The invention discloses a portable foldable-type peritoneal dialysis pipeline-connecting and liquid-changing clean operating box, which comprises an operating box body and a sterilization lamp, wherein the operating box body comprises a front end face, a back end face, an upper end face, a lower end face, a left end face and a right end face; the front end face, the back end face, the upper end face and the lower end face are respectively provided with a metal framework; a fold portion is respectively formed on the clearance between the front end face periphery and the lower end face periphery, the clearance between the lower end face periphery and the back end face periphery, and the clearance between the back end face periphery and the upper end face periphery; the left end face and the right end face are respectively provided with operating windows; each of the operating windows is respectively contained with a seal protective sleeve; a notch that can be opened and closed is formed on the clearance between the upper end face periphery and the front end face periphery; a side corner at the upper anterior of the left end face is provided with an insertion hole A; a side corner at the upper anterior of the right end face is provided with an insertion hole B; and the insertion hole B and the insertion hole A are respectively communicated with the notch. The operating box provided herein has the advantages of simple operation, small volume, good foldability, convenient carry, and strong practicality.