The invention discloses a medicine for treating phlegm-turbidity closed resistance type coronary heart disease and a preparation method thereof. The medicine comprises the following raw medicinal materials: angelica sinensis, lignum dalbergiae odoriferae, white paeony root, cynomorium songaricum, cassia twig, rhodobryum roseum, asarum, lotus plumule, allium macrostemon, trichosanthes kirilowii maxim, fructus psoraleae, pinellia ternata, amethyst, semen brassicae, ophiopogon root, mulberry twig, lamiophlomis rotata, turmeric, rubia cordifolia, cinnamon, blighted wheat, astragalus, radix codonopsis, roasted rhizoma atractylodis macrocephalae, water dropwort, calcined keel, camphortree root, fructus aurantii, flower of official magnolia, betel nut, korean pine seed, semen boitae, semen aesculi, notopterygium, olgaea leucophylla, medicated leaven, oyster-cap fungus and oroxylum indicum. The medicine disclosed by the invention has the following beneficial effects: the medicine has the effects of warming and strengthening the heart-yang, promoting circulation and removing stasis, filling the heart fluid, dispersing the moisture, reconciling middle-Jiao and combing qi function, is mainly used for curing the phlegm turbidity closed resistance type coronary heart disease, and has the advantages of fast effectiveness, high effective rate, exact curative effect, short treatment course, zero toxic or side effect, low price and the like.