110 results about "Nasal spray" patented technology

The invention discloses a sleep-promoting nasal spray based on mesenchymal stem cell-derived exosomes and preparation and application thereof.The preparation method comprises the steps that 1, mesenchymal stem cells separated from umbilical cord tissue are cultured to P3-P5 generations, cell culture supernate is collected, cells are digested, and then cell debris and macromolecular impure protein are removed through pretreatment; (2) filtering and concentrating the pretreated cell culture supernatant and replacing a part of solution; (3) carrying out degerming filtration on the solution obtained in the step (2) through a 0.22 [mu] m filter membrane to obtain an MSC-Exos solution; and (4) adding a stabilizer with a proper concentration into the MSC-Exos solution to obtain a compound MSC-Exos solution, namely the sleep-promoting nasal spray. The product is a cell-derived natural active substance, can significantly improve sleep, and does not involve any pharmaceutical ingredient.

The utility model discloses a nasal spray actuator. In the nasal spray actuator, an inner cavity of a shell is used for containing a medicine bottle, and an opening allowing the medicine bottle to be inserted into the inner cavity of the shell is formed in the position, above the shell, of the inner cavity of the shell; the front side wall of the shell is provided with a spray pipe which obliquely extends upwards in the radial outward direction; a first notch for assembling the counting device is formed in the rear side wall of the shell, and the counting device is fixed between the shell and the rear cover; the protective cap is rotationally connected with the bottom wall of the shell, and the protective cap can rotate to a first state of covering the spraying pipe and can also rotate to a second state of exposing the spraying pipe; a first buckle is arranged on the brim of the protective cap, a first buckling position is arranged on the front side wall of the shell, and when the protective cap is in a first state, the first buckle is inserted into the first buckling position; when a user presses the medicine bottle, the medicine bottle triggers the counting device to count; the rear cover covers the first notch, and a second notch for avoiding the protective cap is formed in the center area of the lower portion of the rear cover. The product is convenient and sanitary to use and convenient to carry.

The invention discloses an oyster enzymolysis ultrafiltration extract nasal spray and a preparation method thereof, the nasal spray comprises the following components: 5-10 wt% of oyster extract, 0.1-0.3 wt% of preservative, 0.05-0.15 wt% of sodium chloride and 0.1-0.3 wt% of emulsifier, the pH value is 5.5-6.5, the content of the preservative is 0.1-0.3 wt%, the content of the sodium chloride is 0.05-0.15 wt%, the content of the emulsifier is 0.1-0.3 wt%, and the balance is water. The preservative is one of benzalkonium chloride, sorbic acid and potassium sorbate, and the emulsifier is polysorbate 80. Through definite raw material composition, a step-by-step process and quality control, the bioavailability of active components is improved, the flavor of the product is optimized, the effect of safely and efficiently improving sleep is achieved, the problems of low bioavailability, poor flavor and potential safety hazards of an existing sleep improving product are solved, the process repeatability is high, and the preparation method is suitable for industrial production. The long-term use of people with chronic insomnia is facilitated.

A management system for medication includes an electronic case configured to support a user's medication and a computing device configured to communicate with the case. The case includes one or more sensors, such as a pressure sensor, to produce sensor information indicating whether the medication is disposed in the case, a battery sensor to indicate a charge level of the case, and, in some examples, a location sensor to indicate a location of the case. A controller obtains the sensor information and provides status information to the computing device. The computing device provides notifications based on the status information and, in some examples, automatically or semi-automatically initiates communications to designated emergency contacts in response to determining that medication has been removed from the case. The case can include light sources and a speaker controlled by the controller. An identifier, such as a near-field communication tag, can associate the case with a user. Status information can be shared with additional users (e.g., caregivers). The system is suitable for emergency medications such as epinephrine nasal spray.

1. Name of the design product: nasal spray head (two spray modes). 2. Use of the design product: the design product is used for a spray head. 3. Design points of the design product: in shape. 4. Picture or photo best indicating the design points: perspective view.

This utility model discloses a pump head and a metering nasal spray device with the pump head, including a connecting cap for connection to a bottle body, and a pump assembly for metering liquid dispensing connected inside the connecting cap. The pump assembly includes a pump chamber, an upper pump rod disposed within the pump chamber, an inlet channel within the upper pump rod, an inlet on the outer wall of the upper pump rod communicating with the inlet channel, a limiting part on the outer wall of the upper pump rod, a piston movably sleeved on the upper pump rod, an upper pressure spring between the piston and the limiting part, a lower pump rod disposed below the piston, and a one-way valve mechanism at the inlet end of the pump chamber. The one-way valve mechanism includes a fixed seat and a pump ball disposed in the fixed seat, and a receiving groove on the fixed seat for accommodating the end of the upper pump rod. This utility model has a simple structure. By restricting the movement of the pump ball in a limited space through the fixed seat, the fixed seat can guide the upper pump rod to maintain axial movement, avoiding lateral swing, allowing the pump ball and pump chamber to seal and open quickly, resulting in a more stable and precise pumping volume.

This utility model discloses a child-protective nasal spray device with a safety lock function, including a push button, a nasal spray pump, and a medicine bottle. The upper wall of the nasal spray pump housing is installed inside the push button housing via an elastic component and a locking component. The lower wall of the nasal spray pump housing is installed on the mouth of the medicine bottle via an anti-opening component. The elastic component is an elastic protrusion on the inner wall of the push button housing, and the locking component is a transverse track on the outer surface of the upper wall of the nasal spray pump housing, with locking points on the transverse track. The anti-opening component includes a pawl on the lower wall of the nasal spray pump housing and a pawl on the mouth of the medicine bottle, with the two pawls interlocking. This device not only effectively prevents children from accidentally ingesting the medicine, improving safety, but also avoids the safety hazards caused by aluminum shavings in the crimping sealing method, simplifies the medicine filling process, and reduces production costs.

This invention proposes a traditional Chinese medicine preparation and its preparation method for treating olfactory dysfunction in Parkinson's disease of the liver and kidney yin deficiency type. Belonging to the field of traditional Chinese medicine preparations, it is made from the following raw materials: 10-15g of Rehmannia glutinosa (processed), 20-30g of Paeonia lactiflora, 10-15g of Spatholobus suberectus, 12-15g of Eclipta prostrata, 10-15g of Ligustrum lucidum, 8-10g of Centipeda minima, 10-15g of Acorus tatarinowii, and 10-15g of Angelica dahurica. The entire formula works synergistically to nourish the liver and kidneys, invigorate blood circulation, and clear the nasal passages, exhibiting good clinical therapeutic effects. This invention assesses the olfactory function of patients with olfactory dysfunction in Parkinson's disease of the liver and kidney yin deficiency type using the T&T olfactory test and other methods, and applies a traditional Chinese medicine nasal spray treatment, systematically exploring the therapeutic efficacy of this external application of traditional Chinese medicine for the aforementioned symptoms. This invention can provide clinical data support for the standardized diagnosis and treatment of olfactory dysfunction in Parkinson's disease and has significant clinical application value for improving patients' quality of life and optimizing the prognostic assessment system.

The nasal cavity sprayer convenient to adjust comprises a bottle body, the top of the bottle body is in threaded connection with a cover plate used for blocking the top of the bottle body, the outer surface of the upper portion of the cover plate is fixedly connected with a supporting block, and a pressing mechanism is arranged on the right side of the upper portion of the supporting block; comprising a mounting sleeve fixedly connected to the outer surface of the upper portion of a supporting block, a pressing chamber is arranged in the mounting sleeve, a piston is arranged in the pressing chamber, two fixing blocks are fixedly connected to the left side of the upper portion of the supporting block, a limiting block is arranged between the two fixing blocks, and a spray head is arranged at the other end of the limiting block; and the limiting block rotates to drive the spray head to rotate, so that the spraying angle is adjusted. By means of the structure, the spraying angle can be adjusted, mist can be sprayed to different areas of the nasal cavity more accurately, and meanwhile different spraying amounts can be selected according to requirements.

This invention provides a nasal spray pharmaceutical composition containing CNI 3176, the composition comprising: a therapeutically effective amount of CNI 3176, or a pharmaceutically acceptable salt of CNI 3176, or a mixture of CNI 3176 and a pharmaceutically acceptable salt of CNI 3176. It may also contain pharmaceutically acceptable excipients, such as pharmaceutically used solvents, surfactants, and stabilizers. The composition of this invention contains surfactants and stabilizers, which can improve drug bioavailability and increase drug stability, without requiring control of raw material particle size.

The invention discloses a chitosan modified turmeric-broccoli exosome hybrid nasal spray and application thereof, and belongs to the technical field of biological medicine and drug delivery. The nasal spray is formed by dispersing double plant exosome-lipidosome hybrids in a carrier for nasal cavities. The preparation method comprises the following steps: fusing curcumin carried by a turmeric exosome and sulforaphane carried by a broccoli bud exosome with a pH response liposome membrane containing 1, 2-dioleoyl-sn-glycerol-3-phosphoethanolamine, and modifying by chitosan to form a three-layer structure; the preparation method comprises the steps of exosome extraction, ultrasonic drug loading, liposome hybridization, chitosan coating and preparation blending. The nasal spray is high in entrapment efficiency and uniform in particle size, the chitosan enhances nasal adhesion, inflammation targeted drug release is achieved through pH response, the brain targeting efficiency and stability are excellent, and the adaptability to children is good. The curcumin and sulforaphane are used for targeted therapy of children autism spectrum disorder neuroinflammation, anti-inflammation and anti-oxidation are achieved through synergism of curcumin and sulforaphane, the curative effect is remarkable, and a new scheme is provided for treatment of related diseases.

The application belongs to the technical field of medicine, and specifically discloses a kind of nasal spray composition and nasal spray and application, the nasal spray composition includes the following components: hyaluronic acid, trehalose, N-acetyl-L-cysteine, methylene succinic acid, gallic acid, taurine, coenzyme Q10, rosemary essential oil.The nasal spray composition provided by the application is accurately adjusted, can give full play to the advantages of each component, provide better nasal ventilation and humidity.The nasal spray composition provided by the application can inhibit the excessive activation of LPS-induced neutrophil Netosis in vitro culture and the excessive activation of LPS-induced mouse airway neutrophil Netosis, thereby reducing the inflammatory response in the nasal cavity.

The present invention discloses a novel stable, single phase aqueous suspension for nasal administration to treat bacterial sinusitis. The composition takes azithromycin dihydrate as an active ingredient, and adopts a suspending agent system to prevent phase separation during storage. Embodiments include a formulation comprising a sorbitan monolaurate, or a combination of chitosan and a sorbitan monolaurate, to maintain the stability of the suspension. The present invention has a variety of advantages, including local delivery of azithromycin to an infected site, which can reduce systemic exposure and associated side effects compared to oral formulations.

The application discloses a preparation method of a novel nanoemulsion nasal spray dressing which is composed of nano-micelles, isopropyl myristate, purified water, sodium chloride, potassium sorbate and citric acid monohydrate, wherein the nano-micelles are composed of RH-60 hydrogenated castor oil, polyethylene glycol 400 and hydroxypropyl-beta-cyclodextrin; the preparation steps of the nano-micelles are as follows: the preparation steps of the nanoemulsion nasal spray dressing are as follows: when the isopropyl myristate is mixed with the nano-micelles, the stirring speed is adjusted to 900-1200 rpm, the temperature is increased to 40-50 DEG C, stirring is carried out for 20-30 min, the stirring speed is adjusted to 1200-1350 rpm, the purified water is slowly added along the wall of a beaker at a temperature of 30-35 DEG C, and stirring is continuously carried out for 35-45 min; the stirring speed is reduced to 600-800 rpm, the sodium chloride and the potassium sorbate are added at a temperature of 22-28 DEG C, and stirring is carried out for 8-15 min; the nanoemulsion nasal spray dressing prepared by the method is prepared by matching mild ingredients, has simple preparation process, is non-irritating, can further reduce the irritation to the nasal mucosa of patients and protect the nasal mucosa.

The utility model provides a kind of side press nose spray device, it includes: outer shell, bottle, air inlet component, liquid inlet component and liquid outlet component, the bottle is used to store medicament, the air inlet component, the liquid inlet component and the liquid outlet component are all located in the outer shell, the air inlet component is connected in the bottle top, the liquid outlet component, the liquid inlet component and the air inlet component are sequentially connected from top to bottom;The air inlet component is connected with the bottle and the liquid inlet component by a liquid guide pipe.The utility model solves the technical problem caused by the inconvenient operation mode of the unseparated gas-liquid channel of traditional nose spray device.

1. The name of the design product: nebulizer. 2. The use of the design product: the design product is used to contain oral and nasal spray liquid. 3. The design points of the design product: the shape of the product. 4. The picture or photo that best indicates the design points: perspective view.

This utility model discloses an environmentally friendly single-dose nasal spray device, including a nasal spray body, a grip for hand handling, and a nozzle for spraying medication into the nasal cavity. The nasal spray body has an inner cavity containing an atomizing column for atomizing the medication. The atomizing column has a liquid outlet channel communicating with the nozzle. A medicine bottle is slidably disposed within the inner cavity. The medicine bottle has a push rod with one end extending out of the inner cavity for hand pressing to slide the bottle towards the atomizing column. A dynamic sealing assembly is provided within the medicine bottle, including a piston slidably disposed within the bottle and a valve rod with its lower end slidably inserted into the piston. The lower end of the piston and the inner wall of the medicine bottle form a liquid storage cavity. The valve rod has a communication channel sealed by the piston. When the medicine bottle slides, it moves the piston, causing the valve rod to move to the top of the atomizing column. The valve rod then slides downward relative to the piston, opening the communication channel and connecting the liquid storage cavity and the liquid outlet channel.

The invention discloses auxiliary equipment for treatment in the otolaryngology department, relates to the technical field of medical instruments, and aims to solve the technical problem that liquid medicine of traditional nasal cavity administration equipment in the otolaryngology department is prone to acting on the surface layer of the nasal cavity and is difficult to directly reach the focus of infection. A liquid medicine launching cylinder and a trigger assembly are arranged in an inner cavity of the positioning shell, the positioning shell comprises a spherical positioning head, a movable cavity, a first control cavity, a second control cavity and a storage cavity are arranged in the inner cavity of the positioning shell, and the storage cavity communicates with an outlet of the movable cavity through a plurality of backflow channels. The liquid medicine launching cylinder comprises a medicine cylinder arranged in the movable cavity in a sliding mode. The nasal cavity drug delivery device has the advantage that effective drug delivery to the deep layer of the nasal cavity is achieved.

The invention discloses a brain-targeted nasal-spray amphotericin B phospholipid complex and a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the brain-targeted nasal-spray amphotericin B phospholipid complex is prepared by adopting a film dispersion method, and the preparation method comprises the following steps: dissolving 15-hydroxystearic acid polyethylene glycol ester, phospholipid, cholesterol, amphotericin B and optional other auxiliary components in a solvent, removing the solvent until a film is formed, and drying to obtain the brain-targeted nasal-spray amphotericin B phospholipid complex. And carrying out hydration dispersion to obtain the amphotericin B-loaded phospholipid complex. According to the amphotericin B sodium deoxycholate injection, the problems that the traditional amphotericin B sodium deoxycholate injection is high in renal toxicity, the intrathecal injection is poor in solubility, and low in bioavailability and patient compliance, large in side effect and the like due to the fact that the traditional amphotericin B sodium deoxycholate injection is difficult to penetrate through a blood brain After nasal administration, the drug is quickly delivered into the brain, so that the slow release of the drug is realized, the intracerebral bioavailability of the drug is improved, high brain targeting and low systemic toxic and side effects are realized, and good clinical application value and market prospect are achieved.

A oronasal conjunctival spray may include a bottle for fluid and an applicator that may be screwable to the bottle. The spray applicator may include a nasal spray port for spraying fluid into a human nose, a conjunctival spray port for spraying fluid into a human eye, and an oral spray port for spraying fluid into a human oral cavity (mouth).

The invention provides a side pressing nasal spray device which comprises an outer shell, a bottle body, an air inlet assembly, a liquid inlet assembly and a liquid outlet assembly, the bottle body is used for storing medicaments, the air inlet assembly, the liquid inlet assembly and the liquid outlet assembly are all arranged in the outer shell, the air inlet assembly is connected to the top of the bottle body, and the liquid outlet assembly is connected to the bottom of the bottle body. The liquid outlet assembly, the liquid inlet assembly and the air inlet assembly are sequentially connected from top to bottom; the air inlet assembly is communicated with the bottle body and the liquid inlet assembly through a liquid guide pipe. The technical problems that a gas channel and a liquid channel of a traditional nasal spraying device are not separated, and the operation mode is inconvenient are solved.

This invention discloses a compound ointment for protecting the nasal mucosa and repairing skin damage, and its preparation method, belonging to the field of pharmaceutical technology. The compound ointment is formulated with Sophora japonica fruit extract, erythromycin ointment, vitamin B6, levofloxacin hydrochloride tablets, loratadine tablets, fluticasone propionate nasal spray, sesame oil, and honey in specific weight proportions. The components work synergistically, providing protection for the nasal mucosa, treatment of rhinitis, reduction of cold air and external pollutant intrusion, and prevention of colds. It can also treat hemorrhoids, scars, eczema, and other skin damage, achieving "one medicine for multiple uses." This compound ointment has a stable dosage form, is convenient to use, has high utilization rate, high safety, and no obvious side effects, making it suitable for various populations and possessing good industrialization prospects.

A nasal spray device can include housing having a sensor and a nozzle having a housing interface with a graphical image thereon. The sensor can be configured to sense movement of the graphical image when the nozzle moves relative to the housing, for instance during administration of medicine from the nasal spray device. The sensor can include an infrared proximity sensor that senses infrared reflectivity from the graphical image. The infrared proximity sensor can also be used to measure distance to a surface of a vial within the housing to thereby detect insertion of the vial into the housing.

Provided are an influenza vaccine as a nasal spray, and a preparation method therefor and the use thereof. In the vaccine, a fusion protein contains an influenza virus strain HA protein or a fragment thereof, an influenza virus protein epitope and ferritin; and an adjuvant is a CpG1009 adjuvant for enhancing humoral immunity and cellular immunity. The vaccine composed of the fusion protein and the new CpG adjuvant can induce a strong protective effect against challenge.

1. The name of the design product: nasal spray device. 2. The use of the design product: for nasal medication. 3. The design points of the design product: in the shape of the product. 4. The picture or photo that best shows the design points: perspective view.

In alternative embodiments, manufactured products are provided that are made or manufactured as medical devices, such as inhalers, ionizers, asthma "blower-type" devices, nebulizers or nasal spray devices, respirators or respirators, warm air or hot air delivery devices, and / or CPAP (continuous positive air pressure) devices or equivalents, a drug delivery system for delivering a drug or one or combination of drugs, and optionally also warm or hot air, and optionally also ionized air. The manufactured product is used for treating, preventing and improving microbial infection, slowing down the progress of microbial infection, reducing the severity of microbial infection or preventing microbial infection. In alternative embodiments, a manufactured product as provided herein administers a combination or mixture of one or more drugs by inhalation, for example by using an aerosol, aerosol, liquid or powder formulation for inhalation.

The invention relates to pharmaceutical compositions comprising ketamine or pharmaceutically acceptable salt thereof for nasal administration, and methods for using such compositions.

The utility model discloses a split type nasal spray and aspiration device relates to mist spray and aspirator technical field, wherein the split type nasal spray and aspiration device comprises a suction and spray assembly and a host machine, the suction and spray assembly comprises a shell, a suction part and a mist spray part, a mounting cavity is arranged in the shell, the suction part is connected with the mist spray part, the suction part is provided with a suction end exposed out of the mounting cavity, and the suction end is connected with the mist spray part. The spraying part is provided with a spraying end exposed out of the mounting cavity; the main machine comprises an air pump and a connecting air pipe, the connecting air pipe is connected with the air pump and the suction-spraying assembly, the air pump is provided with an air suction port and an exhaust port, the connecting air pipe is connected with the air suction port and the suction part, and the exhaust port communicates with the air pump and the outside. According to the technical scheme provided by the utility model, the problems that when the integrated nasal spraying and sucking device is cleaned, due to the fact that a structure needing to be cleaned is integrated with non-waterproof structures such as an air pump and a battery, cleaning and disinfection are not thorough, unnecessary sanitation problems are caused, and use of a user is influenced can be solved.

An exhalation-enhanced nozzle apparatus constructed and arranged for use on a generic nasal spray medication container having a medication bottle, a pump assembly fixed to the bottle neck, and a removable nozzle. The apparatus has a base that envelops the pump assembly and connects in fluid communication with the pump assembly, an axially-extending nozzle, means for aerosolizing medication and expelling it through an expulsion port, and a mouthpiece into which a patient can blow to create airflow through the nozzle and out the expulsion port. The apparatus is constructed and arranged so that air blown into the mouthpiece flows through the nozzle, then mixes with and accelerates the flow rate of medication exiting the expulsion port so that the nasal medication can be delivered deeper into a patient's nasal cavity.

1. Name of the product in this design: Sprayer (nasal sprayer). 2. Purpose of this design: A spray device for moisturizing the nasal skin. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.