indication. The efficacy indication may relate to sleep efficiency, sleep stage, sleep onset latency, daytime sleepiness, CPAP compliance, or patient physiological response indicating TOMAC.

The invention discloses a compound composition for improving sleep disorders, which is characterized by comprising the following components: an inhibitory neurotransmitter component, melatonin and a nano-lipid carrier, the nano-lipid carrier comprises phospholipid and cholesterol, the weight ratio of phospholipid to cholesterol is (1-6): 1, the weight ratio of phospholipid to cholesterol is (1-6): 1, and the weight ratio of melatonin to cholesterol is (1-6): 1. The inhibitory neurotransmitter component is wrapped in the nano-lipid carrier to form lipid nanoparticles, and the weight ratio of the inhibitory neurotransmitter component to the nano-lipid carrier is 1: (1-15). The compound composition can be prepared into a compound oral mucosa preparation, can be rapidly disintegrated when encountering saliva in the oral cavity, is good in patient compliance and small in side effect, all the components play a synergistic effect from different mechanisms through multiple target points, and the compound oral mucosa preparation can improve the sleep quality, prolong the sleep time and shorten the sleep latency; and patients with sleep disorders are helped to improve insomnia from the pathologic root.

The invention belongs to the technical field of sleep-aiding oral liquids, and discloses a sleep-aiding nerve-calming oral liquid and a preparation process thereof, the oral liquid is composed of the following components: a plant fermentation broth, fructo-oligosaccharide, gamma-aminobutyric acid, casein hydrolysis peptide, a saussurea involucrata culture, and pyrroloquinoline quinone disodium salt; wherein the plant fermentation liquor is prepared from spina date seeds, poria cocos, lilies, Chinese dates, lotus seeds, lophatherum gracile, seville orange flowers, red roses with double petals, roselle, wheat, licorice roots, peach kernels, sweet-scented osmanthus and plant lactobacillus BXM2. The core component spina date seed saponin A is combined with gamma-aminobutyric acid to directly regulate the GABAergic nervous system, shorten the sleep latency and effectively help sleep and tranquilize the nerves; casein hydrolysis peptide promotes secretion of melatonin, and cooperates with the saussurea involucrata culture to resist oxidative stress, improve the sleep structure and restore circadian rhythm; small molecular active peptides and flavonoid glycosides are generated through fermentation, and anxiety mood, fatigue state and qi and blood circulation are improved; nano embedding and targeted delivery technologies are adopted in the whole process, the bioavailability is high, and the risk of drug dependence is avoided.

The invention discloses a sleep-aiding traditional Chinese medicine composition and a preparation method and application thereof. The sleep-aiding traditional Chinese medicine composition is prepared from 50-80 parts of spina date seeds, 50-80 parts of polygala tenuifolia, 50-80 parts of lilies, 50-80 parts of poria cocos, 30-50 parts of red dates, 30-50 parts of lotus seeds, 30-50 parts of longan aril, 30-50 parts of mulberries, 20-30 parts of seaweed polyphenols and 20-30 parts of gamma-aminobutyric acid. Pharmacodynamic tests show that the composition can remarkably shorten the sleep latency time of mice, prolong the total sleep time and remarkably improve the levels of 5-hydroxytryptamine, melatonin and gamma-aminobutyric acid in serum of the mice, so that the composition has an obvious sleep aiding effect through scientific proportioning and synergistic interaction of the raw materials.

The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to fingered citron-albizia flower compatible traditional Chinese medicine oral liquid for soothing nerves, helping sleep and resisting depression and a preparation method thereof. The oral liquid consists of medicinal materials such as fingered citron, albizia flower, fried jujube kernel, polygala tenuifolia, lily, angelica sinensis, ginseng, radix curcumae, platycladi seed, rhizoma acori graminei and poria cocos, and is supplemented with components such as honeysuckle, liquorice, medlar, honey, phaseolus calcaratus, salvia miltiorrhiza and lophatherum gracile. The preparation method comprises the following steps: stir-frying jujube kernels, soaking medicinal materials, performing double-stage water decoction extraction, performing vacuum concentration, blending honey, performing ultrasonic treatment, performing pasteurization, filling and the like. Animal experiment results show that the traditional Chinese medicine composition is superior to a plurality of contrast groups in the aspects of improving sleep latency, prolonging sleep time, reducing depression-like behaviors, improving sweet water preference and the like, and shows good compatibility synergy and behavior regulation potential.

Some aspects provide an approach for optimizing sleep quality by addressing several components of sleep: falling asleep, maintaining sleep, and waking up refreshed. Some aspects include example systems, devices, and techniques that describe the significance of distal and core body temperatures to achieve these sleep components. For example, by facilitating an increase in distal skin temperature, the example systems, devices, and techniques promote a decrease in core body temperature, which can be associated with reduced sleep onset latency. Maintaining a steady decrease in core body temperature during the initial sleep cycle can support prolonged sleep maintenance. As users approach their wake time, an increase in core body temperature can be encouraged to enhance alertness and improve the waking experience. These example systems, devices, and techniques allow for a tailored sleep environment (e.g., an in-bed microenvironment) that adapts to the physiological needs of the user, contributing to overall improved sleep quality and user satisfaction.

The application discloses an indole compound, a preparation method and application thereof. Specifically, the application provides a compound as shown in formula I, a pharmaceutically acceptable salt or an enantiomer thereof, and the compound can effectively shorten sleep latency, prolong sleep time, and has a better sleep promoting effect.

The invention provides a semen ziziphi spinosae and poria cocos composition. The composition comprises semen ziziphi spinosae extract, poria cocos extract and gamma-aminobutyric acid, wherein the semen ziziphi spinosae extract is formed by combining semen ziziphi spinosae whole powder, semen ziziphi spinosae aqueous extract and semen ziziphi spinosae, and the poria cocos extract is formed by poria cocos powder and poria cocos aqueous extract. The invention also provides a preparation comprising the composition, and a food product comprising the composition or the preparation. The invention further provides application of the composition or the preparation in preparation of health care products or medicines. The composition provided by the invention is prepared by compatibility of pure natural components according to the theory of traditional Chinese medicine, can effectively prolong the sleep time of pentobarbital sodium and remarkably shorten the sleep latency of mice under the condition of not influencing direct sleep of the mice, and has a certain improvement effect on the sleep of the mice. The composition and the preparation provided by the invention have a remarkable improvement effect on sleep-related symptoms, and have important market value and development prospect.

The invention provides albizia flower compound essential oil with sleep aiding and depression relieving functions and a preparation method of the albizia flower compound essential oil, and relates to the technical field of aromatherapy and natural product application. The compound essential oil takes an albizia flower low-temperature two-stage extract as a core carrier and is compounded with various functional essential oil components such as bitter orange leaf essential oil, FCF bergamot essential oil and Egypt nymphaea tetragona original essence, and the compound essential oil is prepared through three core innovations of albizia flower carrier synergistic technology, multi-channel nerve regulation design and safety strengthening design. The technical problems that existing sleep-aiding essential oil is single in effect and high in potential nerve irritation and the bioavailability of albizia flower flavonoid glycoside is low are solved. Experimental verification shows that the compound essential oil can shorten the sleep latency period by 52% and reduce the anxiety score by 47%, can cooperatively regulate the GABA energy system, 5-hydroxytryptamine secretion and hypothalamus-pituitary-adrenal axis through an olfaction-nerve reflex path, realizes efficient anxiety resistance, deep sleep promotion and emotion balance, and is suitable for people with various anxiety insomnia and emotional disorder.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a composition containing zolpidem tartrate and trazodone hydrochloride as well as a preparation and application of the composition, the trazodone hydrochloride can treat sleep disorders under the condition of single use and can remarkably treat the sleep disorders when being combined with zolpidem tartrate, and pharmacological experiments find that the trazodone hydrochloride can be used for treating the sleep disorders. The sleep latency can be remarkably shortened and the sleep time can be prolonged by combined medication; the content of 5HT and NE in blood is improved.

Methods of increasing tonic inhibition in a subject in need thereof, for example a subject with Fragile X syndrome or Angelman syndrome are disclosed. Methods of treating secondary insomnia in a subject with a neurodegenerative disease or disorder are also disclosed. The methods can include administering the subject an effective amount of 4,5,6,7-tetrahydroisoxazolo (5,4-c)pyridin-3-ol (THIP) or a derivative thereof, or a pharmaceutically acceptable salt thereof, increase tonic inhibition in neurons of the subject; to increase slow wave sleep (SWS) and / or slow wave activity (SWA), normalize sleep architecture, reduce secondary insomnia, increase non-rapid eye movement (NREM) sleep, increase sleep continuity, enhance delta activity within NREM, increase or improve total sleep time (TST), increase or improve sleep efficiency, reduce total time awake (TAA), reduce number of awakenings (NWA), reduce latency to persistent sleep (LPS), or to reduce wake after sleep onset (WASO), in the subject, or any combination thereof.

The invention belongs to the technical field of medicines, and particularly discloses a preparation method and application of a medicine extracted from gynura procumbens, fermented soya beans and chilies and used for preventing or treating polyuria and sleep disorders. Dry powder of corresponding extracts is obtained from gynura procumbens, fermented soya beans and chilies through certain extraction reagents, then the three kinds of powder are mixed, then the mixed powder and auxiliary materials are mixed and granulated, and the medicine for preventing or treating polyuria and sleep disorders is obtained. Experiments prove that the traditional Chinese medicine composition has the curative effects of improving polyuria and sleep disorders: 1) inhibiting excessive generation of urine, and remarkably reducing the frequency of urination day and night; (2) the sleep latency period is short, the sleep rate is increased, drowsiness or faint sleep caused by medicines is eliminated, and the sleep quality is improved;

The application provides tea natural lipid nanovesicle and a preparation method and application thereof, and belongs to the field of biotechnology and medicine. The method comprises the following steps: (1) washing fresh tea leaves and placing the tea leaves in a grinder, adding ddH2O, and grinding to obtain tea leaf grinding liquid; (2) centrifuging the tea leaf grinding liquid and collecting supernatant; (3) filtering the supernatant through a 0.22-0.45 mu m filter membrane to obtain clear liquid containing intact tea natural lipid nanovesicles; and (4) concentrating, washing and filtering and / or purifying the clear liquid to obtain intact tea natural lipid nanovesicles. The application of the tea natural lipid nanovesicle in improving sleep quality can shorten the sleep latency, improve sleep continuity and reduce the comprehensive sleep burden score; and can selectively regulate part of specific bacteria without significantly disturbing the overall structure of the intestinal flora, and exhibits a mild, selective and steady-state friendly microecological regulation characteristic.

The invention relates to a cerebroprotein peptide and casein hydrolysate composition and application thereof in improving sleep and memory, and belongs to the technical field of biological protein peptides. According to the preparation method disclosed by the invention, Maillard modification of the casein enzymolysis primary product is realized by screening the enzymolysis protease of the bovine milk casein and screening the carbonyl compound which is subjected to Maillard reaction with the casein enzymolysis primary product, so that the reducing power, the metal ion chelating capacity and the antioxidant capacity of the casein hydrolysate are effectively improved; furthermore, free radicals in the body are removed, oxidative stress reaction is relieved, and a good foundation is laid for improving sleep quality. The brain protein peptide and the casein hydrolysate are compounded, so that the sleep latency can be effectively shortened, the sleep rate can be increased, the sleep can be effectively improved, the content of dopamine and noradrenaline in hypothalamus can be reduced, the content of 5-hydroxytryptamine and the content of aminobutanoin can be increased, and the brain protein peptide composition has good effects of relieving and treating sleep disorders and improving memory.

The invention provides an agilawood leaf-containing sleep-aiding beverage and a preparation method thereof, the agilawood leaf-containing sleep-aiding beverage takes agilawood leaf, spina date seed, lily and longan as main raw materials, and is added with South African drunken solanum extract, shiitake mushroom theanine, crocetin nano-liposome and other components. The agilawood leaves are subjected to alkaline aqueous solution soaking debitterizing and CO2 supercritical degreasing, and the processes of raw material gradient extraction, nano-liposome preparation and the like are combined, so that a finished product is prepared. All the components have a synergistic effect, so that neurotransmitter is adjusted, brain circulation is improved, the sleep latency is effectively shortened, and the sleep duration is prolonged. Animal experiments and electronic tongue tests show that the beverage is remarkable in sleep aiding effect, smooth in taste, low in bitter taste and astringent taste and good in stability, and a natural and healthy sleep aiding beverage choice is provided for people suffering from mild sleep disorder.

The present disclosure relates to a system and method for providing sleep position therapy and rhythmic breathing to a user within a sleep session. The system and method can be used to treat positional obstructive sleep apnea, positional snoring, and / or other conditions to improve sleep onset latency, relaxation, lower blood pressure, and / or improve other physiological characteristics. The system includes a posture sensor, a sensory stimulator, a controller, and / or other components. The system is configured to generate information related to the user's posture, determine whether the user's posture breaks a posture threshold, provide vibration to the user to prompt the user to change posture, and guide the user to perform rhythmic breathing exercises to help the user fall asleep.

The present invention discloses a pharmaceutical composition comprising more than 26 substances, obtained by mixing ethanol extracts of costus root, agarwood, jujube, terminalia chebula, nutmeg, kapok, and frankincense with travertine. The composition can improve myocardial ischemia in subjects; increase the ejection fraction of subjects with myocardial infarction; increase the fractional shortening of the heart; reduce the left ventricular end-diastolic diameter in subjects with myocardial infarction; reduce the left ventricular end-systolic diameter in subjects with myocardial infarction; shorten the sleep latency in subjects with insomnia; prolong the sleep duration in subjects; and upregulate the expression of GAD67 protein in the brain tissue of subjects.

The invention discloses Keemun'an tea polysaccharide ANTP-1 for improving insomnia and a preparation method thereof, and belongs to the field of separation and purification of plant active ingredients. The Keemun'an tea polysaccharide ANTP-1 is prepared from mannose, rhamnose, glucose, galactose, xylose and arabinose, the molar ratio of the mannose to the rhamnose to the glucose to the galactose to the xylose to the arabinose is 1.00: 0.36: 16.78: 1.96: 4.50: 8.21, and the relative molecular weight of the Keemun'an tea polysaccharide ANTP-1 is 26.58 kDa. The Keemun'an tea polysaccharide ANTP-1 disclosed by the invention can be used for remarkably shortening the sleep latency period of a sleep deprivation mouse, prolonging the sleep duration and effectively improving insomnia. The Keemun'an tea polysaccharide ANTP-1 disclosed by the invention is clear in composition and remarkable in effect, and has a wide development and application prospect in the aspect of aiding sleep.

The invention provides a depression-resolving and nerve-soothing composition for improving sleep quality as well as a preparation method and application thereof, and belongs to the technical field of health-care products. The composition for dispelling melancholy and soothing nerves is prepared from a traditional Chinese medicine extract, astaxanthin, theanine, probiotics and chitosan, the traditional Chinese medicine extract consists of a polygala tenuifolia extract, a spina date seed extract and a cortex albiziae extract. During preparation, the chitosan and the acetic acid solution are mixed into a solution, then the traditional Chinese medicine extract, the astaxanthin and the theanine are added to prepare a suspension, and the suspension is mixed with the probiotics after being subjected to vacuum freeze drying. Animal experiments show that the composition can shorten the sleep latency, prolong the total sleep time and increase the content of 5-hydroxytryptamine and gamma-aminobutyric acid in brain tissue, can be used for preparing products for improving sleep, has the effects of relieving depression, soothing nerves and soothing nerves, and is high in safety and wide in applicability.

The invention relates to application of clostridium butyricum in preparation of a product for improving sleep, and a gene sequence of the clostridium butyricum comprises one of the following nucleotide sequences: (1) a nucleotide sequence as shown in SEQ ID NO: 1; (2) a nucleotide sequence having at least 99.8%, 99.9% or higher homology with the nucleotide sequence as shown in SEQ ID NO: 1; and (3) a nucleotide sequence with one or more, such as 1, 2, 3, 4, 5 nucleotide substitution, deletion or insertion, in the nucleotide sequence as shown in SEQ ID NO: 1. The clostridium butyricum provided by the invention can remarkably shorten the sleep latency period and improve the subthreshold dose hypnotic effect, and has a remarkable positive effect in the aspect of improving sleep. In addition, the clostridium butyricum provided by the invention has relatively high safety.

The invention provides traditional Chinese medicine formula essential oil for improving or treating insomnia, and relates to the technical field of traditional Chinese medicine essential oil. The traditional Chinese medicine formula essential oil is prepared from radix bupleuri essential oil, longan aril essential oil, tuber fleeceflower stem essential oil, allium macrostemon essential oil, angelica sinensis essential oil and borneol. The traditional Chinese medicine formula essential oil can significantly improve the sleep quality of drosophila melanogaster; through sniffing administration on an insomnia model mouse, the insomnia state of the insomnia model mouse can be obviously improved, the behavior activity of the model mouse can be recovered, the sleep rate of the mouse can be obviously increased, the sleep latency period can be obviously shortened, the sleep time can be obviously prolonged, the levels of hypothalamic homogenate 5-HT, GABA and Glu of the mouse can be obviously increased, and the level of hypothalamic homogenate DA can be obviously reduced; the traditional Chinese medicine composition has a remarkable treatment effect on insomnia model mice. The traditional Chinese medicine formula essential oil provided by the invention has a relatively good application prospect in preparation of aromatherapy medicines for treating insomnia.

This invention discloses a compound composition for synergistically improving sleep and its preparation method, relating to the fields of health food and functional technology. By weight, the raw materials include: 30-60 parts of broken-cell wall Ganoderma lucidum spore powder, 20-40 parts of roasted jujube seed extract, 5-20 parts of γ-aminobutyric acid (GABA), and 5-15 parts of lily extract, with an optimal ratio of 9:6:3:2. The composition strictly follows the traditional Chinese medicine principle of "principal, assistant, adjuvant, and guide" in its formulation, combined with modern nutritional research findings. The four ingredients synergistically enhance each other's effects, simultaneously shortening sleep latency, prolonging deep sleep duration, improving sleep maintenance disorders, and alleviating anxiety associated with insomnia. This solves the technical problems of existing sleep aids, such as single effects, lack of synergy, and significant side effects. Furthermore, all raw materials in the composition are nationally approved medicinal and edible materials and new food ingredients, ensuring safety and non-addictive properties. The preparation process is simple and easily industrialized, making it widely applicable in the preparation of various health foods and functional foods for improving sleep.

The application discloses Pediococcus pentosaceus SC009 and an application thereof, is preserved in the China General Microbiological Culture Collection Center, and has a preservation time of June 28, 2021 and a preservation number of CGMCC No.22796.The bacteria have the effects of promoting sleep and resisting oxidation, and can be used for preparing sleep-improving and oxidation-resisting food and sleep-disorder treating medicine.In animal experiments, the bacteria can significantly shorten the sleep latency of mice and prolong the sleep time length, improve the sleep quality of mice, significantly improve the total SOD and reduced glutathione content in serum of middle-aged and old rats, reduce the MDA and protein carbonyl content, and have significant antioxidant activity, and can prolong the survival time of old rats.Pediococcus pentosaceus SC009 has the effects of promoting sleep and resisting oxidation, is conducive to market popularization and utilization, and has a broad application prospect.

The invention belongs to the technical field of application of natural products, and particularly relates to a composition with nerve soothing and sleep aiding effects, sleep aiding aromatherapy and a preparation method. The preparation method comprises the following steps: firstly, carrying out step-by-step enzymolysis by adopting multiple enzyme preparations, carrying out ultrasonic treatment, carrying out molecular distillation purification and the like to obtain an active component, namely an enzymolysis extract of rhizoma acori graminei, and compounding the enzymolysis extract with essential oil components, such as sweet marjoram essential oil, cardamom essential oil and coriander seed essential oil, so as to obtain the composition with good effects of soothing the nerves and helping sleep. The sleep-aiding aromatherapy prepared by using the nerve-soothing and sleep-aiding composition provided by the invention has the advantages that in a mouse experiment, the sleep latency period of a mouse is obviously shortened, the sleep duration is prolonged, and a good improvement effect on the sleep quality of the mouse is achieved.

The application belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating chronic insomnia and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-18 parts of mimusops elengi, 6-18 parts of lotus seed, 6-18 parts of lily, 9-30 parts of clematis, and 0.25-1 part of safflower. According to the pathogenesis of yang failing to enter yin in traditional Chinese medicine, the plant medicine with the characteristic of night movement is used for treating insomnia. The clinical curative effect of the traditional Chinese medicine composition presents multilink, can shorten the sleep latency of chronic insomnia patients, prolong the sleep time, reduce the number of night awakenings, improve the daytime function, has no obvious adverse reactions, is high in safety, and is worthy of clinical popularization and application.

Methods and related compositions using Dichrostachys glomerata to provide a variety of health and wellness benefits in a mammal. More specifically, methods and compositions using Dichrostachys glomerata to improve and or reduce insomnia, improve total sleep duration and quality, improve deep sleep duration and time in light sleep, improve sleep latency, improve the amount of time awake and improve sleep efficiency, readiness and balance in a mammal.

The invention belongs to the technical field of traditional Chinese medicine compounds, and provides a depression-resolving and nerve-calming formula for treating insomnia and relieving anxiety and a preparation method thereof, the depression-resolving and nerve-calming formula comprises the following raw materials: 10-30 parts of radix curcumae, 8-24 parts of radix asparagi, 5-15 parts of flos albiziae, 2-6 parts of cortex cinnamomi, 1-3 parts of semen ziziphi spinosae, 1-3 parts of magnetite and 1-3 parts of amber; the depression-resolving and nerve-soothing compound prescription can effectively improve the physical conditions such as eating, hair color and weight of rats with insomnia; the sleep latency period of rats with insomnia is shortened, the sleep duration is prolonged, and the in-vivo 5-HT level is adjusted, so that an exact treatment effect on insomnia is achieved; for a depression rat model, the total activity distance of depression rats can be effectively increased, and the autonomous swimming time and the tail suspension struggling time are prolonged.

The invention relates to the technical field of plant extracts, in particular to an apocynum venetum extract composition, a preparation method and application of the apocynum venetum extract composition in nerve soothing and sleep aiding products. The composition is prepared from the following raw materials in parts by weight: 30 to 50 parts of semen ziziphi spinosae, 20 to 30 parts of bulbus lilii, 5 to 10 parts of modified zein nanoparticles loaded with apocynum venetum extract, 4 to 6 parts of theanine and 1 to 3 parts of vitamin B6. The invention also provides a preparation method of the composition. Compared with the prior art, the composition prepared by the invention can effectively shorten the sleep latency and prolong the sleep time, and has good effects of soothing the nerves and helping sleep.

Methods and related compositions using Dichrostachys glomerata to provide a variety of health and wellness benefits in a mammal. More specifically, methods and compositions using Dichrostachys glomerata to improve and or reduce insomnia, improve total sleep duration and quality, improve deep sleep duration and time in light sleep, improve sleep latency, improve the amount of time awake and improve sleep efficiency, readiness and balance in a mammal.

The invention belongs to the technical field of medicine preparation, discloses a preparation method of a composite microbial preparation, focuses on a specific co-disease group of'depression-constipation-sleep disorder 'for the first time, provides a single-preparation comprehensive solution for comprehensively adjusting'intestine-brain axis' through multi-strain synergy, and fills the market blank. Constipation indexes are as follows: the intestinal tract propulsion rate of mice is increased by 50%, and the discharge time of first black feces is shortened by 30%. The depression index is as follows: in a forced swimming experiment, the immobile time is reduced by 40%, and the sweet water preference is obviously increased. Sleep indexes are as follows: the total sleep time is prolonged by 25%, and the sleep latency period is shortened by 20%. Biochemical indexes are as follows: the level of inflammatory factor IL-6 in serum is reduced by 60%, and the content of 5-HT and GABA in colon tissue is remarkably increased.