697results about How to "Improve liver function" patented technology

The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

A device for performing a biological modification of a fluid, the device includes (a) a chamber having an inlet for intake of the fluid and an outlet for outflow of the fluid; and (b) a collection of micro-organ cultures of at least one organ for performing the biological modification of the fluid, each individual micro-organ culture of the collection including cells and having dimensions, such that cells positioned deepest within the individual micro-organ culture are at least about 100 micrometers and not more than about 225 micrometers away from a nearest surface of the individual micro-organ culture, thereby in vivo organ architecture (organ structure) of organ units (e.g., acinus of liver) is maintained within each individual micro-organ culture, the collection of micro-organ cultures being located within the chamber and the collection of micro-organ cultures being in contact with at least a portion of the fluid flowing through the chamber.

Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.

The embodiments provide compounds of the general Formulae (I) through general Formula (VIII), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

The present invention is directed to a composition for use in liver function improvement, blood alcohol level reduction and in-vivo antioxidant activity enhancement, comprising Lactobacillus brevis HY7401, Lactobacillus fermentum CS332, Lactobacillus acidophilus CSG, Bifidobacterium longum HY8001, an Alder tree extract, a Selfheal extract, a milk thistle extract, a green bean-rice bran fermentation extract, a turnip extract, a tomato extract, a broccoli extract, a pineapple extract, a colostrum powder, betaine, vitamin B1, B2, B3, B6, B9, B12, C, and E. The composition can improve declined liver functions and shows excellent hepatoprotective and hepatocurative activity against alcohol on excessive or habitual drinking with the ability to reduce blood alcohol levels. Its superior enhancement of in-vivo antioxidant activity also contributes to the use of the composition in the prevention of liver diseases and the improvement of liver functions. Also disclosed are fermented dairy foods, beverages, and health foods, containing the composition as an effective component.

A device for performing a biological modification of a fluid, the device includes (a) a chamber having an inlet for intake of the fluid and an outlet for outflow of the fluid; and (b) a collection of micro-organ cultures of at least one organ for performing the biological modification of the fluid, each individual micro-organ culture of the collection including cells and having dimensions, such that cells positioned deepest within the individual micro-organ culture are at least about 100 micrometers and not more than about 225 micrometers away from a nearest surface of the individual micro-organ culture, thereby in vivo organ architecture (organ structure) of organ units (e.g., acinus of liver) is maintained within each individual micro-organ culture, the collection of micro-organ cultures being located within the chamber and the collection of micro-organ cultures being in contact with at least a portion of the fluid flowing through the chamber.

The present invention is related to powder or extracts of plant leaves with anti-obesity effects and anti-obesity food comprising them and more particularly, anti-obesity food compositions comprising powder or extracts of one or more selected from group consisting of persimmon leaves, buckwheat leaves, Chinese matrimony vine leaves, endive leaves, and a ginseng. The present invention is related to compositions comprising plant extracts or powder to reduce the weight of animals or human, and more particularly, boiling water extracts of persimmon leaves, buckwheat leaves and Chinese matrimony vine leaves and powder of persimmon leaves, buckwheat leaves and Chinese matrimony vine leaves were prepared and administered to animals or human to confirm effects of reduction of their weight and then health foods comprising the extracts or powder are produced wherein the healthy foods have very excellent effects on the reduction of weight of animals or human without side effects, thereby they have prominent effects on healthy food industry.

The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

A Chinese medicine for preventing and treating cholecystitis, cholelithiasis and the inflammation of biliary tract, and improving the function of gallbladder and liver is prepared from 23 Chinese-medicinal materials including tackahoe, capejasmine fruit, white peony root, cyprus tuber, etc.

Health function-improving agents, such as an immunological function-improving agent, an antioxidation function-improving agent, a exercise function-improving agent and a liver function-improving agent, comprising, as an effective ingredient, a δ-amino acid, a derivative thereof or a salt thereof

The invention relates to a preparation method of a xylitol liver-protecting tablet, belonging to the technical field of medical health care. The formula of the xylitol liver-protecting tablet comprises the following raw materials in proportion: 15-45 parts of kudzu root extract, 2-20 parts of glycyrrhizic acid, 5-35 parts of propolis powder, 20-60 parts of xylitol, 1-10 parts of low-substituted hydroxypropyl cellulose, 1-10 parts of cross-linked sodium carboxymethyl cellulose and 0.5-5 parts of magnesium stearate; and a coating agent comprises 0.5-40 parts of hydroxypropyl methylcellulose, 1-30 parts of polyethylene glycol 6000, 0.5-40 parts of talcum powder, 0.5-30 parts of titanium pigment, 0.5-30 parts of iron oxide brown and 10-75 parts of maltitol. The finished product of the xylitol liver-protecting tablet is prepared by the processing steps of crushing, mixing, tabletting, coating and the like. In the invention, by using the xylitol as a main raw material and adding partial auxiliary materials, the xylitol liver-protecting tablet which is a health food and has auxiliary protection effect on chemical liver injury is prepared. The xylitol liver-protecting tablet can effectively prevent and treat fatty liver; and after patients suffering from the fatty liver take the xylitol liver-protecting tablet, severe fatty liver can be relieved into moderate fatty liver, and moderate fatty liver can be relieved into mild fatty liver. Thus, the xylitol liver-protecting tablet has obvious benefit to improve liver functions of human bodies and has wide market prospects.

The invention discloses a natural yeast powder, which is prepared by the method comprising the following steps of: preparing a yeast solution soaking fruit, grains or plant flowers into honey, malt extract and purified water, and extracting the yeast solution of the fruit, grains or plant flowers containing saccharomyces cerevisiae strains and lactobacillus strains after placing; preparing yeast paste: kneading rye flour, the malt extract and the purified water into the yeast paste to be cultivated for four stages; cultivation of microzyme: combining the yeast solution with the yeast paste into wet cenobium for cultivation; enlarging cultivation of the microzyme: mixing the wet cenobium with an enlarging cultivation medium according to a certain ratio to carry out enlarging cultivation of the microzyme multiplying 100-10000 times, and preparing a mixed yeast solution; and concocting yeast powder: mixing dry substances such as glucose, alpha dry rice meal, vitamin C, corn starch, and cane sugar into the mixed yeast solution to finally obtain the natural yeast powder. The natural yeast powder is completely prepared by natural products, does not contain a preservative, and has the advantages of ageing resistance, anti-mildew and long retention period.

The invention discloses a feed additive for improving the digestion utilization ratio of fat and a method for preparing the same. The feed additive comprises the following components in weight portion: 0 to 35 portions of bile acid, 0 to 15 portions of taurine and 20 to 80 portions of defatted rice bran. The invention has the advantages that: by practice, we finds that if proper amount of bile acid and taurine is added in the feed, the activity of pancreatic lipase is enhanced, the digestion utilization ratio of fat is greatly improved, the liver function is strengthened, the incidence rate of animal fatty liver and the death rate of animals are lowered, so that the addition level of fat in the feed can be reduced, and the aim of saving feed cost is achieved. In poultry breeding, the utilization ratio of fat is improved by 10 to 25 percent; in pig feeding, the utilization ratio of fat is improved by 10 to 25 percent; and in the fish, the utilization ratio of fat is improved by 10 to 25 percent, and the incidence rate of liver-gall syndrome of fish is greatly lowered.

The invention discloses a Chinese pharmaceutical composition for treating hepatitis and fatty liver, which comprises cornus officinalis, oriental wormwood, cape jasmine, baikal skullcap root, plantain seeds, clematis stem, polyporus umbellatus, poria cocos, rush pith, curcuma aromatica, licorice root, cyperus tuber, dandelion, white atractylodes rhizome, magnolia bark, Bupleurum root, chicken's gizzard-skin, green tangerine orange peel, banksia rose, malt, isatic root, haw, turtle shell, burred tuber, Loranthus mulberry mistletoe, talcum powder, bitter orange, zedoary, fleece-flower root, root of herbaceous peony, medicated leaven, Chinese angelica root, rhubarb horsetails.

The invention discloses pediococcus pentosaceus and application thereof. The Latin name of the pediococcus pentosaceus is Pediococcus pentosaceus LI05, and the pediococcus pentosaceus is preserved in the China General Microbiological Culture Collection Center and has a preservation number of CGMCC No.7049. The pediococcus pentosaceus disclosed by the invention has the morphological characteristics that the thallus is rod-shaped, dose not generate spores, does not have motility, and has masculine Gram staining. The whole-cell fatty acid of the pediococcus pentosaceus disclosed by the invention comprises the following main components in percentage by weight: about 1.45% of 14:0, about 3.26% of 16:1w7c / 16:1w6c, about 31.25% of 16:0, about 6.31% of 18:1w9c, about 38.59% of 18:1w7c, about 1.37% of 18:0 and about 14.59% of un18.846 / 19:1w6c. The invention also discloses a complete sequence of 16S ribosome DNA (16SrDNA) of the pediococcus pentosaceus. The pediococcus pentosaceus and a preparation thereof disclosed by the invention can be used for adjusting the micro-ecological balance of intestinal tracts of human or animals, promoting digestive absorption and slowing down the happening and development of liver failure of experimental animals.

The invention relates to the field of natural medicaments, in particular to a cassia bark polyphenol extract and a preparation method and application thereof. The preparation method is characterized by comprising the following steps of: removing fat soluble substances from cassia bark by using CO2 supercritical extraction, extracting extraction residues by water or a water mixed solvent to obtaina cassia bark polyphenol coarse extract of which the content of total phenol is about 6 percent, and purifying by using SP207 macroporous adsorbent resin to obtain the cassia bark polyphenol extract,wherein the content of total polyphenol is over 26 percent, the purity is high, and the quality is stable. In the cassia bark polyphenol extract, cassia bark polyphenol has the effects of reducing blood sugar, regulating blood fat and improving liver functions in the treatment and prevention of type 2 diabetes.

The invention relates to a preparation method of cinnamon extract, the cinnamon extract prepared thereby, a composition containing the extract and the use of the extract in pharmacy or preparation of health products. The preparation method comprises the following steps: a) uniformly mixing the cinnamon raw material with an aqueous solvent; b) extracting the mixture obtained in step a); c) separating the residue to obtain the cinnamon extract. The obtained cinnamon extract contains cinnamyl alcohol, cinnamic acid, cinnamaldehyde, eugenol, etc., and the appearance is a yellow clear liquid with a pH of about 4.6. The invention also provides a composition containing the extract. The cinnamon extract of the invention can be used to prepare medicines or health care products that have the dual effects of lowering blood sugar and blood fat and protecting liver function.

The invention discloses a production method and an application of high-yield gamma-aminobutyric acid. The conservation number of high-yield gamma-aminobutyric acid (GABA) raffinose enterococcus M1 is CGMCC (China General Microbiological Culture Collection Center) No.5584. The production method comprises the following steps of: separating and selecting strains to obtain an Entercoccusraffinosus TCCC11660 (CGMCCNo. 5584) strain of high-yield gamma-aminobutyric acid; optimizing a fermentation culture medium and fermentation conditions; and carrying out a 10L fermentation tank experiment. The production method has the advantages of cheap raw materials, low production energy consumption, low production cost, good product safety and the like, and industrial production is easy to realize. The strain is applied to production of gamma-aminobutyric acid through glutamic acid fermentation and has good social and economic benefits.

Disclosed is a functional food composition, which is effective in relieving alcohol-induced hangover symptoms and improving liver function. The composition includes 6-18% by dry weight of Polygonati Rhizoma, 10-40% by dry weight of Astragalus membranaceus Bge., 5-15% by dry weight of Artemisiae Scopariae Herba, 10-30% by dry weight of White Hoelen, 5-25% by dry weight of Atractylodes rhizome white, 4-12% by dry weight of Rehmanniae Radix, 2-10% by dry weight of Mentha arvensis, 2-10% by dry weight of Curcuma longa, and 2-10% by dry weight of Puerariae Radix, based on the total dry weight of the composition. The composition, including herbal components known to have no side effects, is effective in relieving hangover symptoms and improving liver function by removing or neutralizing factors responsible for hangover symptoms, such as alcohol absorbed in the body or acetaldehyde, the oxidation product of alcohol.

The invention discloses an okra juice drink and a preparation method therefor. The drink comprises the following ingredients, by weight, 45 parts of okra original juice, 4 parts of white granulated sugar, 0.5 part of xylitol, 0.01 part of sucralose, 0.1 part of citric acid, 0.01 part of tartaric acid, 0.03 part of sodium citrate, 0.01 part of glycine, 0.03 part of taurine, 0.03 part of vitamin C, 50.28 parts of purified water for drinking and 0.08-0.1 part of essence. The drink has good taste, and is beneficial for absorption of nutrition and health care components in human body. The bioavailability of active ingredients is raised, and the drink is suitable for popularization and application.

The invention discloses a preparation method of a folium mori green tea bag and relates to a simple preparation method of folium mori pan-fired green tea, solving the problems of short plucking cycle and long operation time of a tea preparation process of tender leaves used for preparing the traditional folium mori tea. The method comprises the following steps of: (1) wilting; (2) removing water; (3) kneading; and (4) frying to dry to obtain the folium mori green tea bag. The preparation method of the folium mori green tea bag can utilize folium mori for a long time, the folium mori green tea can be prepared from June to August, and the plucking cycle of the folium mori is longer. Moreover, the whole tea preparation process only needs 23-45min, thus the tea preparation time is shorter so as to sufficiently utilize nutrition constituents in the folium mori, and the drinking is convenient. The tea soup color of the folium mori green tea is clear and bright and is light green or yellow green, and the tea soup has peculiar faint scent, refreshment, aftertaste and good mouthfeel.

The present invention discloses one kind of sour ewe milk and its production process, and belongs to the field of sour milk producing technology. Fresh ewe milk or remade ewe milk as the material is produced into curd type sour ewe milk, stirred sour ewe milk or flavored sour ewe milk through purifying, standardizing, compounding, thickening, sterilizing, fermenting, cooling and other steps. These sour ewe milk products are healthful, and the production process is simple and suitable for industrial application.

The present invention relates to a promoter region of a microRNA, the use of a microRNA, in particular miR-21, and related elements for the diagnosis and for the manufacture of a medicament for the treatment and / or prevention of fibrosis and / or fibrosis related diseases. Additionally, the invention concerns antisense oligonucleotides against targets of miR-21. A cell deficient for miR-21, the promoter region and targets of miR-21 and a knock-out organism thereof are also encompassed. Finally, the invention is directed to a method for diagnosing fibrosis and / or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and / or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and / or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and / or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and / or prevention of fibrosis.

The invention provides, in part, methods for treating liver disease in a subject in need thereof. The invention further provides methods for improving liver function in a subject in need thereof, such as a subject with an ischemic liver or a cirrhotic liver. In some aspects, the methods of treatment comprise the administration of AC133+ alone or in combination with other cell populations.

The invention discloses a sweet potato-based functional cake and a preparation method thereof. Most of sweet potatoes are utilized for extracting a sweet potato protein fluid and preparing a dietary fiber in the preparation process, so that the content of sweet potato protein and the dietary fiber in the obtained cake is increased; the cake prepared by the method has the efficacies of preventing and treating constipation, is rich in sweet potato protein and dietary fiber, can play a role in preventing bowel cancer and hyperlipidemia without being greatly taken, and does not cause discomfort symptoms such as abdominal distension and heartburn; meanwhile, liver function damage can be effectively prevented; the abdominal pain symptoms caused by constipation are relieved; and the sweet potato-based functional cake is abundant and balanced in nutrient, easy to digest and absorb, free of a toxic or side effect, and suitable for being taken for a long period of time.

The invention provides a preparation method for pickling radishes containing natural pigment and fruit fragrance. Working procedures of desalting pickled radishes after cleaning and cutting off the pickled radishes, dipping the desalted radishes into seasoning liquid with the addition of the natural pigment and the fruit fragrance to cure the radishes, and the like ensure that the radishes prepared by the method are different from ordinary radishes with the addition of artificial edible pigment. The natural pigment is added to the radishes, which can not only increase the confidence of consumers in food security, but also give the nutrient function of the natural pigment and various colors to the radishes. The addition of various and blending tastes and the fragrance ensures that all people regardless of age and sex can like the radishes.