195 results about "Nasal spray" patented technology

The invention discloses a sleep-promoting nasal spray based on mesenchymal stem cell-derived exosomes and preparation and application thereof.The preparation method comprises the steps that 1, mesenchymal stem cells separated from umbilical cord tissue are cultured to P3-P5 generations, cell culture supernate is collected, cells are digested, and then cell debris and macromolecular impure protein are removed through pretreatment; (2) filtering and concentrating the pretreated cell culture supernatant and replacing a part of solution; (3) carrying out degerming filtration on the solution obtained in the step (2) through a 0.22 [mu] m filter membrane to obtain an MSC-Exos solution; and (4) adding a stabilizer with a proper concentration into the MSC-Exos solution to obtain a compound MSC-Exos solution, namely the sleep-promoting nasal spray. The product is a cell-derived natural active substance, can significantly improve sleep, and does not involve any pharmaceutical ingredient.

The utility model discloses a nasal spray actuator. In the nasal spray actuator, an inner cavity of a shell is used for containing a medicine bottle, and an opening allowing the medicine bottle to be inserted into the inner cavity of the shell is formed in the position, above the shell, of the inner cavity of the shell; the front side wall of the shell is provided with a spray pipe which obliquely extends upwards in the radial outward direction; a first notch for assembling the counting device is formed in the rear side wall of the shell, and the counting device is fixed between the shell and the rear cover; the protective cap is rotationally connected with the bottom wall of the shell, and the protective cap can rotate to a first state of covering the spraying pipe and can also rotate to a second state of exposing the spraying pipe; a first buckle is arranged on the brim of the protective cap, a first buckling position is arranged on the front side wall of the shell, and when the protective cap is in a first state, the first buckle is inserted into the first buckling position; when a user presses the medicine bottle, the medicine bottle triggers the counting device to count; the rear cover covers the first notch, and a second notch for avoiding the protective cap is formed in the center area of the lower portion of the rear cover. The product is convenient and sanitary to use and convenient to carry.

The present invention relates to the technical field of nasal spray, and provides a nasal spray head with adjustable liquid spray state, comprising: a pressing buckle cover, which comprises a cover body, a liquid drawing piece arranged on an inner side of the cover body, an insertion piece arranged on an outer side of the cover body, and a liquid-tight tube sleeved at the periphery of the insertion piece; a fixed piston, which comprises a piston body, wherein the piston body is constrainedly sleeved on the insertion piece, a bottom end of the piston body is in sealing fit with an inner circumferential wall of the liquid-tight tube, and a top end of the piston body is provided with a liquid outlet hole and a fluid-guiding insertion column which is provided with water outflow channels; and a spray head, which comprises a spray head body, wherein the spray head body is rotatably sleeved outside the liquid-tight tube, the top of the spray head body is provided with a liquid spray end in insertion fit with the fluid-guiding insertion column, and the liquid spray end is provided with an ejection hole, spray forming grooves, and jet flow forming grooves. The nasal spray head with adjustable liquid spray state of the present invention can be switched to a spray state or a jet flow state when a user rotates it to a preset angle according to his / her own needs, and has a simple structure with convenient operation.

The invention discloses an oyster enzymolysis ultrafiltration extract nasal spray and a preparation method thereof, the nasal spray comprises the following components: 5-10 wt% of oyster extract, 0.1-0.3 wt% of preservative, 0.05-0.15 wt% of sodium chloride and 0.1-0.3 wt% of emulsifier, the pH value is 5.5-6.5, the content of the preservative is 0.1-0.3 wt%, the content of the sodium chloride is 0.05-0.15 wt%, the content of the emulsifier is 0.1-0.3 wt%, and the balance is water. The preservative is one of benzalkonium chloride, sorbic acid and potassium sorbate, and the emulsifier is polysorbate 80. Through definite raw material composition, a step-by-step process and quality control, the bioavailability of active components is improved, the flavor of the product is optimized, the effect of safely and efficiently improving sleep is achieved, the problems of low bioavailability, poor flavor and potential safety hazards of an existing sleep improving product are solved, the process repeatability is high, and the preparation method is suitable for industrial production. The long-term use of people with chronic insomnia is facilitated.

The utility model discloses a precise injection mechanism for nasal cavity administration and a nasal spray device thereof. The precise injection mechanism comprises a stepping motor, a cam, a roller, a push rod spring, a push rod, a push rod shell, a piston rod spring, a piston rod and a medicine storage bin. The medicine storage bin is sealed through a piston, and the piston is connected with a piston rod spring and coaxially connected with a push rod. The contour surface of the cam is connected with the roller which is vertically connected with the center shaft of the push rod. By the adoption of the precise injection mechanism, the constant amount of liquid medicine can be delivered to the atomization device each time, precise dosage of medicine administration each time is achieved, and parallelism of medicine administration and safety of medicine administration are guaranteed.

Multi-route drug delivery device designed with two modular bodies. The first body houses batteries, heaters, vials containing extracts, formulations, diluents or cleaners, and the control unit. This unit features two or more peristaltic pumps that enable precise dosage control and ensure homogeneous mixing of substances. The pumps also incorporate purging and cleaning process cross-contamination. The second body is the administration unit, which can be fitted with interchangeable nozzles to different delivery methods. These options include an atomizer, nasal spray, or sublingual spray. By changing the dispenser nozzles, it can accommodate a wide range of delivery routes, including pulmonary, sublingual, nasal, and mucosal. Designed to meet the needs of patients, clinical trial participants, general users, and livestock.

A management system for medication includes an electronic case configured to support a user's medication and a computing device configured to communicate with the case. The case includes one or more sensors, such as a pressure sensor, to produce sensor information indicating whether the medication is disposed in the case, a battery sensor to indicate a charge level of the case, and, in some examples, a location sensor to indicate a location of the case. A controller obtains the sensor information and provides status information to the computing device. The computing device provides notifications based on the status information and, in some examples, automatically or semi-automatically initiates communications to designated emergency contacts in response to determining that medication has been removed from the case. The case can include light sources and a speaker controlled by the controller. An identifier, such as a near-field communication tag, can associate the case with a user. Status information can be shared with additional users (e.g., caregivers). The system is suitable for emergency medications such as epinephrine nasal spray.

The invention discloses an influenza virus nano vaccine as well as a preparation method and application thereof. The invention relates to the field of biomedicine, and provides an influenza virus nano vaccine, which comprises nano particles and an STING agonist adsorbed on the surfaces of the nano particles, the nanoparticle comprises a polysaccharide antigen conjugate and a dendritic macromolecule, wherein the polysaccharide antigen conjugate is formed by coupling beta-glucan and influenza virus antigen protein, and the dendritic macromolecule and the polysaccharide antigen conjugate are adsorbed together. The immune response induced by the vaccine is higher than that of monomer immunogen protein without the adjuvant, body fluid, cell and mucosa immune response can be remarkably activated, lethal attack of an organism to H1N1 and H5N1 viruses can be effectively protected through nasal spray inoculation, and the nano vaccine can stimulate cross immune response and immune protection effect to different subtype influenza viruses.

A coronavirus-targeting antibody nasal spray comprising: a coronavirus-targeting antibody or antigen-binding fragment, a buffer, a stabilizer, a surfactant, and a thickening agent, and optionally further comprising a preservative. The nasal spray can improve the physicochemical stability of the coronavirus-targeting antibody, and the nasal spray can maintain protein stability under conditions such as room temperature, long-term refrigeration, and repeated freeze-thawing, thereby improving the safety and effectiveness of clinical use.

Described are methods of treating neurodegenerative disease by administering a therapeutically effective amount of fenchol to a patient in need thereof. Additionally, described are methods of activating FFAR2 signaling in a patient by administering a therapeutically effective amount of fenchol to a patient in need thereof. Methods of treating gastrointestinal disorders in a patient being treated for cancer and methods of improving cognition in a patient being treated for cancer are also described. Further, the present disclosure provides for a pharmaceutical composition including fenchol and an Alzheimer's disease drug. Additionally, a nasal spray including fenchol, a buccal tablet including fenchol, and a dietary supplement including fenchol are described.

1. Name of the design product: nasal spray head (two spray modes). 2. Use of the design product: the design product is used for a spray head. 3. Design points of the design product: in shape. 4. Picture or photo best indicating the design points: perspective view.

The invention discloses an alprazolam nasal spray and a preparation method thereof, and provides the alprazolam nasal spray which is good in stability, small in irritation, convenient, quick to take effect and extremely small in side effect, so that the medication compliance of a patient and the convenience of clinical medication are improved, and the preparation process is simple to operate, safe, environment-friendly and suitable for industrial mass production.

This utility model discloses a pump head and a metering nasal spray device with the pump head, including a connecting cap for connection to a bottle body, and a pump assembly for metering liquid dispensing connected inside the connecting cap. The pump assembly includes a pump chamber, an upper pump rod disposed within the pump chamber, an inlet channel within the upper pump rod, an inlet on the outer wall of the upper pump rod communicating with the inlet channel, a limiting part on the outer wall of the upper pump rod, a piston movably sleeved on the upper pump rod, an upper pressure spring between the piston and the limiting part, a lower pump rod disposed below the piston, and a one-way valve mechanism at the inlet end of the pump chamber. The one-way valve mechanism includes a fixed seat and a pump ball disposed in the fixed seat, and a receiving groove on the fixed seat for accommodating the end of the upper pump rod. This utility model has a simple structure. By restricting the movement of the pump ball in a limited space through the fixed seat, the fixed seat can guide the upper pump rod to maintain axial movement, avoiding lateral swing, allowing the pump ball and pump chamber to seal and open quickly, resulting in a more stable and precise pumping volume.

This utility model discloses a child-protective nasal spray device with a safety lock function, including a push button, a nasal spray pump, and a medicine bottle. The upper wall of the nasal spray pump housing is installed inside the push button housing via an elastic component and a locking component. The lower wall of the nasal spray pump housing is installed on the mouth of the medicine bottle via an anti-opening component. The elastic component is an elastic protrusion on the inner wall of the push button housing, and the locking component is a transverse track on the outer surface of the upper wall of the nasal spray pump housing, with locking points on the transverse track. The anti-opening component includes a pawl on the lower wall of the nasal spray pump housing and a pawl on the mouth of the medicine bottle, with the two pawls interlocking. This device not only effectively prevents children from accidentally ingesting the medicine, improving safety, but also avoids the safety hazards caused by aluminum shavings in the crimping sealing method, simplifies the medicine filling process, and reduces production costs.

The invention discloses a nasal spray preparation containing a diketo dioxane compound and a preparation method thereof, and belongs to the technical field of medicines. The technical problem to be solved is to provide the nasal spray preparation containing the diketo dioxins, which is non-irritant and higher in cumulative transmittance. The key point of the technical scheme is as follows: the raw materials comprise an active component, a preservative, glycerol, an isotonic regulator, a humectant and a penetration enhancer, wherein the penetration enhancer is a diketodioxane compound.

The present invention patent discloses a double-dose nasal spray device, including a nasal spray mechanism, a delivery mechanism and a medium reservoir. The nasal spray mechanism has a medium channel. The delivery mechanism is slidably assembled to the nasal spray mechanism. The medium reservoir is assembled to the delivery mechanism. The delivery mechanism is configured to perform two discharge strokes on the medium reservoir, so that the medium in the medium reservoir is sprayed into the nasal cavity through the medium channel twice. The delivery mechanism is provided with a first locking portion and a second locking portion along its sliding direction. The nasal spray mechanism is provided with a first receiving portion and a second receiving portion that are locked together. When the first locking portion and the first receiving portion are locked together, the first discharge stroke is completed, so that part of the medium in the medium reservoir is sprayed through the medium channel. When the second locking portion and the second receiving portion are locked together, the second discharge stroke is completed, so that the remaining medium in the medium reservoir is sprayed through the medium channel. This patent greatly improves the user experience of patients.

The invention discloses a dexketoprofen trometamol nasal spray and a preparation method thereof, a buffering agent is used as a stabilizer, and the dexketoprofen trometamol nasal spray which is good in stability, small in irritation, convenient, rapid in effect taking and extremely small in side effect is provided, so that the medication compliance of patients and the convenience of clinical medication are improved; after being administrated, the nasal spray can be quickly absorbed through nasal mucosa, the absorption speed is equivalent to that of intramuscular injection, the nasal spray can quickly reach the peak concentration as intramuscular injection, and the curative effect can be quickly exerted; the preparation has the advantages of no first-pass effect during nasal mucosa administration, high bioavailability and rapid absorption, is suitable for self-rapid analgesia, and is stable in process and suitable for large-scale production.

This invention proposes a traditional Chinese medicine preparation and its preparation method for treating olfactory dysfunction in Parkinson's disease of the liver and kidney yin deficiency type. Belonging to the field of traditional Chinese medicine preparations, it is made from the following raw materials: 10-15g of Rehmannia glutinosa (processed), 20-30g of Paeonia lactiflora, 10-15g of Spatholobus suberectus, 12-15g of Eclipta prostrata, 10-15g of Ligustrum lucidum, 8-10g of Centipeda minima, 10-15g of Acorus tatarinowii, and 10-15g of Angelica dahurica. The entire formula works synergistically to nourish the liver and kidneys, invigorate blood circulation, and clear the nasal passages, exhibiting good clinical therapeutic effects. This invention assesses the olfactory function of patients with olfactory dysfunction in Parkinson's disease of the liver and kidney yin deficiency type using the T&T olfactory test and other methods, and applies a traditional Chinese medicine nasal spray treatment, systematically exploring the therapeutic efficacy of this external application of traditional Chinese medicine for the aforementioned symptoms. This invention can provide clinical data support for the standardized diagnosis and treatment of olfactory dysfunction in Parkinson's disease and has significant clinical application value for improving patients' quality of life and optimizing the prognostic assessment system.

The nasal cavity sprayer convenient to adjust comprises a bottle body, the top of the bottle body is in threaded connection with a cover plate used for blocking the top of the bottle body, the outer surface of the upper portion of the cover plate is fixedly connected with a supporting block, and a pressing mechanism is arranged on the right side of the upper portion of the supporting block; comprising a mounting sleeve fixedly connected to the outer surface of the upper portion of a supporting block, a pressing chamber is arranged in the mounting sleeve, a piston is arranged in the pressing chamber, two fixing blocks are fixedly connected to the left side of the upper portion of the supporting block, a limiting block is arranged between the two fixing blocks, and a spray head is arranged at the other end of the limiting block; and the limiting block rotates to drive the spray head to rotate, so that the spraying angle is adjusted. By means of the structure, the spraying angle can be adjusted, mist can be sprayed to different areas of the nasal cavity more accurately, and meanwhile different spraying amounts can be selected according to requirements.

1. The name of the design product: the connected cover of nasal spray. 2. The use of the design product: used in the spray cover of the aerosol of nasal cavity cleaning liquid. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: design 1 perspective view. 5. Design 1 is designated as the basic design.

The invention relates to a nasal spray device which comprises a shell and a valve assembly, and the shell comprises a nose bell mouth, an air blowing mouth and an air flow channel communicating the air blowing mouth with the nose bell mouth; the valve assembly comprises a valve element and a valve switch, the valve element comprises an elastic film with a gap, and the gap can be closed through the elasticity of the elastic film. The valve switch can open the elastic film so that the valve assembly can conduct the air blowing opening and the nose bell mouth through the gap. Compared with a valve assembly which is closed through cooperation of a valve switch and a valve element, closing of the valve assembly is achieved through elasticity of the valve assembly, the closing effect is more reliable, and the structure is simpler.

This invention provides a nasal spray pharmaceutical composition containing CNI 3176, the composition comprising: a therapeutically effective amount of CNI 3176, or a pharmaceutically acceptable salt of CNI 3176, or a mixture of CNI 3176 and a pharmaceutically acceptable salt of CNI 3176. It may also contain pharmaceutically acceptable excipients, such as pharmaceutically used solvents, surfactants, and stabilizers. The composition of this invention contains surfactants and stabilizers, which can improve drug bioavailability and increase drug stability, without requiring control of raw material particle size.

Described are methods of treating neurodegenerative disease by administering a therapeutically effective amount of fenchol to a patient in need thereof. Additionally, described are methods of activating FFAR2 signaling in a patient by administering a therapeutically effective amount of fenchol to a patient in need thereof. Methods of treating gastrointestinal disorders in a patient being treated for cancer and methods of improving cognition in a patient being treated for cancer are also described. Further, the present disclosure provides for a pharmaceutical composition including fenchol and an Alzheimer's disease drug. Additionally, a nasal spray including fenchol, a buccal tablet including fenchol, and a dietary supplement including fenchol are described.

The invention discloses a chitosan modified turmeric-broccoli exosome hybrid nasal spray and application thereof, and belongs to the technical field of biological medicine and drug delivery. The nasal spray is formed by dispersing double plant exosome-lipidosome hybrids in a carrier for nasal cavities. The preparation method comprises the following steps: fusing curcumin carried by a turmeric exosome and sulforaphane carried by a broccoli bud exosome with a pH response liposome membrane containing 1, 2-dioleoyl-sn-glycerol-3-phosphoethanolamine, and modifying by chitosan to form a three-layer structure; the preparation method comprises the steps of exosome extraction, ultrasonic drug loading, liposome hybridization, chitosan coating and preparation blending. The nasal spray is high in entrapment efficiency and uniform in particle size, the chitosan enhances nasal adhesion, inflammation targeted drug release is achieved through pH response, the brain targeting efficiency and stability are excellent, and the adaptability to children is good. The curcumin and sulforaphane are used for targeted therapy of children autism spectrum disorder neuroinflammation, anti-inflammation and anti-oxidation are achieved through synergism of curcumin and sulforaphane, the curative effect is remarkable, and a new scheme is provided for treatment of related diseases.

The application belongs to the technical field of medicine, and specifically discloses a kind of nasal spray composition and nasal spray and application, the nasal spray composition includes the following components: hyaluronic acid, trehalose, N-acetyl-L-cysteine, methylene succinic acid, gallic acid, taurine, coenzyme Q10, rosemary essential oil.The nasal spray composition provided by the application is accurately adjusted, can give full play to the advantages of each component, provide better nasal ventilation and humidity.The nasal spray composition provided by the application can inhibit the excessive activation of LPS-induced neutrophil Netosis in vitro culture and the excessive activation of LPS-induced mouse airway neutrophil Netosis, thereby reducing the inflammatory response in the nasal cavity.

The present invention discloses a novel stable, single phase aqueous suspension for nasal administration to treat bacterial sinusitis. The composition takes azithromycin dihydrate as an active ingredient, and adopts a suspending agent system to prevent phase separation during storage. Embodiments include a formulation comprising a sorbitan monolaurate, or a combination of chitosan and a sorbitan monolaurate, to maintain the stability of the suspension. The present invention has a variety of advantages, including local delivery of azithromycin to an infected site, which can reduce systemic exposure and associated side effects compared to oral formulations.

The application discloses a preparation method of a novel nanoemulsion nasal spray dressing which is composed of nano-micelles, isopropyl myristate, purified water, sodium chloride, potassium sorbate and citric acid monohydrate, wherein the nano-micelles are composed of RH-60 hydrogenated castor oil, polyethylene glycol 400 and hydroxypropyl-beta-cyclodextrin; the preparation steps of the nano-micelles are as follows: the preparation steps of the nanoemulsion nasal spray dressing are as follows: when the isopropyl myristate is mixed with the nano-micelles, the stirring speed is adjusted to 900-1200 rpm, the temperature is increased to 40-50 DEG C, stirring is carried out for 20-30 min, the stirring speed is adjusted to 1200-1350 rpm, the purified water is slowly added along the wall of a beaker at a temperature of 30-35 DEG C, and stirring is continuously carried out for 35-45 min; the stirring speed is reduced to 600-800 rpm, the sodium chloride and the potassium sorbate are added at a temperature of 22-28 DEG C, and stirring is carried out for 8-15 min; the nanoemulsion nasal spray dressing prepared by the method is prepared by matching mild ingredients, has simple preparation process, is non-irritating, can further reduce the irritation to the nasal mucosa of patients and protect the nasal mucosa.

The utility model provides a kind of side press nose spray device, it includes: outer shell, bottle, air inlet component, liquid inlet component and liquid outlet component, the bottle is used to store medicament, the air inlet component, the liquid inlet component and the liquid outlet component are all located in the outer shell, the air inlet component is connected in the bottle top, the liquid outlet component, the liquid inlet component and the air inlet component are sequentially connected from top to bottom;The air inlet component is connected with the bottle and the liquid inlet component by a liquid guide pipe.The utility model solves the technical problem caused by the inconvenient operation mode of the unseparated gas-liquid channel of traditional nose spray device.

1. The name of the design product: nebulizer. 2. The use of the design product: the design product is used to contain oral and nasal spray liquid. 3. The design points of the design product: the shape of the product. 4. The picture or photo that best indicates the design points: perspective view.

The application relates to the medical technology field and relates to a rhinitis spray and a preparation method thereof. The rhinitis spray comprises, in percentage by mass, 0.05-0.15% of oxymetazoline hydrochloride, 0.1-1% of sodium chloride, 0.01-0.02% of a preservative, 0.1-0.3% of a modified eucalyptus leaf extract, 0.05-0.3% of sodium citrate, and the rest is water. The modified eucalyptus leaf extract is derived from a natural plant, is safe in composition, environment-friendly, and convenient to obtain. Compared with the prior art, the rhinitis spray prepared by the application has good curative effect, high stability, and can more effectively relieve rhinitis symptoms.