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Alloxan, sometimes referred to as alloxan hydrate, refers to the organic compound with the formula OC(N(H)CO)₂C(OH)₂. It is classified as a derivative of pyrimidine. The anhydrous derivative (OC(N(H)CO)₂CO is also known as well as a dimeric derivative. These are some of the earliest known organic compounds. They also exhibit a variety of biological activities.
Method for constructing a rabbit comorbidity model of diabetic nephropathy combined with acute kidney injury
The application discloses a kind of construction methods of diabetic nephropathy combined with acute kidney injury rabbit comorbidity model, it is related to biological medicine technical field, the construction method includes the following steps: rabbit is fed with high-fat high-sugar feed, then injection tetraoxypyrimidine, constructs type 2 diabetes rabbit model, continue to feed high-fat high-sugar feed, detect rabbit blood sugar, blood fat and urine albumin / creatinine ratio, carries out pathological examination of kidney tissue, determines whether the diabetic nephropathy rabbit model is established successfully, to the diabetic nephropathy rabbit model that is successfully constructed injection folic acid-sodium bicarbonate solution, detect blood urea and creatinine level, carry out pathological examination of kidney tissue, determine whether the diabetic nephropathy combined with acute kidney injury rabbit comorbidity model is successfully constructed.The application provides effective animal model for the pathogenesis and new treatment target of diabetic comorbidity, effectively solves the problem that single animal model cannot comprehensively reflect complex disease and the influence of drug side effects on experimental animals.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV