307 results about "Nasal spray" patented technology

A nasal spray device comprises a non-pressurized reservoir for containing a liquid formulation; a spray nozzle; and a manually energizable pump, configured to pressurize a quantity of said liquid formulation and causing the liquid formulation to move through the spray nozzle such that the liquid formulation is discharged from the spray nozzle as an aerosol spray. The spray nozzle comprises a membrane having a plurality of micropores of a substantially identical size below 8 micron and beyond 3 micron through which the liquid formulation passes as the liquid formulation is discharged from the device. Said membrane is configured to release said dose of said liquid formulation in a period of at least 500 milliseconds as a conically shaped plume having an apex. An energy of less than 20 Joule / gram is being dissipated in the liquid to preserve the molecular integrity of macromolecules within the liquid.

The invention is suitable for the technical field of anti-allergy agents, and provides an anti-allergy agent containing compound plant anti-allergy active ingredients. Comprising 5-10 parts of a bletilla striata extract, 8-15 parts of an aloe extract, 7-12 parts of an angelica sinensis extract, 10-20 parts of a centella asiatica extract, 5-15 parts of a rosemary extract, 8-18 parts of a polygonum cuspidatum extract, 12-25 parts of a scutellaria baicalensis extract, 3-10 parts of a tea extract, 6-15 parts of a liquorice extract and 4-12 parts of a matricaria recutita extract. The preparation method of the anti-allergy agent containing the compound plant anti-allergy active ingredients comprises the following steps: step 1, extracting and concentrating in groups; step 2, compounding additional ingredients; and step 3, mixing and forming the preparation. The anti-allergy agent containing the compound plant anti-allergy active component is specifically applied to allergic rhinitis nasal spray, postoperative wound repair, pet skin anti-allergy spray, anti-allergy baby clothes treating agent, low-allergy household cleaning agent and air purification spray. And through the synergistic effect of multiple targets and multiple channels, the balanced synergism of the repairing effect and the relieving effect is realized.

The invention discloses a sleep-promoting nasal spray based on mesenchymal stem cell-derived exosomes and preparation and application thereof.The preparation method comprises the steps that 1, mesenchymal stem cells separated from umbilical cord tissue are cultured to P3-P5 generations, cell culture supernate is collected, cells are digested, and then cell debris and macromolecular impure protein are removed through pretreatment; (2) filtering and concentrating the pretreated cell culture supernatant and replacing a part of solution; (3) carrying out degerming filtration on the solution obtained in the step (2) through a 0.22 [mu] m filter membrane to obtain an MSC-Exos solution; and (4) adding a stabilizer with a proper concentration into the MSC-Exos solution to obtain a compound MSC-Exos solution, namely the sleep-promoting nasal spray. The product is a cell-derived natural active substance, can significantly improve sleep, and does not involve any pharmaceutical ingredient.

The invention relates to the technical field of biological medicine, in particular to a medicine solution composition, a preparation method thereof and a nasal spray. The pharmaceutical composition comprises active pharmaceutical ingredients, a pH regulator, an osmotic pressure regulator and water, the active pharmaceutical ingredient is rizatriptan or a salt thereof; the pH regulator is used for regulating the pH of the pharmaceutical composition to 4.0-7.0; and the osmotic pressure regulator is used for regulating the osmotic pressure of the pharmaceutical composition to 280-350mOsm / kg. The nasal spray can be used for rapidly relieving migraine in the acute stage, rapid analgesia is achieved, the drug stability is good, the nasal spray is not affected by food, the components are simple and effective, and the nasal spray has commercial production value.

The invention relates to an antiviral composition for nasal delivery comprising favipiravir dissolved in an aqueous solvent which comprises an aqueous buffer adjusted to a pH within a range of from pH 4 to pH 6, at least one saponin component selected from the group consisting of escin and glycyrrhizin at or above a critical micelle concentration, dexpanthenol at a concentration within a range of from 0.5 to 5 %wt, and favipiravir as an antiviral agent at a concentration of at least 5 or 6 or 8 or 10 mg / ml, wherein the composition is preferably free of an organic solvent. The invention further relates to said antiviral composition when used in the treatment of viral infections of the airways or the respiratory tract.

Disclosed in the present invention are a preparation method for a brain-targeting agomelatine nasal spray micelle and use thereof, which belong to the technical field of pharmaceutical formulations. According to the present invention, an injectable pharmaceutical excipient polyethylene glycol (15)-hydroxystearate (HS15) is taken as a carrier material, HS15 and agomelatine are dissolved in an organic solvent, and the resulting solution is subjected to rotary evaporation under reduced pressure to form a uniform film, which, upon hydration, forms an agomelatine micelle solution capable of being sprayed nasally for treating depression and insomnia. According to the present invention, the problem of low oral bioavailability of agomelatine due to poor solubility, serious first pass effect of hepar, difficulty in penetrating a blood-brain barrier, etc., is solved. The micelle structure constructed in the present invention is quickly delivered into the brain after nasal administration, and it is stable in cerebrospinal fluid and can achieve slow release of the drug, thereby improving the intracerebral bioavailability of the drug and achieving high brain targeting property and low systemic toxic and side effects. The micelle structure has good clinical application value and market prospects.

The invention provides a nasal spray drug delivery adjusting device and method, and relates to the technical field of medical instruments, and the nasal spray drug delivery adjusting device is characterized in that a constant-pressure air bag is arranged in a bottle body; the nozzle assembly comprises a flow regulating valve and a nozzle; the administration adjusting module comprises a sensing module, a control module and a Bluetooth module; wherein the drug administration adjusting module conducts self-adaptive analysis on the spraying data and the Bluetooth interaction data to obtain flow adjusting parameters, and the control module controls the flow of the flow adjusting valve according to the flow adjusting parameters. According to the nasal spray dosing device, the technical problems that in a traditional nasal spray dosing device, the liquid medicine spraying pressure is unstable, the dosing amount is difficult to accurately regulate and control, and intelligent monitoring is lacked can be solved, the spraying pressure is stabilized through the constant-pressure air bag structure, the liquid medicine flow is accurately controlled in combination with the flow regulating valve, the dosing accuracy and the intelligent level are improved, and the application range is wide. Meanwhile, the use experience of the patient is enhanced.

The invention relates to an atomization assembly, a container assembly and a nasal spray device, the atomization assembly comprises a mouth bearing structure, a nose bearing structure and a blocking piece, and the mouth bearing structure is provided with a blowing nozzle; the nose bearing structure is provided with a nose bearing opening, a fluid channel and an auxiliary channel, and the nose bearing opening at least can communicate with the fluid channel; the blocking piece can open or close the fluid channel; under the condition that the atomization assembly is connected with the container assembly containing liquid, the blocking piece is located at the locking position, and the liquid tends to flow to the fluid channel under the driving action of a power source of the container assembly; under the condition that air is blown to the blowing nozzle, the blocking piece moves from the locking position to the opening position so that liquid can be sprayed to the nose bell mouth through the fluid channel under the driving effect of the power source, and airflow blown in through the blowing nozzle can also provide driving force for spraying of the liquid through the auxiliary channel. The atomization assembly does not need to be pressed, the fluid channel can be opened only by blowing, liquid injection can be assisted, and the operation difficulty of the nasal spray device is reduced.

The invention belongs to the technical field of biological medicines, and particularly relates to an MAF vaccine as well as a preparation method and application thereof. In order to develop a nasal spray type vaccine capable of effectively preventing and treating fibrotic interstitial lung diseases and avoiding risk increase caused by local inflammatory reaction, the invention adopts two modes of taking a synthesized MAF protein as a model antigen, encapsulating the MAF protein by using a TLR7 adjuvant to form a peptide fragment vaccine or constructing an MAF adenovirus vaccine based on an adenovirus vector. Two vaccines based on the MAF target spot are successfully constructed. Animal experiment results prove that the two vaccines based on the MAF target spot have treatment and prevention effects on bleomycin-induced mouse pulmonary fibrosis models during nasal dripping immunization, and also have good safety in vivo. A good candidate vaccine is provided for future fibrotic disease prevention and treatment vaccine transformation research and clinical experiment development.

The invention discloses an environment-friendly single-dose nasal spray device which comprises a nasal spray body, the nasal spray body is provided with a holding part for a hand to hold and a nozzle for being aligned with a nasal cavity to spray liquid medicine, an inner cavity is formed in the nasal spray body, an atomizing column for atomizing the liquid medicine is arranged in the inner cavity, and a liquid outlet channel communicated with the nozzle is arranged in the atomizing column. A medicine bottle is arranged in the inner cavity in a relative sliding mode, a push rod is arranged on the medicine bottle, one end of the push rod extends out of the inner cavity to be pressed by a hand to drive the medicine bottle to slide in the direction close to the atomization column along the inner cavity, and a dynamic sealing assembly is arranged in the medicine bottle and comprises a piston arranged in the medicine bottle in a relative sliding mode and a valve rod with the lower end inserted into the piston in a sliding mode. A liquid storage cavity is defined by the lower end of the piston and the inner wall of the medicine bottle, a communicating channel sealed by the piston is arranged in the valve rod, and after the medicine bottle slides to drive the piston to enable the piston to drive the valve rod to move to abut against the atomization column, the valve rod slides downwards relative to the piston to enable the communicating channel to be opened, and the liquid storage cavity and the liquid outlet channel are communicated.

The utility model discloses a nasal spray actuator. In the nasal spray actuator, an inner cavity of a shell is used for containing a medicine bottle, and an opening allowing the medicine bottle to be inserted into the inner cavity of the shell is formed in the position, above the shell, of the inner cavity of the shell; the front side wall of the shell is provided with a spray pipe which obliquely extends upwards in the radial outward direction; a first notch for assembling the counting device is formed in the rear side wall of the shell, and the counting device is fixed between the shell and the rear cover; the protective cap is rotationally connected with the bottom wall of the shell, and the protective cap can rotate to a first state of covering the spraying pipe and can also rotate to a second state of exposing the spraying pipe; a first buckle is arranged on the brim of the protective cap, a first buckling position is arranged on the front side wall of the shell, and when the protective cap is in a first state, the first buckle is inserted into the first buckling position; when a user presses the medicine bottle, the medicine bottle triggers the counting device to count; the rear cover covers the first notch, and a second notch for avoiding the protective cap is formed in the center area of the lower portion of the rear cover. The product is convenient and sanitary to use and convenient to carry.

A nasal spray containing an aqueous solution or a fluid with an anxiolytic or anticonvulsant substance, wherein the nasal spray is characterized in that with the nasal spray, two sprays with each an equivalent, defined volume of the aqueous solution or liquid of the active agent, can be intranasally administered to a patient. The nasal spray allows for an administration, independent of the spatial orientation of the nasal spray in any position of the patient (standing upright, sitting, lying or in any intermediate position). The nasal spray can be used directly without prior activation. It is apparent from the nasal spray whether a spray or even a second spray has been made with the nasal spray. A spray can be administered one-handed by the patient or a third person. The active agent is midazolam or a salt thereof.

1. Name of the design product: Nasal spray. 2. Use of the design product: This design product is used to directly spray medicine into the olfactory region of the nasal cavity. 3. Design key points of the design product: Lies in the shape. 4. Picture or photograph that best shows the design key points: Perspective view.

The present invention relates to the technical field of nasal spray, and provides a nasal spray head with adjustable liquid spray state, comprising: a pressing buckle cover, which comprises a cover body, a liquid drawing piece arranged on an inner side of the cover body, an insertion piece arranged on an outer side of the cover body, and a liquid-tight tube sleeved at the periphery of the insertion piece; a fixed piston, which comprises a piston body, wherein the piston body is constrainedly sleeved on the insertion piece, a bottom end of the piston body is in sealing fit with an inner circumferential wall of the liquid-tight tube, and a top end of the piston body is provided with a liquid outlet hole and a fluid-guiding insertion column which is provided with water outflow channels; and a spray head, which comprises a spray head body, wherein the spray head body is rotatably sleeved outside the liquid-tight tube, the top of the spray head body is provided with a liquid spray end in insertion fit with the fluid-guiding insertion column, and the liquid spray end is provided with an ejection hole, spray forming grooves, and jet flow forming grooves. The nasal spray head with adjustable liquid spray state of the present invention can be switched to a spray state or a jet flow state when a user rotates it to a preset angle according to his / her own needs, and has a simple structure with convenient operation.

The invention discloses an oyster enzymolysis ultrafiltration extract nasal spray and a preparation method thereof, the nasal spray comprises the following components: 5-10 wt% of oyster extract, 0.1-0.3 wt% of preservative, 0.05-0.15 wt% of sodium chloride and 0.1-0.3 wt% of emulsifier, the pH value is 5.5-6.5, the content of the preservative is 0.1-0.3 wt%, the content of the sodium chloride is 0.05-0.15 wt%, the content of the emulsifier is 0.1-0.3 wt%, and the balance is water. The preservative is one of benzalkonium chloride, sorbic acid and potassium sorbate, and the emulsifier is polysorbate 80. Through definite raw material composition, a step-by-step process and quality control, the bioavailability of active components is improved, the flavor of the product is optimized, the effect of safely and efficiently improving sleep is achieved, the problems of low bioavailability, poor flavor and potential safety hazards of an existing sleep improving product are solved, the process repeatability is high, and the preparation method is suitable for industrial production. The long-term use of people with chronic insomnia is facilitated.

The utility model discloses a precise injection mechanism for nasal cavity administration and a nasal spray device thereof. The precise injection mechanism comprises a stepping motor, a cam, a roller, a push rod spring, a push rod, a push rod shell, a piston rod spring, a piston rod and a medicine storage bin. The medicine storage bin is sealed through a piston, and the piston is connected with a piston rod spring and coaxially connected with a push rod. The contour surface of the cam is connected with the roller which is vertically connected with the center shaft of the push rod. By the adoption of the precise injection mechanism, the constant amount of liquid medicine can be delivered to the atomization device each time, precise dosage of medicine administration each time is achieved, and parallelism of medicine administration and safety of medicine administration are guaranteed.

Multi-route drug delivery device designed with two modular bodies. The first body houses batteries, heaters, vials containing extracts, formulations, diluents or cleaners, and the control unit. This unit features two or more peristaltic pumps that enable precise dosage control and ensure homogeneous mixing of substances. The pumps also incorporate purging and cleaning process cross-contamination. The second body is the administration unit, which can be fitted with interchangeable nozzles to different delivery methods. These options include an atomizer, nasal spray, or sublingual spray. By changing the dispenser nozzles, it can accommodate a wide range of delivery routes, including pulmonary, sublingual, nasal, and mucosal. Designed to meet the needs of patients, clinical trial participants, general users, and livestock.

A management system for medication includes an electronic case configured to support a user's medication and a computing device configured to communicate with the case. The case includes one or more sensors, such as a pressure sensor, to produce sensor information indicating whether the medication is disposed in the case, a battery sensor to indicate a charge level of the case, and, in some examples, a location sensor to indicate a location of the case. A controller obtains the sensor information and provides status information to the computing device. The computing device provides notifications based on the status information and, in some examples, automatically or semi-automatically initiates communications to designated emergency contacts in response to determining that medication has been removed from the case. The case can include light sources and a speaker controlled by the controller. An identifier, such as a near-field communication tag, can associate the case with a user. Status information can be shared with additional users (e.g., caregivers). The system is suitable for emergency medications such as epinephrine nasal spray.

The present invention discloses a nasal spray device for otolaryngology, which relates to the technical field of nasal spray, and comprises a shell, the inner wall of the shell is penetrated by a push rod and slidably connected, and one end of the push rod is fixedly connected to a connector, the connector is fixedly connected to a first tension spring on the side close to the push rod, the side wall of the shell is fixedly connected to a medicine storage cartridge, and the inner wall of the medicine storage cartridge is provided with a mounting groove, and the end of the first tension spring away from the connector is provided with an adjustment mechanism, so that the amount of medicine sprayed can be freely controlled before spraying, and an extrusion mechanism is provided inside the mounting groove, so that the components in the medicine liquid can be mixed more evenly when spraying. This nasal spray device for otolaryngology can ensure accurate drug administration, improve patient comfort and treatment effect, and achieve more flexible and precise drug application control by pressing the extrusion plate to adjust the slider and the limit ring, and combining the scale to accurately control the spray flow rate.

The invention relates to the technical field of medicines, and particularly discloses an application of 4-chloro-2, 5-dimethoxy-N-[(2-methoxyphenyl) methyl] phenylethylamine (25C-NBOMe) in preparation of a medicine for inhibiting addiction, and a preparation method of the 4-chloro-2, 5-dimethoxy-N-[(2-methoxyphenyl) methyl] phenylethylamine (25C-NBOMe). As a selective 5-HT2A receptor agonist, the compound can regulate a neural circuit from the prefrontal cortex to the marginal system and indirectly influence dopamine release, so that active drug foraging, relapse and preference behaviors of addicted individuals are inhibited. The invention further covers pharmaceutical salt forms and structural analogues of the compound and application of the compound in pharmaceutical compositions, and administration can be achieved through multiple dosage forms such as sustained-release implants and nasal spray. Compared with the existing drug for treating addiction, the invention has the advantages of independence, definite target spot, obvious curative effect, high safety and the like, is suitable for intervention of various addiction substances, and provides a new strategy for prevention and treatment of addiction behaviors.

The invention discloses an influenza virus nano vaccine as well as a preparation method and application thereof. The invention relates to the field of biomedicine, and provides an influenza virus nano vaccine, which comprises nano particles and an STING agonist adsorbed on the surfaces of the nano particles, the nanoparticle comprises a polysaccharide antigen conjugate and a dendritic macromolecule, wherein the polysaccharide antigen conjugate is formed by coupling beta-glucan and influenza virus antigen protein, and the dendritic macromolecule and the polysaccharide antigen conjugate are adsorbed together. The immune response induced by the vaccine is higher than that of monomer immunogen protein without the adjuvant, body fluid, cell and mucosa immune response can be remarkably activated, lethal attack of an organism to H1N1 and H5N1 viruses can be effectively protected through nasal spray inoculation, and the nano vaccine can stimulate cross immune response and immune protection effect to different subtype influenza viruses.

A coronavirus-targeting antibody nasal spray comprising: a coronavirus-targeting antibody or antigen-binding fragment, a buffer, a stabilizer, a surfactant, and a thickening agent, and optionally further comprising a preservative. The nasal spray can improve the physicochemical stability of the coronavirus-targeting antibody, and the nasal spray can maintain protein stability under conditions such as room temperature, long-term refrigeration, and repeated freeze-thawing, thereby improving the safety and effectiveness of clinical use.

Described are methods of treating neurodegenerative disease by administering a therapeutically effective amount of fenchol to a patient in need thereof. Additionally, described are methods of activating FFAR2 signaling in a patient by administering a therapeutically effective amount of fenchol to a patient in need thereof. Methods of treating gastrointestinal disorders in a patient being treated for cancer and methods of improving cognition in a patient being treated for cancer are also described. Further, the present disclosure provides for a pharmaceutical composition including fenchol and an Alzheimer's disease drug. Additionally, a nasal spray including fenchol, a buccal tablet including fenchol, and a dietary supplement including fenchol are described.

1. Name of the design product: nasal spray head (two spray modes). 2. Use of the design product: the design product is used for a spray head. 3. Design points of the design product: in shape. 4. Picture or photo best indicating the design points: perspective view.

The invention discloses an alprazolam nasal spray and a preparation method thereof, and provides the alprazolam nasal spray which is good in stability, small in irritation, convenient, quick to take effect and extremely small in side effect, so that the medication compliance of a patient and the convenience of clinical medication are improved, and the preparation process is simple to operate, safe, environment-friendly and suitable for industrial mass production.

This utility model discloses a pump head and a metering nasal spray device with the pump head, including a connecting cap for connection to a bottle body, and a pump assembly for metering liquid dispensing connected inside the connecting cap. The pump assembly includes a pump chamber, an upper pump rod disposed within the pump chamber, an inlet channel within the upper pump rod, an inlet on the outer wall of the upper pump rod communicating with the inlet channel, a limiting part on the outer wall of the upper pump rod, a piston movably sleeved on the upper pump rod, an upper pressure spring between the piston and the limiting part, a lower pump rod disposed below the piston, and a one-way valve mechanism at the inlet end of the pump chamber. The one-way valve mechanism includes a fixed seat and a pump ball disposed in the fixed seat, and a receiving groove on the fixed seat for accommodating the end of the upper pump rod. This utility model has a simple structure. By restricting the movement of the pump ball in a limited space through the fixed seat, the fixed seat can guide the upper pump rod to maintain axial movement, avoiding lateral swing, allowing the pump ball and pump chamber to seal and open quickly, resulting in a more stable and precise pumping volume.

This utility model discloses a child-protective nasal spray device with a safety lock function, including a push button, a nasal spray pump, and a medicine bottle. The upper wall of the nasal spray pump housing is installed inside the push button housing via an elastic component and a locking component. The lower wall of the nasal spray pump housing is installed on the mouth of the medicine bottle via an anti-opening component. The elastic component is an elastic protrusion on the inner wall of the push button housing, and the locking component is a transverse track on the outer surface of the upper wall of the nasal spray pump housing, with locking points on the transverse track. The anti-opening component includes a pawl on the lower wall of the nasal spray pump housing and a pawl on the mouth of the medicine bottle, with the two pawls interlocking. This device not only effectively prevents children from accidentally ingesting the medicine, improving safety, but also avoids the safety hazards caused by aluminum shavings in the crimping sealing method, simplifies the medicine filling process, and reduces production costs.

The invention discloses a nasal spray preparation containing a diketo dioxane compound and a preparation method thereof, and belongs to the technical field of medicines. The technical problem to be solved is to provide the nasal spray preparation containing the diketo dioxins, which is non-irritant and higher in cumulative transmittance. The key point of the technical scheme is as follows: the raw materials comprise an active component, a preservative, glycerol, an isotonic regulator, a humectant and a penetration enhancer, wherein the penetration enhancer is a diketodioxane compound.

A method using a nasal spray (1) comprising a reservoir (2) with two compressible walls, an outlet (4), and a metering device (6) fluidly connected to the reservoir (2) and the outlet (4). The method comprises: placing the nasal spray (1) in a first position where the reservoir (2) is above the metering device (6), such that liquid flows from the reservoir (2) to the metering device (6) by gravity; moving the nasal spray (1) from the first position to a second position where the reservoir (2) is below the metering device (6), such that the metering device (6) retains a dose (L1) of the liquid by capillary action and allows an excess amount (L2) of the liquid to flow back by gravity to the reservoir (2); compressing the two walls so as to cause the dose of liquid to be expelled through the outlet (4) and then out of the nasal spray (1). Figure for the abstract: Figure 3d

The present invention patent discloses a double-dose nasal spray device, including a nasal spray mechanism, a delivery mechanism and a medium reservoir. The nasal spray mechanism has a medium channel. The delivery mechanism is slidably assembled to the nasal spray mechanism. The medium reservoir is assembled to the delivery mechanism. The delivery mechanism is configured to perform two discharge strokes on the medium reservoir, so that the medium in the medium reservoir is sprayed into the nasal cavity through the medium channel twice. The delivery mechanism is provided with a first locking portion and a second locking portion along its sliding direction. The nasal spray mechanism is provided with a first receiving portion and a second receiving portion that are locked together. When the first locking portion and the first receiving portion are locked together, the first discharge stroke is completed, so that part of the medium in the medium reservoir is sprayed through the medium channel. When the second locking portion and the second receiving portion are locked together, the second discharge stroke is completed, so that the remaining medium in the medium reservoir is sprayed through the medium channel. This patent greatly improves the user experience of patients.