Abuse potential low compound buprenorphin hydrochloride naloxone hydrochloride sublingual tablet
A buprenorphine hydrochloride and naloxone hydrochloride tongue technology is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc., to achieve low abuse potential, maintain effectiveness, and avoid abuse. and recreational use
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[0028] In order to better illustrate the present invention, the following examples are given. However, the scope of the present invention is not limited thereto, and the scope of protection is described in the claims.
[0029] formula
Example 1
Example 2
Example 3
Buprenorphine Hydrochloride
1.5
10
6.67
Naloxone Hydrochloride
0.25
5
1.67
filler
Xylitol
30
15
Mannitol
50
25
15
Sorbitol
28
15
lactose
20
32
internal adhesive,
disintegrant
Low-substituted hydroxypropyl cellulose
10
3
microcrystalline cellulose
5
2
Adhesive
Povidone K-30
4
2.5
Copovidone S-630
1.5
1.16
PH value adjuster,
flavoring agent
citrate
3
1
2
tartaric acid
0.5
1
...
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