188results about How to "Short curative effect" patented technology

The invention relates to a traditional Chinese medicine biological agent for improving immunity of livestock and a preparation method thereof; the traditional Chinese medicine biological agent is prepared by combining traditional Chinese medicine formulas and modern microbiological technology; the biological agent adopts folium cortex eucommiae, grifola frondosa, astragalus root and herba epimedii, which belong to traditional Chinese medicines, as raw materials; bran, bean pulp, ammonium sulfate, magnesium sulfate, calcium carbonate and water are added in the raw materials after the raw materials are crushed, so as to form fermentation medium, strain nutrient solution with a certain proportion is added in the fermentation medium for fermentation, the mature solid fermentation broth is added in alcohol for extraction, separation, filtration, concentration, so as to prepare various dosage forms. The traditional Chinese medicine biological agent prepared by microbial fermentation metabolism can remarkably improve the immunity of livestock organisms, enhance the immunity of the organisms, improves the production performance of the livestock and effectively prevent immunity inhibitive diseases.

The invention discloses a traditional Chinese biological preparation for preventing and treating livestock diarrhea and a preparation method thereof. The traditional Chinese biological preparation isprepared by combining a traditional prescription and a modern microbiological transformation technology, utilizing the strong transformation capacity of microorganism and fermenting and metabolizing the traditional Chinese pulsatilla root. The preparation method comprises the following steps: crushing the Chinese pulsatilla root; adding bran, glucose, urea, inorganic salt and water as a fermentation medium; adjusting the pH value; adding a strain culture liquid with a certain proportion for fermenting after sterilization; adding ethanol into matured solid leavening for lixiviating, separating,filtering, concentrating and preparing various preparations. The traditional Chinese biological preparation is prepared by the Chinese pulsatilla root after being fermented and metabolized by yeast,and has greatly superior treatment effect to Chinese pulsatilla root medicinal powder and decoctum thereof for the livestock diarrhea.

The black-bone chicken white phoenix medicine preparation has the functions of invigorating vital energy, nourishing blood, normalize menstruation and arresting bleeding, and is used to treat vital energy and blood deficiency, debility, sourness of waist and legs, dysmenorrhea, and metrorrhagia. It is prepared with black-bone chicken, red sage, oyster, deglued antler powder, astragalus root and other 15 kinds of Chinese medicinal materials and through macroporous resin separation, enzymolysis and other process. It is prepared into concentrated pill, micro pill, granule, tablet, ointment, syrup, mixture, dripping pill or capsule. It has controlled effective component content, raised biological utilization, ensured curative effect and small dosage.

The invention discloses a compound shown as a formula I or pharmaceutically acceptable salt thereof. In the formula I, R1, R2, R3, R4, R5 and n are defined as the specification. The invention also discloses a preparation method for the compound of the formula I, a composition containing the compound and application of the compound. The compound of the formula I is stable in vitro, has good dissolubility in a pharmaceutically applied organic solvent, and has good bioavailability in the body of an animal. Meanwhile, the invention discloses the preparation method for the compound of the formula I and the application of the compound of the formula I in preparation of medicaments for regulating blood fat and preventing and treating biliary calculus.

The invention provides a traditional Chinese medicine composition for treating colpitis mycotica, wherein the oral medicines are: 10-20 parts of viscum album, 10-20 parts of angelica, 10-20 of bighead atractylodes rhizome, 10-20 parts of motherwort, 10-20 of astragalus root, 10-20 parts of fructus zizyphi sativae, 10-20 parts of semen cuscutae, 10-20 parts of fruit of glossy privet, 10-20 of mulberry, 10-20 parts of rhizoma anemarrhenae, 10-20 of fructus rubi, 10-20 parts of Chinese magnoliavine fruit, 10-20 parts of scutellaria baicalensis, and 10-20 parts of patrinia; the external medicines are: 10-30 parts of root of Chinese pulsatilla, 10-30 parts of golden cypress, 10-30 parts of radix sophorae flavescentis, 10-30 parts of fructus cnidii, 10-30 parts of cortex dictamni, 10-30 parts of folium artemisiae argyi, 10-30 parts of clove, 10-30 parts of Chinese prickly ash, 10-30 parts of smoked plum, 10-30 parts of rhizoma smilacis glabrae, 10-30 parts of borneol, 10-30 parts of herba, and 10-30 parts of mint. The composition has fast effects of relieving itching, killing insect and degerming, strongly diminishes inflammation antibiotic property, and is high in bacteriostasis ratio, convenient for administration, easy for manufacturing and low in cost.

The invention discloses a traditional Chinese medicine composition for treating senile vaginitis; the oral medicine includes: herba epimedii, angelica sinensis, rhizoma atractylodis macrocephalae, motherwort, astragalus mongholicus, peach kernel, cuscuta chinensis, fructus ligustri lucidi, mulberry, radix polygonum multiflorum, eclipta alba, raspberry, scutellaria baicalensis, dogwood, cape jasmine and ligusticum wallichii; and the external medicine includes: myrrh, radix sophorae flavescentis, fructus cnidii, oldenlandia diffusa, Chinese violet, radix stemonae, sargent gloryvine, patrinia, golden cypress, safflower, fructus kochiae, pearl and motherwort. The traditional Chinese medicine composition in the invention has androgen-like action and estrogen-like action, and can enhance resistance of senile vagina and urethra mucosa; the contained polysaccharide and general flavone components further have antioxidant and anti-aging effects. The traditional Chinese medicine composition further has the effects of clearing heat and detoxicating, killing parasites to relieve itching, and can be used for treating the senile vaginitis and relieving symptoms such as itching, and can diminish inflammation and disinfect; and the traditional Chinese medicine composition is obvious in medical effect, safe in administration, simple and good in compliance of old patients.

The invention discloses a novel near-infrared two-zone organic small-molecule fluorescent probe and includes a concrete structure, a preparation and application. The main component of the novel near-infrared two-zone organic small-molecule fluorescent probe is a diketopyrrolopyrrole (DPP) derivative; and nano-particles with good water solubility, biocompatibility and targeting are prepared furtherwith a nanometer coprecipitation method, have excellent near-infrared two-zone fluorescence imaging and photoacoustic imaging abilities as well as photodynamic and photothermal conversion propertiesand can be used for tumor targeted photothermal and photodynamic combination therapy under the guidance of near-infrared two-zone fluorescence imaging, photoacoustic imaging, so that the therapeutic effect is remarkably improved; in addition, based on photodynamics therapy (PDT) and photothermal therapy (PTT), the toxic and side effects and the tumor drug resistance to normal tissues can be prevented and lowered; and the novel near-infrared two-zone organic small-molecule fluorescent probe is excellent in imaging effect, small in toxic and side effects and remarkable in curative effect and hasa relatively good clinical application prospect as a novel imaging probe and a tumor targeted combination therapy reagent.

The present invention relates to a compound medicine for preventing and curing angiocardiopathy and cerebrovascular disease, belonging to the field of chemical medicine. It is characterized by that said compound medicine includes sexual hormones medicine, lipid-reducing medicine, hypotenser, hypoglycemic medicine and anticoagulant medicine. Said compound medicine can be made into various dosage forms. Besides, said compound medicine also can be used for curing the diseases of climacteric syndrome, osteoporosis, endometrial carcinoma, diabetes and metabolic syndrome, etc.

The invention relates to a Chinese preparation for treating skin diseases and process for preparation, wherein the medicament is prepared from the following constituents (by weight proportions): Chinese angelica root, astragalus root, notoginseng, corktree bark, ledebouriella root, dahurian angelica root, rhubarb horsetails, pubescent angelica root, licorice root, baikal skullcap root, flavescent sophora root, garden burnet root, curcuma longa, goldthread root, dipsacus root, root of red rooted saliva and panicled swallowwort root by the ratio of 9-32 : 9-40 : 5-15 : 10-40 : 3-25 : 10-40 : 9-40 : 10-35 : 5-10 : 10-40 : 10-40 : 9-40 : 6-25 : 3-15 : 9-40 : 15-50 : 6-30.

The invention discloses a substituted arone derivate, an aryloxy-phenoxy, and a carboxylic acids compound formed by the derivates of the aryloxy-phenoxy. The compound shows a good effect in pharmacological research, can reduce cholesterol, low-density lipoprotein and triglyceride in the blood at the same time, and has obvious advantages on efficacy. The conventional p-hydroxyacetophenone or aryloxy-phenoxy compound has no capacity of reducing the three components at the same time and nearly plays no effect to the p-hydroxyacetophenone and triglyceride; and the aryloxy-phenoxy compound does not work well with respect to the cholesterol and the low-density lipoprotein. The compound with a dosage of 80mg/kg has the capacity of reducing the cholesterol and the low-density lipoprotein similar to the capacity of the p-hydroxyacetophenone with the dosage of 150mg/kg.

The invention provides a preparation method of stomachic pill with cyperus and amomum, including following steps: banksian rose, amomum fruit, astraolylis lancea formalyrata, dried old orange peel, tuckahoe, pinellia(processed), autgrass galingale rhizome(processed with vinegar), fruit of immature citron(sauted), round cardamom(decladded), bark of official magnolia( baked with ginger),patchouli and liquorice are respectively pulverized and mixed at first, then through the steps such as adding adhesive, granulating, drying, finishing granule, pelleting and lagging cover orderly, the product can be obtained; the adhesive is decoction solution of ginger and jujube. The preparation method has the advantages of simple technology and convenient operation, moreover, the finished product has steady quality, and compared with the former stomachic pill with cyperus and amomum, the stomachic pill with cyperus and amomum can shorten dissolving time by over 70 to 90 percent, thereby the medicine can be absorbed faster, and the contents of magnolol and honokiol are higher, thus solving the problem of nonuniform size of the pellet prepared by the water-pill method, and the dosage of the medicine can be more exact; at the same time, the invention also increases rate of finished products at one time.

The invention discloses cancer diffusion transfer therapeutic equipment which ingrates a targeted function restoration therapy with a therapy chemoradiotherapy and prevents and cures the diffusion transfer of a cancer. The cancer diffusion transfer therapeutic equipment is advanced therapeutic technology integrally formed by a direct current low-medium frequency multifunctional rubbing head, lasers, ultrasonic waves, microwaves, radio frequencies, medicine external application injection intervention in a symmetrically combined mode, and is used for conducting a therapy of function restoration of a diseased region and prevention of diffusion transfer of cancer cells through the symmetrical combination of medicine massage, electrical stimulation, deep layer heating, medicine injection and anti-cancer drugs. According to the 'principle scheme of disease generation and development' in an explanatory memorandum, the cancer diffusion transfer therapeutic equipment aims at the fact that the reasons for generation of cancer diffusion transfer are function degradation and structural pathological changes of system levels of a human body, enables a recovery system level function therapy and a system level structural anti-damage therapy in which the chemoradiotherapy operation is used for killing the cancer cells to be combined in a symmetrical, equivalent, and mutually promoting mode to form an integrated therapeutic method aimed at the reasons, and therefore achieves the targets of controlling and eliminating the cancer diffusion transfer.

The invention relates to a Chinese herbal medicine compound preparation for treating skin and mucous membrane disease. The Chinese herbal medicine compound preparation is prepared from the following raw materials: cortex moutan, polygonum chinense, radix salviae miltiorrhizae, herba lycopi, common dayflower herb, rhizoma smilacis glabrae, ramulus cinnamomi, caulis dendrobii officinalis, gorgon fruit and cortex cinnamomi; the ingredient of the Chinese herbal medicine compound preparation comprises a cortex moutan extract, a polygonum chinense extract, a radix salviae miltiorrhizae extract, a herba lycopi extract, a common dayflower herb extract, a rhizoma smilacis glabrae extract, a ramulus cinnamomi extract, a caulis dendrobii officinalis extract, a gorgon fruit extract and a cortex cinnamomi extract; and the effective ingredient of the cortex moutan extract is paeonol, the effective ingredient of the polygonum chinense extract is quercitrin, the effective ingredient of the radix salviae miltiorrhizae extract is tanshinone IIA, the effective ingredient of herba lycopi is ursolic acid, the effective ingredient of common dayflower herb is commelinin, the effective ingredient of rhizoma smilacis glabrae is astilbin, the effective ingredient of ramulus cinnamomi is cinnamaldehyde, the effective ingredient of caulis dendrobii officinalis is erianin, the effective ingredient of gorgon fruit is cyclo(profilum), and the effective ingredient of cortex cinnamomi is cinnamaldehyde.

The invention discloses an application of d-borneol serving as an antitumor drug sensitizer. According to the application of d-borneol serving as the antitumor drug sensitizer, d-borneol serving as the antitumor drug sensitizer is used for assisting in antitumor drugs. The inventor discovers that after the concentration of d-borneol which has no remarkable growth influence on cells is increased, the sensitivity of non-resistant cells to antitumor chemical drugs is greatly improved, that is, the concentration of the antitumor chemical drugs for killing tumor cells can be reduced on the basis of addition of d-borneol, the curative effect is not reduced, toxic and side effects of the chemical drugs are reduced along with reduction of the concentration of the chemical drugs, and normal cells of people are protected. D-borneol has low toxicity for normal cells of people and does not have remarkable influence basically, and accordingly, d-borneol is a potential high-efficient low-toxicity chemical drug sensitizer.

A compound medicine for preventing and treating the cardiovascular and cerebrovascular diseases of climacteric woman and adult man, climacteric syndrome, osteoporosis, endometrial carcinoma, senile dementia, diabetes and metabolism syndrome contains sexual hormones, hypolipemic component, antihypertensive component and anticoagulating component. It features that the ratio of its components is adjustable according to actual disease.

The invention provides a compound traditional Chinese medicine composition capable of inhibiting colorectal liver metastases. The compound traditional Chinese medicine composition is prepared from the following components in parts by weight: 15 to 30 parts of prepared radix astragali seu hedysari, 15 to 30 parts of fried radix codonopsis, 10 to 20 parts of fried bighead atractylodes rhizome, 15 to 30 parts of poria cocos, 15 to 30 parts of rhizoma dioscoreae, 5 to 10 parts of prepared liquorice root, 10 to 20 parts of prepared fructus mume, 10 to 20 parts of rhizoma sparganii, 10 to 20 parts of curcuma zedoary, 15 to 30 parts of herba agrimoniae and 15 to 30 parts of herba patriniae. The invention further discloses a preparation method of the compound traditional Chinese medicine composition and application of the compound traditional Chinese medicine composition to preparation of medicines for treating the colorectal liver metastases.

The invention discloses application of a compound traditional Chinese medicine to prevention and treatment of an osteoporosis disease, belonging to new application of the traditional Chinese medicine. The compound traditional Chinese medicine is prepared from the following Chinese medicinal herbs in percentage by weight: 15-35 percent of glossy privet fruit, 10-25 percent of Japanese thistle herbor root, 5-20 percent of largehead atractylodes rhizome, 5-20 percent of root of red-rooted salvia, 5-15 percent of coptis root, 5-15 percent of pseudo-ginseng root, 5-15 percent of eucommia and 5-15percent of fingered citron. As proved by an experiment, the compound traditional Chinese medicine has remarkable treatment effects on the prevention and treatment of primary osteoporosis, secondary osteoporosis, osteoporosis caused by hyperlipidaemia or an osteoporosis disease caused by glucose metabolism syndrome, definite clinical curative effect and no remarkable side effect according to observation.

The invention relates to a novel 16,17-ketal intermediate for preparing ciclesonide, which discloses a compound of formula (III), a method for synthesizing the compound of formula (III) from a compound of formula (I), and a method for synthesizing ciclesonide from the compound of formula (III).

The invention relates to the technical field of medicine, and specifically relates to benzene sulfonamide derivatives in different substitution types, wherein the derivatives are represented by the formula (A), and the definitions of each group are listed in the description. The derivatives have an excellent performance on inhibiting the activity of PI3K kinase, and moreover have high antitumor activities on tumors such as human lung cancer, human colon cancer, human liver cancer, human breast cancer, and the like. So the derivatives can be used to prepare target antitumor drugs having the advantages of high efficiency, low toxicity, and strong specificity, and thus the derivatives have very good development values. The invention further relates to a composition composed of the derivatives, a preparation method thereof, and applications of the composition in preparation of antitumor drugs.

The invention relates to a rheumatism pain relief medicine for treating rheumatic arthritis and rheumatoid arthritis and a preparation method thereof. The preparation method comprises the following steps: (1) respectively distilling rhizoma atractylodis, radix clematidis, turmeric, radix angelicae pubescentis and notopterygium root, and extracting volatile oil; (2) adding water into the decoction dregs of the rhizoma atractylodis and radix clematidis and red flower for decocting and extracting; (3) adding water into the decoction dregs of the turmeric, radix angelicae pubescentis and notopterygium root, golden cypress and Caulis Spatholobi for decocting and extracting; (4) extracting the decoction dregs by using ethanol; (5) adding the filtrates in the step (2) and the step (3) into the distilled aqueous solution in the step (1), and concentrating into extract for later use; (6) adding apiary and the fried frankincense into ethanol for extracting, and concentrating into thick paste; and (7) grinding nine raw material medicines such as Bungarus Parvus, long-noded pit viper, zaocys dhumnade, ground beeltle, fried myrrh, scorpio, centipede, earthworm and cassia twig, and screening for later use; merging the thick paste obtained in the steps (4), (5) and (6), performing dry mixing on the raw medicine powder in the step (7), wetting the extract, uniformly mixing, preparing granules, spraying the volatile oil, moistening and performing split charging. The method has the characteristic that the extraction rate of active ingredients is increased.

The invention discloses a pharmaceutical composition containing tropisetron compound and a preparation method thereof. The pharmaceutical composition comprises the following ingredients in parts by weight: 1 part of tropisetron or pharmaceutical salt, 30-55 parts of mannitol, 8.2-13.1 parts of citric acid and 6.9-11.8 parts of sodium citrate. The pharmaceutical composition containing tropisetron compound provided by the invention is easy to form freeze-dried injections in preparation and has good stability and high safety after re-dissolution.

The invention discloses a production method and a donkey-hide gelatin of a Chinese herbal donkey-hide gelatin material, which belong to the deep development of rare herbal donkey-hide gelatins, the technology for replacing materials of the rare herbal donkey-hide gelatins and relevant products of the rare herbal donkey-hide gelatins in the sustainable utilization field of Chinese herbal resources. According to the method, any one or multiple or all of litsea cubeba oil, lucid ganoderma, mushroom, hericium erinaceus, trametes robiniophila Murr, poria cocos, polyporus umbellatus, rainbow conk, marasmius androsaceus, armillaria mellea, false armillaria mellea, cordyceps sinensis, cordyceps militaris, tremella fuciformis, flammulina velutipes, edible fungus, grifola frondosa, gloeostereum incarnatum, schizophyllum commune, fomitopsis pinicola, cordyceps cephalosporium, paecilomyces hepialid, cordyceps gunnii penicillium, litsea cubeba, bamboo fungus, phellinus igniarius and edible fungus are added into water for peel soaking, peel removing, peel cutting, peel washing, complete peel removing and gelatin juice extraction during the production process of the Chinese herbal gelatin. The method has the most obvious characteristic that the problems that the donkey-hide gelatin material is deficient, the putrefactive odor is dispersive by the donkey-hide gelatin material during the production of the donkey-hide gelatin and the finished donkey-hide gelatin product is poor in taste are solved.

The present invention relates to medicine, and is medicine for regulating blood fat and its preparation process. The medicine for regulating blood fat is prepared with rhubarb, cassia seed, red sage, dried orange peel, ginseng and tuckahoe in certain proportion. The preparation process includes the following steps: crushing dried orange peel, ginseng and tuckahoe into fine powder; cutting rhubarb, cassia seed, red sage into sections, extracting with alcohol, filtering and concentrating filtrate while recovering alcohol. Long clinical test shows that the medicine has obvious curative effect on hyperlipemia and coronary heart disease.