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Compound medicine for preventing and treating cardio vascular cerebral vascular disease and its application

A cardiovascular and cerebrovascular disease and compound technology, applied in the field of chemical drugs, can solve problems such as incompetent prevention and treatment of cardiovascular and cerebrovascular diseases, and achieve the effects of preventing cardiovascular and cerebrovascular events, ensuring curative effect, and reducing dosage.

Inactive Publication Date: 2006-08-30
张士东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because any single drug is not up to the task of preventing and treating complex cardiovascular and cerebrovascular diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0004] Example 1: This compound medicine is composed of 0.5 mg of 17β estradiol, 0.3 mg of medroxyprogesterone, 2.5 mg of simvastatin, 2.0 mg of metoprolol, 0.5 mg of amlodipine, and 75 mg of aspirin. Preparations, according to oral preparations (common tablets, dispersible tablets, film-coated tablets, sublingual tablets, orally disintegrating tablets, enteric-coated tablets, sustained-release tablets, immediate-release tablets, controlled-release tablets, hard capsules, enteric-coated capsules, Sustained-release capsules, etc.) preparation process is carried out. For early menopausal women. Control blood pressure, blood lipids, and blood sugar in an ideal state (blood pressure: 115 / 70mmHg; LDL_C: 1.0mmol / l; blood sugar: <6.0mmol / l). Control metabolic syndrome, monitor sex hormone levels.

Embodiment 2

[0005] Example 2: This compound medicine consists of 0.5 mg of 17β estradiol, 0.3 mg of medroxyprogesterone, 5 mg of simvastatin, and 2.0 mg of metoprolol 2 , amlodipine 0.5mg, aspirin 100mg to make combination preparations, according to oral preparations (common tablets, dispersible tablets, film-coated tablets, sublingual tablets, orally disintegrating tablets, enteric-coated tablets, sustained-release tablets, Immediate-release tablets, controlled-release tablets, hard capsules, enteric-coated capsules, sustained-release capsules, etc.) preparation process is carried out. For late menopausal women. Control blood pressure, blood lipids, and blood sugar in an ideal state (blood pressure: 115 / 70mmHg; LDL_C: 1.0mmol / l; blood sugar: <6.0mmol / l). Control metabolic syndrome, monitor sex hormone levels.

Embodiment 3

[0006] Example 3: The compound medicine is made of 300 mg of soybean isoflavones and / or 0.05 mg of 17β estrogen, 2.5 mg of simvastatin, 2.0 mg of metoprolol, 0.5 mg of amlodipine, and 40 mg of aspirin. , according to oral preparations (common tablets, dispersible tablets, film-coated tablets, sublingual tablets, orally disintegrating tablets, enteric-coated tablets, sustained-release tablets, immediate-release tablets, controlled-release tablets, hard capsules, enteric-coated capsules, sustained-release tablets, Release capsules, etc.) preparation process is carried out. For adult male high-risk groups. Control blood pressure, blood lipids, and blood sugar in an ideal state (blood pressure: 115 / 70mmHg; LDL_C: 1.0mmol / l; blood sugar: <6.0mmol / l). Control metabolic syndrome, monitor sex hormone levels.

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PUM

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Abstract

A compound medicine for preventing and treating the cardiovascular and cerebrovascular diseases of climacteric woman and adult man, climacteric syndrome, osteoporosis, endometrial carcinoma, senile dementia, diabetes and metabolism syndrome contains sexual hormones, hypolipemic component, antihypertensive component and anticoagulating component. It features that the ratio of its components is adjustable according to actual disease.

Description

technical field [0001] A compound medicine for preventing and treating cardiovascular and cerebrovascular diseases. It belongs to the field of chemical medicine. Background technique [0002] 1. Cardiovascular and cerebrovascular diseases are the number one killer threatening human health. The morbidity rate is the highest, the mortality rate is the highest, and it is still showing a growing trend. Therefore, it is an urgent task and a social responsibility to find new ideal drugs and therapies, and to control and prevent the development of diseases. 2. Before menopause, the incidence of cardiovascular and cerebrovascular diseases is very low in women, but after menopause, the incidence and mortality are the same as men. At present, it is believed that it may be related to female hormones. 3. A large number of animal experiments and clinical observations show that sex hormones, especially estrogen, can reduce the damage of inflammatory factors to blood vessels, protect d...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/56A61K9/20A61K9/48A61P15/12A61P15/00A61P9/00A61P3/10A61P3/00A61P35/00
Inventor 吴立群张士东熊世钢李爱民吴立范
Owner 张士东
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