Care solution for cleaning nasal cavity and preparation method of care solution

A cleaning and solution technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as the high toxicity of medicinal materials and the neglect of the acceptance of nasal cleaning preparations.

Active Publication Date: 2014-04-23
刘少华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 2. Neglect of user acceptance (i.e., compliance) of nasal wash preparations
[0010] 3. The selected medicinal materials are highly toxic
For example, Xanthii has nephrotoxicity, high dose or long-term use may induce respiratory, circulatory, and renal failure

Method used

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  • Care solution for cleaning nasal cavity and preparation method of care solution
  • Care solution for cleaning nasal cavity and preparation method of care solution
  • Care solution for cleaning nasal cavity and preparation method of care solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: Take 10,000g of fresh Houttuynia cordata, add 100,000ml of water, carry out steam distillation, collect 5,000g of distillate (equivalent to 2g of raw medicinal material per g), filter with 0.45μm filter membrane, add 50g of Tween 80, 1g of benzalkonium Ammonium bromide, 70g glycerin, 30g xylitol, 4780g purified water, stir well, add 1.5g citric acid, 28g sodium citrate to adjust the pH value to 6.0, add 40g sodium chloride to adjust the osmotic pressure to 290mOsm / kg, Stir well, filter with a 0.22μm filter membrane, and dispense it into a special nasal washing device.

Embodiment 2

[0076] Example 2: Take 5000g of honeysuckle, add 100000ml of water, carry out steam distillation, collect 5000g of distillate (equivalent to containing 1g of raw medicinal material per milliliter), filter through a 0.45μm membrane, add 20g of Tween 80, 0.1g of benzalkonium chloride , 30g xylitol, 1g hyaluronic acid, 4856g purified water, after stirring well, add 17g sodium dihydrogen phosphate, 11g disodium hydrogen phosphate to adjust the pH value to 5.8, add 65g sodium chloride to adjust the osmotic pressure to 300mOsm / kg, Stir well, filter with a 0.22μm filter membrane, and dispense into nasal drops.

Embodiment 3

[0077] Example 3: Take 20,000g of mint, add 100,000ml of water, carry out steam distillation, collect 5,000g of distillate (equivalent to containing 4g of raw medicinal material per ml), filter through a 0.45μm membrane, add 40g of Tween 80, 0.8g of benzalkonium bromide , 5g hyaluronic acid, 4845g purified water, stir well, add 1.5g citric acid, 30g sodium citrate to adjust the pH value to 6.1, add 78g sodium chloride to adjust the osmotic pressure to 308mOsm / kg, stir well, and use 0.22μm Sterilize and filter through a special filter membrane, and distribute it in a nasal spray bottle.

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Abstract

The invention discloses a care solution for cleaning a nasal cavity and a preparation method of the care solution. The care solution is prepared from 5,000 parts of traditional Chinese medicine distillate, 0.1-2 parts of preservatives, 1-100 parts of glyceryl polymethacrylate, 20-100 parts of tween 80, 30-80 parts of sodium chloride, 20-60 parts of a pH conditioning agent and 4658-4928.9 parts of purified water. The osmotic pressure of the care solution is 280-310mosm/Kg, and the pH value is 5.5-7.0. The preparation method of the care solution mainly comprises the following steps: by taking one or combination of houttuynia cordata, mint, honeysuckle and radix angelicae as raw materials, carrying out steam distillation to obtain the traditional Chinese medicine distillate; matching with auxiliary materials, and then filtering and carrying out split charging, so as to obtain the care solution. The solution disclosed by the invention has a strong inhibiting effect on nasal common microbe streptococcus infection, staphylococcus, bacillus influenza, influenza viruses and rhinoviruses, and can achieve the target of preventing rhinitis infection and recurrence.

Description

technical field [0001] The invention relates to a cleaning care preparation and a preparation method thereof, in particular to a nasal cavity cleaning care solution and a preparation method thereof. Background technique [0002] Everyone knows the importance of breathing to sustain life. The first point of contact between the human body and the outside air is the nasal cavity. It is the first guard of the human respiratory system and the necessary place for the human respiratory system to exchange materials with nature. . The nasal cavity is a long and narrow cavity with a narrow top and a wide bottom. It starts from the anterior nostril at the front and ends at the posterior nostril at the back, communicating with the nasopharynx. Most of the nasal cavity is covered by mucous membrane, with cilia growing from ciliated cells on the surface, and a layer of mucus secreted by goblet cells and other secretory cells is covered on the cilia, forming a layer on the surface of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/232A61K36/355A61K36/534A61K36/78A61K47/34A61P11/02A61P11/00
Inventor 刘少华
Owner 刘少华
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