15 results about "Prolonged sleep" patented technology

Some aspects provide an approach for optimizing sleep quality by addressing several components of sleep: falling asleep, maintaining sleep, and waking up refreshed. Some aspects include example systems, devices, and techniques that describe the significance of distal and core body temperatures to achieve these sleep components. For example, by facilitating an increase in distal skin temperature, the example systems, devices, and techniques promote a decrease in core body temperature, which can be associated with reduced sleep onset latency. Maintaining a steady decrease in core body temperature during the initial sleep cycle can support prolonged sleep maintenance. As users approach their wake time, an increase in core body temperature can be encouraged to enhance alertness and improve the waking experience. These example systems, devices, and techniques allow for a tailored sleep environment (e.g., an in-bed microenvironment) that adapts to the physiological needs of the user, contributing to overall improved sleep quality and user satisfaction.

The application discloses an indole compound, a preparation method and application thereof. Specifically, the application provides a compound as shown in formula I, a pharmaceutically acceptable salt or an enantiomer thereof, and the compound can effectively shorten sleep latency, prolong sleep time, and has a better sleep promoting effect.

This invention relates to the application of frog seeds and their extracts in the preparation of sleep-improving products, belonging to the field of sleep health technology. Specifically, it relates to the application of frog seeds in the preparation of drugs, health products, or special diets with sleep-improving functions, and the application of frog seed extract in the preparation of drugs, health products, or special diets with sleep-improving functions. The frog seed extract is frog seed oil, obtained from frog seeds through supercritical CO2 extraction or cold pressing. The advantage is that animal pharmacodynamic experiments have confirmed that the frog seeds and their extracts of this invention can improve sleep. The sleep-improving functions specifically include one or more of the following aspects: shortening sleep onset time and alleviating sleep anxiety; improving sleep onset efficiency; prolonging sleep duration and increasing total sleep volume; reducing the number of nighttime awakenings and improving sleep continuity; improving the quality of deep sleep, increasing the proportion of deep sleep, and promoting bodily recovery.

The present application belongs to the technical field of health care products, and particularly relates to an anti-anxiety gamma-aminobutyric acid composition and a preparation method thereof. The anti-anxiety gamma-aminobutyric acid composition comprises the following components in parts by weight: 1-2 parts of a paeonol derivative, 0.1-0.5 parts of gamma-aminobutyric acid, 0.1-0.3 parts of astaxanthin, and 0.01-0.05 parts of a sea star saponin. The present application uses the gamma-aminobutyric acid, the paeonol derivative and the sea star saponin in combination. The paeonol derivative promotes passive diffusion of the gamma-aminobutyric acid into intestinal epithelial cells through a cell membrane, thereby greatly improving the ability of the gamma-aminobutyric acid to passively diffuse through the cell membrane of the intestinal epithelial cells. The sea star saponin has the effects of sedation, anti-anxiety and regulation of insomnia, and can effectively promote absorption of the gamma-aminobutyric acid. The present application can effectively promote absorption of active substances and has high bioavailability. The composition has the advantages of small dosage, good anti-anxiety effect, prolonged sleep duration and the like.

The present application relates to the technical field of charging time calibration for electric vehicles, and discloses a real-time clock calibration method and apparatus, a device, and a medium. The method comprises: acquiring clock calibration parameters on the basis of a preset time interval; executing a compensation error calculation process on the basis of the clock calibration parameters to obtain a compensation error; and upon receiving a sleep instruction and determining that a vehicle is not in a sleep state, calibrating a wake-up timestamp by using the compensation error, to obtain a target wake-up timestamp. The present application is used for solving the problem in the prior art that, when a vehicle is in a sleep state, the depletion of battery power due to long-term parking or a prolonged sleep state of the vehicle results in the vehicle being unable to function properly; thus, when a sleep instruction is received, a target wake-up timestamp can be determined, in order to wake up a sleep vehicle control unit at the target wake-up timestamp, so that the vehicle control unit controls a high-voltage system to charge the battery, thereby solving the problem of the vehicle being unable to function properly due to the battery voltage falling below a critical voltage.

This invention discloses a *Ligilactobacillus salivarius* YS-SA09, with accession number CGMCC NO.37763 and Latin name *Ligilactobacillus salivarius*. This invention also discloses a *Citrus aurantium* ferment, obtained by fermenting *Citrus aurantium* with the aforementioned *Ligilactobacillus salivarius* YS-SA09. This invention further discloses the applications of *Ligilactobacillus salivarius* YS-SA09 and the *Citrus aurantium* ferment, which can effectively improve sleep in mice with insomnia models, effectively shorten sleep latency, and prolong sleep onset time; effectively improve depressive-like behavior in mice with CUMS models; significantly reverse the decrease in neurotransmitter levels caused by CUMS in mice, effectively increase the levels of GABA, 5-HT, DA, and NE in the serum of depressed mice; reduce serum TNF-α and IL-6 levels, and improve inflammatory factor levels.

The invention provides a nerve-soothing and sleep-aiding compound for improving sleep quality and application of the nerve-soothing and sleep-aiding compound. The nerve soothing and sleep aiding compound for improving sleep quality comprises the following components in parts by weight: 10-30 parts of a spina date seed extract, 5-15 parts of a polygala tenuifolia extract, 2-5 parts of sandalwood, 2-3 parts of bergamot, 2-3 parts of corydalis tuber, 1-2 parts of albizia flower, 1-2 parts of chamomile, 2-3 parts of lavender, 3-5 parts of sweet orange and 8-20 parts of a poria cocos extract. According to the nerve-soothing and sleep-aiding compound for improving the sleep quality and the application thereof, the nerve-soothing and sleep-aiding compound adopts various natural plant extracts and functional components, is safe and free of side effects, does not generate drug dependence and drug resistance after being used for a long time, is suitable for being used by people with various sleep disorders, and is free of toxic and side effects. According to the compound, through the synergistic effect of various components, the sleep time can be remarkably shortened, the sleep time can be prolonged, the sleep depth can be improved, the sleep quality can be effectively improved, and the compound has a good improvement effect on sleep disorders caused by pressure, anxiety and the like.

The invention belongs to the technical field of biological medicine preparations, and discloses an application of a compound preparation with effects of clearing away heart fire and soothing nerves in preparation of a product for improving insomnia. The compound preparation is based on syndrome differentiation and treatment of traditional Chinese medicine, the five medicinal materials synergistically play the roles of clearing away heart-fire, relieving restlessness, calming the heart, soothing the nerves and regulating qi activity, insomnia core symptoms such as difficulty in falling asleep and easy awakening at night can be improved, and based on the characteristics of the traditional Chinese medicine compound, obvious side effects and drug dependence are expected not to be generated easily; the granule solves the problems that a traditional decoction is troublesome to decoct and unstable in dosage, and the medication compliance of a patient is improved. Animal experiments show that the compound can promote sleep and prolong sleep time in a dose-dependent manner, has a remarkable sleep improvement effect, and is suitable for preparing insomnia treatment medicines or health care products and the like.

This invention belongs to the field of food processing technology, specifically disclosing a sleep-improving active peptide complex, its preparation method, and its application. The preparation method includes the following steps: S1, mixing and grinding jujube seed and lily bulb, sieving, mixing with kale powder, adding deionized water, heating under reflux for extraction, combining the extracts, filtering, and concentrating under reduced pressure to obtain extract A; S2, mixing dried tangerine peel, hawthorn, and kiwi fruit powder, adding a 70% (w / w) ethanol solution, heating under reflux for extraction, combining the extracts, filtering, and concentrating under reduced pressure to obtain extract B; S3, mixing extract A obtained in S1 with extract B obtained in S2, inoculating with *Lactobacillus plantarum*, fermenting to obtain a reactant; S4, mixing the reactant obtained in S3 with collagen cyclic dipeptide, spray drying to obtain the active peptide complex. This active peptide complex has good stability and solubility, can significantly shorten sleep latency, prolong sleep duration, and improve sleep quality.

The invention belongs to the field of medicinal chemistry, and particularly relates to a dibenzyl tetrahydroisoquinoline derivative, a preparation method thereof and application of the dibenzyl tetrahydroisoquinoline derivative in treatment of insomnia. The dibenzyl tetrahydroisoquinoline derivative is a compound as shown in a formula (I), or an optical isomer, a crystal and a pharmaceutically acceptable salt thereof, and in the formula (I), R1 is selected from hydrogen, benzoyl, substituted benzoyl, substituted acylamino, R5-CO-, C1-C6 alkoxy-C1-C6 alkyl, substituted silicon group and-R11OC (= O) OR12. The compound provided by the invention has antagonistic activity on OX1R and OX2R. In an insomnia rat model, the compound provided by the invention significantly prolongs the sleep time, increases the sleep duration of NREM and REM, and has an effect of reducing sleep-awakening conversion times superior to that of a positive drug Darlirasone.

The utility model provides an accompanying pillow. The accompanying pillow comprises a pillowcase, a filling layer and a covered edge, the pillowcase is of a rectangular structure, the filling layer is arranged in the pillowcase, the thickness of the filling layer ranges from 2 cm to 5 cm, the wrapping edge is arranged in the circumferential direction of the pillowcase and fixed to the pillowcase, the wrapping edge is provided with a first elastic band, the first elastic band is arranged in the length direction of the wrapping edge, and the second elastic band is arranged in the length direction of the wrapping edge. The first elastic band is arranged on the side, away from the pillowcase, of the covered edge so that the covered edge can be gathered towards one side face of the pillowcase. When the accompanying pillow is used, the accompanying pillow not only can be used for temporary rest in a journey, but also can be suitable for long-time sleeping scenes such as night, and the accompanying pillow can be completely used by people who depend on pillows. Meanwhile, the accompanying pillow is small in overall thickness, so that machine washing can be achieved during use, and the use effect of the accompanying pillow is further improved.

The application relates to the technical field of probiotics, and discloses probiotic protein powder for promoting sleep. A preparation method comprises the following steps: co-fermenting protein raw materials and GABA-producing Lactobacillus brevis starter, stopping fermentation when the final pH value of fermentation is controlled to be reduced to 4.5-5.5, collecting the fermentation product and drying the fermentation product to obtain the probiotic protein powder. Through regulation of the final pH value of fermentation, the application realizes accurate control of the fermentation degree, guarantees the GABA yield, and retains the structural integrity of 500-3000 Da active peptides generated by hydrolysis of the protein raw materials, so that the fermentation product contains high-content GABA and high-proportion active peptides, the two coexist, respectively activate GABA A receptors and up-regulate GABA A receptor genes and protein expression, form a double synergistic mechanism of rapid activation and long-term regulation, and improve the overall sleep-promoting activity. The probiotic protein powder prepared by the application can effectively improve sleep quality, prolong sleep time and shorten sleep latency, and is suitable for the fields of functional food or health products.

A herbal composition for relieving sleep disorder, comprising, by percentage weight, active ingredients of 2.5% Hovenia extract, 12.5% rattan extract, 7.5% lemon extract, 7.5% jujube kernels extract, 15% valerian root extract, and 5% panax notoginseng; auxiliary ingredients of 0.05% vitamin B1, 0.50% vitamin B3, 0.05% vitamin B6, 0.01% folic acid (vitamin B9), and 0.10% vitamin B12; and an accessory composition of 36.97% xylitol, 7.39% cellulose, 1.97% stearic acid, 0.99% natural color and flavor, 0.99% silicon dioxide, 0.49% croscarmellose Na, and 0.49% magnesium stearate. The herbal composition has significant anxiolytic effect, well-maintained bioavailability of DHM, no significant toxic or side effect and not causing addictive or withdrawal effect, thereby prolonging sleep duration and quality without causing any significant side effect.

The invention belongs to the technical field of air purification and health intervention, and discloses a preparation method of small-particle-size ecological negative oxygen ions and application of the small-particle-size ecological negative oxygen ions in the aspect of sleep aiding, the preparation method comprises the following steps: 1) performing supercritical COextraction and multi-stage filtration purification compounding on natural plants to prepare a non-toxic and non-irritant negative oxygen ion stock solution; 2) the generating device comprises a low-temperature plasma ion generating module, an air filtering module and an intelligent control module; and 3) mixing the atomized stock solution with clean air, enabling the mixture to enter an ion generation module, and enabling active components to be attached with negative oxygen ions to improve stability and inactivation capability. The prepared negative oxygen ions are small in particle size and can penetrate through a blood brain barrier to adapt to sensitive people; the non-medicine with the concentration of 6000-8000 / cm is used for helping sleep, so that the sleep time is shortened, and the sleep is prolonged; air can be purified, breathing and cardiovascular diseases can be improved in an auxiliary mode, and an efficient and healthy scheme is provided.

This invention belongs to the field of microbial technology, specifically relating to *Lactobacillus plantarum* PB13 and its application in improving sleep function. This invention provides a *Lactobacillus plantarum* PB13 strain, whose taxonomic name is... Lactobacillus plantarum The preservation number is GDMCC No: 67088. This invention also provides the application of *Lactobacillus plantarum* PB13 in the preparation of a drug for improving sleep, wherein improving sleep includes shortening sleep latency and prolonging sleep duration.