31results about How to "Improve liver function" patented technology

The invention discloses a high-stability oat milk beverage and a preparation method thereof, and belongs to the technical field of grain deep processing. The preparation method of the oat milk beverage comprises the following steps: cleaning and drying oat to obtain dry oat, adding water, grinding into thick liquid, and boiling and gelatinizing to obtain gelatinized liquid; adding alpha-amylase, debranching enzyme, saccharifying enzyme and neutral protease into the gelatinized liquid, stirring, performing enzymolysis, performing enzyme deactivation, sieving, and collecting slurry; and finally homogenizing to obtain the oat milk. According to the preparation method disclosed by the invention, the stability of the oat milk is improved by optimizing process conditions and enzymes used for enzymolysis in the preparation of the oat milk, the preparation of the functional oat milk is realized by further adding functional components under the condition that the stability of the oat milk is not influenced, and the prepared oat milk can realize various effects of reducing blood sugar, resisting fatigue and the like.

The invention discloses a lactobacillus johnsonii and related products and applications thereof, and relates to the field of microorganisms. The Lactobacillus johnsonii GJ231 provided by the invention has a preservation number of CCTCC NO: M 2023981. Compared with other lactobacillus johnsonii, GJ231 is acid-resistant and bile-resistant, has a higher survival rate in the intestine, has a better antibacterial effect on a variety of pathogens, and can be used to prevent and treat related diseases caused by pathogens; secondly, GJ231 has a better high temperature tolerance and has a higher survival rate in the process of spraying and preparing pet food; furthermore, GJ231 also has a strong antioxidant capacity, can reduce the peroxidation reaction caused by oxidative stress, and can be used for anti-aging and anti-oxidation; in addition, GJ231 also has a bacteriocin gene cluster, which may be used to produce bacteriocin, and has the potential to replace antibiotics and food preservation.

The invention belongs to the technical field of medicine, and provides a traditional Chinese medicine composition, a traditional Chinese medicine preparation and application thereof, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of astragalus membranaceus, 20-30 parts of phaseolus calcaratus, 5-10 parts of radix rehmanniae, 10-20 parts of endothelium corneum gigeriae galli, 10-15 parts of hawthorn and 5-20 parts of fingered citron. The traditional Chinese medicine composition disclosed by the invention has an exact curative effect on improving the liver function, total bile acid metabolism and the like of intrahepatic cholestasis in the gestation period. Clinical, animal and cell test results show that the traditional Chinese medicine composition can effectively improve symptoms and signs of intrahepatic cholestasis in the gestation period.

The invention belongs to the technical field of biological medicine, and particularly discloses a hangover-alleviating and liver-protecting preparation which comprises a liver-protecting agent layer, a first coating layer, a hangover-alleviating layer and a second coating layer which are sequentially arranged from inside to outside, the component of the liver-protecting agent layer is a mixture A, the component of the hangover-alleviating layer is a mixture B, the component of the first coating layer is a mixture C, the component of the second coating layer is a mixture B, and the component of the third coating layer is a mixture C; the component of the coating layer II is a mixture D. The hangover-alleviating and liver-protecting preparation provided by the invention is of a multi-layer structure, and can continuously release active ingredients for a long time, so that the concentration of medicines in blood is kept stable; meanwhile, side effects caused by too high drug concentration in a short time can be avoided.

The application discloses application of tamibarotene in preparation of a medicine for preventing and / or treating liver fibrosis, and belongs to the technical field of biological medicine. The application finds that tamibarotene has a significant anti-liver fibrosis effect for the first time. Experimental results show that in two kinds of liver fibrosis animal models induced by CCl4 and TAA, tamibarotene can significantly down-regulate the expression of alpha-SMA and type I collagen, reduce the liver inflammatory response, and improve liver function. In particular, the anti-fibrosis effect of tamibarotene is significantly better than that of RARbeta selective agonist KCL-286 and RARalpha selective agonist Am580, and an unexpected technical effect is achieved. The application provides a new medicine selection for the treatment of liver fibrosis, and has a good clinical application prospect and development value.

The invention provides application of rhizoma atractylodis macrocephalae polysaccharide in preparation of a medicine for treating diabetes mellitus complicated with steatohepatitis, and belongs to the field of traditional Chinese medicines. The atractylodes macrocephala polysaccharide (APMs) composed of glucose, arabinose, galactose, galacturonic acid and glucuronic acid is prepared through a water extraction and alcohol precipitation method, can be used for treating diabetes mellitus complicated with steatohepatitis, and has a remarkable treatment effect on diabetes mellitus complicated with steatohepatitis; insulin resistance, lipid metabolism disorder, liver inflammation, liver injury and liver fibrosis caused by diabetes mellitus complicated with steatohepatitis can be improved.

The invention discloses an immune reconstruction compound for improving the immune function and preventing and assisting in treating tumors as well as a preparation method and application of the immune reconstruction compound, and relates to the technical field of preparation of related preparations for improving immunity. Comprising 180-220 parts of selenium-enriched garlic powder, 15-25 parts of grifola frondosa extract, 7-13 parts of lucid ganoderma extract, 9-12 parts of cordyceps militaris extract, 14-24 parts of dandelion extract, 17-25 parts of broccoli extract and 8-14 parts of turmeric. The selenium-rich garlic powder is used as a main component, the selenium-rich garlic powder is rich in selenium element, the effects of resisting tumors and improving immunity can be achieved, meanwhile, multiple components including the grifola frondosa extract, the ganoderma lucidum extract, the cordyceps militaris extract, the dandelion extract and the broccoli extract are used as auxiliary materials, and the effects of resisting tumors or preventing tumors are jointly achieved. Meanwhile, the inventor accidentally finds that the selenium-enriched garlic powder, the grifola frondosa extract and the cordyceps militaris extract have a synergistic effect in the experiment process, and the effects of resisting tumors, diminishing inflammation and improving immunity can be remarkably improved by compounding the selenium-enriched garlic powder, the grifola frondosa extract and the cordyceps militaris extract.

The present invention relates to a composition containing Antrodia cinnamomea powder and a preparation method and application thereof, belonging to the technical field of medicines, the composition comprises Antrodia cinnamomea extract, Hovenia dulcis extract, Pueraria root extract, Psoralea corylifolia extract, Cyperus rotundus extract and cotton sugar; Antrodia cinnamomea extract contains triterpenoid compounds; Pueraria root extract is an extract below 10kDa obtained by graded enzymolysis of Pueraria root with hemicellulase and trypsin; Psoralea corylifolia extract is an extract below 5kDa obtained by enzymolysis of Psoralea corylifolia protein with alkaline protease; Cyperus rotundus extract is an extract below 5kDa obtained by enzymolysis of Cyperus rotundus with subtilisin and trypsin. Pueraria root extract, Psoralea corylifolia extract and Cyperus rotundus extract all have the effect of promoting hangover, and have a significant synergistic effect when used in combination with Antrodia cinnamomea extract, can promote cell and enzyme activity, promote the decomposition of alcohol in the body, quickly improve the drunken state, and do not cause vomiting.

The invention belongs to the technical field of animal nutrition, and particularly relates to application of capsaicin and concentrated feed in conservation of giraffe in the perinatal period. The invention provides application of capsaicin and concentrated feed in conservation of giraffe in a perinatal period. The concentrated feed comprises the following nutritional ingredients in percentage by weight: 12.69%-19.25% of crude protein, 1.71%-2.59% of crude fat, 2.78%-4.07% of crude ash, 8.61%-14.42% of crude fibers, 0.27%-0.36% of total calcium and 0.87%-1.40% of total phosphorus. The capsaicin and the concentrated feed are used for nursing the perinatal giraffe, the growth performance and blood biochemical indexes of the perinatal giraffe are influenced to a certain extent, and the capsaicin is beneficial for improving the liver function of the giraffe caused by the concentrated feed, reducing the liver burden and reducing the risk of intestinal inflammation at the same time; the method is of great significance to the health of the perinatal giraffe and the healthy growth of cubs.

The invention relates to the technical field of medicines, and discloses application of lactobacillus plantarum GUANKE in prevention and treatment of liver injury. According to the invention, a liver injury mouse model is established through a ZEN infected mouse, and lactobacillus plantarum GUANKE powder is fed into the stomach of the liver injury mouse, so that compared with a model group, the serum, liver function, antioxidant enzyme activity and liver related inflammation indexes of the mouse fed with the lactobacillus plantarum GUANKE are correspondingly improved; and the effect of high-dose treatment of the lactobacillus plantarum GUANKE is more remarkable than that of low-dose treatment of the lactobacillus plantarum GUANKE. Moreover, the tissue pathological section of the liver shows that compared with the inflammation, necrosis and lipid degeneration of the mouse tissue of the model group, the inflammation, necrosis and lipid degeneration of the mouse tissue are relieved after the treatment of the lactobacillus plantarum GUANKE. In conclusion, the lactobacillus plantarum GUANKE has the beneficial effect of treating the liver injury.

The invention relates to the technical field of biology, and particularly discloses clostridium praeparatum capable of improving metabolism-related steatohepatitis and application of the clostridium praeparatum. The clostridium pralaense is Faecalibacteria pralausnitziiGZSY3214, the clostridium pralaense is preserved in the Guangdong Microbial Culture Collection Center on August 7, 2024, and the preservation number of the clostridium pralaense is GDMCC (China General Microbiological Culture Collection Center) No: 64992. The clostridium pralaense has been preserved in the Guangdong Microbial Culture Collection Center on August 7, 2024. After being treated by the clostridium pralaense, the clostridium pralaense has a good curative effect on improving the progress of metabolism-related steatohepatitis diseases, and has a remarkable inhibition effect on NF-kB and MAPK signal pathways, participating in inflammatory reaction, of the liver; wherein the strain can also improve liver function and lipid metabolism, down-regulate contents of ALT, AST, TG, LDL and the like, inhibit expression of inflammation-related inflammatory cytokines and chemotactic factors, and significantly inhibit expression of liver fibrosis-related collagen and transforming growth factor-beta.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a preparation, a pharmaceutical composition and application thereof. The traditional Chinese medicine composition consists of bulbus fritillariae cirrhosae, kelp, thunberg fritillary bulb, turmeric, endothelium corneum gigeriae galli, raw hawthorn and selfheal. According to the application, the bulbus fritillariae cirrhosae and the bulbus fritillariae thunbergii are compatible to synergistically exert the effects of reducing phlegm and resolving The endothelium corneum gigeriae galli and the raw hawthorn have the effect of removing food retention, the selfheal has the effect of clearing liver and removing stasis, and all the medicines are combined to achieve the effects of reducing phlegm, removing blood stasis, softening hard mass and eliminating diseases. Experiments show that the traditional Chinese medicine composition can significantly improve the liver function of Wilson disease model mice, reduce collagen deposition of liver tissues, down-regulate fibrosis markers and inhibit activation of hepatic stellate cells.

The invention relates to the field of feed processing, and discloses a compound premix feed for aquatic products, which comprises the following raw materials in percentage by weight: 15% of sweet wormwood, 15% of Sanhuang, 5% of ginger powder, 15% of wormwood, 15% of honeysuckle, 15% of dandelion, 5% of ferrous sulfate and 15% of vitamin B6, the weight ratio of the rhizoma coptidis to the cortex phellodendri to the radix scutellariae is 1: 1: 1. Amur corktree bark has the effects of clearing away heat and toxic materials, eliminating dampness and stopping diarrhea and can improve water quality and reduce reproduction and pollution of harmful microorganisms, honeysuckle flowers have the effects of clearing away heat and toxic materials and resisting bacteria and can directly act on fishes and shrimps and can indirectly purify water quality and maintain cleanliness and stability of water, ferrous sulfate supplements iron elements needed by the fishes and shrimps, and the fish and shrimp feed additive is free of toxic and side effects. The fish and shrimps can effectively absorb nutrient substances in water, promote synthesis of hemoglobin, improve oxygen transport capacity, help the fish and shrimps to better absorb the nutrient substances in the water, and reduce dependence and pollution on the environment.

The invention discloses an application of dapam nitrile and a medicine. The invention relates to the field of medicines, in particular to application of dapam nitrile in preparation of medicines for treating and / or preventing metabolism-related fatty liver diseases and the medicines for treating and / or preventing the metabolism-related fatty liver diseases, and active ingredients of the medicines comprise dapam nitrile and further comprise pharmaceutically acceptable excipients, carriers and / or diluents. The dapam-susulonitrile can target NLRP3 inflammasomes, maintain the mitochondrial homeostasis in liver cells, reduce lipid deposition of the liver cells and the liver and improve glucose metabolism and lipid metabolism.

The invention discloses a pure traditional Chinese medicine for treating acute and chronic liver diseases and a preparation method thereof, and belongs to the technical field of liver disease treatment. The pure traditional Chinese medicine preparation comprises the following components in parts by weight: 1-10 parts of vinegar tortoise plastron, 1-5 parts of American ginseng, 1-6 parts of Sichuan yellow, 1-3 parts of donkey-hide gelatin, 1-4 parts of cordyceps sinensis, 1-5 parts of lucid ganoderma, 1-4 parts of prinsepia utilis royle, 1-3 parts of olean, 1-4 parts of cedar parasitism, 1-3 parts of parasitic loranthus, 1-5 parts of grifola, 1-4 parts of couch grass root, 0.5-3 parts of saffron crocus, 1-4 parts of angelica sinensis, 1-4 parts of polygonum cuspidatum, 1-5 parts of penthorum chinense pursh, 0.5-3 parts of calculus bovis factitius and 1-4 parts of radix paeoniae alba. The traditional Chinese medicine composition is prepared from 1-3 parts of oregano, 1-4 parts of fructus lycii, 1-3 parts of schisandra chinensis, 1-4 parts of fructus gardeniae, 1-4 parts of artemisia capillaris, 1-3 parts of dandelion, 1-3 parts of safflower, 1-4 parts of abrus herb, 1-3 parts of selfheal, 1-3 parts of verbena, 1-3 parts of fennel, 1-3 parts of tangerine seed and 1-4 parts of liquorice. According to the invention, through accurate component proportion, the optimal combination of the medicinal components is ensured, the curative effect and safety of the medicine are improved, the preparation process of the traditional Chinese medicine is simplified, and the extraction and purification degree of the medicinal components is improved.

The invention provides radish polysaccharide oral liquid with an auxiliary protection effect on chemical liver injury, and belongs to the technical field of prevention and treatment of chemical liver injury. The preparation method of the radish polysaccharide provided by the invention comprises the following steps: drying radishes, and crushing the dried radishes to obtain radish powder; mixing the radish powder with absolute ethyl alcohol, standing at 50 DEG C for 8 hours, and filtering with gauze to obtain filter residues; mixing the filter residues with water to obtain a mixture, mixing the mixture with cellulase, performing enzymolysis for 40-70 minutes at the temperature of 30-55 DEG C, taking filtrate, performing alcohol precipitation, collecting precipitates, adding water, performing redissolution, performing centrifugation, taking supernatant, and performing freeze drying to obtain the radish polysaccharide. According to the method for preparing the radish polysaccharide with the auxiliary protection effect on the chemical liver injury, provided by the invention, the high-content radish polysaccharide with the auxiliary protection effect on the alcoholic liver injury can be obtained from radishes. The radish polysaccharide oral liquid and the green radish polysaccharide oral liquid provided by the invention have a remarkable protection effect on acute liver injury caused by alcohol.

The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition and a preparation method and application thereof, in particular to a traditional Chinese medicine composition and a preparation method thereof and application in preparation of medicines for treating diabetes mellitus, especially diabetes mellitus complicated with metabolism-related fatty liver diseases. The traditional Chinese medicine composition is prepared from the following raw materials: 920 to 1200 parts of fructus crataegi, 240 to 400 parts of radix bupleuri, 580 to 700 parts of radix salviae miltiorrhizae, 240 to 400 parts of radix curcumae, 352 to 500 parts of semen cassiae, 240 to 400 parts of rhizoma pinellinae praeparata, 352 to 500 parts of rhizoma alismatis and 240 to 400 parts of pericarpium citri reticulatae. Furthermore, the mass ratio of hawthorn to radix bupleuri to salvia miltiorrhiza to radix curcumae to semen cassiae to rhizoma pinellinae praeparata to rhizoma alismatis to pericarpium citri reticulatae is (3-4): (1-2): (2-3): (1-2): (1-3): (1-2): (1-3): (1-2). The composition is prepared by the following steps: respectively removing impurities and dust from hawthorn, radix bupleuri, salvia miltiorrhiza, radix curcumae, semen cassiae, rhizoma pinellinae praeparata, rhizoma alismatis and pericarpium citri reticulatae, drying, respectively grinding, and mixing in proportion. The composition disclosed by the invention not only has an obvious effect of reducing blood sugar, but also has an effect of reducing blood fat, and is better for diabetes mellitus complicated with fatty liver.

The present application relates to the technical field of biological medicine, in particular to a kind of tricyclic sophoridine compound and its preparation method and application, pharmaceutical composition.The tricyclic sophoridine compound provided in the present application has good potential in preventing and / or treating diseases with lipid metabolic disorder syndrome such as fatty liver disease, diabetes, obesity, etc., and the tricyclic sophoridine compound has low toxicity and high safety.As shown in the test results of examples, the tricyclic sophoridine compound provided in the present application can significantly reduce the body weight of MASLD model mice induced by high-fat feed, improve liver function, glucose-lipid metabolic disorder, insulin resistance index and liver steatosis and other pathological abnormalities, and no toxic side effects are observed for 6 weeks of 100mg / kg dose gavage, and acute toxicity test also shows that it has very high safety.

The invention discloses application of a traditional Chinese medicine composition in preparation of traditional Chinese medicines for adjuvant therapy of AIDS. The traditional Chinese medicine composition is mainly prepared from the following medicinal materials: radix bupleuri, celosia cristata, salvia miltiorrhiza, fructus lycii, liquorice, artemisia capillaris, snake slough, schisandra chinensis, cordyceps sinensis and pig bile powder. The traditional Chinese medicine for adjuvant therapy of AIDS has the effects of resisting HIV, soothing liver-qi stagnation and tonifying spleen and qi, and can be used for clearing away heat and toxic materials, resisting inflammation and viruses and adjuvant therapy of AIDS. The traditional Chinese medicine composition has the pharmacological effects of resisting viruses, resisting inflammation and the like, can effectively inhibit reverse transcription of viruses, and has a good treatment effect on HIV (human immunodeficiency virus) and HBV (hepatitis B virus) infection. In addition, main components of the traditional Chinese medicine composition come from the nature, so that the traditional Chinese medicine composition has the advantages of being natural and safe, and has good safety in clinical application.

Provided is a composition for improving liver function, which uses a plant-derived resorcinol fat or oil, and which is useful, for example, for improving the symptoms of non-alcoholic hepatitis. A plant-derived resorcinol lipid is used as an active ingredient of the composition for improving liver function. It is preferable that the resorcinol lipid is alkyl resorcinol. In addition, preferably, the composition is derived from gramineous plants. Furthermore, preferably bran and / or whole grains derived from wheat and / or rye. The composition for improving liver function is particularly suitable for improving the symptoms of non-alcoholic hepatitis.

The invention relates to an application of a traditional Chinese medicine composition in preparation of a medicine for treating primary biliary cholangitis, which is characterized in that the traditional Chinese medicine composition is prepared from monkshood, dried ginger, liquorice, honeysuckle, spina gleditsiae, humulus scandens, pogostemon cablin and pericarpium citri reticulatae. The composition can obviously inhibit liver injury of a mouse primary biliary cholangitis model induced by operation and chemical induction, inhibits gene expression levels of inflammatory cytokines IL-33, chemotactic factors MCP-1 and CXCL1 in liver tissues, and has a good treatment effect on primary biliary cholangitis.

The invention provides application of PCSK9 in preparation of a medicine for treating metabolic steatohepatitis or related diseases thereof, and relates to the technical field of biology. According to the invention, the MASH model is constructed by utilizing methionine choline lacking feed, and the PCSK9 protein expression level in liver and serum is obviously increased; liver lipid accumulation of a PCSK9 gene knockout mouse is remarkably reduced, both liver inflammation and liver fibrosis are relieved, and the liver function is remarkably improved; and the silenced liver PCSK9 can be used for treating MASH, so that a theoretical basis is provided for preparing medicines for preventing and / or treating metabolic steatohepatitis or related diseases thereof, and a new medicine treatment target is provided.

The invention discloses application of rhizoma menispermi total alkaloids in preparation of a medicine for preventing and treating non-alcoholic fatty liver disease, and belongs to the technical field of biological medicine. Evaluation of the effect of the traditional Chinese medicine extract rhizoma menispermi total alkaloids on treatment of the non-alcoholic fatty liver disease shows that the extract can significantly reduce the body weight of high-fat and high-sugar diet obese mice, effectively improve the non-alcoholic fatty liver disease, effectively relieve liver fatty degeneration in vivo, reduce blood fat and improve liver functions, and can be used for treating the non-alcoholic fatty liver disease. The content of ALT, AST and TG in the blood of a mouse with obesity caused by high-fat and high-sugar diet is reduced, and the expression of inflammatory factors and hepatic fibrosis genes is inhibited at the same time. Therefore, the rhizoma menispermi total alkaloid can be used as a potential medicine for treating the non-alcoholic fatty liver disease.

The invention discloses pediococcus pentosaceus as well as a fermented product of the pediococcus pentosaceus and corn stigma and application of the pediococcus pentosaceus and the corn stigma to The invention discloses a pediococcus pentosaceus and corn stigma co-fermentation product. The pediococcus pentosaceus and corn stigma co-fermentation product is obtained by co-fermentation of pediococcus pentosaceus and corn stigma. Researches find that a fermentation product obtained by co-fermentation of the pediococcus pentosaceus and the corn stigma has the effects of reducing blood sugar, improving liver functions and relieving liver fatty degeneration, and the effect is better than that of fermentation liquor obtained by independent fermentation of the pediococcus pentosaceus and the corn stigma. In addition, a strain of pediococcus pentosaceus is obtained through separation and is named as BCST003. The pediococcus pentosaceus BCST003 is obtained by screening from corn stigma, and is safe and reliable. And experiments prove that compared with the existing pediococcus pentosaceus strain, the pediococcus pentosaceus BCST003 has the advantage that the effect of reducing blood sugar and blood fat of fermentation liquor obtained by co-fermenting the pediococcus pentosaceus BCST003 and the corn stigma is better. The invention provides a new thought and direction for further development and utilization of corn stigma and fermented products thereof, and has good application prospect and value.

The invention discloses a Chinese medicine composition, a pharmaceutical preparation and an application for treating fatty liver disease associated with childhood metabolism, and belongs to the technical field of traditional Chinese medicine. The Chinese medicine composition is made of the following raw materials in parts by weight: 9-30 parts of Pseudostellariae Radix, 6-24 parts of Salviae Miltiorrhizae, 6-24 parts of Poriae, 5-18 parts of Atractylodes macrocephala, 4-15 parts of Crataegus pinnatifida, 4-15 parts of Millettia reticulata, 4-15 parts of Caulis Sargentodoxae, 1-12 parts of Uncaria rhynchophylla, 4-15 parts of Semen persicae, 4-15 parts of Zedoariae Radix, 3-12 parts of Citrus reticulatae, and 2-10 parts of Radix Glycyrrhizae Preparata. The total clinical efficacy of the Chinese medicine composition in treating fatty liver disease associated with childhood metabolism is better than the existing simple lifestyle improvement combined with liver protection drug treatment, and has the advantages of good compliance, small dosage, and quick effect.

The present invention relates to a composite probiotic for improving the flavor of Chinese mitten crab meat and an application thereof. The composite probiotic for improving the flavor of Chinese mitten crab meat comprises Bacillus coagulans Bacillus coagulans BC66 strain, Lactobacillus plantarum Lactobacillus plantarum LP194 strain and Lactobacillus acidophilus Lactobacillus acidophilus LA71 strain. The present invention finds that the above three strains can cooperate with each other and promote each other, and play a synergistic effect in promoting the growth and development of Chinese mitten crab and improving the meat flavor of Chinese mitten crab. When the amount of bacteria used is the same, the three bacteria compound is compared with the combination of any two strains, and the effect of promoting the growth and development of Chinese mitten crab and improving the meat flavor of Chinese mitten crab is significantly improved.

The invention belongs to the technical field of medicines, and discloses an application of a combination of 1-Oleoyl-2-palmitoy-sn-glycino-3-phodopholine (OPPC) and gamma-Linolenic acid in preparation of a medicine for treating autoimmune liver diseases (ALD), and a preparation method of the combination of the 1-Oleoyl-2-palmitoy-sn-glycino-3-phodopholine (OPPC) and the gamma-Linolenic acid in the preparation of the medicine for treating the ALD and the application of the combination of the 1-Oleoyl-2-palmitoy-sn-glycino-3-phodopholine (OPPC). The medicine for treating the autoimmune liver diseases, disclosed by the invention, is prepared from OPPC and / or gamma-Linolenic acid, and a derivative of the OPPC and / or the gamma-Linolenic acid. The medicine disclosed by the invention is used for treating MRL / MpJ-Fastlpr (MRL / lpr) mice through administration, so that the plasma metabolism level and the liver function of the MRL / lpr mice can be improved, and a new direction is provided for clinical treatment of the autoimmune liver diseases.

Disclosed herein are compositions comprising a siRNA capable of down-regulating expression of a mitochondrial glycerol-3-phosphate acyltransferase (GPAM) gene or a variant thereof. Also disclosed herein are methods of treating liver diseases, such as fatty liver (FLD), non-alcoholic fatty liver disease (NAFLD), or non-alcoholic steatohepatitis (NASH), or liver injury using such compositions.

The invention provides a liver-clearing medicine formula and a preparation process thereof, and relates to the technical field of liver and gall disease treatment, liver-clearing soup is prepared from dandelion, patrinia, fructus forsythiae, polygonum cuspidatum and oriental wormwood, the proportion of the medicines can be increased and decreased along with symptoms, and during the taking period of the liver-clearing soup, eating of greasy fried food is forbidden, so that the liver-clearing soup is free of toxic and side effects. The taking method of the liver-clearing decoction adopts a low-temperature frequent taking mode. The preparation process of the liver-clearing medicine formula comprises the following steps: A, selecting raw materials; b, weighing the raw materials; c, decocting the raw materials with water; d, taking at low temperature. The traditional Chinese medicine composition has the advantages of being capable of rapidly benefiting gallbladder, relieving jaundice, improving liver functions and reducing the number of hepatitis B viruses, superior to other traditional Chinese medicine prescriptions, simple in using method, convenient to collect, low in price and remarkable in curative effect.

Disclosed herein are compositions comprising a siRNA capable of down-regulating expression of a cell death-inducing DFF45-like effector protein B (CIDEB) or a variant gene thereof. Also disclosed herein are methods of treating a liver disease or injury, such as fatty liver (FLD), non-alcoholic fatty liver disease (NAFLD), or non-alcoholic steatohepatitis (NASH), using such compositions.