32 results about "Cinnamic acid" patented technology

This invention discloses a multi-effect sunscreen agent and its preparation method, relating to the field of cosmetic technology. This invention adds vetiver root extract, winged fruit oil, and rice bran oil extract to existing conventional chemical sunscreen ingredients, which not only reduces the amount of isoamyl methoxycinnamate, ethylhexyl triazine ketone, methylene bis-benzotriazolyl tetramethylbutylphenol, and bis-ethylhexyloxyphenol methoxyphenyl triazine used in existing chemical sunscreens, but also synergistically increases the sun protection effect. The active ingredients of this multi-effect sunscreen agent are plant-derived substances, making the ingredients safe and mild. Furthermore, the preparation method is simple, the ingredients are readily available, and it has broad market application prospects.

The application discloses a kind of phenylacrylamide derivatives and preparation method and purposes thereof, belong to organic synthesis chemistry and pesticide technical field.Phenylacrylamide derivatives are prepared by condensation reaction from cinnamic acid or its derivatives and benzimidazole derivatives.Biological activity test shows that the compounds exhibit different degrees of inhibitory activity on rice sheath blight pathogen, barley root rot pathogen, wheat scab pathogen and brassica rapa sclerotinia pathogen, and can be used for preparing fungicide for preventing and treating agricultural plant diseases.

This application relates to the field of PET plastics technology, and more particularly to a UV absorber and PET plastic. The UV absorber is prepared by the following method: under a protective gas atmosphere, alkyl α-cyano-4-hydroxy-3-alkoxycinnamic acid, an inorganic base, and an epoxy chain extender are dissolved in a polar aprotic solvent, and the mixture is stirred and reacted at 100°C~120°C for 2~8 hours. After the reaction, acidification, filtration, washing, and drying are performed sequentially. The solution provided in this application can effectively improve the dispersion stability of the UV absorber in the PET matrix, reduce the risk of migration and precipitation, and maintain the advantage of high material transparency.

This invention discloses a cinnamic acid-black phosphorus nanocomposite targeting Aβ, its preparation method, and its application. The composition uses 4-(dimethylamino)cinnamic acid as the Aβ-targeting group and consists of a drug-loaded host (BP, black phosphorus nanosheets), a modifying material C18-PEG-NH2 (amino polyethylene glycol stearic acid), a targeting material Tar (4-(dimethylamino)cinnamic acid), and a therapeutic material Cur (curcumin). The preparation method includes the following steps: (1) preparation of PEG-Tar, (2) preparation of PEG-Tar@Cur, and (3) preparation of the BP-PEG-Tar@Cur composition. This invention utilizes black phosphorus nanosheets to load Curcumin, whose excellent specific surface area significantly increases the drug loading capacity. Furthermore, by using 4-(dimethylamino)cinnamic acid as a group targeting Aβ, diffuse distribution of the drug in the brain is avoided, greatly improving the drug utilization rate of Curcumin. The synthesis process of this invention is simple, highly reproducible, and easy to scale up for industrial application, and it has a positive effect in the treatment of Alzheimer's disease.

The present invention relates to a method for obtaining an extract of the leaves of Rosmarinus officinalis (rosemary) involving two stages of maceration, filtration, concentration of the two drained products and drying, guaranteeing an extract comprising mainly hydroxycinnamic derivatives, rosmarinic acid, luteolin, neptin and carnosol, and the use of the extract in cosmetic compositions in the prevention and treatment of androgenetic alopecia, in which the extract of the invention acts through multiple mechanisms of action, and can be used in men and women.

The present disclosure relates to cinnamobactin and the use thereof in the treatment of bacterial infections. The cinnamobactin has the following chemical structural formula (I-1). The cinnamobactin uses cinnamoylhydroxamic acid as a parent nucleus, has a modification group at the para-position or the meta-position of a benzene ring, and can be used for treating bacterial infections.

This invention provides a method for separating and converting components from herbal biomass, comprising the following steps: placing herbal biomass and a high specific surface area catalyst in a first solvent, and carrying out a catalytic reaction under an inert gas atmosphere and a temperature of 140-220°C, yielding a cellulose solid product and a liquid product after the reaction; rotary evaporating, extracting, and recrystallizing the liquid product to obtain lignin and vinylphenol, wherein vinylphenol is a conversion product of hydroxycinnamic acid; wherein the preparation of the high specific surface area catalyst includes: mixing a soluble metal precursor salt solution with a precipitant solution for a co-precipitation reaction and aging to obtain a precursor precipitate; separating, washing, and drying the precursor precipitate to obtain a precursor powder; and calcining the precursor powder to obtain the high specific surface area catalyst. This method can separate lignin, cellulose, and hydroxycinnamic acid from herbal plants and convert hydroxycinnamic acid into a high-value product.

The present application relates to a method for preparing (Z / E)-2- β -D-glucopyranosyloxy-4-methoxycinnamic acid geometric isomers from chamomile medicinal materials. The method takes chamomile medicinal materials as raw materials, extracts by refluxing with ethanol, concentrates and dries to obtain extract powder; then dissolves in methanol, centrifuges and filters, separates the soluble part by supercritical fluid chromatography to obtain target fraction rich in (Z / E)-2- β -D-glucopyranosyloxy-4-methoxycinnamic acid geometric isomers, purifies by semi-preparative liquid chromatography to obtain (Z / E)-2- β -D-glucopyranosyloxy-4-methoxycinnamic acid geometric isomers. The method has clear separation route and good repeatability, can realize effective preparation and separation of GMCA geometric isomers, and can provide material basis for structure confirmation, quality evaluation, in-vivo process research and related activity research. The method solves the problems of difficult separation and difficult obtaining of high-purity single isomer sample of (Z / E)-2- β -D-glucopyranosyloxy-4-methoxycinnamic acid (GMCA) geometric isomers in the prior art.

This invention discloses a polymeric flame-retardant material and its preparation method, relating to the field of polymeric materials technology. In preparing the polymeric flame-retardant material, epichlorohydrin is used as a bridging agent to graft 2-(diphenylphosphino)ethylamine onto luteolin to obtain modified luteolin; polypropylene glycol, dimethylolpropionic acid, 1,4-butanediol, and isophorone diisocyanate are polymerized to obtain polyurethane; the polyurethane is reacted with methyl 4-aminocinnamate to obtain modified polyurethane; cerium dioxide is reacted sequentially with γ-glycidoxypropyltrimethoxysilane and 3-amino-1,2,4-triazole to obtain modified cerium dioxide; the modified polyurethane, modified luteolin, and modified cerium dioxide are mixed and kneaded to obtain the polymeric flame-retardant material. The polymeric flame-retardant material prepared by this invention exhibits superior flame retardancy and weather resistance.

A prenyltransferase capable of producing bakuchiol or its analogues from geranyl pyrophosphate (GPP) and cinnamic acid, coumaric acid, caffeic acid and / or ferulic acid is disclosed herein. Manipulated cells expressing a prenyltransferase capable of producing bakuchiol or its analogues, as well as methods of using the prenyltransferase and cells to produce bakuchiol or its analogues, are also disclosed herein.

The invention provides application of p-hydroxycinnamic acid in preparation of a medicine for preventing and treating noise-induced deafness. The invention has the advantages that the p-hydroxycinnamic acid has the advantages of strong pertinence, high safety, convenience in medication, good patient compliance and the like, not only effectively overcomes the defects of the existing noise-induced hearing loss treatment medicines, but also provides a brand-new preventive treatment thought; important clinical popularization significance and industrial application prospects are realized.

The present invention relates to the field of pharmaceutical technology, and particularly, to a pirfenidone co-crystal and a method for preparing same, a pharmaceutical composition, and use thereof. The pirfenidone co-crystal provided in the present invention is prepared from pirfenidone and a co-crystal ligand selected from one of pimelic acid, cinnamic acid, and saccharin. The pirfenidone co-crystal provided in the present invention can not only improve the effect of pirfenidone in relieving acute pancreatitis, but also improve the safety of pirfenidone.

The application discloses a heat-resistant hydroxycinnamic acid decarboxylase derived from abnormal Wickerham sp., and belongs to the technical field of enzyme engineering. The optimal reaction temperature of the hydroxycinnamic acid decarboxylase is 40 DEG C, and the activity is stable in the range of 40 DEG C to 70 DEG C. This provides certain theoretical basis and practical significance for industrialization of high-efficiency preparation of 4-vinyl derivatives and other high-grade perfume materials by using the hydroxycinnamic acid decarboxylase.

This invention discloses a chitosan-organic acid supramolecular ionic salt and its preparation method, belonging to the supramolecular field. The invention involves mixing chitosan with an organic acid (one or more of maleic acid, sorbic acid, ferulic acid, caffeic acid, cinnamic acid, and fumaric acid) and a solvent, followed by drying to obtain the chitosan-organic acid supramolecular ionic salt. The chitosan-organic acid supramolecular ionic salt prepared by this invention can improve the water solubility of chitosan and improve severely damaged hair, offering multiple functions such as repair and smoothing, making it suitable for hair care products. Furthermore, the preparation method is simple, requiring no catalyst or high temperature and pressure, making it suitable for industrial use.

This invention belongs to the field of pharmaceutical technology, specifically relating to a tetravalent platinum complex based on cinnamic acid, its preparation method, and its application. This invention is the first to introduce a cinnamic acid group into the structure of a tetravalent platinum complex, designing and synthesizing a series of novel platinum-based anticancer prodrugs, namely cinnamic acid-platinum (IV) complexes. Biological evaluation shows that these complexes exhibit stronger anticancer activity than classic divalent platinum drugs and good selectivity for cancer cells, demonstrating the potential of highly effective, low-toxicity, and drug-resistant novel anticancer drugs.

This invention discloses a halitosis-eliminating toothpaste containing galangal extract and its preparation process. The toothpaste comprises a galangal volatile oil-cyclodextrin inclusion complex and / or positively charged nanoparticles loaded with galangal flavonoids, as well as a pH adjuster, sodium bicarbonate. Ethyl p-methoxycinnamate and ethyl cinnamate in the galangal volatile oil undergo a Michael addition reaction with methanethiol under weakly alkaline conditions, rapidly neutralizing existing odor-causing sulfides. The positively charged nanoparticles are electrostatically adsorbed onto the tooth surface, slowly releasing flavonoids and providing long-lasting inhibition of odor-producing bacteria. The preparation process includes gel preparation, graded pre-dispersion, sequential addition and mixing, and vacuum degassing, further specifying the preparation methods of the inclusion complex and nanoparticles. This invention is free of metal ions and chemical bactericides, achieving immediate neutralization and long-lasting antibacterial synergy, and is characterized by safety, stability, naturalness, and high efficiency in eliminating halitosis.

The application discloses a method for improving the stability of a microorganism whole cell catalyzed forsythia nuclease cinnamyl reaction, and adopts an organic solvent-natural low eutectic solvent mixed system as a solvent, and the specific steps are as follows: S1: dissolving forsythia nuclease in the organic solvent-natural low eutectic solvent mixed system, adding ethylene cinnamate and a whole cell catalyst, uniformly mixing, heating and oscillating for reaction, and obtaining a reaction liquid; S2: separating and purifying the reaction liquid to obtain forsythia nuclease 6'-O-cinnamate, and simultaneously analyzing the substrate conversion rate of the forsythia nuclease acylation reaction in the reaction liquid to evaluate the reaction stability. The method adopts a THF-NADES mixed solvent system, is green and mild, significantly improves the stability and reusability of the whole cell catalyst, the conversion rate of the whole cell catalyst is still higher than 95% when the whole cell catalyst is used for the sixth time, the process stability is good, has a significant industrial application advantage, can greatly improve the application effect of the catalyst, and reduces the production cost of enterprises.

本发明公开了一种来源于乳酸乳球菌(Lactococcus lactis)的支链α‑酮酸脱羧酶及其突变体，以及采用支链α‑酮酸脱羧酶及其突变体作为催化剂在催化生成顺式肉桂酸类化合物中的应用。本发明的支链α‑酮酸脱羧酶具有高反应性、高立体选择性、广泛的底物范围、可以产出克级产物等优点，产率高达97%，顺反式肉桂酸比例大于20:1，有利于实现低成本生产，具有工业化应用前景。

The application belongs to the technical field of mass spectrometry, and particularly relates to application of 2-hydrazinylpyrazine as a reactive matrix in MALDI-TOF-MS analysis of carbohydrates and a method. 2-hydrazinylpyrazine is an organic small molecule with a hydrazine group, can specifically react with the aldehyde group at the reducing end of carbohydrates to generate a hydrazone derivative, significantly improve ionization efficiency and move the target molecule to the high mass region, and avoid matrix interference. The application also provides a matrix system comprising 2-hydrazinylpyrazine and alpha-cyano-4-hydroxycinnamic acid propyl ester and a layered spotting method, wherein the derivatization reaction solution is first spotted, and then alpha-cyano-4-hydroxycinnamic acid propyl ester solution is overlaid after drying, which significantly improves the uniformity of crystallization, eliminates the "sweet spot effect", and improves the detection reproducibility. The method of the application can directly analyze carbohydrates in complex biological samples without purification and enrichment, and can obtain rich fragment ions in tandem mass spectrometry analysis, and successfully distinguish isomers.

The present application relates to the technical field of medicine, in particular to an extraction and separation method and application of an anti-inflammatory active compound in Leucophyllum angustifolium. Seven compounds are separated and identified from Leucophyllum angustifolium by a specific extraction and separation method, the separated and identified compounds are classified in the first level, there are six benzyl alcohol compounds, which are phellodenol-A (1), chengzhong wintergreen (2), 2,4-dimethoxy cinnamic acid (4), alternaria alternata phenol (5), alternaria alternata phenol monomethyl ether (6) and alternaria alternata phenol-3,9-dimethyl ether (7); there is one alkaloid compound, which is new sea urchin spirit A (3). Among them, four compounds are separated from the plant of Leucophyllum for the first time, which are phellodenol-A (1), new sea urchin spirit A (3), 2,4-dimethoxy cinnamic acid (4) and alternaria alternata phenol-3,9-dimethyl ether (7).

Oil-in-water emulsion without cyclic volatile silicone oil and without Ethylhexyl Methoxycinnamate comprising a mixture of particular fatty acid esters, a non-cyclic silicone oil, a hydrophobic silica aerogel and a pigment. The present invention is a skincare and / or makeup composition for keratinous materials, in particular, skin, in the form of a water-in-oil emulsion comprising, in particular in a physiologically acceptable medium: a) at least one continuous oily phase comprising (i) a mixture of fatty acid ester and alcohol comprising DIPENTAERYTHRITYL PENTAISONONANOATE, ISONONYL ISONONANOATE and ISOCETYL STEAROYL STEARATE; and (ii) at least one non-cyclic silicone oil; and b) at least one aqueous phase dispersed in said oily phase; and c) at least some hydrophobic silica aerogel particles; and d) at least one silicone emulsifying surfactant with HLB ≤ 8.0;ete) at least one powdered coloring material of said composition not containing cyclic volatile silicone oil or Ethylhexyl Methoxycinnamate.;

The application discloses an anti-cracking and impact-resistant PVC-O cable protection pipe and a preparation method thereof, and belongs to the technical field of cable protection pipes, and aims to solve the technical problem that the impact resistance and the flame resistance of the PVC-O cable protection pipe in the prior art need to be further improved. The PVC-O cable protection pipe is formed by synergistically constructing phosphorus-silicon hybrid flame-retardant microfiller, epoxy imidazole core-shell copolymer microparticles and cinnamic acid modified photo-crosslinking PVC in a system, so that the PVC-O cable protection pipe forms a stable multi-scale oriented structure, a hierarchical interface and a hybrid flame-retardant network. The above structure units form a synergistic effect in terms of thermal decomposition regulation, interface stress transmission and orientation maintenance, so that the synchronous improvement of the flame resistance, the thermal stability, the impact toughness, the stiffness retention and the wear resistance is realized.

This invention provides a continuous process for producing phenylalanine using carbon dioxide as the main raw material, relating to the field of amino acid production. The process includes: Step 1: Adding styrene, a photocatalyst, a solvent, an electron donor, and an alkaline additive to a photoreactor; introducing CO2 into the photoreactor until the pressure reaches a set level; turning on the light source of the photoreactor; and conducting a photocatalytic reaction under stirring conditions. After the reaction, filtering to recover the catalyst, distilling to recover the solvent, and purifying cinnamic acid by crystallization or chromatography. Step 2: Adding the cinnamic acid obtained in Step 1 to a fermentation medium; inoculating the fermentation medium with genetically engineered bacterial strains and controlling the fermentation conditions; during fermentation, adding carbon source, nitrogen source, and cinnamic acid according to the carbon and nitrogen concentration of the fermentation broth and the growth of the bacterial cells; after fermentation, separating the bacterial cells and purifying L-phenylalanine. This two-stage integrated system of photocatalytic carboxylation and bio-fermentation achieves efficient conversion from inexpensive raw materials to high-value-added amino acids.

The application discloses an organic amine supramolecular ionic salt, a preparation method and application thereof in hair care, and belongs to the technical field of supramolecules. The organic amine supramolecular ionic salt is prepared by mixing organic amine (one of tetrahydroxypropyl ethylenediamine, triethylene glycol diamine and polyether amine) and organic acid (one or two of maleic acid, sorbic acid, ferulic acid, coffee acid, cinnamic acid and fumaric acid). The organic amine supramolecular ionic salt prepared by the application can repair disulfide bonds in hair from the structure, so that the hair is repaired and smooth.

The application provides a lipid-lowering sugar-free white tea probiotic fermentation liquor and a preparation method and application thereof, and belongs to the technical field of functional food processing. The method comprises the following steps: (1) white tea is crushed and sieved, then sterile distilled water is added, water extraction is performed in a boiling water bath, and finally cooling is performed; (2) probiotic powder is inoculated into the white tea culture medium obtained in step (1) for fermentation. The fermentation method provided by the application can effectively enrich flavonoids and polyphenolic compounds in the white tea water extract without adding glucose, and improve the content of various functional active ingredients such as hesperetin, quercetin, epigallocatechin and cinnamic acid. The sugar-free fermented white tea prepared by the application has a significantly improved flavonoid content compared with the sugar-containing white tea. The fermented white tea significantly reduces the oil and TC content of high-fat HepG2 cells, significantly improves the antioxidant activity, and reduces the expression amount of inflammatory factors. The application can provide ideas for further development of lipid-lowering functional foods mainly using white tea as a raw material, and has good application prospect.

This will diversify the options for adhesives whose adhesive strength can be altered by light irradiation. [Solution] The adhesive composition comprises a modified cinnamic acid monomer which is an esterified product of a reaction component containing cinnamic acid, hydroxyethyl methacrylate, and a catalyst, a propylene glycol methyl ether acrylate monomer, an initiator, and a solvent containing butyl acetate.

This invention belongs to the field of medicinal chemistry, specifically relating to a highly antioxidant cinnamic acid derivative and its preparation method. The preparation method involves preparing a copper triazole-modified mesoporous silica nanocatalytic support, including the preparation and amination of mesoporous silica, grafting of triazole functional groups, copper ion coordination chelation, and high-temperature heat treatment stabilization steps. Then, using this catalytic support, a one-pot condensation reaction is carried out with trihydroxybenzaldehyde and malonic acid as raw materials under heating and ultrasonic assistance. After simple operations such as centrifugation, acid-base adjustment for precipitation, and vacuum filtration and drying, the cinnamic acid derivative is obtained. The catalytic support prepared by this invention has a novel and stable structure, effectively catalyzing the reaction and inhibiting the loss of metal ions. The preparation process of the derivative is extremely simple and mild, the catalyst can be recycled, and the obtained product has extremely high antioxidant activity, making it suitable for industrial production.

The present application relates to a kind of composite film and its preparation method and application, wherein, the preparation method of composite film, it includes the following steps: multiple amine, water-soluble polymer, crosslinking agent, acid absorbent and water are mixed, obtain reversible hydrogel, wherein, water-soluble polymer is selected from at least one in guar gum, carrageenan;Providing porous support film, reversible hydrogel is placed on the surface of porous support film, forms hydrogel layer, and hydrogel layer extends from surface to the inside of porous support film;Under the irradiation of ultraviolet light, oil phase solution is placed on the surface of hydrogel layer away from porous support film, wherein, oil phase solution includes multiple acyl chloride, polyvinyl alcohol cinnamate and isomeric alkane solvent;And heat treatment and acid treatment are sequentially carried out, obtain composite film.The composite film prepared by the preparation method of composite film of the present application has high water flux and desalination rate when applied to water treatment.

The present invention relates to a composition for absorbing ultraviolet (UV) electromagnetic radiation, wherein the composition comprises a UV absorbing agent and a film forming agent, wherein the UV absorbing agent is a compound Ar-Xn-R with Ar, X, n and R as defined in the specification, particularly the UV absorbing agent is cinnamic acid, cinnamyl alcohol or gallic acid, or a derivative thereof. The invention further relates to a substrate comprising a coating and a method for protecting a surface of a substrate from UV electromagnetic radiation.

This application discloses a novel phenolic acid decarboxylase, its preparation method, and its applications, relating to the field of enzyme engineering technology. The novel enzyme was extracted from *Mycobacterium avium*, and its amino acid sequence is shown in SEQ ID NO: 3. This enzyme can efficiently catalyze the decarboxylation of hydroxycinnamic acid substrates such as ferulic acid, p-coumaric acid, caffeic acid, and sinapic acid to generate corresponding 4-vinylphenol compounds, with yields of 93.37%, 98.12%, 85.24%, and 11.21%, respectively. The catalytic activity against sinapic acid is significantly superior to most reported phenolic acid decarboxylases. Furthermore, under pH 8.5 and CO2 conditions, this enzyme can also reverse-catalyze the carboxylation reaction of 4-vinylphenol compounds to generate the corresponding hydroxycinnamic acid, with yields between 12% and 20%. It shows promising applications in the high-value utilization of lignin, food flavoring synthesis, and CO2 bioimmobilization.