The invention discloses a sublingual tablet for anaesthesia. The preparation method of the sublingual tablet comprises the following steps: taking dexmedetomidinehydrochloride and ketamine hydrochloride as raw materials, adding a certain amount of a filling agent, a disintegrating agent, a corrigent, an adhesive and a lubricant, and performing pretreatment, mixing, granulatinganddrying, total blending, aluminum plastic inner packaging, outer packaging and the likeseparately. The sublingual tablet does not require building a special administrationchannel, is directly dosed through sublingual veins, avoids the liver first pass effect, takes effect quickly and is good in effect; particle angles of the sublingual tablet are all smaller than 35 DEG C duringpreparation, so that the particle mobility of the sublingual tablet is good, finished products is rapid to disintegrate and can be completelydisintegrated within 3 minutes, the weight difference of finished products is small, the increment of impurities is small during storage, the stability is good, the shelf life reaches 24 months, the preparation technology is simple and practical, and the sublingual tablet is worthy of market promotion.