15results about How to "Improve liver function" patented technology

The invention discloses a lactobacillus johnsonii and related products and applications thereof, and relates to the field of microorganisms. The Lactobacillus johnsonii GJ231 provided by the invention has a preservation number of CCTCC NO: M 2023981. Compared with other lactobacillus johnsonii, GJ231 is acid-resistant and bile-resistant, has a higher survival rate in the intestine, has a better antibacterial effect on a variety of pathogens, and can be used to prevent and treat related diseases caused by pathogens; secondly, GJ231 has a better high temperature tolerance and has a higher survival rate in the process of spraying and preparing pet food; furthermore, GJ231 also has a strong antioxidant capacity, can reduce the peroxidation reaction caused by oxidative stress, and can be used for anti-aging and anti-oxidation; in addition, GJ231 also has a bacteriocin gene cluster, which may be used to produce bacteriocin, and has the potential to replace antibiotics and food preservation.

The application discloses application of tamibarotene in preparation of a medicine for preventing and / or treating liver fibrosis, and belongs to the technical field of biological medicine. The application finds that tamibarotene has a significant anti-liver fibrosis effect for the first time. Experimental results show that in two kinds of liver fibrosis animal models induced by CCl4 and TAA, tamibarotene can significantly down-regulate the expression of alpha-SMA and type I collagen, reduce the liver inflammatory response, and improve liver function. In particular, the anti-fibrosis effect of tamibarotene is significantly better than that of RARbeta selective agonist KCL-286 and RARalpha selective agonist Am580, and an unexpected technical effect is achieved. The application provides a new medicine selection for the treatment of liver fibrosis, and has a good clinical application prospect and development value.

The present invention relates to a composition containing Antrodia cinnamomea powder and a preparation method and application thereof, belonging to the technical field of medicines, the composition comprises Antrodia cinnamomea extract, Hovenia dulcis extract, Pueraria root extract, Psoralea corylifolia extract, Cyperus rotundus extract and cotton sugar; Antrodia cinnamomea extract contains triterpenoid compounds; Pueraria root extract is an extract below 10kDa obtained by graded enzymolysis of Pueraria root with hemicellulase and trypsin; Psoralea corylifolia extract is an extract below 5kDa obtained by enzymolysis of Psoralea corylifolia protein with alkaline protease; Cyperus rotundus extract is an extract below 5kDa obtained by enzymolysis of Cyperus rotundus with subtilisin and trypsin. Pueraria root extract, Psoralea corylifolia extract and Cyperus rotundus extract all have the effect of promoting hangover, and have a significant synergistic effect when used in combination with Antrodia cinnamomea extract, can promote cell and enzyme activity, promote the decomposition of alcohol in the body, quickly improve the drunken state, and do not cause vomiting.

The invention relates to the technical field of medicines, and discloses application of lactobacillus plantarum GUANKE in prevention and treatment of liver injury. According to the invention, a liver injury mouse model is established through a ZEN infected mouse, and lactobacillus plantarum GUANKE powder is fed into the stomach of the liver injury mouse, so that compared with a model group, the serum, liver function, antioxidant enzyme activity and liver related inflammation indexes of the mouse fed with the lactobacillus plantarum GUANKE are correspondingly improved; and the effect of high-dose treatment of the lactobacillus plantarum GUANKE is more remarkable than that of low-dose treatment of the lactobacillus plantarum GUANKE. Moreover, the tissue pathological section of the liver shows that compared with the inflammation, necrosis and lipid degeneration of the mouse tissue of the model group, the inflammation, necrosis and lipid degeneration of the mouse tissue are relieved after the treatment of the lactobacillus plantarum GUANKE. In conclusion, the lactobacillus plantarum GUANKE has the beneficial effect of treating the liver injury.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a preparation, a pharmaceutical composition and application thereof. The traditional Chinese medicine composition consists of bulbus fritillariae cirrhosae, kelp, thunberg fritillary bulb, turmeric, endothelium corneum gigeriae galli, raw hawthorn and selfheal. According to the application, the bulbus fritillariae cirrhosae and the bulbus fritillariae thunbergii are compatible to synergistically exert the effects of reducing phlegm and resolving The endothelium corneum gigeriae galli and the raw hawthorn have the effect of removing food retention, the selfheal has the effect of clearing liver and removing stasis, and all the medicines are combined to achieve the effects of reducing phlegm, removing blood stasis, softening hard mass and eliminating diseases. Experiments show that the traditional Chinese medicine composition can significantly improve the liver function of Wilson disease model mice, reduce collagen deposition of liver tissues, down-regulate fibrosis markers and inhibit activation of hepatic stellate cells.

The invention discloses an application of dapam nitrile and a medicine. The invention relates to the field of medicines, in particular to application of dapam nitrile in preparation of medicines for treating and / or preventing metabolism-related fatty liver diseases and the medicines for treating and / or preventing the metabolism-related fatty liver diseases, and active ingredients of the medicines comprise dapam nitrile and further comprise pharmaceutically acceptable excipients, carriers and / or diluents. The dapam-susulonitrile can target NLRP3 inflammasomes, maintain the mitochondrial homeostasis in liver cells, reduce lipid deposition of the liver cells and the liver and improve glucose metabolism and lipid metabolism.

The invention discloses a pure traditional Chinese medicine for treating acute and chronic liver diseases and a preparation method thereof, and belongs to the technical field of liver disease treatment. The pure traditional Chinese medicine preparation comprises the following components in parts by weight: 1-10 parts of vinegar tortoise plastron, 1-5 parts of American ginseng, 1-6 parts of Sichuan yellow, 1-3 parts of donkey-hide gelatin, 1-4 parts of cordyceps sinensis, 1-5 parts of lucid ganoderma, 1-4 parts of prinsepia utilis royle, 1-3 parts of olean, 1-4 parts of cedar parasitism, 1-3 parts of parasitic loranthus, 1-5 parts of grifola, 1-4 parts of couch grass root, 0.5-3 parts of saffron crocus, 1-4 parts of angelica sinensis, 1-4 parts of polygonum cuspidatum, 1-5 parts of penthorum chinense pursh, 0.5-3 parts of calculus bovis factitius and 1-4 parts of radix paeoniae alba. The traditional Chinese medicine composition is prepared from 1-3 parts of oregano, 1-4 parts of fructus lycii, 1-3 parts of schisandra chinensis, 1-4 parts of fructus gardeniae, 1-4 parts of artemisia capillaris, 1-3 parts of dandelion, 1-3 parts of safflower, 1-4 parts of abrus herb, 1-3 parts of selfheal, 1-3 parts of verbena, 1-3 parts of fennel, 1-3 parts of tangerine seed and 1-4 parts of liquorice. According to the invention, through accurate component proportion, the optimal combination of the medicinal components is ensured, the curative effect and safety of the medicine are improved, the preparation process of the traditional Chinese medicine is simplified, and the extraction and purification degree of the medicinal components is improved.

The invention provides radish polysaccharide oral liquid with an auxiliary protection effect on chemical liver injury, and belongs to the technical field of prevention and treatment of chemical liver injury. The preparation method of the radish polysaccharide provided by the invention comprises the following steps: drying radishes, and crushing the dried radishes to obtain radish powder; mixing the radish powder with absolute ethyl alcohol, standing at 50 DEG C for 8 hours, and filtering with gauze to obtain filter residues; mixing the filter residues with water to obtain a mixture, mixing the mixture with cellulase, performing enzymolysis for 40-70 minutes at the temperature of 30-55 DEG C, taking filtrate, performing alcohol precipitation, collecting precipitates, adding water, performing redissolution, performing centrifugation, taking supernatant, and performing freeze drying to obtain the radish polysaccharide. According to the method for preparing the radish polysaccharide with the auxiliary protection effect on the chemical liver injury, provided by the invention, the high-content radish polysaccharide with the auxiliary protection effect on the alcoholic liver injury can be obtained from radishes. The radish polysaccharide oral liquid and the green radish polysaccharide oral liquid provided by the invention have a remarkable protection effect on acute liver injury caused by alcohol.

The present application relates to the technical field of biological medicine, in particular to a kind of tricyclic sophoridine compound and its preparation method and application, pharmaceutical composition.The tricyclic sophoridine compound provided in the present application has good potential in preventing and / or treating diseases with lipid metabolic disorder syndrome such as fatty liver disease, diabetes, obesity, etc., and the tricyclic sophoridine compound has low toxicity and high safety.As shown in the test results of examples, the tricyclic sophoridine compound provided in the present application can significantly reduce the body weight of MASLD model mice induced by high-fat feed, improve liver function, glucose-lipid metabolic disorder, insulin resistance index and liver steatosis and other pathological abnormalities, and no toxic side effects are observed for 6 weeks of 100mg / kg dose gavage, and acute toxicity test also shows that it has very high safety.

The invention discloses application of a traditional Chinese medicine composition in preparation of traditional Chinese medicines for adjuvant therapy of AIDS. The traditional Chinese medicine composition is mainly prepared from the following medicinal materials: radix bupleuri, celosia cristata, salvia miltiorrhiza, fructus lycii, liquorice, artemisia capillaris, snake slough, schisandra chinensis, cordyceps sinensis and pig bile powder. The traditional Chinese medicine for adjuvant therapy of AIDS has the effects of resisting HIV, soothing liver-qi stagnation and tonifying spleen and qi, and can be used for clearing away heat and toxic materials, resisting inflammation and viruses and adjuvant therapy of AIDS. The traditional Chinese medicine composition has the pharmacological effects of resisting viruses, resisting inflammation and the like, can effectively inhibit reverse transcription of viruses, and has a good treatment effect on HIV (human immunodeficiency virus) and HBV (hepatitis B virus) infection. In addition, main components of the traditional Chinese medicine composition come from the nature, so that the traditional Chinese medicine composition has the advantages of being natural and safe, and has good safety in clinical application.

The invention discloses application of rhizoma menispermi total alkaloids in preparation of a medicine for preventing and treating non-alcoholic fatty liver disease, and belongs to the technical field of biological medicine. Evaluation of the effect of the traditional Chinese medicine extract rhizoma menispermi total alkaloids on treatment of the non-alcoholic fatty liver disease shows that the extract can significantly reduce the body weight of high-fat and high-sugar diet obese mice, effectively improve the non-alcoholic fatty liver disease, effectively relieve liver fatty degeneration in vivo, reduce blood fat and improve liver functions, and can be used for treating the non-alcoholic fatty liver disease. The content of ALT, AST and TG in the blood of a mouse with obesity caused by high-fat and high-sugar diet is reduced, and the expression of inflammatory factors and hepatic fibrosis genes is inhibited at the same time. Therefore, the rhizoma menispermi total alkaloid can be used as a potential medicine for treating the non-alcoholic fatty liver disease.

The present invention relates to a composite probiotic for improving the flavor of Chinese mitten crab meat and an application thereof. The composite probiotic for improving the flavor of Chinese mitten crab meat comprises Bacillus coagulans Bacillus coagulans BC66 strain, Lactobacillus plantarum Lactobacillus plantarum LP194 strain and Lactobacillus acidophilus Lactobacillus acidophilus LA71 strain. The present invention finds that the above three strains can cooperate with each other and promote each other, and play a synergistic effect in promoting the growth and development of Chinese mitten crab and improving the meat flavor of Chinese mitten crab. When the amount of bacteria used is the same, the three bacteria compound is compared with the combination of any two strains, and the effect of promoting the growth and development of Chinese mitten crab and improving the meat flavor of Chinese mitten crab is significantly improved.

The invention belongs to the technical field of medicines, and discloses an application of a combination of 1-Oleoyl-2-palmitoy-sn-glycino-3-phodopholine (OPPC) and gamma-Linolenic acid in preparation of a medicine for treating autoimmune liver diseases (ALD), and a preparation method of the combination of the 1-Oleoyl-2-palmitoy-sn-glycino-3-phodopholine (OPPC) and the gamma-Linolenic acid in the preparation of the medicine for treating the ALD and the application of the combination of the 1-Oleoyl-2-palmitoy-sn-glycino-3-phodopholine (OPPC). The medicine for treating the autoimmune liver diseases, disclosed by the invention, is prepared from OPPC and / or gamma-Linolenic acid, and a derivative of the OPPC and / or the gamma-Linolenic acid. The medicine disclosed by the invention is used for treating MRL / MpJ-Fastlpr (MRL / lpr) mice through administration, so that the plasma metabolism level and the liver function of the MRL / lpr mice can be improved, and a new direction is provided for clinical treatment of the autoimmune liver diseases.

The invention provides a liver-clearing medicine formula and a preparation process thereof, and relates to the technical field of liver and gall disease treatment, liver-clearing soup is prepared from dandelion, patrinia, fructus forsythiae, polygonum cuspidatum and oriental wormwood, the proportion of the medicines can be increased and decreased along with symptoms, and during the taking period of the liver-clearing soup, eating of greasy fried food is forbidden, so that the liver-clearing soup is free of toxic and side effects. The taking method of the liver-clearing decoction adopts a low-temperature frequent taking mode. The preparation process of the liver-clearing medicine formula comprises the following steps: A, selecting raw materials; b, weighing the raw materials; c, decocting the raw materials with water; d, taking at low temperature. The traditional Chinese medicine composition has the advantages of being capable of rapidly benefiting gallbladder, relieving jaundice, improving liver functions and reducing the number of hepatitis B viruses, superior to other traditional Chinese medicine prescriptions, simple in using method, convenient to collect, low in price and remarkable in curative effect.

The invention discloses a liver-protecting postbiotic composition and application thereof, and belongs to the technical field of probiotics, and the liver-protecting postbiotic composition is an inactivated liver-protecting probiotic composition and a metabolite thereof; the liver-protecting probiotic composition is prepared from the following strains in parts by weight: 1 to 15 parts of animal bifidobacterium subsp. Lactis F1-7, 1 to 10 parts of animal bifidobacterium subsp. Lactis KV9, 5 to 25 parts of lactobacillus paracasei J5 and 10 to 40 parts of lactobacillus casei YRL577. According to the present invention, the matching of the bifidobacterium animalis subsp. Lactis F1-7, the bifidobacterium animalis subsp. Lactis KV9, the lactobacillus paracasei J5 and the lactobacillus casei YRL577 can regulate the liver metabolism, significantly reduce the fat accumulation in the liver, improve the antioxidant ability of the liver and protect the liver from being damaged, and the liver protection product has good liver function strengthening effect, and can be used for preparing the liver protection product. Especially, the traditional Chinese medicine composition has a relatively good treatment effect on non-alcoholic fatty liver.