Sublingual tablet of natural hirudin

A technology of natural hirudin and sublingual tablet, which is applied in the directions of medical preparations containing active ingredients, pill delivery, metabolic diseases, etc. Film research reports, sabotage, etc.

Inactive Publication Date: 2006-10-04
周维海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as Chinese patent application number is 200410041302.X, publication number is 1593656A disclosed natural hirudin compound medicinal health product, it mainly is that natural hirudin is added certain auxiliaries to make tablet, capsule, powder or oral liquid supply It is used for oral administration, but studies have shown that after oral administration, hirudin enters the gastrointestinal tract and is easily destroyed by digestive enzymes secreted in the body, such as pepsin, which significantly reduces or loses its biological activity, thereby affecting the medicinal effect of natural hirudin
[0006] So far, there is no research report on sublingual lozenges containing natural hirudin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Recipe: Freeze-dried natural hirudin powder (containing natural hirudin 20000AT-U / g) 0.3g

[0046] Mannitol 299.7g

[0047] Preparation method: After fully stirring hirudin freeze-dried powder and mannitol and mixing evenly, adopt conventional wet granulation method to prepare 1000 sublingual buccal tablets, 0.3 g per tablet (containing natural hirudin 6AT-U).

Embodiment 2

[0049] Formula: natural hirudin freeze-dried powder (containing natural hirudin 20000AT-U / g) 599.4g

[0050] Mannitol 0.6g

[0051] Preparation method: After fully stirring hirudin freeze-dried powder and mannitol and mixing evenly, adopt direct compression method to prepare 2000 sublingual buccal tablets, 0.3 g per tablet (containing natural hirudin 5994AT-U).

Embodiment 3

[0053] Recipe: Freeze-dried natural hirudin powder (containing natural hirudin 5000AT-U / g) 10.0g

[0054]Mannitol 71.5g

[0055] Sodium carboxymethyl starch 5.5g

[0056] Magnesium Stearate 1.0g

[0057] Micronized silica gel 2.0g

[0058] Microcrystalline Cellulose 10.0g

[0059] Preparation method: After the above-mentioned raw materials are fully stirred and mixed evenly, 250 sublingual buccal tablets are prepared by direct compression method, each tablet contains 0.4 g (containing natural hirudin 200AT-U).

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Abstract

Disclosed is a natural hirudin lozenge, which comprises natural hirudin and water-soluble bulking agent, each tablet of contains natural hirudin 5-6000 international units. The lozenge has good effect in treating and preventing cardiovascular and cerebrovascular diseases such as hypertension, hyperlipoidemia, apoplexy and sequelae.

Description

technical field [0001] The invention relates to a medicinal preparation, in particular to a sublingual lozenge capable of preventing and treating human cardiovascular and cerebrovascular diseases. Background technique [0002] Leeches, commonly known as leeches, are the general term for leech animals. It is a traditional and precious Chinese medicinal material in my country. It has the functions of promoting blood circulation and removing blood stasis, dredging menstrual flow and dispelling stagnation. embolism. [0003] Modern scientific research has shown that the salivary glands of all blood-sucking leeches (including blood-sucking leeches of the phylum Annelida, class Hirudophylum, Hirudophaera, and family Hirudidae, such as Hirudo philippines, Hirudo japonica, Hirudo hainanensis, etc.) and their salivary glands The secreted saliva contains various bioactive components such as hirudin, hyaluronidase, prostaglandin, vasodilator and fibrinol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K38/58A61K9/20A61P7/02A61P7/04A61P3/06A61P29/00
Inventor 周维海
Owner 周维海
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