The invention discloses a traditional Chinese medicine combination and a preparation method for intestinal depression disease treatment; the traditional Chinese medicine combination includes the following raw materials: rhizoma acori graminei, semen raphani, dried tangerine, immature bitter orange, medicated leaven, fried malt, costustoot, cyperus rotundus, storax, agilawood, dalbergia wood, bunge cherry seed, angelica, white paeony root, rehmannia glutinosa, dendrobe, radix polygonati officinalis, ligusticum wallichii, radix asparagi, liriope, medlar, radices trichosanthis, gypsum, the root of kudzu vine, rhizome of Chinese goldthread and scutellaria baicalensis. The traditional Chinese medicine combination can be prepared into any type of common oral preparation according to the conventional traditional Chinese medicine preparation method. The invention can significantly improve the symptoms of abdominal distension, abdominal pain, nausea, vomit, belching, body energy loss and loss of appetite, and also has definite clinical curative effect, significant curative and quick effect. As the traditional Chinese medicine combination basically combines medicinal and edible medicine sources specified in the National Formulary, the traditional Chinese medicine combination has low cost and basically has no toxic and side effect.