The invention discloses a health care cooking wine and a preparation method thereof. The health care cooking wine is prepared from 24 Chinese medicinal herb raw materials: gecko, lucid ganoderma, longan, semen juglandis, red dates, medlar, Chinese angelica, astragalus membranaceus, codonopsis pilosula, polygonum multiflorum, radix rehmanniae preparata, rhizoma polygonati, Chinese yam, poria cocos, dried tangerine or orange peel, radix sileris, radix angelicae pubescentis, ligusticum wallichii, eucommia bark, honeysuckle, mint, fennel, anise and pepper. The cooking wine is prepared through sealing and soaking the Chinese medicinal herb raw material powder by adopting a 35-40-degree rice wine, is scientific and reasonable in formula and simple to make, and has effects of seasoning, aroma enhancement and fish smell removal, also has functions of nourishing liver and kidney and tonifying qi and blood, and is especially suitable for crowds suffering from liver-kidney deficiency, qi-blood deficiency, debility, abnormal myocardial-echo, pale complexion, fatigue, inappetence and premature graying of hair, thereby being a nutritional cooking wine with an extremely better health care effect.