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Preparation of high purity chlorogenic acid preparation and clinical application thereof

A chlorogenic acid and high-purity technology, which is applied in the preparation and clinical application of high-purity chlorogenic acid preparations

Inactive Publication Date: 2012-03-28
肖文辉 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, there are no reports and researches on making oral preparations with high-purity chlorogenic acid and using them clinically.

Method used

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  • Preparation of high purity chlorogenic acid preparation and clinical application thereof
  • Preparation of high purity chlorogenic acid preparation and clinical application thereof
  • Preparation of high purity chlorogenic acid preparation and clinical application thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0055] ① Take Liaoning viola, add 20 times of 65% ethanol, extract twice at 60°C for 1 hour each time, combine the decoction, recover ethanol, and concentrate under reduced pressure to form a clear paste with a ratio of 2:1 to the medicinal material.

[0056] ②The pretreated D101 macroporous resin was added with an extract volume 5 times the volume of the resin, passed through the resin column at a flow rate of 4BV / H, then eluted with water 3 times the volume of the resin, removed the eluent, and washed with 20% The ethanol was eluted at a flow rate of 4BV / H, the eluate was collected, the ethanol was recovered, and spray-dried to obtain the product, and the purity was 60.9% as detected by HPLC.

[0057] ③ Take the purified chlorogenic acid extract, add 10 times the volume of acetone to dissolve, filter, take the filtrate to recover acetone, vacuum dry until the moisture meets the requirements, and refine it once more in the same way, with a purity of 95.3%.

example 2

[0059] ① Prescription

[0060]

[0061] ②Add starch and carboxymethyl starch sodium to chlorogenic acid, mix well, add binder to make soft material, after drying, granulate; add appropriate amount of magnesium stearate, mix well and divide into capsules; or press tablets to make tablet.

example 3

[0063] ① Prescription

[0064]

[0065] ② Take chlorogenic acid, add 800ml of water to dissolve, add 20g of flavoring agent (sucrose), mix well, adjust pH to 4.5-5.5 with hydrochloric acid or sodium hydroxide, mix well, add water to dilute to the mark, mix well, filter, divide packed, sterilized or non-sterilized, packaged, ready to serve.

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PUM

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Abstract

Chlorogenic acid, i.e. 1, 3, 4, 5-tetrahydroxycyclohexanecarboxylic acid-(3, 4-dihydroxycinnamic acid ester), exists in a plurality of plants, and also, high purity chlorogenic acid can be prepared through synthesis. Chlorogenic acid has a lot of biological activity, such as antibacterium, antivirus, antioxidation, antitumor and the like. However, there exists no report and research on oral preparations prepared by high purity chlorogenic acid and application of the preparations in clinics. In the invention, high purity chlorogenic acid is extracted from plants or obtained through synthesis, and is then added with a proper amount of accessories, thus obtaining oral preparations like tablets, capsules, granules, oral solutions, etc. The preparations provided in the invention can be applied in clinics for treating cardio-cerebrovascular diseases, infections, hepatitis B, tumors and other diseases, and also can be used in health care medicines for heat clearing and detoxifying, face nursing and skin moistening, as well as hangover relieving, etc.

Description

1. Technical field [0001] The invention belongs to the preparation and clinical application of high-purity chlorogenic acid preparation. 2. Background technology [0002] Chlorogenic acid, that is, 1,3,4,5-tetrahydroxycyclohexanecarboxylic acid-(3,4-dihydroxycinnamate), chlorogenic acid exists in many plants and can also be obtained by synthetic methods , high-purity chlorogenic acid can be obtained, and chlorogenic acid has a variety of biological activities, such as antibacterial, antiviral, antioxidative and antitumor. But at present, there are no reports and researches on making oral preparations with high-purity chlorogenic acid and using them clinically. [0003] The present invention extracts high-grade chlorogenic acid from plants, or obtains high-purity chlorogenic acid through synthesis, and makes the high-purity chlorogenic acid into oral preparations such as tablets, capsules, granules, and oral liquids by adding appropriate amount of auxiliary materials etc., ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/732C07C67/48A61K31/216A61P31/04A61P31/12A61P39/06A61P35/00A61P9/00A61P9/12A61P31/20A61P1/16A61P25/32A61P17/16
Inventor 肖文辉熊祥珍曹艳汪建平徐海星
Owner 肖文辉
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