The invention discloses a blind man guide method and a blind man guide system based on real-time road condition information optimization. The method comprises the steps of voice collection and analysis, route planning and design, real-time navigation information determination, timely navigation and broadcasting, and the like. The system comprises a storage module, a voice collection module, a voice data processing module, a positioning device module, a communication module, a route design determination algorithm module, a real-time navigation information determination module and an informationtransmitting and broadcasting module. The method and the system are stable and reliable, good in anti-interference performance and wide in application range, are capable of conveniently and timely guiding a blind man to travel in a complex environment, and have the advantages of being high in system intelligence, advanced and scientific in method, safe and accurate in travel route, and the like,thus greatly improving the freedom of movement of the blind man; the method and the system are practical and achievable, and have a higher practical value and a broad application prospect.