51 results about "Naloxone Hydrochloride" patented technology

The present invention is nasal cavity spray of Naloxine hydrochloride and its preparation process. The preparation of the present invention may be applied in single dosage form or multiple dosage form. The spray of the present invention includes Naloxine hydrochloride, osmotic pressure regulator, preservative, osmotic promoter and water.

The process of producing naloxone hydrochloride injection in new package includes the following steps: preparing naloxone hydrochloride injection intermediate; bacteria-free filtering the intermediate to obtain filtrate; bacteria-free packing the filtrate in Schering bottle; and sterilizing with flowing steam. While bacteria-free filtering, the insoluble particles in the medicine liquid are also eliminated, and this can greatly reduce the phlebitis attacking probability. The product is safe and reliable.

The invention relates to hydrochloric naloxone nose powder preparation and its preparation method, the invention also relates to the hydrochloric naloxone single dosage and multiple dosage administration nose powder preparation, which comprises hydrochloric naloxone and one or more selected from mannitol, glucose, and soluble starch, sodium chloride, microcrystalline cellulose and sodium carboxymethylcellulose as medicinal findings.

The invention discloses a preparator of a naloxone hydrochloride injection and a preparation method thereof. The preparation method comprises the steps that a certain amount of water for injection, sodium chloride and naloxone hydrochloride are added into an upper tank body of the preparator, nitrogen is introduced, mixing and stirring are performed to obtain a mixed solution, then edetate disodium is added to regulate a pH value, and the mixed solution is filtered by a first filter membrane in the middle of the preparator and delivered to a lower tank body; a certain amount of water for injection is added into the lower tank body, stirring is performed under the situation that nitrogen is introduced, and a hydrochloric acid solution is used for regulating the pH value; finally, visible foreign matter checking is performed after filtration of a second filter membrane at the lower portion of the lower tank body, nitrogen charging is performed for filling encapsulation after qualification, and sterilization is performed to obtain the sterilization. No auxiliary material is added, and the purity and use safety of the prepared injection are ensured. The preparation method is simple and easy to operate, and the preparation cost is effectively reduced. In addition, the invention provides the preparator of the naloxone hydrochloride injection. Device replacement in the preparation process of the naloxone hydrochloride injection is avoided, the drug quality is improved, and drug safety is ensured.

A nasal application system or composition of naloxone hydrochloride contains the naloxone hydrochloride or its free alkali or its other medicinal salts, absorption promoter, osmotic pressure regulator, antiseptic, and solvent or other medicinal auxiliaries. Its preparing process s also disclosed.

A naloxone hydrochloride pill is disclosed in the invention, which is formed by naloxone hydrochloride, naloxone free alkali or the other naloxone acceptable in medicine having a ratio by weight of 1:5~10000 with pharmaceutic edjuvant based on general pill preparation process. Active ingredient of the naloxone hydrochloride pill in the invention can directly participate intracorporeal circulation after absorbed by capillary tube under oral mucosa of a patient, thus has advantages of fast absorption and high bioavailability, additionally, suffering of intramuscular injection of the patient is prevented. In particular, the drugs of the invention can be taken with no requirement of use situation, so that it is convenient for taking the medicine which dosage is controllable and has little side effect.

The invention belongs to the technical field of medicines, relates to a pharmaceutical composition of a naloxone hydrochloride injection and a preparation method of pharmaceutical composition, and particularly relates to a pharmaceutical composition of a naloxone hydrochloride injection. The pharmaceutical composition comprises naloxone hydrochloride, and particularly comprises naloxone hydrochloride, saccharides, organic acid and injection water. The naloxone hydrochloride in the pharmaceutical composition is added to the composition in a form of 17-allyl-4,5alpha-epoxy-3,14-dihydroxy-pyran-6-methadone hydrochloride dehydrate; the saccharides are selected from one or more of the following components: mannitol, sorbitol, lactose, maltose, glycine, mycose, glucose and the like. The pharmaceutical composition disclosed by the invention can be used after opioid compound anaesthesia to resist respiratory depression caused by the medicine and prompt patients to revive, is used for respiratory depression caused by excessive opioids and complete or partial reversion of the opioids, is used for saving acute alcohol poisoning, and is used for diagnosing excessive acute opioids.

The invention belongs to the technical field of medicines, and particularly relates to a naloxone hydrochloride crystal form compound shown as formula (I). The X-ray powder diffraction pattern obtained by measuring the compound with Cu-Ka rays is shown in figure 1. The naloxone hydrochloride crystal form compound provided by the invention has improved stability; compared with the preparation in the prior art, the preparation prepared by adopting the naloxone hydrochloride crystal form compound disclosed by the invention has a better medicinal effect.

The invention belongs to the technical field of medicament synthesis, and relates to a synthetic method of naloxone hydrochloride. The method comprises the following steps: by adopting thebaine as a starting material, oxidizing and then reducing thebaine to obtain a compound 2, reacting the compound 2 with acetic anhydride to obtain an ester compound 3, then removing methyl and performing hydrolysis to obtain a compound 4, reacting the compound 4 with an alkylating reagent (such as the reagent selected from chloropropene, bromopropene, iodopropylene or the combination thereof), performing allylation on the Nth bit of a mother nucleus structure to obtain a compound 5, then removing methyl to obtain naloxone free alkali, then forming acid addition salts with hydrochloric acid, and then refining to obtain naloxone hydrochloride which can be used as a medicinal raw material medicament. By adopting the method disclosed by the invention, a high-quality medicinal raw material medicament can be prepared.