8 results about "Prolonged sleep" patented technology

The application discloses an indole compound, a preparation method and application thereof. Specifically, the application provides a compound as shown in formula I, a pharmaceutically acceptable salt or an enantiomer thereof, and the compound can effectively shorten sleep latency, prolong sleep time, and has a better sleep promoting effect.

This invention relates to the application of frog seeds and their extracts in the preparation of sleep-improving products, belonging to the field of sleep health technology. Specifically, it relates to the application of frog seeds in the preparation of drugs, health products, or special diets with sleep-improving functions, and the application of frog seed extract in the preparation of drugs, health products, or special diets with sleep-improving functions. The frog seed extract is frog seed oil, obtained from frog seeds through supercritical CO2 extraction or cold pressing. The advantage is that animal pharmacodynamic experiments have confirmed that the frog seeds and their extracts of this invention can improve sleep. The sleep-improving functions specifically include one or more of the following aspects: shortening sleep onset time and alleviating sleep anxiety; improving sleep onset efficiency; prolonging sleep duration and increasing total sleep volume; reducing the number of nighttime awakenings and improving sleep continuity; improving the quality of deep sleep, increasing the proportion of deep sleep, and promoting bodily recovery.

The present application relates to the technical field of charging time calibration for electric vehicles, and discloses a real-time clock calibration method and apparatus, a device, and a medium. The method comprises: acquiring clock calibration parameters on the basis of a preset time interval; executing a compensation error calculation process on the basis of the clock calibration parameters to obtain a compensation error; and upon receiving a sleep instruction and determining that a vehicle is not in a sleep state, calibrating a wake-up timestamp by using the compensation error, to obtain a target wake-up timestamp. The present application is used for solving the problem in the prior art that, when a vehicle is in a sleep state, the depletion of battery power due to long-term parking or a prolonged sleep state of the vehicle results in the vehicle being unable to function properly; thus, when a sleep instruction is received, a target wake-up timestamp can be determined, in order to wake up a sleep vehicle control unit at the target wake-up timestamp, so that the vehicle control unit controls a high-voltage system to charge the battery, thereby solving the problem of the vehicle being unable to function properly due to the battery voltage falling below a critical voltage.

This invention discloses a *Ligilactobacillus salivarius* YS-SA09, with accession number CGMCC NO.37763 and Latin name *Ligilactobacillus salivarius*. This invention also discloses a *Citrus aurantium* ferment, obtained by fermenting *Citrus aurantium* with the aforementioned *Ligilactobacillus salivarius* YS-SA09. This invention further discloses the applications of *Ligilactobacillus salivarius* YS-SA09 and the *Citrus aurantium* ferment, which can effectively improve sleep in mice with insomnia models, effectively shorten sleep latency, and prolong sleep onset time; effectively improve depressive-like behavior in mice with CUMS models; significantly reverse the decrease in neurotransmitter levels caused by CUMS in mice, effectively increase the levels of GABA, 5-HT, DA, and NE in the serum of depressed mice; reduce serum TNF-α and IL-6 levels, and improve inflammatory factor levels.

This invention belongs to the field of food processing technology, specifically disclosing a sleep-improving active peptide complex, its preparation method, and its application. The preparation method includes the following steps: S1, mixing and grinding jujube seed and lily bulb, sieving, mixing with kale powder, adding deionized water, heating under reflux for extraction, combining the extracts, filtering, and concentrating under reduced pressure to obtain extract A; S2, mixing dried tangerine peel, hawthorn, and kiwi fruit powder, adding a 70% (w / w) ethanol solution, heating under reflux for extraction, combining the extracts, filtering, and concentrating under reduced pressure to obtain extract B; S3, mixing extract A obtained in S1 with extract B obtained in S2, inoculating with *Lactobacillus plantarum*, fermenting to obtain a reactant; S4, mixing the reactant obtained in S3 with collagen cyclic dipeptide, spray drying to obtain the active peptide complex. This active peptide complex has good stability and solubility, can significantly shorten sleep latency, prolong sleep duration, and improve sleep quality.

The application relates to the technical field of probiotics, and discloses probiotic protein powder for promoting sleep. A preparation method comprises the following steps: co-fermenting protein raw materials and GABA-producing Lactobacillus brevis starter, stopping fermentation when the final pH value of fermentation is controlled to be reduced to 4.5-5.5, collecting the fermentation product and drying the fermentation product to obtain the probiotic protein powder. Through regulation of the final pH value of fermentation, the application realizes accurate control of the fermentation degree, guarantees the GABA yield, and retains the structural integrity of 500-3000 Da active peptides generated by hydrolysis of the protein raw materials, so that the fermentation product contains high-content GABA and high-proportion active peptides, the two coexist, respectively activate GABA A receptors and up-regulate GABA A receptor genes and protein expression, form a double synergistic mechanism of rapid activation and long-term regulation, and improve the overall sleep-promoting activity. The probiotic protein powder prepared by the application can effectively improve sleep quality, prolong sleep time and shorten sleep latency, and is suitable for the fields of functional food or health products.

A herbal composition for relieving sleep disorder, comprising, by percentage weight, active ingredients of 2.5% Hovenia extract, 12.5% rattan extract, 7.5% lemon extract, 7.5% jujube kernels extract, 15% valerian root extract, and 5% panax notoginseng; auxiliary ingredients of 0.05% vitamin B1, 0.50% vitamin B3, 0.05% vitamin B6, 0.01% folic acid (vitamin B9), and 0.10% vitamin B12; and an accessory composition of 36.97% xylitol, 7.39% cellulose, 1.97% stearic acid, 0.99% natural color and flavor, 0.99% silicon dioxide, 0.49% croscarmellose Na, and 0.49% magnesium stearate. The herbal composition has significant anxiolytic effect, well-maintained bioavailability of DHM, no significant toxic or side effect and not causing addictive or withdrawal effect, thereby prolonging sleep duration and quality without causing any significant side effect.

This invention belongs to the field of microbial technology, specifically relating to *Lactobacillus plantarum* PB13 and its application in improving sleep function. This invention provides a *Lactobacillus plantarum* PB13 strain, whose taxonomic name is... Lactobacillus plantarum The preservation number is GDMCC No: 67088. This invention also provides the application of *Lactobacillus plantarum* PB13 in the preparation of a drug for improving sleep, wherein improving sleep includes shortening sleep latency and prolonging sleep duration.