Sildenafil citrate sublingual tablet and its preparation method

A technology of sildenafil citrate and sublingual lozenges, which is applied in the direction of pill delivery, drug combination, and active ingredients of heterocyclic compounds, which can solve the problems of increasing liver burden and damage, reducing bioavailability, and prone to adverse reactions and other issues, to achieve the effect of improving bioavailability, reducing intake, and no adverse reactions

Inactive Publication Date: 2007-10-24
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem that the existing sildenafil citrate is all oral tablets and capsules, and the content is relatively large, which increases the burden and damage of the liver, reduces bioavailability, and is prone to adverse reactions. question

Method used

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Examples

Experimental program
Comparison scheme
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specific Embodiment approach 1

[0013] Specific embodiment 1: The sildenafil citrate sublingual lozenges of this embodiment consist of 20-30 parts of sildenafil citrate, 45-65 parts of mannitol, and 65-105 parts of lactose in parts by weight. Sodium cyclamate 0.5~1.5 parts, the concentration is 15% PVP K30 It is made from 30-40 parts of ethanol solution and 4-8 parts of magnesium stearate. The preparation method of sildenafil citrate sublingual lozenges of this embodiment is as follows: 1. Take 20-30 parts of sildenafil citrate, 45-65 parts of mannitol, and 65-105 parts of lactose according to parts by weight. 、Sodium cyclamate 0.5~1.5 parts, the concentration is 15% PVP K30 30-40 parts of ethanol solution and 4-8 parts of magnesium stearate; 2. Crush the solid raw materials through a 110-130 mesh sieve; 3. Mix powders of sildenafil citrate, lactose and mannitol. Dry powder material; 4. Take the concentration of 45-55% of the total weight as 15% PVP K30 Ethanol solution, after the sodium cyclamate is dissolved i...

specific Embodiment approach 2

[0014] Specific embodiment 2: The sildenafil citrate sublingual lozenges of this embodiment consist of 21-29 parts of sildenafil citrate, 46-64 parts of mannitol, and 67-103 parts of lactose in parts by weight. 0.6~1.4 parts of sodium cyclamate, the concentration is 15% PVP K30 31 to 39 parts of ethanol and 4.5 to 7.5 parts of magnesium stearate. The other methods are the same as in the first embodiment.

specific Embodiment approach 3

[0015] Specific embodiment 3: The sildenafil citrate sublingual lozenges of this embodiment consist of 22-28 parts of sildenafil citrate, 48-61 parts of mannitol, and 69-100 parts of lactose in parts by weight. Sodium cyclamate 0.7~1.3 parts, the concentration is 15% PVP K30 It is made from 33 to 37 parts of ethanol solution and 5 to 7 parts of magnesium stearate. The other methods are the same as in the first embodiment.

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Abstract

The invention discloses an acidum citricum hypoglossal tablet and the preparing method, relating to a tablet and the preparation method. The invention means to solve problems: current acidum citricum are all oral tablets and capsule, the content is large and increases liver injury, and it is easy to generate adverse effect. The comprised component and their weight proportion are as follows: acidum citricum 20 -30 units, manna sugar 45-65 units, lactin 65-105 units, sweetener 0. 5-1. 5 units, ethanol solution with concentration being 5%PVPK30 30 -40 units and dolomol 4-8 units. The preparation method comprises following steps: sifting sot material with nylon screen of 18-20 order to produce particular, drying at 55-65 Deg. C; sifting granular with screen of 14-16 order and placing for 5-7 hours for sheeting. The tablet is characterized by small content, increased biological utilization rate, low adverse effect rate, and the method is characterized by short and simple process.

Description

Technical field [0001] The invention relates to a pharmaceutical buccal preparation and a method for preparing the buccal preparation. Background technique [0002] With the increasingly intensified social competition and the increasingly serious environmental pollution, the incidence of male erectile dysfunction is on the rise. Sildenafil citrate (Sildenafil; trade name Viagra, Viagra) is the first oral preparation approved by the FDA for the treatment of erectile dysfunction. During sexual stimulation, the nerves and endothelial cells of the sponge body of the penis release nitric oxide (NO), and NO activates guanylate cyclase (guanylatecyclase) to produce cyclic guanylate (aGMP), which leads to arterioles, arterioles and penile seas. The smooth muscle cells in the sinusoids of the cotton body relax, and the erectile tissues are congested and erect. AGMP is generally degraded by phosphodiesterase, and the content of phosphodiesterase-5 (PDE-5) in the genitals is higher. Patient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K9/20A61P15/10
Inventor 邹积宏刘红梅
Owner HEILONGJIANG UNIV
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