A kind of cinnamon polyphenol extract, its preparation method and use

A technology of extract and cinnamon, which is applied in the field of cinnamon polyphenol extract and its preparation, can solve the problem of lack of clear properties, stability, measurement indicators and quality control methods of the extract, and lack of clear properties of the hypoglycemic active components in cinnamon. Its quality control method, did not mention the chemical composition of MHCP, the specific source and preparation method, etc., to achieve the effect of increasing insulin sensitivity, easy storage, and regulating blood lipids

Inactive Publication Date: 2011-12-14
CHINA PHARM UNIV +1
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Problems solved by technology

[0010] According to modern pharmacological tests, Karalee J et al. found that a methyl hydroxychalcone polymer (MHCP) contained in cinnamon has an insulin-like effect in 3T3-L1 adipocytes (Karalee J. Jarvill-Taylor, et al .A Hydroxychalcone Derived from Cinnamon Functions as a Mimetic for Insulin in 3T3-L1 adipocytes[J]Journal of the American College of Nutrition 2001, 20(4):327-336), Justin A et al found that cinnamon cannot improve type 1 adipocytes Blood glucose metabolism in diabetic patients (Justin A Altschuler, Samuel J. Casella, et al. The effect of Cinnamon on A1C among adolescents with type 1 diabetes[J] Diabetes Care April 2007, 30(4): 813-816); Feng, Wang Houwei, etc. believed that cinnamon polysaccharide had a significant hypoglycemic effect on alloxan-induced experimental diabetic mice (research on the hypoglycemic effect of cinnamon polysaccharide on alloxan-induced experimental diabetic mice[J]. Food and Drugs 2009 , 11(6):25-27); Li Zongxiao, Wen Puhong, Yuan Meijuan's cell experiments showed that the MHCP isolated from cinnamon has insulin-like effects and can effectively regulate various cell responses (chalcone in cinnamon Insulin-like action of [J]. Chinese Medical Journal 2004, 32(5): 72-75), but this document did not mention the chemical composition, specific source and preparation method of MHCP
[0011] CN200610201217.4 discloses the use and product of cinnamon in treating diabetes and its preparation method. CN200610117512.1 discloses a preparation method of cinnamon extract, cinnamon extract, its composition and use. Both of these two patents The properties of the hypoglycemic active components in cinnamon and their quality control methods are not clear, and the preparation of the cinnamon extracts in the two patents is extracted with water or aqueous solvents. The extracts contain a large amount of volatile oil components, mainly cinnamaldehyde, Modern studies have shown that such substances not only have no hypoglycemic activity, but also affect the stability of blood pressure
CN200610023280.3 discloses a method for extracting α-glucosidase inhibitors from Chinese medicine cinnamon. The patent believes that the extract has a strong inhibitory effect on α-glucosidase, but the patent does not clarify the nature of the extract, STABILITY, MEASUREMENTS AND QUALITY CONTROL METHODS

Method used

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  • A kind of cinnamon polyphenol extract, its preparation method and use
  • A kind of cinnamon polyphenol extract, its preparation method and use
  • A kind of cinnamon polyphenol extract, its preparation method and use

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Embodiment 1

[0130] Preparation of cinnamon polyphenol extract

[0131] Cinnamon CO 2 supercritical extraction

[0132] In this embodiment, CO produced by German Wood Company was used. 2 Supercritical extraction unit, extraction tank 1500L×3, 450kg of 40-mesh Guangxi cinnamon (Cinnam om um cassia Presl) was added to each extraction tank, the pressure was controlled at 33-34MPa, the temperature was 51°C, the flow rate was 5T / h, after continuous extraction for 3 hours Out of the cauldron. Obtain cinnamon oil 140kg altogether. It contains about 60% of cinnamaldehyde, about 6% of coumarin, about 20% of oily substances, and 14% of other substances. Can be used as spices or food additives.

[0133] Preparation of Crude Extract of Cinnamon Polyphenols

[0134] The above CO 2 Add 120kg of cinnamon residue after supercritical extraction into a 1500L stainless steel reaction kettle, add 1200L of deionized water, heat up to 65°C, mechanically stir for 1.5 hours, centrifuge, transfer the filtra...

Embodiment 2

[0166] Cinnamon polyphenol extract preparation

[0167] Cinnamon CO 2 supercritical extraction

[0168] In this embodiment, CO produced by German Wood Company was used. 2 Supercritical extraction unit, extraction tank 1500L×3, add 450kg of 40-mesh Guangxi cinnamon (Cinnam om um cassia Presl) to each extraction tank, control pressure 31-32MPa, temperature 48°C, flow rate 6T / h, after continuous extraction for 3.5 hours Out of the cauldron. Obtain cinnamon oil 131kg altogether.

[0169] Preparation of Crude Extract of Cinnamon Polyphenols

[0170] The above CO 2 Add 120kg of cinnamon residue after supercritical extraction into a 1500L stainless steel reaction kettle, add 1200L of 50% ethanol-water solution, heat up to 60°C, stir mechanically for 2 hours, centrifuge, transfer the filtrate to a concentration kettle, and evaporate it at 65°C under normal pressure Ethanol, decompressed to 0.08-0.1MPa, concentrated at 60°C to d=1.05-1.1, and spray-dried to obtain a crude extract...

Embodiment 3

[0176] Preparation of Cinnamon Polyphenol Extract Tablets

[0177] prescription:

[0178] Magnesium stearate: 1g

[0179] Sodium carboxymethylcellulose: 9g

[0180] Microcrystalline cellulose: 26g

[0181] Starch: 9g

[0182] Cinnamon polyphenol extract (28% of total cinnamon polyphenols): 135g

[0183] According to the proportion of the prescription, the cinnamon flower polyphenols and auxiliary materials were evenly mixed, and the single-punch tablet machine, the No. 9 mold, was compressed under a pressure of 0.65MPa to obtain 600 tablets, 300mg / tablet. The stability and dissolution rate of cinnamon polyphenol tablets are qualified.

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Abstract

The invention relates to the field of natural medicaments, in particular to a cassia bark polyphenol extract and a preparation method and application thereof. The preparation method is characterized by comprising the following steps of: removing fat soluble substances from cassia bark by using CO2 supercritical extraction, extracting extraction residues by water or a water mixed solvent to obtaina cassia bark polyphenol coarse extract of which the content of total phenol is about 6 percent, and purifying by using SP207 macroporous adsorbent resin to obtain the cassia bark polyphenol extract,wherein the content of total polyphenol is over 26 percent, the purity is high, and the quality is stable. In the cassia bark polyphenol extract, cassia bark polyphenol has the effects of reducing blood sugar, regulating blood fat and improving liver functions in the treatment and prevention of type 2 diabetes.

Description

technical field [0001] The present invention relates to the field of natural medicines, in particular to a cinnamon polyphenol extract, its preparation method and its use. The cinnamon polyphenols of the present invention have the effects of lowering blood sugar, regulating blood lipids and improving liver function in the treatment and prevention of type 2 diabetes . Background technique [0002] Diabetes is a common metabolic endocrine disease. In 1999, the Diabetes Committee of the World Health Organization defined diabetes as follows: Diabetes is a chronic endocrine metabolic disease caused by the lack or relative lack of insulin in the human body. Metabolic disorders are the prominent manifestations, and the main feature is high blood sugar in the untreated state, accompanied by abnormal protein and fat metabolism. Diabetes is an ancient disease. It was recorded in my country more than 2,000 years ago. Diabetes has been recorded in detail in the "Huangdi Neijing". Discu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P3/10A61K129/00A61K36/54
Inventor 徐开俊郭守河李扬李诚
Owner CHINA PHARM UNIV
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