The invention provides folium apocyni veneti oral liquid for calming the liver, tranquilizing and enhancing immunity. The folium apocyni veneti oral liquid comprises the following raw materials in part by weight: 10 to 50 parts of folium apocyni veneti, 10 to 20 parts of Eclipta alba, 10 to 20 parts of polygala tenuifolia, 10 to 20 parts of tuber fleeceflower stem, 10 to 20 parts of gardenia, 10 to 20 parts of zizyphus jujube benevolence, 10 to 20 parts of salvia miltiorrhiza, 10 to 20 parts of Ligusticum wallichii, 10 to 20 parts of yanhusuo, 10 to 20 parts of epimedium, 10 to 20 parts of codonopsis pilosula, 10 to 20 parts of poria cocos, 10 to 20 parts of rhizoma zedoariae, 10 to 20 parts of glossy privet fruit, 10 to 20 parts of dogwood, 10 to 20 parts of Concha Margaritiferallsta, 10 to 20 parts of mulberry parasitism, 10 to 20 parts of radix paeoniae alba, 10 to 20 parts of gynostemma, 10 to 20 parts of fructus rosae laevigatae, 10 to 20 parts of astragalus membranaceus, 10 to 20 parts of angelica and 10 to 20 parts of curculigo. The folium apocyni veneti is cold in property, sweet and bitter in taste, and capable of calming the liver, tranquilizing, clearing heat and promoting urination. The folium apocyni veneti oral liquid comprises the main components of rutin, catechin, isoquercetin, glutamic acid, alanine, valine, potassium chloride, and the like, and is capable of generating sperms, supplementing marrow, reinforcing qi, nourishing blood, tonifying brain and tranquilizing.