47 results about "Sleep Latencies" patented technology

The invention discloses a compound composition for improving sleep disorders, which is characterized by comprising the following components: an inhibitory neurotransmitter component, melatonin and a nano-lipid carrier, the nano-lipid carrier comprises phospholipid and cholesterol, the weight ratio of phospholipid to cholesterol is (1-6): 1, the weight ratio of phospholipid to cholesterol is (1-6): 1, and the weight ratio of melatonin to cholesterol is (1-6): 1. The inhibitory neurotransmitter component is wrapped in the nano-lipid carrier to form lipid nanoparticles, and the weight ratio of the inhibitory neurotransmitter component to the nano-lipid carrier is 1: (1-15). The compound composition can be prepared into a compound oral mucosa preparation, can be rapidly disintegrated when encountering saliva in the oral cavity, is good in patient compliance and small in side effect, all the components play a synergistic effect from different mechanisms through multiple target points, and the compound oral mucosa preparation can improve the sleep quality, prolong the sleep time and shorten the sleep latency; and patients with sleep disorders are helped to improve insomnia from the pathologic root.

Some aspects provide an approach for optimizing sleep quality by addressing several components of sleep: falling asleep, maintaining sleep, and waking up refreshed. Some aspects include example systems, devices, and techniques that describe the significance of distal and core body temperatures to achieve these sleep components. For example, by facilitating an increase in distal skin temperature, the example systems, devices, and techniques promote a decrease in core body temperature, which can be associated with reduced sleep onset latency. Maintaining a steady decrease in core body temperature during the initial sleep cycle can support prolonged sleep maintenance. As users approach their wake time, an increase in core body temperature can be encouraged to enhance alertness and improve the waking experience. These example systems, devices, and techniques allow for a tailored sleep environment (e.g., an in-bed microenvironment) that adapts to the physiological needs of the user, contributing to overall improved sleep quality and user satisfaction.

The application discloses an indole compound, a preparation method and application thereof. Specifically, the application provides a compound as shown in formula I, a pharmaceutically acceptable salt or an enantiomer thereof, and the compound can effectively shorten sleep latency, prolong sleep time, and has a better sleep promoting effect.

The invention provides a semen ziziphi spinosae and poria cocos composition. The composition comprises semen ziziphi spinosae extract, poria cocos extract and gamma-aminobutyric acid, wherein the semen ziziphi spinosae extract is formed by combining semen ziziphi spinosae whole powder, semen ziziphi spinosae aqueous extract and semen ziziphi spinosae, and the poria cocos extract is formed by poria cocos powder and poria cocos aqueous extract. The invention also provides a preparation comprising the composition, and a food product comprising the composition or the preparation. The invention further provides application of the composition or the preparation in preparation of health care products or medicines. The composition provided by the invention is prepared by compatibility of pure natural components according to the theory of traditional Chinese medicine, can effectively prolong the sleep time of pentobarbital sodium and remarkably shorten the sleep latency of mice under the condition of not influencing direct sleep of the mice, and has a certain improvement effect on the sleep of the mice. The composition and the preparation provided by the invention have a remarkable improvement effect on sleep-related symptoms, and have important market value and development prospect.

The application provides tea natural lipid nanovesicle and a preparation method and application thereof, and belongs to the field of biotechnology and medicine. The method comprises the following steps: (1) washing fresh tea leaves and placing the tea leaves in a grinder, adding ddH2O, and grinding to obtain tea leaf grinding liquid; (2) centrifuging the tea leaf grinding liquid and collecting supernatant; (3) filtering the supernatant through a 0.22-0.45 mu m filter membrane to obtain clear liquid containing intact tea natural lipid nanovesicles; and (4) concentrating, washing and filtering and / or purifying the clear liquid to obtain intact tea natural lipid nanovesicles. The application of the tea natural lipid nanovesicle in improving sleep quality can shorten the sleep latency, improve sleep continuity and reduce the comprehensive sleep burden score; and can selectively regulate part of specific bacteria without significantly disturbing the overall structure of the intestinal flora, and exhibits a mild, selective and steady-state friendly microecological regulation characteristic.

The invention discloses Keemun'an tea polysaccharide ANTP-1 for improving insomnia and a preparation method thereof, and belongs to the field of separation and purification of plant active ingredients. The Keemun'an tea polysaccharide ANTP-1 is prepared from mannose, rhamnose, glucose, galactose, xylose and arabinose, the molar ratio of the mannose to the rhamnose to the glucose to the galactose to the xylose to the arabinose is 1.00: 0.36: 16.78: 1.96: 4.50: 8.21, and the relative molecular weight of the Keemun'an tea polysaccharide ANTP-1 is 26.58 kDa. The Keemun'an tea polysaccharide ANTP-1 disclosed by the invention can be used for remarkably shortening the sleep latency period of a sleep deprivation mouse, prolonging the sleep duration and effectively improving insomnia. The Keemun'an tea polysaccharide ANTP-1 disclosed by the invention is clear in composition and remarkable in effect, and has a wide development and application prospect in the aspect of aiding sleep.

The invention provides a depression-resolving and nerve-soothing composition for improving sleep quality as well as a preparation method and application thereof, and belongs to the technical field of health-care products. The composition for dispelling melancholy and soothing nerves is prepared from a traditional Chinese medicine extract, astaxanthin, theanine, probiotics and chitosan, the traditional Chinese medicine extract consists of a polygala tenuifolia extract, a spina date seed extract and a cortex albiziae extract. During preparation, the chitosan and the acetic acid solution are mixed into a solution, then the traditional Chinese medicine extract, the astaxanthin and the theanine are added to prepare a suspension, and the suspension is mixed with the probiotics after being subjected to vacuum freeze drying. Animal experiments show that the composition can shorten the sleep latency, prolong the total sleep time and increase the content of 5-hydroxytryptamine and gamma-aminobutyric acid in brain tissue, can be used for preparing products for improving sleep, has the effects of relieving depression, soothing nerves and soothing nerves, and is high in safety and wide in applicability.

This invention discloses a compound composition for synergistically improving sleep and its preparation method, relating to the fields of health food and functional technology. By weight, the raw materials include: 30-60 parts of broken-cell wall Ganoderma lucidum spore powder, 20-40 parts of roasted jujube seed extract, 5-20 parts of γ-aminobutyric acid (GABA), and 5-15 parts of lily extract, with an optimal ratio of 9:6:3:2. The composition strictly follows the traditional Chinese medicine principle of "principal, assistant, adjuvant, and guide" in its formulation, combined with modern nutritional research findings. The four ingredients synergistically enhance each other's effects, simultaneously shortening sleep latency, prolonging deep sleep duration, improving sleep maintenance disorders, and alleviating anxiety associated with insomnia. This solves the technical problems of existing sleep aids, such as single effects, lack of synergy, and significant side effects. Furthermore, all raw materials in the composition are nationally approved medicinal and edible materials and new food ingredients, ensuring safety and non-addictive properties. The preparation process is simple and easily industrialized, making it widely applicable in the preparation of various health foods and functional foods for improving sleep.

The application discloses Pediococcus pentosaceus SC009 and an application thereof, is preserved in the China General Microbiological Culture Collection Center, and has a preservation time of June 28, 2021 and a preservation number of CGMCC No.22796.The bacteria have the effects of promoting sleep and resisting oxidation, and can be used for preparing sleep-improving and oxidation-resisting food and sleep-disorder treating medicine.In animal experiments, the bacteria can significantly shorten the sleep latency of mice and prolong the sleep time length, improve the sleep quality of mice, significantly improve the total SOD and reduced glutathione content in serum of middle-aged and old rats, reduce the MDA and protein carbonyl content, and have significant antioxidant activity, and can prolong the survival time of old rats.Pediococcus pentosaceus SC009 has the effects of promoting sleep and resisting oxidation, is conducive to market popularization and utilization, and has a broad application prospect.

The invention belongs to the technical field of application of natural products, and particularly relates to a composition with nerve soothing and sleep aiding effects, sleep aiding aromatherapy and a preparation method. The preparation method comprises the following steps: firstly, carrying out step-by-step enzymolysis by adopting multiple enzyme preparations, carrying out ultrasonic treatment, carrying out molecular distillation purification and the like to obtain an active component, namely an enzymolysis extract of rhizoma acori graminei, and compounding the enzymolysis extract with essential oil components, such as sweet marjoram essential oil, cardamom essential oil and coriander seed essential oil, so as to obtain the composition with good effects of soothing the nerves and helping sleep. The sleep-aiding aromatherapy prepared by using the nerve-soothing and sleep-aiding composition provided by the invention has the advantages that in a mouse experiment, the sleep latency period of a mouse is obviously shortened, the sleep duration is prolonged, and a good improvement effect on the sleep quality of the mouse is achieved.

The application belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating chronic insomnia and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-18 parts of mimusops elengi, 6-18 parts of lotus seed, 6-18 parts of lily, 9-30 parts of clematis, and 0.25-1 part of safflower. According to the pathogenesis of yang failing to enter yin in traditional Chinese medicine, the plant medicine with the characteristic of night movement is used for treating insomnia. The clinical curative effect of the traditional Chinese medicine composition presents multilink, can shorten the sleep latency of chronic insomnia patients, prolong the sleep time, reduce the number of night awakenings, improve the daytime function, has no obvious adverse reactions, is high in safety, and is worthy of clinical popularization and application.

The invention belongs to the technical field of medicine preparation, discloses a preparation method of a composite microbial preparation, focuses on a specific co-disease group of'depression-constipation-sleep disorder 'for the first time, provides a single-preparation comprehensive solution for comprehensively adjusting'intestine-brain axis' through multi-strain synergy, and fills the market blank. Constipation indexes are as follows: the intestinal tract propulsion rate of mice is increased by 50%, and the discharge time of first black feces is shortened by 30%. The depression index is as follows: in a forced swimming experiment, the immobile time is reduced by 40%, and the sweet water preference is obviously increased. Sleep indexes are as follows: the total sleep time is prolonged by 25%, and the sleep latency period is shortened by 20%. Biochemical indexes are as follows: the level of inflammatory factor IL-6 in serum is reduced by 60%, and the content of 5-HT and GABA in colon tissue is remarkably increased.

The invention provides gastrodia elata and lucid ganoderma compound fermentation liquor and application thereof in preparation of a product for improving insomnia, and gastrodia elata and lucid ganoderma are extracted and chelated through a fermentation process to form the product with the function of improving insomnia. The gastrodia elata and ganoderma lucidum composite fermentation liquor inhibits oxidative stress and neuroinflammation, regulates neurotransmitter balance in the brain, inhibits abnormal increase of excitatory transmitter glutamic acid and relieves decrease of the content of inhibitory transmitter gamma-aminobutyric acid and 5-hydroxytryptamine by reducing proinflammatory factors and oxidative damage markers in serum and improving the activity of antioxidant enzyme SOD. Therefore, the sleep-awakening period is intervened in multiple ways, so that the sleep rate of an insomnia mouse can be remarkably improved, the sleep latency period is shortened, and the sleep duration is prolonged. Compared with single gastrodia elata or lucid ganoderma fermentation liquor, the compound group shows a synergistic effect and has a better effect.

Described herein are apparatuses and methods for classifying a patient as being asleep or awake. Such an apparatus can include an accelerometer and a processor. The accelerometer, alone or in combination with the processor, is used to determine an activity level of the patient and a posture of the patient. The processor is configured to classify the patient as being asleep in response to both (i) the posture of the patient being recumbent or reclined for at least a sleep latency duration, and (ii) the activity level of the patient not exceeding an activity threshold for at least the sleep latency duration; and classify the patient as being awake in response to at least one of (iii) the posture of the patient being upright for at least an awake latency duration, or (iv) the activity level of the patient exceeding the activity threshold for at least the awake latency duration.

This invention discloses a *Ligilactobacillus salivarius* YS-SA09, with accession number CGMCC NO.37763 and Latin name *Ligilactobacillus salivarius*. This invention also discloses a *Citrus aurantium* ferment, obtained by fermenting *Citrus aurantium* with the aforementioned *Ligilactobacillus salivarius* YS-SA09. This invention further discloses the applications of *Ligilactobacillus salivarius* YS-SA09 and the *Citrus aurantium* ferment, which can effectively improve sleep in mice with insomnia models, effectively shorten sleep latency, and prolong sleep onset time; effectively improve depressive-like behavior in mice with CUMS models; significantly reverse the decrease in neurotransmitter levels caused by CUMS in mice, effectively increase the levels of GABA, 5-HT, DA, and NE in the serum of depressed mice; reduce serum TNF-α and IL-6 levels, and improve inflammatory factor levels.

The invention discloses a biofeedback-driven multi-mode sleep-aiding earphone control system, which belongs to the technical field of biomedical engineering and artificial intelligence, and is characterized in that an electroencephalogram signal, a heart rate variability signal, a respiratory rate signal and a body temperature signal of a user are collected in real time through a sensor array arranged in an earphone; the sleep preparation stage and physiological tension of the user are evaluated, the audio content and parameters are adaptively adjusted according to the evaluation result, the system innovatively integrates the respiration guiding function, the user respiratory frequency is induced to be synchronized through the audio rhythm, the parasympathetic nervous system is activated, and the personalized optimization engine based on reinforcement learning continuously learns historical data of the user. A sleep aiding scheme for thousands of people is achieved, the biological feedback closed-loop control module monitors the intervention effect in real time and dynamically adjusts the strategy, clinical tests show that the system can shorten the sleep latency period by 52% and improve the sleep quality score by 31%, and an intelligent solution is provided for improving the sleep problem.

The invention provides a plant beverage with an effect of improving sleep as well as a preparation method and application of the plant beverage, and belongs to the technical field of food processing. The health-care food is mainly prepared from the following raw materials in parts by weight: 2-15 parts of Chinese wolfberry fruits, 2-15 parts of raspberries, 2-15 parts of longan aril, 2-15 parts of radix polygonati officinalis and 2-15 parts of walnut kernels. The traditional Chinese medicine theory is combined with screening of medicinal and edible traditional Chinese medicinal materials, a unique heart-nourishing, qi-tonifying and qi-blood-regulating formula is established, and the traditional Chinese medicine composition has the function of improving sleep, does not have side effects after being taken for a long time, and is safe and effective. The plant beverage provided by the invention can remarkably prolong the pentobarbital sodium sleep time of mice, increase the subthreshold dose sleep number of the mice and shorten the sleep latency period of the pentobarbital sodium of the mice; and the content of inhibitory neurotransmitters is increased. The composition has important significance on physiological function regulation of sub-health people with poor sleep quality caused by body function reduction due to long-term mental stress and fatigue disorder.

This invention provides a composition for soothing nerves and improving sleep quality, and its preparation method, relating to the fields of functional foods and neurohealth technologies. The preparation method uses birch water as a base, compounded with thirteen medicinal and edible herbs including Ganoderma lucidum, jujube seed, and Poria cocos, combined with compound probiotics such as *Lactobacillus plantarum* JYLP-326, casein peptides, yeast β-glucan, γ-aminobutyric acid, and tea theanine, and blended with pear, mulberry, and blueberry fruit and vegetable purees to harmonize taste and nutrition. The mixture is prepared into an oral polypeptide beverage through low-temperature extraction of traditional Chinese medicine, anaerobic fermentation with compound probiotics, multi-stage homogenization, and low-temperature sterilization. This invention employs a four-fold combined mechanism of traditional Chinese medicine—soothing the nerves, calming nerves, regulating the gut-brain axis, and nutritional repair—to synergistically soothe nerves, relieve anxiety, shorten sleep latency, prolong deep sleep duration, and improve sleep quality. It is melatonin-free, non-addictive, and has no side effects, making it suitable for long-term consumption by people with insomnia, anxiety, and sub-health conditions.

The invention belongs to the field of sleep disorder treatment, and particularly relates to intelligence-promoting polygonatum kingianum tablet candies and application thereof. The fructus alpiniae oxyphyllae and rhizoma polygonati composition takes fructus alpiniae oxyphyllae and rhizoma polygonati as main components, through reasonable compatibility of herba cistanche, spina date seeds, poria cocos, gordon euryale seeds, Chinese yam, black pepper, herba houttuyniae, endothelium corneum gigeriae galli and lotus leaves, all the components act synergistically and have a synergistic addition effect, and experimental verification shows that the fructus alpiniae oxyphyllae and rhizoma polygonati composition can prolong the sleep time of mice and shorten the sleep latency of the mice; the obvious sleep improving effect is realized. Tableted candies prepared by adding a sweetening agent into the intelligence-improving rhizoma polygonati composition are simple in preparation process, can be taken as food for patients with sleep disorders for a long time, and fundamentally solve the problem of sleep disorders of the patients.

The present invention addresses the problem of providing: a novel alkyne derivative or a pharmaceutically acceptable salt thereof; and a medicine containing said compound as an active ingredient.　This alkyne derivative or a pharmaceutically acceptable salt thereof exhibited an activity characteristic with respect to an α1 subunit in a GABAAα1β2γ2PAM test, showed, like eszopiclone, a decrease in the awake period and the REM sleep period, an increase in the Non-REM sleep period, and shortening of sleep onset latency, in a sleep test, and showed a weaker bitterness than eszopiclone in a bitterness test. Therefore, this compound has an excellent characteristic in which bitterness is reduced compared to eszopiclone, and is useful as a medicine such as an agent for ameliorating or treating sleep disorders.

The application relates to the technical field of smart home, and provides a smart bed control system and method, an electronic device, a medium and a working machine, the system comprising a smart bed and a control module, the control module comprising: a sleep monitoring unit for acquiring physiological data of a target user of the smart bed to monitor a sleep state of the target user; a mechanical driving unit for controlling the smart bed according to the sleep state of the target user to adjust an angle of the smart bed to an optimal sleeping posture angle when it is monitored that the target user has not entered the sleep state; wherein when the angle of the smart bed is the optimal sleeping posture angle, the sleep onset latency of the target user entering the sleep state on the smart bed is the shortest. The smart bed control system provided by the application can help users fall asleep quickly by monitoring the sleep state of the user, adjusting the angle of the smart bed to the optimal sleeping posture angle with the shortest sleep onset latency of the user when it is monitored that the user has not entered the sleep state.

The invention discloses a sleep data acquisition and analysis method of an intelligent sleep monitoring pillow, which comprises a monitoring pillow main body, a sensor module, a data processing module and a data analysis module, and is characterized in that the sensor module is used for acquiring head movement data, respiratory rate data and snore decibel data of a user; the data processing module is electrically connected with the sensor module and is used for carrying out preprocessing, time-frequency domain conversion and sleep stage classification on collected data, and the data analysis module is used for processing time sequence signals, predicting sleep stages and utilizing the sleep latency period, the awakening frequency, the sleep efficiency and the sleep stage proportion as sleep continuity evaluation indexes; head movement data, respiratory rate data and snore decibel data are integrated through cooperative work of the three-axis acceleration sensor, the piezoelectric film sensor and the microphone sound receiver, a multi-dimensional sleep quality analysis model is constructed, and respiratory disorder is accurately warned early by monitoring apnea and hypopnea events and pathological snore in real time.

The application discloses Qimen Ancha polysaccharide ANTP-1 for improving insomnia and a preparation method thereof, and belongs to the field of separation and purification of plant active ingredients. The Qimen Ancha polysaccharide ANTP-1 is composed of mannose, rhamnose, glucose, galactose, xylose and arabinose, and the molar ratio is 1.00:0.36:16.78:1.96:4.50:8.21, and the relative molecular weight is 26.58 kDa. The Qimen Ancha polysaccharide ANTP-1 can significantly shorten the sleep latency of sleep-deprived mice, prolong the sleep duration, and effectively improve insomnia. The Qimen Ancha polysaccharide ANTP-1 has a clear composition, remarkable efficacy, and a broad development and application prospect in sleep aid.

The invention relates to the technical field of biological medicine, in particular to application of vanillyl alcohol in preparation of a dopamine receptor D2 antagonist, and the application proves that the vanillyl alcohol can be specifically combined with a D2 receptor with micromole-level affinity through micro-thermophoresis and biological layer interference technologies. Cell experiments show that vanillyl alcohol can antagonize D2 receptor mediated ERK signal pathway activation in a concentration-dependent manner, and has no agonist activity. In a PCPA-induced insomnia mouse model, vanillyl alcohol can shorten the sleep latency and prolong the total sleep time in a dose-dependent manner. After a D2 receptor is knocked down in nucleus septum, the sleep promoting effect of vanillyl alcohol disappears, and it is confirmed that the drug effect of vanillyl alcohol has target dependence. As a low-toxicity natural small molecule, vanillyl alcohol provides a new choice for developing a novel insomnia treatment medicine.

The invention belongs to the field of wine, and provides donkey-hide gelatin and spina date seed wine capable of improving sleep quality and a preparation method of the donkey-hide gelatin and spina date seed wine. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of poria cocos, 20-30 parts of pericarpium citri reticulatae, 20-30 parts of astragalus membranaceus, 30-40 parts of fried spina date seed, 15-25 parts of lily, 30-40 parts of radix ophiopogonis, 15-25 parts of radix rehmanniae recen, 15-25 parts of longan aril, 15-25 parts of lophatherum gracile, 15-25 parts of oyster, 15-25 parts of rose, 15-25 parts of Chinese yam, 15-25 parts of fructus gardeniae, 10-20 parts of colla corii asini and 10-20 parts of liquorice. The colla corii asini and spina date seed wine prepared by the invention can effectively shorten the sleep latency period and further improve the sleep quality, and has a better effect compared with melatonin tablets sold in the market at present.

The invention belongs to the technical field of health-care products, and particularly relates to nutritional oral liquid for assisting in improving sleep quality and a preparation method and application thereof. The nutritional oral liquid comprises the following components in percentage by mass: 20-25% of polypeptide, 30-35% of protein and the balance of water, the polypeptide is peanut protein peptide; the protein comprises rice protein and isolated whey protein in a mass ratio of (1.2-1.5): 1. The nutritional oral liquid disclosed by the invention has remarkable effects of shortening the sleep latency and prolonging deep sleep at the same time.

The invention relates to the field of food health care, in particular to a plant beverage with nerve soothing and sleep aiding effects and a preparation method thereof.The plant beverage with the nerve soothing and sleep aiding effects comprises the following components: a spina date seed extracting solution, a schisandra chinensis extract, mulberry concentrated juice, high fructose corn syrup, white granulated sugar, citric acid, sodium citrate, carboxymethylcellulose, mulberry essence and water; the preparation method of the plant beverage with the nerve soothing and sleep aiding effects comprises the step of mixing and homogenizing the components, and the preparation is simple. According to the plant beverage, three medicinal and edible raw materials including spina date seeds, schisandra chinensis and mulberries serve as cores, addition of melatonin and other ingredients prone to dependence is avoided, the spina date seed extracting solution, the schisandra chinensis extract and the mulberry concentrated juice act synergistically, and by promoting synthesis of 5-hydroxytryptamine and stimulating generation of melatonin, sleep latency is effectively shortened, and the problem of difficulty in falling asleep is solved; by adjusting the ratio of glutamic acid to gamma-aminobutyric acid, excessive nerve activity is inhibited, the number of times of awakening at night is reduced, and deep sleep is prolonged.

The application discloses a composition for synergistically improving sleep and application of the composition in preparation of sleep-improving products, components of the composition include green tea extract, ganoderma lucidum polysaccharide and saffron powder, any two components can be compounded in a specific proportion, or the three components can be compounded in a specific proportion, and the sleep of mice is significantly improved, and the improvement effect of the three components is more significant and is equivalent to that of melatonin. It is verified through experiments that the compounded powder of ganoderma lucidum polysaccharide, green tea extract and saffron powder has significant effects on sleep improvement rate, sleep round number and sleep duration by increasing 5-hydroxytryptamine level and gamma-aminobutyric acid / glutamic acid ratio and reducing glutamic acid level, significantly shortens the sleep latency of mice, increases the sleep duration, and thus improves the sleep quality of mice. Important experimental basis and data support are provided for development of a new sleep-improving health-care food.

To provide a new composition having sleep-improving effect.SOLUTION: There are provided a sleep-improving agent for shortening sleep latency, containing a black soybean seed coat extract as an active ingredient, a food and drink, a supplement, a pharmaceutical, a quasi-drug, a feed, a pet food, or the like, containing the sleep-improving agent, and a method for imparting a sleep-improving action, or the like.SELECTED DRAWING: None