4 results about "Sublingual spray" patented technology

The present application relates to the field of food and medicine, and particularly relates to a vitamin D emulsion and a preparation method thereof. The vitamin D emulsion provided by the present application comprises vitamin D, an oil-phase solvent, an emulsifier, a stabilizer, an antioxidant, a preservative, water, and can further comprise a pH regulator and a flavoring agent. The vitamin D emulsion provided by the present application is of the O / W type, is easily soluble in water, has good stability, and has good palatability. The emulsion provided by the present application can be further prepared into oral liquid, drops, sublingual spray, etc., and can be used as health food, functional food or beverage, feed, etc., and has a wide application scenario.

The disclosure provides stable liquid non-aqueous epinephrine and epinephrine prodrug formulations, including non-aqueous liquid dipivefrin HCl formulations. The formulations are suitable for use as oral spray, oral film, liquid-filled capsules or buccal, lingual, or sublingual drop formulation. The oral spray, oral film and liquid-filled capsule can be placed on the tongue, under the tongue (sublingual) or in the buccal space. Preferably, the oral spray is a sublingual spray. The disclosure provides a method for systemic delivery of a therapeutically effective amount of epinephrine to a subject comprising orally administering a non-aqueous liquid formulation of an epinephrine prodrug, such as dipivefrin HCl to the subject. The disclosure also includes a method of treatment of a disease amenable to treatment by in vivo delivery of systemic epinephrine comprising administering the disclosed formulations. The disease can be a respiratory disorder, type I allergic reactions including anaphylaxis and urticaria, or the disease can be cancer or a microbial infection.

The disclosure provides stable liquid non-aqueous epinephrine and epinephrine prodrug formulations, including non-aqueous liquid dipivefrin HCl formulations. The formulations are suitable for use as oral spray, oral film, liquid-filled capsules or buccal, lingual, or sublingual drop formulation. The oral spray, oral film and liquid-filled capsule can be placed on the tongue, under the tongue (sublingual) or in the buccal space. Preferably, the oral spray is a sublingual spray. The disclosure provides a method for systemic delivery of a therapeutically effective amount of epinephrine to a subject comprising orally administering a non-aqueous liquid formulation of an epinephrine prodrug, such as dipivefrin HCl to the subject. The disclosure also includes a method of treatment of a disease amenable to treatment by in vivo delivery of systemic epinephrine comprising administering the disclosed formulations. The disease can be a respiratory disorder, type I allergic reactions including anaphylaxis and urticaria, or the disease can be cancer or a microbial infection.

This application relates to a sublingual spray formulation containing the active ingredients of Basang Pill and its preparation method, belonging to the field of pharmaceutical technology. The sublingual spray formulation containing the active ingredients of Basang Pill provided by this application includes the active ingredients, which consist of Basang Pill extract and a Western-style sleep-aiding ingredient, with a weight ratio of (20~1):2. The Western-style sleep-aiding ingredient is selected from one or more of melatonin, γ-aminobutyric acid, and L-theanine. The Basang Pill extract is obtained from a traditional Chinese medicine composition including Terminalia chebula, Terminalia chebula, Phyllanthus emblica, Polygonatum sibiricum, Asparagus cochinchinensis, Celery scabra, Tribulus terrestris, and Mirabilis jalapa. This application achieves a synergistic effect by scientifically combining the Basang Pill extract with the Western-style sleep-aiding ingredient, realizing a new use for an old drug and providing a solution for insomnia patients with rapid onset and high bioavailability.