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Abuse potential low compound buprenorphin hydrochloride naloxone hydrochloride sublingual tablet

A buprenorphine hydrochloride and naloxone hydrochloride tongue technology is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc., to achieve low abuse potential, maintain effectiveness, and avoid abuse. and recreational use

Inactive Publication Date: 2007-04-11
岳振江
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by this invention is to overcome the deficiencies of the above-mentioned existing buprenorphine pharmaceutical preparations, and provide a kind of buprenorphine pharmaceutical preparations that cannot be utilized by drug addicts——compound buprenorphine hydrochloride hydrochloride with low abuse potential Naloxone sublingual tablet and preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] In order to better illustrate the present invention, the following examples are given. However, the scope of the present invention is not limited thereto, and the scope of protection is described in the claims.

[0029] formula

Example 1

Example 2

Example 3

Buprenorphine Hydrochloride

1.5

10

6.67

Naloxone Hydrochloride

0.25

5

1.67

filler

Xylitol

30

15

Mannitol

50

25

15

Sorbitol

28

15

lactose

20

32

internal adhesive,

disintegrant

Low-substituted hydroxypropyl cellulose

10

3

microcrystalline cellulose

5

2

Adhesive

Povidone K-30

4

2.5

Copovidone S-630

1.5

1.16

PH value adjuster,

flavoring agent

citrate

3

1

2

tartaric acid

0.5

1

...

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PUM

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Abstract

A buprenorphine hydrochloride / naloxone hydrochloride sublingual tablets with low misuse potential , said tablets contain medicinal contents of buprenorphine hydrochloride and naloxone hydrochloride, part by weight thereof is 2:1-6:1, 1) using alcohol to dissolve regulator corrigent and bond of PH of prescription amount for use; 2) grinding main medicine buprenorphine hydrochloride / naloxone hydrochloride, filler and lubricant and sifting out thereof; 3) mixing evenly the prescription amount of buprenorphine hydrochloride / naloxone hydrochloride, filler, bond and disintegrating agent, thereafter adding contents in step 1 to prepare into soft stuff, again making into pellet, drying, sorting out, adding lubricant again, mixing evenly and pressing into tablet.

Description

technical field [0001] The invention relates to a pharmaceutical preparation of buprenorphine hydrochloride and a preparation method thereof, in particular to a pharmaceutical preparation of buprenorphine hydrochloride which cannot be utilized by drug addicts—compound buprenorphine hydrochloride naloxone tongue with low abuse potential The next sheet and its preparation method. Background technique [0002] In recent years, with the reform and opening up, the number of people abusing heroin and other opioids in our country is also on the rise. The harm caused by the abuse of heroin and other opioids and dependence on heroin and other opioids poses a serious threat to the whole society and its public health. In order to curb the abuse of heroin and other opioid substances, while strengthening the crackdown on drug crimes, the state actively advocates the implementation of medical treatment for heroin and other opioid substance dependent persons. Drug ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K9/20A61K47/38A61P25/36
Inventor 徐进杨丽英滑千里赵学刚王英利杨彦肖王翠欣康海霞
Owner 岳振江
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