The invention discloses a distiller's yeast for relaxing tendons and activating collaterals, wherein the raw material comprises rhizoma arisaematis in parts by weight ratio of 5-10 parts of rhizoma arisaematis, peony 5-10 parts, Drynaria 5-10 parts, black beans 5-10 parts, Dalijian 5-10 parts, 5-10 parts of aconite root, natural copper 2-5 parts, daemonorops draco 2-6 parts, asarum 5-10 part, angelica dahurica 5-10 part, Momordica cochinchinchinensis 2-5 part, cyathula root 5-10 parts, myrrh 1-4 part, frankincense 2-5 part, green mulberry carbon 20-30 parts, glutinous rice 700-1000 part, starch 50-80 part, soybean 20-50 parts and broad beans 10-20 part; stir-fry soybean, glutinous rice and broad bean with wheat bran, cook and cool; Green mulberry pow, chestnut powder, black soybean pow, rhizoma Drynariae powder, rhizoma arisaematis powder, and myrrh powder are prepared into main material; a Chinese medicinal composition is prepare from radix Paeoniae powder, radix Aconiti pow, naturalcopper powder, sanguis Draxonis powder, herba asari pow, radix Angelicae Dahuricae powder, radix Momordicae powder, radix Cyathulae powder, olibanum powder, and starch. Atractylodes rhizome pow, radixAchyranthis bidentatae powder, radix Aconiti lateralis Preparata pow, Cinnamomi radix powder, rhizoma Zingiberis recens powder, Glycyrrhrizae radix powder and starch to obtain a supplement; a main material, a secondary material and a supplemental material are taken out and mix and then made into a cake shape and put into a fermentation chamber for fermentation to obtain distiller's yeast.