3results about How to "Improve liver function" patented technology

The application discloses application of tamibarotene in preparation of a medicine for preventing and / or treating liver fibrosis, and belongs to the technical field of biological medicine. The application finds that tamibarotene has a significant anti-liver fibrosis effect for the first time. Experimental results show that in two kinds of liver fibrosis animal models induced by CCl4 and TAA, tamibarotene can significantly down-regulate the expression of alpha-SMA and type I collagen, reduce the liver inflammatory response, and improve liver function. In particular, the anti-fibrosis effect of tamibarotene is significantly better than that of RARbeta selective agonist KCL-286 and RARalpha selective agonist Am580, and an unexpected technical effect is achieved. The application provides a new medicine selection for the treatment of liver fibrosis, and has a good clinical application prospect and development value.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a preparation, a pharmaceutical composition and application thereof. The traditional Chinese medicine composition consists of bulbus fritillariae cirrhosae, kelp, thunberg fritillary bulb, turmeric, endothelium corneum gigeriae galli, raw hawthorn and selfheal. According to the application, the bulbus fritillariae cirrhosae and the bulbus fritillariae thunbergii are compatible to synergistically exert the effects of reducing phlegm and resolving The endothelium corneum gigeriae galli and the raw hawthorn have the effect of removing food retention, the selfheal has the effect of clearing liver and removing stasis, and all the medicines are combined to achieve the effects of reducing phlegm, removing blood stasis, softening hard mass and eliminating diseases. Experiments show that the traditional Chinese medicine composition can significantly improve the liver function of Wilson disease model mice, reduce collagen deposition of liver tissues, down-regulate fibrosis markers and inhibit activation of hepatic stellate cells.

The present application relates to the technical field of biological medicine, in particular to a kind of tricyclic sophoridine compound and its preparation method and application, pharmaceutical composition.The tricyclic sophoridine compound provided in the present application has good potential in preventing and / or treating diseases with lipid metabolic disorder syndrome such as fatty liver disease, diabetes, obesity, etc., and the tricyclic sophoridine compound has low toxicity and high safety.As shown in the test results of examples, the tricyclic sophoridine compound provided in the present application can significantly reduce the body weight of MASLD model mice induced by high-fat feed, improve liver function, glucose-lipid metabolic disorder, insulin resistance index and liver steatosis and other pathological abnormalities, and no toxic side effects are observed for 6 weeks of 100mg / kg dose gavage, and acute toxicity test also shows that it has very high safety.