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Preparation method of xylitol liver-protecting tablet

A technology of xylitol and liver-protecting tablets, which is applied in the direction of medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of lack of liver protection and liver protection products, and achieve prevention and treatment. Treatment of fatty liver, broad market prospect, effect of improving liver function

Inactive Publication Date: 2010-06-23
FUTASTE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to utilize the hepatoprotective and liver-protecting functions of xylitol to provide a preparation method of xylitol liver-protecting tablets, so as to solve the problems in the field of medicine and health care. Problems with xylitol liver protection and liver protection products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1. Take 200g of kudzu root extract, 40g of glycyrrhizic acid, 100g of propolis powder, 36g of low-substituted hydroxypropyl cellulose, 30g of croscarmellose sodium, and 5g of magnesium stearate, mix them evenly, and pulverize them with a universal grinder , cross 80 mesh sieves to obtain mixed fine powder 380g;

[0017] 2. Take 260g of micronized xylitol, pour it into the multi-dimensional mixer together with the above mixed fine powder, and mix for 40 minutes to make it uniform;

[0018] 3. Put the mixed fine powder of 2 into a tablet press, control the tableting pressure to 0.3MPa, and compress the mixed fine powder to obtain 1000 tablets;

[0019] 4. Take 5g of hydroxypropyl methylcellulose, 5g of talc, and 15g of maltitol, mix well, add 10mL of pure water to dissolve, stir well to obtain a suspension coating solution, and use a high-efficiency non-porous coating machine to coat the tablet. Film-coated to obtain the finished product of Xylitol Liver-protecting Table...

Embodiment 2

[0021] 1. Take 260g of kudzu root extract, 30g of glycyrrhizic acid, 110g of propolis powder, 25g of low-substituted hydroxypropyl cellulose, 20g of croscarmellose sodium, and 8g of magnesium stearate, mix them evenly, and pulverize them with a universal grinder , cross 100 mesh sieves to obtain mixed fine powder 420g;

[0022] 2. Take 380g of micronized xylitol, pour it into the multi-dimensional mixer together with the above-mentioned mixed fine powder, and mix for 60 minutes to make it uniform;

[0023] 3. Put the mixed fine powder of 2 into a tablet press, control the tableting pressure to 0.4MPa, and compress the mixed fine powder to obtain 1400 tablets;

[0024] 4. Take 60008g of polyethylene glycol, 10g of titanium dioxide, 7g of iron oxide brown, and 12g of hydroxypropyl methylcellulose, mix well, add 30mL of pure water to dissolve, stir well, and obtain a suspension coating solution, use high-efficiency non-porous The tablet is film-coated by a coating machine to obt...

Embodiment 3

[0026] 1. Take 180g of kudzu root extract, 50g of glycyrrhizic acid, 90g of propolis powder, 50g of low-substituted hydroxypropyl cellulose, 40g of croscarmellose sodium, and 6g of magnesium stearate, mix well, and pulverize with a universal grinder , cross 60 mesh sieves to obtain mixed fine powder 400g;

[0027] 2. Take 400g of micronized xylitol, pour it into the multi-dimensional mixer together with the above-mentioned mixed fine powder, and mix for 20 minutes to make it uniform;

[0028] 3. Put the mixed fine powder of 2 into a tablet press, control the tableting pressure to 0.2MPa, and compress the mixed fine powder to obtain 1300 tablets;

[0029] 4. Take 10g of talc powder and 25g of maltitol, mix well, add 20mL of pure water to dissolve, stir well to obtain a suspension coating solution, and use a high-efficiency non-porous coating machine to film-coat the tablet to obtain xylitol The finished Hugan Tablets weigh 0.67g each.

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PUM

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Abstract

The invention relates to a preparation method of a xylitol liver-protecting tablet, belonging to the technical field of medical health care. The formula of the xylitol liver-protecting tablet comprises the following raw materials in proportion: 15-45 parts of kudzu root extract, 2-20 parts of glycyrrhizic acid, 5-35 parts of propolis powder, 20-60 parts of xylitol, 1-10 parts of low-substituted hydroxypropyl cellulose, 1-10 parts of cross-linked sodium carboxymethyl cellulose and 0.5-5 parts of magnesium stearate; and a coating agent comprises 0.5-40 parts of hydroxypropyl methylcellulose, 1-30 parts of polyethylene glycol 6000, 0.5-40 parts of talcum powder, 0.5-30 parts of titanium pigment, 0.5-30 parts of iron oxide brown and 10-75 parts of maltitol. The finished product of the xylitol liver-protecting tablet is prepared by the processing steps of crushing, mixing, tabletting, coating and the like. In the invention, by using the xylitol as a main raw material and adding partial auxiliary materials, the xylitol liver-protecting tablet which is a health food and has auxiliary protection effect on chemical liver injury is prepared. The xylitol liver-protecting tablet can effectively prevent and treat fatty liver; and after patients suffering from the fatty liver take the xylitol liver-protecting tablet, severe fatty liver can be relieved into moderate fatty liver, and moderate fatty liver can be relieved into mild fatty liver. Thus, the xylitol liver-protecting tablet has obvious benefit to improve liver functions of human bodies and has wide market prospects.

Description

technical field [0001] The invention belongs to the technical field of medicine and health care, and relates to a preparation method of xylitol liver-protecting tablets. Background technique [0002] Xylitol is a sweet substance with medicinal and physiological functions, which is quickly absorbed by the human body. It is not only a substitute for daily sugar for healthy people, but also a nutritional and therapeutic agent for diabetics. According to experiments, 80% of xylitol entering the body is metabolized by the liver. In addition to producing energy, part of it is stored in the liver as glycogen, so that the liver can be nourished, and the detoxification function of cells can be enhanced, thereby improving liver function. In the 1960s, the Ministry of Health and Welfare of Japan reported that taking xylitol for patients with liver disease can supplement calories, enhance detoxification and improve liver function. At present, the adjuvant medicine "xylitol infusion" an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61K47/38A61K9/36A61P1/16A61K31/047A61K35/64A61K35/644
Inventor 王成福杜瑞锋孙鲁赵光辉
Owner FUTASTE PHARM CO LTD
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