Sublingual tablet of natural hirudin
A technology of natural hirudin and sublingual tablet, which is applied in the directions of medical preparations containing active ingredients, pill delivery, metabolic diseases, etc. Film research reports, sabotage, etc.
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Embodiment 1
[0045] Recipe: Freeze-dried natural hirudin powder (containing natural hirudin 20000AT-U / g) 0.3g
[0046] Mannitol 299.7g
[0047] Preparation method: After fully stirring hirudin freeze-dried powder and mannitol and mixing evenly, adopt conventional wet granulation method to prepare 1000 sublingual buccal tablets, 0.3 g per tablet (containing natural hirudin 6AT-U).
Embodiment 2
[0049] Formula: natural hirudin freeze-dried powder (containing natural hirudin 20000AT-U / g) 599.4g
[0050] Mannitol 0.6g
[0051] Preparation method: After fully stirring hirudin freeze-dried powder and mannitol and mixing evenly, adopt direct compression method to prepare 2000 sublingual buccal tablets, 0.3 g per tablet (containing natural hirudin 5994AT-U).
Embodiment 3
[0053] Recipe: Freeze-dried natural hirudin powder (containing natural hirudin 5000AT-U / g) 10.0g
[0054]Mannitol 71.5g
[0055] Sodium carboxymethyl starch 5.5g
[0056] Magnesium Stearate 1.0g
[0057] Micronized silica gel 2.0g
[0058] Microcrystalline Cellulose 10.0g
[0059] Preparation method: After the above-mentioned raw materials are fully stirred and mixed evenly, 250 sublingual buccal tablets are prepared by direct compression method, each tablet contains 0.4 g (containing natural hirudin 200AT-U).
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